LOCUS       NM_001191643            1755 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus alkB homolog 5, RNA demethylase (Alkbh5), mRNA.
ACCESSION   NM_001191643 XM_220525
VERSION     NM_001191643.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Song,K., Cao,Q., Yang,Y., Zuo,Y. and Wu,X.
  TITLE     ALKBH5 modulates bone cancer pain in a rat model by suppressing
            NR2B expression
  JOURNAL   Biotechnol Appl Biochem 71 (5), 1105-1115 (2024)
   PUBMED   38764325
  REMARK    GeneRIF: ALKBH5 modulates bone cancer pain in a rat model by
            suppressing NR2B expression.
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Zhou,J., Tang,J., Zhang,C., Li,G., Lin,X., Liao,S., Luo,J., Yu,G.,
            Zheng,F., Guo,Z., Shao,W., Hu,H., Xu,L., Wu,S. and Li,H.
  TITLE     ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in
            hyperbilirubinemia-induced brain damage
  JOURNAL   Free Radic Biol Med 220, 271-287 (2024)
   PUBMED   38734267
  REMARK    GeneRIF: ALKBH5 targets ACSL4 mRNA stability to modulate
            ferroptosis in hyperbilirubinemia-induced brain damage.
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Fan,D., Geng,Q., Wang,B., Wang,X., Xia,Y., Yang,L., Zhang,Q.,
            Deng,T., Xu,Y., Zhao,H., Liu,B., Lu,C., Gu,X. and Xiao,C.
  TITLE     Hypoxia-induced ALKBH5 aggravates synovial aggression and
            inflammation in rheumatoid arthritis by regulating the m6A
            modification of CH25H
  JOURNAL   Clin Immunol 261, 109929 (2024)
   PUBMED   38331303
  REMARK    GeneRIF: Hypoxia-induced ALKBH5 aggravates synovial aggression and
            inflammation in rheumatoid arthritis by regulating the m6A
            modification of CH25H.
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Huang,Z., Zhang,Y., Wang,S., Qi,R., Tao,Y., Sun,Y., Jiang,D.,
            Jiang,X. and Tao,J.
  TITLE     FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain
            via m6A-dependent stabilization of 5-HT3A mRNA in sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 121 (6), e2312861121 (2024)
   PUBMED   38285939
  REMARK    GeneRIF: FOXD3-mediated transactivation of ALKBH5 promotes
            neuropathic pain via m[6]A-dependent stabilization of 5-HT3A mRNA
            in sensory neurons.
REFERENCE   5  (bases 1 to 1755)
  AUTHORS   Kuang,Y., Li,R., Wang,J., Xu,S., Qiu,Q., Lin,S., Liu,D., Shen,C.,
            Liu,Y., Xu,M., Lin,W., Zhang,S., Liang,L., Xu,H. and Xiao,Y.
  TITLE     ALKBH5-Mediated RNA m6 A Methylation Regulates the Migration,
            Invasion, and Proliferation of Rheumatoid Fibroblast-Like
            Synoviocytes
  JOURNAL   Arthritis Rheumatol 76 (2), 192-205 (2024)
   PUBMED   37584615
  REMARK    GeneRIF: ALKBH5-Mediated RNA m[6] A Methylation Regulates the
            Migration, Invasion, and Proliferation of Rheumatoid
            Fibroblast-Like Synoviocytes.
REFERENCE   6  (bases 1 to 1755)
  AUTHORS   Zheng,G., Dahl,J.A., Niu,Y., Fedorcsak,P., Huang,C.M., Li,C.J.,
            Vagbo,C.B., Shi,Y., Wang,W.L., Song,S.H., Lu,Z., Bosmans,R.P.,
            Dai,Q., Hao,Y.J., Yang,X., Zhao,W.M., Tong,W.M., Wang,X.J.,
            Bogdan,F., Furu,K., Fu,Y., Jia,G., Zhao,X., Liu,J., Krokan,H.E.,
            Klungland,A., Yang,Y.G. and He,C.
  TITLE     ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism
            and mouse fertility
  JOURNAL   Mol Cell 49 (1), 18-29 (2013)
   PUBMED   23177736
REFERENCE   7  (bases 1 to 1755)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 1755)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 1755)
  AUTHORS   Thalhammer,A., Bencokova,Z., Poole,R., Loenarz,C., Adam,J.,
            O'Flaherty,L., Schodel,J., Mole,D., Giaslakiotis,K.,
            Schofield,C.J., Hammond,E.M., Ratcliffe,P.J. and Pollard,P.J.
  TITLE     Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent
            oxygenase and a direct target of hypoxia-inducible factor 1alpha
            (HIF-1alpha)
  JOURNAL   PLoS One 6 (1), e16210 (2011)
   PUBMED   21264265
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1755)
  AUTHORS   Simon,G.M. and Cravatt,B.F.
  TITLE     Endocannabinoid biosynthesis proceeding through
            glycerophospho-N-acyl ethanolamine and a role for
            alpha/beta-hydrolase 4 in this pathway
  JOURNAL   J Biol Chem 281 (36), 26465-26472 (2006)
   PUBMED   16818490
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Sep 17, 2011 this sequence version replaced XM_220525.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.36905.1,
                                           SRR26643289.27904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-773               JAXUCZ010000010.1  45844411-45845183
            774-854             JAXUCZ010000010.1  45854032-45854112
            855-1010            JAXUCZ010000010.1  45864592-45864747
            1011-1755           JAXUCZ010000010.1  45865109-45865853
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1755
                     /gene="Alkbh5"
                     /gene_synonym="RGD1309496"
                     /note="alkB homolog 5, RNA demethylase"
                     /db_xref="GeneID:303193"
                     /db_xref="RGD:1309496"
     CDS             1..1188
                     /gene="Alkbh5"
                     /gene_synonym="RGD1309496"
                     /EC_number="1.14.11.53"
                     /note="alkylated DNA repair protein alkB homolog 5;
                     alpha-ketoglutarate-dependent dioxygenase alkB homolog 5;
                     alkB, alkylation repair homolog 5; AlkB family member 5,
                     RNA demethylase"
                     /codon_start=1
                     /product="RNA demethylase ALKBH5"
                     /protein_id="NP_001178572.1"
                     /db_xref="GeneID:303193"
                     /db_xref="RGD:1309496"
                     /translation="MAAASGYTDLREKLKSMTSRDNYKAGSREAAAAAAAAVAAAAAA
                     AAAAEPYPVSGTTKRKYQEDSDPERSDYEEHQLQKEEEARKVKSGIRQIRLFSQDECS
                     KIEARIDEVVSRAEKGLYNEHTVDRAPLRNKYFFGEGYTYGAQLQKRGPGQERLYPPG
                     DVDEIPEWVHQLVIQKLVEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVS
                     VSFFSDSALCFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKE
                     RRAVIILRKTRLDAPRLETKSLSSSTLPPSYASDRLSGNTRDPALKPKRSHRKADPDA
                     AHRPRILEMDKEENRRSVLLPTHRRRGSFSSENYWRKSYESSEDCPEAASSPTRKVKM
                     RRH"
     exon            1..773
                     /gene="Alkbh5"
                     /gene_synonym="RGD1309496"
                     /inference="alignment:Splign:2.1.0"
     exon            774..854
                     /gene="Alkbh5"
                     /gene_synonym="RGD1309496"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1010
                     /gene="Alkbh5"
                     /gene_synonym="RGD1309496"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1755
                     /gene="Alkbh5"
                     /gene_synonym="RGD1309496"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggccg ccagcggcta cacggacctg cgtgagaagc tcaagtccat gacgtcccgg
       61 gacaactaca aggcaggcag ccgggaggcc gccgccgctg cagccgctgc tgtggccgcc
      121 gccgcggctg ccgcggccgc cgccgagcct tacccggtgt ccgggaccac caaacggaag
      181 taccaggagg actcagaccc cgaacgcagt gactacgagg agcatcagtt gcagaaggag
      241 gaggaggcgc gcaaggtgaa gagcggcatc cggcagatac gtctcttcag ccaggatgag
      301 tgctccaaga tcgaggcccg catcgacgag gtggtgtccc gcgctgagaa gggcctgtac
      361 aacgagcaca ctgtggatcg ggcccccctg cgcaacaagt acttcttcgg cgagggctac
      421 acgtacggtg cccagctgca aaagcgcggg ccaggccagg agcgcctcta cccgccaggc
      481 gacgtcgatg agatcccgga atgggtgcat cagctggtga tccagaagct ggtggagcac
      541 cgcgtcatcc ccgagggctt cgtcaacagc gcagtcatca acgactacca gcctggcggc
      601 tgcatcgtat ctcacgtaga ccccatccac atcttcgagc gcccgatcgt gtccgtgtct
      661 ttctttagcg actcggcact ttgcttcggt tgcaagttcc agttcaagcc catccgggtg
      721 tcggaacctg tgctttccct gccggtgcgc agggggagcg tgactgtgct cagtgggtat
      781 gctgctgatg agatcactca ctgcatacgg cctcaggaca tcaaagaacg ccgggcggtc
      841 atcattctca ggaagacaag attagatgca ccacgattgg aaacaaaatc cctgagcagc
      901 tccacattgc cacccagcta tgcttcagat cgtctgtcag gaaacaccag agaccctgcg
      961 ctgaaaccca aaaggtccca ccgcaaggca gaccctgatg ctgcccatag gccccggatc
     1021 ctggaaatgg acaaagaaga aaaccggcgg tctgtgcttc tgcccacaca ccggcggaga
     1081 gggagtttta gctctgagaa ctattggcgc aagtcctatg agtcctcaga agattgccca
     1141 gaggcagcca gcagccccac ccgcaaggtg aagatgagga gacactgagg ccctgtgccc
     1201 tcctggaact ctggctaatc ctgatgtagc taccccatct tctgttccat tttgagtgtt
     1261 ttttctttgt tattttggcc ctatatatgt tttccttgct ttgttgccca ttaaggctaa
     1321 agaacagaat tggtgaaaga cctgggttct tatgttcttg gctttcctcc ttgatggata
     1381 gcttctgtag gggatcgctc acaccagagt agccagtaga gataatgggg acagctgtct
     1441 tcaagtggaa ctatgtcagg ctaagttcat tgaaacacac aaaatgtttt ggttacgaaa
     1501 ttctagtttg ggctttaaat gtaaacctat gtagtgtttt aaacaatgtc tattcttttg
     1561 ccagcccttt tcttccactg atgttcatgc ttgaatgagg tctcttggag ccatgcaggc
     1621 cctgcattgg gtctgctgcc ctacatctca cttgctgtcc aggctctgga agctcatgca
     1681 aataccctgt tccccactgt tcaggttggc tgtgtatggg gcttaaacag tgccagcctc
     1741 tgccatccca tttct
//
