LOCUS       NM_031010               2216 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus arachidonate 15-lipoxygenase (Alox15), mRNA.
ACCESSION   NM_031010
VERSION     NM_031010.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2216)
  AUTHORS   Mead,A.J., Ahluwalia,K., Ebright,B., Zhang,Z., Dave,P., Li,Z.,
            Zhou,E., Naik,A.A., Ngu,R., Chester,C., Lu,A., Asante,I.,
            Pollalis,D., Martinez,J.C., Humayun,M. and Louie,S.
  TITLE     Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats
  JOURNAL   Int J Mol Sci 25 (4), 2309 (2024)
   PUBMED   38396985
  REMARK    GeneRIF: Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2216)
  AUTHORS   Wu,S., Wang,C., Yao,M., Han,D. and Li,Q.
  TITLE     Photothermal lipolysis accelerates ECM production via
            macrophage-derived ALOX15-mediated p38 MAPK activation in
            fibroblasts
  JOURNAL   J Biophotonics 16 (4), e202200321 (2023)
   PUBMED   36529997
  REMARK    GeneRIF: Photothermal lipolysis accelerates ECM production via
            macrophage-derived ALOX15-mediated p38 MAPK activation in
            fibroblasts.
REFERENCE   3  (bases 1 to 2216)
  AUTHORS   Wang,S., Gan,J., Li,J., Wang,Y., Zhang,J., Song,L., Yang,Z., Guo,M.
            and Jiang,X.
  TITLE     Shengmai Yin formula exerts cardioprotective effects on rats with
            chronic heart failure via regulating Linoleic Acid metabolism
  JOURNAL   Prostaglandins Other Lipid Mediat 158, 106608 (2022)
   PUBMED   34958945
REFERENCE   4  (bases 1 to 2216)
  AUTHORS   Shalini,S.M., Ho,C.F., Ng,Y.K., Tong,J.X., Ong,E.S., Herr,D.R.,
            Dawe,G.S. and Ong,W.Y.
  TITLE     Distribution of Alox15 in the Rat Brain and Its Role in Prefrontal
            Cortical Resolvin D1 Formation and Spatial Working Memory
  JOURNAL   Mol Neurobiol 55 (2), 1537-1550 (2018)
   PUBMED   28181190
  REMARK    GeneRIF: Alox15 processing of DHA contributes to production of
            resolvin D1 and LTP at hippocampo-prefrontal cortical synapses and
            associated spatial working memory performance.
REFERENCE   5  (bases 1 to 2216)
  AUTHORS   Wakabayashi,M., Yoshioka,T., Higashino,K., Numata,Y., Igarashi,Y.
            and Kihara,A.
  TITLE     Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model
            rats
  JOURNAL   J Dermatol Sci 85 (3), 186-196 (2017)
   PUBMED   28024685
  REMARK    GeneRIF: Consistent with the decreases in the 15-LOX metabolites,
            expression levels of the genes that encode the 15-LOXs, Alox15 and
            Alox15b, were largely reduced in Olmsted syndrome model rats.
REFERENCE   6  (bases 1 to 2216)
  AUTHORS   Katoh,T., Lakkis,F.G., Makita,N. and Badr,K.F.
  TITLE     Co-regulated expression of glomerular 12/15-lipoxygenase and
            interleukin-4 mRNAs in rat nephrotoxic nephritis
  JOURNAL   Kidney Int 46 (2), 341-349 (1994)
   PUBMED   7967345
REFERENCE   7  (bases 1 to 2216)
  AUTHORS   Chen,X.S., Kurre,U., Jenkins,N.A., Copeland,N.G. and Funk,C.D.
  TITLE     cDNA cloning, expression, mutagenesis of C-terminal isoleucine,
            genomic structure, and chromosomal localizations of murine
            12-lipoxygenases
  JOURNAL   J Biol Chem 269 (19), 13979-13987 (1994)
   PUBMED   8188678
REFERENCE   8  (bases 1 to 2216)
  AUTHORS   Hada,T., Hagiya,H., Suzuki,H., Arakawa,T., Nakamura,M., Matsuda,S.,
            Yoshimoto,T., Yamamoto,S., Azekawa,T., Morita,Y. et al.
  TITLE     Arachidonate 12-lipoxygenase of rat pineal glands: catalytic
            properties and primary structure deduced from its cDNA
  JOURNAL   Biochim Biophys Acta 1211 (2), 221-228 (1994)
   PUBMED   8117750
REFERENCE   9  (bases 1 to 2216)
  AUTHORS   Sloane,D.L., Leung,R., Craik,C.S. and Sigal,E.
  TITLE     A primary determinant for lipoxygenase positional specificity
  JOURNAL   Nature 354 (6349), 149-152 (1991)
   PUBMED   1944593
REFERENCE   10 (bases 1 to 2216)
  AUTHORS   Chang,W.C., Nakao,J., Orimo,H. and Murota,S.
  TITLE     Effects of reduced glutathione on the 12-lipoxygenase pathways in
            rat platelets
  JOURNAL   Biochem J 202 (3), 771-776 (1982)
   PUBMED   6807297
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from S69383.1.
            
            On Jun 9, 2003 this sequence version replaced NM_031010.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L06040.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132267 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2216
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2216
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /note="arachidonate 15-lipoxygenase"
                     /db_xref="GeneID:81639"
                     /db_xref="RGD:70493"
     exon            1..141
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1998
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /EC_number="1.13.11.31"
                     /EC_number="1.13.11.33"
                     /EC_number="1.13.11.12"
                     /note="arachidonate 12-lipoxygenase, leukocyte-type;
                     12/15-LOX; 12/15-lipoxygenase; arachidonate omega-6
                     lipoxygenase; linoleate 13S-lipoxygenase; hepoxilin A3
                     synthase Alox15"
                     /codon_start=1
                     /product="polyunsaturated fatty acid lipoxygenase ALOX15"
                     /protein_id="NP_112272.2"
                     /db_xref="GeneID:81639"
                     /db_xref="RGD:70493"
                     /translation="MGVYRIRVSTGDSKYAGSNNEVYLWLVGQHGEASLGKLLRPCRD
                     SEAEFKVDVSGYLGPLLFVRVQKWHYLTDDAWFCNWISVKGPGDQGSEYMFPCYRWVQ
                     GRSILSLPEGTGCTVVEDSQGLFRKHREEELEERRSLYRWGNWKDGSILNVAAASISD
                     LPVDQRFREDKRIEFEASQVIGVMDTVVNFPINTVTCWKSLDDFNCVFKSGHTKMAER
                     VRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLNKELQKGTLFE
                     ADFFLLDGIKANVILCSQQYLAAPLVMLKLMPDGQLLPIAIQLELPKTGSTPPPIFTP
                     SDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLMAEVFAVATMRCLPSVHPVFKLLVP
                     HLLYTMEINVRARSDLISERGFFDKAMSTGGGGHLDLLKQAGAFLTYCSLCPPDDLAE
                     RGLLDIETCFYAKDALRLWQIMNRYVVGMFNLHYKTDKAVQDDYELQSWCREITDIGL
                     QGAQDRGFPTSLQSRAQACYFITMCIFTCTAQHSSVHLGQLDWFYWVPNAPCTMRLPP
                     PTTKEATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVL
                     KKFREELAALDKEIEIRNKSLDIPYEYLRPSMVENSVAI"
     exon            142..346
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            347..428
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            429..551
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            552..655
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            656..816
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            817..960
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1170
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1257
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1427
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1549
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1650
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1818
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2189
                     /gene="Alox15"
                     /gene_synonym="12-LOX; 15-LOX; Alox12; Alox12l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcaagatgg gtgtctaccg catccgcgtc tccaccggag actccaagta cgcgggctcc
       61 aacaacgagg tctacctgtg gttggttgga cagcatggag aggcatctct cgggaagctg
      121 ctacgaccct gtcgggactc ggaagcagaa ttcaaagtgg atgtgtcagg ataccttggg
      181 ccactgctgt tcgtaagagt gcagaaatgg cattatctca cggatgacgc ctggttctgc
      241 aactggattt ctgtgaaggg ccccggagac caaggatcag agtacatgtt cccctgttac
      301 cgatgggttc agggcagaag catcctgagc ctccctgagg gcactggctg caccgtggtt
      361 gaagattctc aaggactgtt caggaaacat agggaagagg agcttgaaga gaggaggagt
      421 ctgtacaggt ggggcaactg gaaggatggc tcaatcctga atgtggcggc ggccagtata
      481 tctgacctcc ctgtagacca acgatttcga gaggacaaaa gaattgaatt tgaagcttca
      541 caggttatag gggtaatgga tactgttgtc aactttccta taaacactgt gacctgctgg
      601 aaaagcctag atgacttcaa ctgcgttttc aagagtggcc ataccaaaat ggctgagcgg
      661 gttcgaaact cctggaagga agatgcgttc tttgggtacc aattcctcaa tggtgctaac
      721 cccatggtgc tgaagcgctc tacttgtctt cctgcccgcc tggtattccc tccaggaatg
      781 gagaagctac aggcccagct gaacaaggag ctccagaaag gcactctgtt tgaagcggat
      841 ttcttccttc tggatgggat caaggccaat gtcatccttt gtagccagca gtacctggct
      901 gcccctctcg tcatgctgaa gctgatgcct gatggacaac tcttgcccat agccatccag
      961 cttgaacttc ccaaaactgg gtctactcca ccacctattt tcacgccctc ggatccccca
     1021 atggactggc tcctagccaa atgctgggtc cggagctccg acttacagct ccatgagctg
     1081 caggctcatc ttctgagggg acacttgatg gctgaggtct ttgctgtggc caccatgagg
     1141 tgcctgcctt ccgtgcaccc tgtttttaag cttctagttc ctcatctgct ttacaccatg
     1201 gaaattaatg tccgggccag gagtgacctg atctcagaga gaggcttttt tgacaaggca
     1261 atgagcacag gtgggggagg ccacctggat cttctcaagc aagctggagc ctttctgacc
     1321 tattgctcat tgtgtccccc cgatgacttg gctgagcgag gactcttgga tatcgagact
     1381 tgcttctatg ctaaagacgc cctgcgactc tggcagatca tgaatcggta cgtggtggga
     1441 atgttcaatc tccactacaa gaccgacaaa gctgtgcaag acgactatga actgcagagc
     1501 tggtgtcgag agatcactga cattggtctt caaggggccc aggacagagg cttccctacc
     1561 tctcttcagt cccgggctca ggcttgctac ttcatcacca tgtgcatctt cacgtgcacc
     1621 gcacagcact cttccgtcca tcttggccag ctggattggt tctactgggt tcctaatgca
     1681 ccctgcacca tgcggctgcc accacccacc accaaggaag caacaatgga gaagctgatg
     1741 gctacactgc ccaaccctaa tcagtctact ctccagataa atgtcgtttg gctcctgggc
     1801 agacgccagg ctgttatggt gcccctgggc cagcattcag aggaacactt tccaaaccct
     1861 gaggccaagg ctgtgctgaa gaagttcaga gaggaactgg ctgccttgga taaggaaatt
     1921 gagattcgta ataagagctt ggacatacct tatgagtacc tgcggcccag catggtggaa
     1981 aacagcgtgg ccatatgagc atccccagac tcctgctttg ttgtttagtt aagaccaccc
     2041 aagtacatcc ctgtgcttga gtggtggcag tcctgccctc ccaagccccg ccctctgacc
     2101 ctcaaagccc caccccctgc ccatgtggga ccctcctcca agctgtccat tgtctgctgc
     2161 aatgaataca ttttgctttg gatgcattaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
