LOCUS       NM_001105798            2838 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus arachidonate 12-lipoxygenase, 12S type (Alox12),
            mRNA.
ACCESSION   NM_001105798 XM_001079600 XM_001079612 XM_213369
VERSION     NM_001105798.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2838)
  AUTHORS   Xu,H.Z., Wang,W.N., Zhang,Y.Y., Cheng,Y.L. and Xu,Z.G.
  TITLE     Effect of angiotensin II type 1 receptor blocker on 12-lipoxygenase
            activity and slit diaphragm protein expression in type 2 diabetic
            rat glomeruli
  JOURNAL   J Nephrol 29 (6), 775-782 (2016)
   PUBMED   27021232
  REMARK    GeneRIF: Angiotensin II type 1 receptor blocker potentially
            ameliorates diabetic nephropathy via the up-regulation of
            glomerular nephrin and P-cadherin expression through the inhibition
            of 12-LO activation in the glomeruli of rats with type 2 diabetes.
REFERENCE   2  (bases 1 to 2838)
  AUTHORS   Cui,Y., Liu,N., Ma,F., Sun,W., Wu,H., Xu,Z. and Yuan,H.
  TITLE     Role of histone modification in 12-lipoxygenase-associated p21 gene
            regulation
  JOURNAL   Mol Med Rep 14 (4), 3978-3984 (2016)
   PUBMED   27600103
  REMARK    GeneRIF: The aim of the present study was to examine the impacts
            and mechanisms of 12lipoxygenase (12LO) and its metabolites on the
            acetylation and methylation of histone3lysine (H3K) in the p21
            gene. associated epigenetic changes, including increased histone
            H3K9Ac and H3K4Me1, and reduced H3K9M.e3 may involved in 12
            (S)hydroxyeicosatetraenoic acid mediated p21 gene regulation.
REFERENCE   3  (bases 1 to 2838)
  AUTHORS   Teder,T., Boeglin,W.E. and Brash,A.R.
  TITLE     Lipoxygenase-catalyzed transformation of epoxy fatty acids to
            hydroxy-endoperoxides: a potential P450 and lipoxygenase
            interaction
  JOURNAL   J Lipid Res 55 (12), 2587-2596 (2014)
   PUBMED   25293588
REFERENCE   4  (bases 1 to 2838)
  AUTHORS   Deng,B., Wang,C.W., Arnardottir,H.H., Li,Y., Cheng,C.Y., Dalli,J.
            and Serhan,C.N.
  TITLE     Maresin biosynthesis and identification of maresin 2, a new
            anti-inflammatory and pro-resolving mediator from human macrophages
  JOURNAL   PLoS One 9 (7), e102362 (2014)
   PUBMED   25036362
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2838)
  AUTHORS   Lu,M.J., Chen,Y.S., Huang,H.S. and Ma,M.C.
  TITLE     Hypoxic preconditioning protects rat hearts against
            ischemia-reperfusion injury via the
            arachidonate12-lipoxygenase/transient receptor potential vanilloid
            1 pathway
  JOURNAL   Basic Res Cardiol 109 (4), 414 (2014)
   PUBMED   24816396
  REMARK    GeneRIF: Hypoxic preconditioning reduces heart susceptibly to
            ischemia-reperfusion injuryvia ALOX12/TRPV1/PKC pathway.
REFERENCE   6  (bases 1 to 2838)
  AUTHORS   Gao,X., Grignon,D.J., Chbihi,T., Zacharek,A., Chen,Y.Q., Sakr,W.,
            Porter,A.T., Crissman,J.D., Pontes,J.E., Powell,I.J. et al.
  TITLE     Elevated 12-lipoxygenase mRNA expression correlates with advanced
            stage and poor differentiation of human prostate cancer
  JOURNAL   Urology 46 (2), 227-237 (1995)
   PUBMED   7624992
REFERENCE   7  (bases 1 to 2838)
  AUTHORS   Chen,Y.Q., Duniec,Z.M., Liu,B., Hagmann,W., Gao,X., Shimoji,K.,
            Marnett,L.J., Johnson,C.R. and Honn,K.V.
  TITLE     Endogenous 12(S)-HETE production by tumor cells and its role in
            metastasis
  JOURNAL   Cancer Res 54 (6), 1574-1579 (1994)
   PUBMED   7511046
REFERENCE   8  (bases 1 to 2838)
  AUTHORS   Hada,T., Ueda,N., Takahashi,Y. and Yamamoto,S.
  TITLE     Catalytic properties of human platelet 12-lipoxygenase as compared
            with the enzymes of other origins
  JOURNAL   Biochim Biophys Acta 1083 (1), 89-93 (1991)
   PUBMED   1851637
REFERENCE   9  (bases 1 to 2838)
  AUTHORS   Izumi,T., Hoshiko,S., Radmark,O. and Samuelsson,B.
  TITLE     Cloning of the cDNA for human 12-lipoxygenase
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7477-7481 (1990)
   PUBMED   2217179
REFERENCE   10 (bases 1 to 2838)
  AUTHORS   Funk,C.D., Furci,L. and FitzGerald,G.A.
  TITLE     Molecular cloning, primary structure, and expression of the human
            platelet/erythroleukemia cell 12-lipoxygenase
  JOURNAL   Proc Natl Acad Sci U S A 87 (15), 5638-5642 (1990)
   PUBMED   2377602
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001105798.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.43500.1,
                                           SRR26643294.40066.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000010.1  55469018-55469199   c
            183-384             JAXUCZ010000010.1  55468320-55468521   c
            385-466             JAXUCZ010000010.1  55467127-55467208   c
            467-589             JAXUCZ010000010.1  55466900-55467022   c
            590-693             JAXUCZ010000010.1  55466685-55466788   c
            694-854             JAXUCZ010000010.1  55466271-55466431   c
            855-998             JAXUCZ010000010.1  55465276-55465419   c
            999-1208            JAXUCZ010000010.1  55463954-55464163   c
            1209-1295           JAXUCZ010000010.1  55461525-55461611   c
            1296-1465           JAXUCZ010000010.1  55461133-55461302   c
            1466-1587           JAXUCZ010000010.1  55460514-55460635   c
            1588-1688           JAXUCZ010000010.1  55458263-55458363   c
            1689-1859           JAXUCZ010000010.1  55458016-55458186   c
            1860-2838           JAXUCZ010000010.1  55456928-55457906   c
FEATURES             Location/Qualifiers
     source          1..2838
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2838
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /note="arachidonate 12-lipoxygenase, 12S type"
                     /db_xref="GeneID:287454"
                     /db_xref="RGD:1311159"
     exon            1..182
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2039
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /EC_number="1.13.11.31"
                     /EC_number="1.13.11.33"
                     /note="platelet 12-LOX; platelet-type lipoxygenase 12;
                     12S-lipoxygenase; lipoxin synthase 12-LO; linoleate
                     13S-lipoxygenase; arachidonate 15-lipoxygenase,15S-type;
                     arachidonate (12S)-lipoxygenase; arachidonate
                     (15S)-lipoxygenase"
                     /codon_start=1
                     /product="polyunsaturated fatty acid lipoxygenase ALOX12"
                     /protein_id="NP_001099268.2"
                     /db_xref="GeneID:287454"
                     /db_xref="RGD:1311159"
                     /translation="MGRYRVRVVTGAWLFSGSVNLVRLWLVGAHREARLELQLRPARG
                     KEEEFDFDVAEDLGPLQFVKLHKEHTVVDDAWFCNLITVQGPGMSAEAVFPCYRWVQG
                     EGILRLPEGTARLAGDNALDVFQKHREKELKERQQTYRWATWKQGLPQTIAADCKDDL
                     PPNMRFHEEKRLDFEWTLKAGVLEMGLKRVYTLLRSWNRLEDFDQIFWGQKSALAEKV
                     HRCWQEDELFGYQFLNGANPMLLRRSTSLPSRLVLPPGTEELQAQLEKELKDGCLFEA
                     DFILLDGIPANVIRGEQQYLAAPLVMLRMDPSGKLLPMAIQIQPPNPSSPAPTLFLPS
                     DPPLAWLLAKIWVRNSDFQLQELQFHLLNTHLVAEVIAVATMRCLPGLHPIFKLLVPH
                     IRYTMEINTRSRTQLISDGGIFDQVVSTGGGGHVQLLTRAVAQLTYCSLCPPDDLATR
                     GLLRVPSALYAQDALQLWEVTARYVNGMVHLFYQSDDIVRGDPELQAWCREITEVGLC
                     HAQDRGFPVSFQSRAQLCHFLTMCVFTCTSQHAAINQGQLDWYGWVPNAPCTMRMPPP
                     TSKDDVTMETIMGSLPDVQKSCLQMTITWHLGRLQPDMVPLGHHKEKYFSDPRTKAVL
                     SQFQADLENLEKEITARNQQLDLPYEYLKPSRIENSITI"
     exon            183..384
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            385..466
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            467..589
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            590..693
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            694..854
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            855..998
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1208
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1295
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1465
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1587
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1688
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1859
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2838
                     /gene="Alox12"
                     /gene_synonym="12-LO; 12S-LOX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcgcattga acttgacttg gatcgcctcc tgaggccaga gggcgccatg ggccgctacc
       61 gcgtccgcgt ggtcactggg gcctggctct tctcgggatc cgtcaacctg gtgcgtctgt
      121 ggctggtcgg ggcgcacagg gaggcgaggc tggagctgca gctgcggcca gcgcggggca
      181 aggaggagga gtttgatttc gatgttgccg aggacttggg gccactgcag ttcgtgaaac
      241 tgcacaaaga gcacacagtt gtggacgacg cctggttctg caacctcatc acagttcagg
      301 ggcccgggat gagcgcagag gccgtcttcc cctgctaccg ctgggtgcag ggagaaggaa
      361 tcctgagact gccggagggg acagcccgtc tggcaggaga caatgccttg gatgtcttcc
      421 agaagcatcg agagaaggaa ctgaaggaaa gacaacagac ctaccgctgg gccacctgga
      481 agcaaggctt acctcagaca atagcagcag actgtaagga tgacctccct ccaaacatga
      541 gattccatga ggagaagaga ctggactttg aatggacgct gaaggcgggg gttctggaaa
      601 tgggcctcaa acgtgtttat accctcctga gaagctggaa ccgtctggaa gactttgatc
      661 agatcttctg gggccagaag agtgccttgg ctgagaaggt tcaccggtgt tggcaggaag
      721 atgagctctt tggctaccag tttctcaatg gcgccaaccc catgctgttg agacgctcca
      781 cctctctgcc ctccagactg gtactgcccc ctgggacaga ggagcttcaa gcgcagctgg
      841 agaaagaact caaggatgga tgcctgtttg aggctgactt tatcctgctg gatggaattc
      901 cagctaatgt gatccgagga gaacagcagt acctggctgc ccctcttgtc atgttgagga
      961 tggaccccag tgggaagctg ctccccatgg ctatccagat tcagcctccc aatcccagct
     1021 ccccagctcc aacattgttc ctgccctcag atcctccact tgcctggctc ttggctaaga
     1081 tctgggtccg aaattcagat ttccaactgc aggagctcca attccatttg ctgaacactc
     1141 atctggtggc tgaggtcatt gctgttgcca ccatgaggtg cctcccagga ctacacccta
     1201 tctttaagct cctagttccg cacatccgtt acactatgga aattaacaca cggagccgga
     1261 cccagctcat ctcagatgga gggatatttg atcaggtagt gagcacaggt ggaggcggcc
     1321 atgttcagtt gctcactcgg gcagtggctc agctgacgta ctgctccctc tgtcctcccg
     1381 atgatctggc tacccgaggc ctgctgagag tcccaagtgc cctctacgct caggatgctt
     1441 tgcagctctg ggaggtcact gccaggtatg tgaacgggat ggtccatctc ttctaccaga
     1501 gtgacgatat tgtgagggga gacccagagc tgcaggcctg gtgtcgggag atcactgagg
     1561 tggggctgtg ccatgcccag gacagaggat tccctgtctc cttccagtcc cgggcacagc
     1621 tctgccattt ccttaccatg tgtgttttca catgtacttc ccagcatgct gccatcaacc
     1681 agggccagct ggactggtac ggttgggtac ctaatgctcc atgcacaatg aggatgcctc
     1741 caccaaccag caaggacgat gtgacgatgg agaccatcat gggctcactc cctgatgttc
     1801 agaagtcctg tctgcagatg accatcacat ggcacctggg ccgcctccag ccagacatgg
     1861 tacctctagg acaccacaaa gaaaagtatt tctcagaccc aaggaccaaa gctgtgctca
     1921 gccaatttca agcagatctg gaaaatttgg agaaagagat tacagcccgg aaccagcagc
     1981 ttgacctgcc ctacgaatac ctcaagccta gccgtataga gaacagcatc accatctgag
     2041 gcagagccac tgggacccag aagacttcgt cagctctagg accgccacta cccacttgat
     2101 tatgtgcctt cttatgtctg ctgctgagac tcaaattcct cttctgaccg aacacatcag
     2161 cattctacta cggggcactg aatgttttgc tgttaagagg aacagtttag tctttggagg
     2221 accacccact ttctaccaca attacttagc tctctcactg taccactaag gcagccacca
     2281 acattatgtg tgtgtgtgac tacgttccaa taaagcttta ggtatggaca ctaagatatg
     2341 aactttgcaa gtcaccgggt agtctttccg ccttgttctg ccatttaaaa acaaaacaaa
     2401 gccaggcgta gtgatgcact cctttaatct cagcacttgg gaggcagatg cagcagatct
     2461 gagttcaaga agagcctgac ctacagagtg agctccagga cagccagggc tgaaaccctg
     2521 tctttacaaa caaaacaaaa caagtacaaa aacaaaagtg ctttgcatga gttcaggtta
     2581 gatttggtct aacctcaaac aagcctcaga ccccattttc aaaacaccca agagccatgg
     2641 ctgaggagag gaaaattata tttctggatg aagtcagcta cttcagctaa ttctccttcg
     2701 ccaggaacca gacctcatgc ttgatggcca acgtgtaaat tccagactct tcccctccac
     2761 cccctacttt cccattttga acccactttg aacacatacc ctaaatagat ctaaataaag
     2821 gtgttgctgg tcccaaat
//
