LOCUS       NM_153301               2062 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus arachidonate 15-lipoxygenase, type B (Alox15b),
            mRNA.
ACCESSION   NM_153301
VERSION     NM_153301.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2062)
  AUTHORS   Wakabayashi,M., Yoshioka,T., Higashino,K., Numata,Y., Igarashi,Y.
            and Kihara,A.
  TITLE     Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model
            rats
  JOURNAL   J Dermatol Sci 85 (3), 186-196 (2017)
   PUBMED   28024685
  REMARK    GeneRIF: Consistent with the decreases in the 15-LOX metabolites,
            expression levels of the genes that encode the 15-LOXs, Alox15 and
            Alox15b, were largely reduced in Olmsted syndrome model rats.
REFERENCE   2  (bases 1 to 2062)
  AUTHORS   Bender,G., Schexnaydre,E.E., Murphy,R.C., Uhlson,C. and
            Newcomer,M.E.
  TITLE     Membrane-dependent Activities of Human 15-LOX-2 and Its Murine
            Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS
  JOURNAL   J Biol Chem 291 (37), 19413-19424 (2016)
   PUBMED   27435673
REFERENCE   3  (bases 1 to 2062)
  AUTHORS   Green,A.R., Barbour,S., Horn,T., Carlos,J., Raskatov,J.A. and
            Holman,T.R.
  TITLE     Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2
            Delineates Its Transcellular Synthesis Potential
  JOURNAL   Biochemistry 55 (20), 2832-2840 (2016)
   PUBMED   27145229
REFERENCE   4  (bases 1 to 2062)
  AUTHORS   Kobe,M.J., Neau,D.B., Mitchell,C.E., Bartlett,S.G. and
            Newcomer,M.E.
  TITLE     The structure of human 15-lipoxygenase-2 with a substrate mimic
  JOURNAL   J Biol Chem 289 (12), 8562-8569 (2014)
   PUBMED   24497644
REFERENCE   5  (bases 1 to 2062)
  AUTHORS   Shen,T., Ma,J., Zhang,L., Yu,X., Liu,M., Hou,Y., Wang,Y., Ma,C.,
            Li,S. and Zhu,D.
  TITLE     Positive feedback-loop of telomerase reverse transcriptase and
            15-lipoxygenase-2 promotes pulmonary hypertension
  JOURNAL   PLoS One 8 (12), e83132 (2013)
   PUBMED   24376652
  REMARK    GeneRIF: Positive feedback-loop of TERT and 15-lipoxygenase-2
            promotes pulmonary hypertension.
            Erratum:[PLoS One. 2024 Aug 8;19(8):e0308871. doi:
            10.1371/journal.pone.0308871.. PMID: 39116122]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2062)
  AUTHORS   Muga,S.J., Thuillier,P., Pavone,A., Rundhaug,J.E., Boeglin,W.E.,
            Jisaka,M., Brash,A.R. and Fischer,S.M.
  TITLE     8S-lipoxygenase products activate peroxisome proliferator-activated
            receptor alpha and induce differentiation in murine keratinocytes
  JOURNAL   Cell Growth Differ 11 (8), 447-454 (2000)
   PUBMED   10965849
REFERENCE   7  (bases 1 to 2062)
  AUTHORS   Jisaka,M., Kim,R.B., Boeglin,W.E. and Brash,A.R.
  TITLE     Identification of amino acid determinants of the positional
            specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2
  JOURNAL   J Biol Chem 275 (2), 1287-1293 (2000)
   PUBMED   10625675
REFERENCE   8  (bases 1 to 2062)
  AUTHORS   Kilty,I., Logan,A. and Vickers,P.J.
  TITLE     Differential characteristics of human 15-lipoxygenase isozymes and
            a novel splice variant of 15S-lipoxygenase
  JOURNAL   Eur J Biochem 266 (1), 83-93 (1999)
   PUBMED   10542053
REFERENCE   9  (bases 1 to 2062)
  AUTHORS   Jisaka,M., Kim,R.B., Boeglin,W.E., Nanney,L.B. and Brash,A.R.
  TITLE     Molecular cloning and functional expression of a phorbol
            ester-inducible 8S-lipoxygenase from mouse skin
  JOURNAL   J Biol Chem 272 (39), 24410-24416 (1997)
   PUBMED   9305900
REFERENCE   10 (bases 1 to 2062)
  AUTHORS   Brash,A.R., Boeglin,W.E. and Chang,M.S.
  TITLE     Discovery of a second 15S-lipoxygenase in humans
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6148-6152 (1997)
   PUBMED   9177185
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF415240.1.
            
            On May 4, 2007 this sequence version replaced NM_153301.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF415240.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMD00132270,
                                           SAMD00132302 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2062              AF415240.1         9-2070
FEATURES             Location/Qualifiers
     source          1..2062
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2062
                     /gene="Alox15b"
                     /note="arachidonate 15-lipoxygenase, type B"
                     /db_xref="GeneID:266604"
                     /db_xref="RGD:628809"
     exon            1..175
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2062
                     /gene="Alox15b"
                     /EC_number="1.13.11.33"
                     /note="arachidonate 15-lipoxygenase type II; arachidonate
                     15-lipoxygenase B; 15-LOX-2; 15-LOX-B; 15-lipoxygenase 2;
                     arachidonate 15-lipoxygenase, second type; linoleate
                     13-lipoxygenase 15-LOb"
                     /codon_start=1
                     /product="polyunsaturated fatty acid lipoxygenase ALOX15B"
                     /protein_id="NP_695213.1"
                     /db_xref="GeneID:266604"
                     /db_xref="RGD:628809"
                     /translation="MAKFRVRVSTGEACGAGTWDKVSVSIVGTHGESPLVPLDHLGKE
                     FSAGAEEDFEVTLPQDVGTVLMLRIHKAPPEAPLPLLSFPPDAWYCRWFELEWLPGAA
                     LRFPCYQWLEGAGELVLREGAAKVSWQDHHRTLQDQRQKELESRKDMYSWKTYIEGWP
                     HCLDHETVKDLDLNIKYSAMKNAKFFFKAQSAFTELKFKGLLDRTGLWRSLREMKRMF
                     NFHNTPAAEYVFAHWQEDAFFASQFLNGLNPVLIRRCRRLPENFPVTDEMVAPVLGPG
                     TSLQAELEKGSLFLVDHGILSGVQTNVINGKPQFSAAPMTLLYQSPGSGPLLPIAIQL
                     KQTPGPDNPIFLPSDDKWDWLLAKTWVRNAEFSIHEALTHLLHAHLIPEVFALATLRQ
                     LPHCHPLFKLLIPHTRYTLHINTLARELLIAPGKVVDKSTGLGIGGFSDLIKRNMEQL
                     SYSVLCLPEDIRARDVGDLPGYYYRDDGMQIWSAIRSFVSEIVDIYYPSDASVRDDQE
                     LQAWVGEIFSEGFLSQESSGMPSLLDTQEALVQYVTMVIFTCSAKHAAVSASQFDSCV
                     WMPNLPPSMQLPPPTSKGQASPEGFIATLPAVNATCDVIIALWLLSKEPGDRRPLGHY
                     PDEHFTEEVPRRSIAAFQRKLIQISSGIRKRNQSLALPYTYLDPPLIENSVSI"
     exon            176..398
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            399..480
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            481..603
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            604..707
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            708..880
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1027
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1231
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1318
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1488
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1610
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1711
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1882
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2062
                     /gene="Alox15b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtagaga gccagactgg tcaggaggat ggctaaattc agggtgagag tatccaccgg
       61 ggaggcctgt ggggcaggca catgggacaa agtgtctgtc agcatcgtgg gaacccatgg
      121 agagagcccc ttagtacctc tggaccatct gggcaaggag ttcagcgctg gagctgaaga
      181 agacttcgag gtgacgcttc cccaggacgt tggcactgtg ctgatgctgc gaatacacaa
      241 ggcacccccg gaggcacccc tcccacttct gtctttccca cctgatgcct ggtactgccg
      301 ctggtttgag ctggagtggc tgccgggggc tgcacttcgc ttcccctgtt atcagtggct
      361 ggaaggggca ggggagctgg tgctgagaga gggagcagcc aaggtgtcct ggcaagacca
      421 ccaccgtacg ctgcaggatc agcgccagaa ggagctggag tccaggaagg acatgtacag
      481 ctggaagact tacattgaag gttggcctca ctgccttgac catgagaccg tgaaagactt
      541 ggacctcaac atcaagtact ctgcaatgaa gaacgccaaa ttcttcttta aagcccagtc
      601 tgcgtttaca gagctgaaat tcaaagggct cctggaccgc acaggactct ggaggagtct
      661 gagggagatg aaaaggatgt ttaacttcca caacactcca gcagcagagt atgtgtttgc
      721 acactggcag gaagatgcct tcttcgcctc ccagttccta aatggcctca acccagttct
      781 gattcgccgc tgtcgcagac tcccagagaa cttcccagtc actgatgaaa tggtggctcc
      841 agtgctgggc cctgggacca gtctgcaggc tgagttagag aagggctccc tgttcttggt
      901 ggaccatgga attctttctg gagtgcaaac caatgtcatc aatggaaagc ctcagttctc
      961 agcagccccg atgaccctat tataccagag tccagggtcc ggacccctgc ttcccatcgc
     1021 catacagctc aaacagactc ccgggccaga caaccccatc ttcctgccca gcgatgacaa
     1081 gtgggactgg ctactggcca agacctgggt gcgcaacgct gagttttcca tccacgaggc
     1141 tctcacgcat ctgctgcatg cccacctgat tccagaagtc tttgccttgg ccacactgcg
     1201 ccagctgccc cactgtcacc ctctcttcaa gctgctgatt cctcacactc ggtacacact
     1261 gcacatcaac acactcgccc gtgagctgct cattgcccct gggaaggtgg tggacaagtc
     1321 cacaggcctt ggcattgggg gattctctga cctgataaag agaaacatgg agcagctgag
     1381 ctattctgtc ctgtgtctcc ctgaagatat ccgagcccga gatgtgggag acctcccagg
     1441 atactattac cgagatgatg ggatgcagat ctggagtgca ataaggagct tcgtctctga
     1501 gatagttgac atctattacc caagtgacgc atctgtccga gatgaccaag agctccaggc
     1561 ctgggtgggg gagatcttct ctgagggctt cctcagccaa gaaagctcag gtatgccctc
     1621 cttgttggat acccaggaag ccctggtcca atatgttacc atggtgatat tcacctgctc
     1681 agccaagcat gcagctgtca gtgcaagcca gtttgactcg tgtgtttgga tgcccaatct
     1741 gccaccttcc atgcagctac caccacctac ttccaaaggc caggcaagcc ctgagggttt
     1801 catagccaca ctcccagcag tcaatgccac atgtgatgtc atcatcgccc tctggctgct
     1861 aagcaaggag ccaggggacc gtaggcccct gggccactat ccagatgagc acttcacaga
     1921 ggaggtccca cggcggagca tcgcggcctt ccagagaaag ctgatccaga tatccagtgg
     1981 catcaggaag aggaaccaaa gcctggcact gccctacacc tacctggatc ctcccctcat
     2041 cgagaacagt gtctccatct aa
//
