LOCUS       NM_001191895            6343 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus alpha-kinase 3 (Alpk3), mRNA.
ACCESSION   NM_001191895 XM_344916
VERSION     NM_001191895.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6343)
  AUTHORS   Van Sligtenhorst,I., Ding,Z.M., Shi,Z.Z., Read,R.W., Hansen,G. and
            Vogel,P.
  TITLE     Cardiomyopathy in alpha-kinase 3 (ALPK3)-deficient mice
  JOURNAL   Vet Pathol 49 (1), 131-141 (2012)
   PUBMED   21441111
REFERENCE   2  (bases 1 to 6343)
  AUTHORS   Hosoda,T., Monzen,K., Hiroi,Y., Oka,T., Takimoto,E., Yazaki,Y.,
            Nagai,R. and Komuro,I.
  TITLE     A novel myocyte-specific gene Midori promotes the differentiation
            of P19CL6 cells into cardiomyocytes
  JOURNAL   J Biol Chem 276 (38), 35978-35989 (2001)
   PUBMED   11418590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 6, 2022 this sequence version replaced NM_001191895.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.1887.1,
                                           SRR26643295.2927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000001.1  144423746-144423922
            178-216             JAXUCZ010000001.1  144430032-144430070
            217-338             JAXUCZ010000001.1  144433721-144433842
            339-456             JAXUCZ010000001.1  144445327-144445444
            457-1741            JAXUCZ010000001.1  144446023-144447307
            1742-3794           JAXUCZ010000001.1  144457603-144459655
            3795-3942           JAXUCZ010000001.1  144460383-144460530
            3943-4070           JAXUCZ010000001.1  144460821-144460948
            4071-4106           JAXUCZ010000001.1  144461079-144461114
            4107-4381           JAXUCZ010000001.1  144464569-144464843
            4382-4470           JAXUCZ010000001.1  144465998-144466086
            4471-4694           JAXUCZ010000001.1  144466685-144466908
            4695-4743           JAXUCZ010000001.1  144469472-144469520
            4744-6343           JAXUCZ010000001.1  144469935-144471534
FEATURES             Location/Qualifiers
     source          1..6343
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..6343
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /note="alpha-kinase 3"
                     /db_xref="GeneID:365298"
                     /db_xref="RGD:1309860"
     exon            1..177
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..5089
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="alpha-protein kinase 3"
                     /protein_id="NP_001178824.1"
                     /db_xref="GeneID:365298"
                     /db_xref="RGD:1309860"
                     /translation="MGSRRALGRGWGLGGRAGTGGDGEDDGPVWTPGPASRSYLLSVR
                     PEASLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRAVSEDSDVRFTCIVTG
                     YPEPEVTWYKDDIELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASARNTKGI
                     VSCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKMREIEQSWKHGKEASGEADTLRKISP
                     DRFQRKRRLSGAEEAVLPAPLRGTEEGPSAAWQEGEAESTQHPGLGMINSFAPGEAPT
                     NGEPAPENGEDGEHGLLTYICEVMELGPQNTPPKESGAKKKRKDEESKPGGQKPELGK
                     AEGSQCSSENGIPSSDKLNSSRREKKSRDVQPTQNQTRDRVARGPGPSGIESTRKTAS
                     VLGTQDKVQDVPALAPAPAPAPAPVPVPAPAPVPSLSSEQVYFSLKDMFMESTRAGRS
                     QEEEKSPPPSTRVAGESPSGKVPVKARGEKVPMVSGQPTSSTVPPPIKPLNRKRFAPP
                     KSKVESTTSSSSSQTPESVAQSLGKAPPPASAQVPTPPARRRHGTRESPLQGQTSHKT
                     PGEALESPATMAPATSASSSSDTISVGHSTSGNQGVTEPMDTETQEEGRTLANGRTSG
                     RQKTQTDGKLQVDGRTQGDEAQTLQRTQTNEKAPMNVVTQGSERPESDRSSQKDLVTQ
                     RRVDTQVGQTQAGERWQQDPRDARIQEEKETQSVGSIPTALETQPEQPSVVSLSSVPG
                     ALKLSPSECPTEPQATECSERSTEASYIQEKSGLMLGSEEADFRSHENTLLGPPSGNH
                     TYSTQLPTEGNSEHLVGETHQRPEWLGEAKQEDSLLQSPKKEQLQETLYVDLAIGHSA
                     DLSQEVPSLPSLPGTDLTNSLQEGLPSTTASQHTNADVPLPSPDQDLPSSAPTLQLGP
                     GSPTQSHPPEVMATSSEGACAKEPDVDGRSSGTRSCDPGLIDSLKNYLLLLLKLSSPE
                     AGEARAESQEVPATGGLTSSSALVPTVEVAGLSPRTSRRILDRVENNHLVQSAQTLLL
                     SPCTSRRLTGLLDREVQAGQQALAAAQCSRGPCPSPSPLTIPAIVVGEEGSATGEGED
                     SRERTSQESDKAGLLGEVDGQTVESRTQEPCQEEAIPGEALTGLPAATPEELALGARR
                     KRFLPKVRAGSDGEVNKAEERESPTVSPRGPRKGLAPGSPGTPGRERRSPTQARKASM
                     LEVPGTEEEPASGDLVTRPKASGLESEPAVDEGKQEALAKPRKAKDLLKAPQVIRKIR
                     VEQFPDSSGSLKLWCQFFNIVSDSVLTWAKDQHLVGEVSRSAGDEGPAALAIVQASPT
                     DCGLYRCTIQNEHGSASTDFRLSPEVLSGFISREEGEVGEEIEMTPMVFAKGLADSGC
                     WGDKLFGRLVSEELRGGGHGLQKASRAKVIYGLEPIFESGRTCIIKVSSLLVFGPSSE
                     TSLLGRNYDVTIQGCKIQNMSREYCKIFAAETRAASGFGEVPEIIPLYLIYRPANNIP
                     YATLEEDLGKPLQTYCSRQWSCAGAPAASSSLEPVQKCQTFQHWLYQWTNGSFLVTDL
                     AGADWKMTDVEIATKLRGYQGLKESCFPALLDQFASSHQCNTYCEMLGLKPLKGPEGA
                     HPQTKAKGSKSPSAGRKGSQLSPQPQKKGLPSPQGSRKSAPSSRATPQASQEATLQLL
                     GQPPAQEGSSKAQGMR"
     exon            178..216
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            217..338
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            339..456
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            457..1741
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..3794
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3942
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..4070
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4106
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            4107..4381
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            4382..4470
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            4471..4694
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            4695..4743
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
     exon            4744..6343
                     /gene="Alpk3"
                     /gene_synonym="RGD1309860"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagccggg gctggaggca ggggctgcgg tgccatgggg tcgcggaggg ccttgggccg
       61 gggctggggc ctgggtggtc gagcaggaac cggtggagat ggcgaggacg acgggccggt
      121 gtggactcct ggcccagcca gtcgcagcta cttgctcagc gtgcggccgg aggctagctt
      181 atcaagcaac cggttgtctc accccagctc tggaaggagc accttctgct ccatcattgc
      241 tcagcttaca gaggagaccc agccgctgtt tgagaccaca ctcaagtccc gagctgtgtc
      301 cgaagacagt gatgtcaggt tcacctgcat tgtcacagga tacccagagc cagaggtgac
      361 ctggtacaag gatgacatag aactggaccg ttactgtggc ttgccaaaat acgagatcac
      421 tcaccaaggc aaccggcaca ccctgcagct gtacaggtgt cgggaagaag atgctgccat
      481 ctaccaggcc tctgcccgga acaccaaggg catcgtgtct tgctcagggg tcctagaggt
      541 gggcactatg acggagtaca agattcacca gcgctggttc gccaagttga agcgtaaggc
      601 tgcggccaag atgagggaga ttgagcagag ctggaagcac gggaaagagg cttcagggga
      661 ggctgacaca cttcgcaaga tcagcccgga ccgcttccaa agaaagcgcc gactgagtgg
      721 agcggaagag gcagtcctcc cggcgccact caggggaacg gaggaagggc cctcagcagc
      781 ttggcaggaa ggagaggctg agtccactca gcacccaggt ttggggatga tcaacagttt
      841 cgctcctggt gaggcaccca ccaatgggga gcctgcccca gagaacgggg aggacggaga
      901 gcacggcctg ctgacctaca tctgtgaggt catggaactg gggcctcaga acacccctcc
      961 aaaggagtct ggggctaaga agaaaaggaa ggatgaggaa tctaaaccag gagggcagaa
     1021 accagagtta gggaaggcag aagggagcca gtgctcttca gaaaatggca tccctagctc
     1081 agacaaactc aattccagta gaagggagaa gaagtccagg gatgtgcagc caactcagaa
     1141 ccagaccaga gacagggtag cacgggggcc tgggccttct gggatagaaa gcaccaggaa
     1201 gacagcctct gttctgggta ctcaagacaa ggtccaggat gtcccggccc tggccccggc
     1261 ccccgccccg gcccccgctc ctgtcccagt ccctgcaccc gcccctgttc caagcctcag
     1321 ctcagagcag gtgtatttct cgctgaagga catgttcatg gagagcaccc gggcaggcag
     1381 gtcccaggaa gaggaaaaat ctccacctcc aagtaccaga gtagctggag aaagtccttc
     1441 agggaaggta cctgtcaagg ctagagggga gaaggtacct atggtctctg gccagcccac
     1501 gtcttccacg gtgcccccgc ctattaaacc tttgaacagg aagagatttg cccctcctaa
     1561 atccaaagtg gagtcaacta cctcctcttc ctcaagtcag actccagaat ctgtggccca
     1621 gagcttaggg aaggccccac cgccagcctc tgcccaggtc ccaacacccc ctgcccgacg
     1681 gagacatggc actcgagaga gccccttgca aggacaaaca agccacaaga ctccaggaga
     1741 ggctctggag tccccagcaa ccatggcccc tgccacgtct gccagcagca gttccgatac
     1801 catctctgtt ggtcacagca cctctgggaa tcaaggtgtc acggagccca tggatacaga
     1861 aactcaggaa gaggggagga cacttgccaa tgggagaacc agtggcaggc agaaaacaca
     1921 gacagacgga aagttgcaag tggatgggag gactcaggga gacgaagcac aaactttgca
     1981 gaggacacag acaaatgaga aggcaccgat gaacgttgta acacaaggaa gcgaaaggcc
     2041 agagtcagac aggagttcac agaaggattt ggtgacacag agaagggtgg atacacaggt
     2101 aggacagaca caggcaggtg agaggtggca gcaagacccg agagacgcaa ggatacagga
     2161 ggaaaaggag acacagtcag tgggcagcat tcccacagct ttggaaaccc aaccagaaca
     2221 accgtctgtg gtcagtctca gctcagtacc aggagccctc aaactctcgc cgtcagagtg
     2281 ccctacagag cctcaggcta cagaatgttc tgagaggagc acagaagcat cttacatcca
     2341 agaaaagtca ggcttgatgc ttggatctga agaggcagac ttcagaagcc atgagaacac
     2401 tctgctaggg cccccatcag ggaaccatac ctactcaaca cagttgccca ctgagggcaa
     2461 ctcagagcat ctggtaggag aaacacacca aaggccagag tggttaggtg aggccaagca
     2521 ggaggacagc ctgcttcaga gtcccaagaa ggagcagctc caggagacgc tgtatgtgga
     2581 tctcgctatt ggacattcag cggacttgag tcaggaggtg cccagtctgc cttctcttcc
     2641 tggaactgac ctaaccaata gtctgcagga ggggctaccc agcaccacag cttctcagca
     2701 cacaaacgct gatgtccccc tcccctcccc ggaccaggac ctgcccagtt ctgctcccac
     2761 tctgcaactg ggaccagggt ccccgactca gagtcaccca ccagaagtca tggctactag
     2821 cagtgaggga gcctgtgcca aggagccaga tgtggacggg aggtcctcag gtacccggag
     2881 ctgtgaccct ggccttatag actccctgaa gaactacttg ctcctgctgc taaagctatc
     2941 cagtccagag gcaggcgaag ccagggcaga gtcccaggaa gtgcctgcca ccggaggctt
     3001 aacttcctcc tctgctctgg tccccaccgt ggaagtggct ggcttgagtc ccaggacgtc
     3061 caggcgcatc ctggaccgtg tggagaacaa ccacttggtg cagagcgcac agaccctgct
     3121 gctgagcccc tgcacctccc gccgcctcac tggcctcctg gaccgtgagg ttcaggctgg
     3181 ccagcaggcc ctggctgccg cccagtgctc ccggggccca tgccctagcc ccagccccct
     3241 caccatccct gccattgtgg tgggtgagga aggatctgct actggtgagg gagaggattc
     3301 cagggagagg acctcccagg aaagtgacaa ggctggactg ctaggggagg tggacggaca
     3361 aacagtagag agcagaaccc aggagccctg ccaagaagaa gcaatcccag gggaggcttt
     3421 gacaggtctc cctgcagcta cacctgagga actggctcta ggggcccgga ggaagaggtt
     3481 cctccctaag gtgagagcag ggtcagacgg tgaggtgaac aaggctgaag aaagagagag
     3541 tcccacagtc tccccccggg gacccaggaa gggtctggca cctgggtcac ccgggactcc
     3601 agggcgggag agacggtccc ctacccaggc ccggaaggcc agcatgttag aggtgcctgg
     3661 gacagaagaa gagcctgcat cgggagactt ggtcaccaga cccaaggcca gtggtctgga
     3721 atcagagcct gcggtggatg aaggcaagca ggaagcactg gctaagccaa ggaaagctaa
     3781 agacctgtta aaagccccac aggtgatccg gaaaattcgg gtagaacagt ttccagattc
     3841 ttctggtagt ctgaagcttt ggtgtcagtt tttcaatatc gttagcgact cagtcttgac
     3901 atgggcgaag gatcagcatc tagtgggcga agtgagcagg agtgcagggg acgaggggcc
     3961 agcggccttg gccattgtgc aggcgtcacc tacggactgt ggcctgtatc gctgtaccat
     4021 ccaaaacgag catggctccg cttccactga cttccgcctc agcccggaag tattgtctgg
     4081 cttcatctcc agagaggaag gtgaagttgg agaagagatt gagatgaccc ccatggtatt
     4141 tgctaagggt ctggctgact ctggctgctg gggggacaag ctctttgggc gattggtgag
     4201 cgaggagctt cgagggggtg gacatggcct tcagaaggct tcgcgggcca aggtcatcta
     4261 tgggctggag cccatcttcg aatctggtcg cacgtgcatc atcaaggtat ccagcctgct
     4321 cgtgttcgga cccagcagtg agacttctct tctgggcaga aactatgacg tcactatcca
     4381 gggatgcaag atccagaaca tgagtcgaga gtactgcaaa atctttgcag ctgaaacccg
     4441 ggcagcctct ggcttcgggg aggttcctga gatcatccca ctttacttga tctatcggcc
     4501 tgcaaacaat ataccgtatg ctaccctgga ggaagatctg ggcaagcccc tgcagactta
     4561 ctgttccagg cagtggagct gtgctggggc cccagcagca tccagcagct tggagcctgt
     4621 gcagaaatgc caaaccttcc agcactggct gtatcagtgg acgaacggca gcttccttgt
     4681 cacagatctg gcaggggctg actggaagat gactgatgta gagatcgcta ccaaactccg
     4741 aggataccaa ggcctcaagg agagctgttt tcctgccctg ctggaccagt ttgcctcttc
     4801 ccaccagtgc aacacctact gtgagatgct ggggctgaaa cccctcaagg gccctgaggg
     4861 tgcccaccct caaaccaagg ccaaaggctc caaaagtcca tctgctggca gaaaaggttc
     4921 ccagctgagt cctcagcccc agaagaaagg tcttcccagt cctcagggct ccaggaagag
     4981 cgctccaagc tccagagcca cgcctcaggc ctcccaggag gccactcttc agttactggg
     5041 acagccccct gcccaagagg ggagctctaa ggcccagggc atgcggtagc cccaacagga
     5101 ggctgggggc ctctacccaa gagcagacca accaggaagc agcttcaacc agatggagac
     5161 ggtttcagtt caggactaac cagagaaggt gcccgaagga ggcctatctt gggggacctc
     5221 tctgagtagt tacctcattg gaaggctttg ggcacatgac ctgttggcct cctcttcttc
     5281 ccttatcacc cagggctccc aggccccaag cggggcccac ctccaagtgc ctggtggcct
     5341 aggccctcat ttaagtttac acttgccact gctgggggct cctgagtcct ctgcatgagt
     5401 tctgcactct gcccttgccc cagtcaccac acaagcaaat gttgcactct ggggcattta
     5461 cctttttacc cttgcttttt tatcctgccc ctctccctgt cctcagggcc ctagacttcc
     5521 tgtggggtct agccttgtga ctctcagggt ttcatctcca ttcagcttca ttcatcacag
     5581 tttatcctgc cactaacctg tcctgagtcc ctgggcccca gagctctctg gagcccgtca
     5641 cgtctttgtg cagtgttttt tgatggtaca tgttcttgtc actttgcact tacttgtttc
     5701 ccgtgctgcc ttgcacacat gcccatcccc cccaccccac aggctttgag cccaattcag
     5761 tctgctgcct gcccttcact ggcttgtgct ggtctctttg tccaagggct ccttccatct
     5821 tgcccttgca ccctacccac caatgctggg tgaggaacag cctctctggc ttcaccctac
     5881 cctagtgccc actcccctgg ttctctcagg ttctctgctc aggaggaggg agacagcatg
     5941 agaacctgtg agcagctgtt ggggcggggg attgaccttg aggtgccttg tcctctgttc
     6001 tgaaaaaagt gaggttgcag taaatgtcac agctctgtcc tcaaggacta gaagaccggg
     6061 actcttcctc atgcagggga ggggggacgg tggggcacag gtgttcttag agggtcgaga
     6121 tccattcaca tgcttgtgta gaaaaagatt atcttgatgc ctacctccca ccatttgctc
     6181 ttggtcctgg ggctcaactc cagatgctcc ggtgtgagtt cccggggaat ctctgtgctg
     6241 gatacccttt ctagatgccc ttccttgaga catgggatgg ggtggtctgg agctagcctg
     6301 ctccccttgc tgtgcaataa aggcagcagc tgtgtgtcct gtt
//
