LOCUS       NM_001014180            1286 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus alkB homolog 3, alpha-ketoglutarate-dependent
            dioxygenase (Alkbh3), mRNA.
ACCESSION   NM_001014180 XM_342469
VERSION     NM_001014180.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1286)
  AUTHORS   Li,X., Xiong,X., Wang,K., Wang,L., Shu,X., Ma,S. and Yi,C.
  TITLE     Transcriptome-wide mapping reveals reversible and dynamic
            N(1)-methyladenosine methylome
  JOURNAL   Nat Chem Biol 12 (5), 311-316 (2016)
   PUBMED   26863410
REFERENCE   2  (bases 1 to 1286)
  AUTHORS   Dominissini,D., Nachtergaele,S., Moshitch-Moshkovitz,S., Peer,E.,
            Kol,N., Ben-Haim,M.S., Dai,Q., Di Segni,A., Salmon-Divon,M.,
            Clark,W.C., Zheng,G., Pan,T., Solomon,O., Eyal,E., Hershkovitz,V.,
            Han,D., Dore,L.C., Amariglio,N., Rechavi,G. and He,C.
  TITLE     The dynamic N(1)-methyladenosine methylome in eukaryotic messenger
            RNA
  JOURNAL   Nature 530 (7591), 441-446 (2016)
   PUBMED   26863196
REFERENCE   3  (bases 1 to 1286)
  AUTHORS   Dango,S., Mosammaparast,N., Sowa,M.E., Xiong,L.J., Wu,F., Park,K.,
            Rubin,M., Gygi,S., Harper,J.W. and Shi,Y.
  TITLE     DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA
            alkylation repair and cancer cell proliferation
  JOURNAL   Mol Cell 44 (3), 373-384 (2011)
   PUBMED   22055184
REFERENCE   4  (bases 1 to 1286)
  AUTHORS   Sundheim,O., Vagbo,C.B., Bjoras,M., Sousa,M.M., Talstad,V.,
            Aas,P.A., Drablos,F., Krokan,H.E., Tainer,J.A. and Slupphaug,G.
  TITLE     Human ABH3 structure and key residues for oxidative demethylation
            to reverse DNA/RNA damage
  JOURNAL   EMBO J 25 (14), 3389-3397 (2006)
   PUBMED   16858410
REFERENCE   5  (bases 1 to 1286)
  AUTHORS   Lee,D.H., Jin,S.G., Cai,S., Chen,Y., Pfeifer,G.P. and O'Connor,T.R.
  TITLE     Repair of methylation damage in DNA and RNA by mammalian AlkB
            homologues
  JOURNAL   J Biol Chem 280 (47), 39448-39459 (2005)
   PUBMED   16174769
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083756.1.
            
            On Apr 20, 2005 this sequence version replaced XM_342469.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083756.1, FQ229710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1286
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q31"
     gene            1..1286
                     /gene="Alkbh3"
                     /note="alkB homolog 3, alpha-ketoglutarate-dependent
                     dioxygenase"
                     /db_xref="GeneID:362169"
                     /db_xref="RGD:1359731"
     exon            1..60
                     /gene="Alkbh3"
                     /inference="alignment:Splign:2.1.0"
     exon            61..210
                     /gene="Alkbh3"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1019
                     /gene="Alkbh3"
                     /EC_number="1.14.11.33"
                     /EC_number="1.14.11.54"
                     /note="alkylated DNA repair protein alkB homolog 3; alkB,
                     alkylation repair homolog 3; alkylation repair-like
                     protein 3"
                     /codon_start=1
                     /product="alpha-ketoglutarate-dependent dioxygenase alkB
                     homolog 3"
                     /protein_id="NP_001014202.1"
                     /db_xref="GeneID:362169"
                     /db_xref="RGD:1359731"
                     /translation="MGDKRQRARVQGAWATPTKSQSAARPATPARSRPSQTPGPSWRS
                     KEQQQCDRRFVFKEPQLVVRAAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDLKEA
                     DWILERLCQDVPWKQRMGIREDITYPQPRLTAWYGELPYTYSRVTMEPNPHWLPVLWT
                     LKSRIEENTGHTFNSLLCNFYRDEKDSVDWHSDDEPSLGSCPVIASLSFGATRTFEMR
                     KKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSRERRVNLTFRT
                     VYPDPRGAPGDTSAELPLR"
     exon            211..314
                     /gene="Alkbh3"
                     /inference="alignment:Splign:2.1.0"
     exon            315..349
                     /gene="Alkbh3"
                     /inference="alignment:Splign:2.1.0"
     exon            350..397
                     /gene="Alkbh3"
                     /inference="alignment:Splign:2.1.0"
     exon            398..501
                     /gene="Alkbh3"
                     /inference="alignment:Splign:2.1.0"
     exon            502..590
                     /gene="Alkbh3"
                     /inference="alignment:Splign:2.1.0"
     exon            591..800
                     /gene="Alkbh3"
                     /inference="alignment:Splign:2.1.0"
     exon            801..899
                     /gene="Alkbh3"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1261
                     /gene="Alkbh3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcgtccg gacagctgag cggctaacga aagtcggaaa cttttctcag gcccagccag
       61 gtaaccattc catggtctga atggggaacg aaatctcctg aaatctcaga acagaacgct
      121 ctttcttcaa catgggggac aagagacagc gagcccgagt gcagggagcc tgggccacac
      181 ctaccaagag ccagtctgct gctcggccag ctactcctgc tagaagccgt ccttcccaga
      241 caccagggcc aagctggagg agcaaggaac agcagcaatg tgaccgacgg tttgtgttca
      301 aagaaccgca gctggttgta cgtgcagccc cagagcccag agtgattgac agggagggtg
      361 tgtacgaaat cagcctgtcc cctacaggtg tgtctagggt gtgtttatat cctggctttg
      421 tggacttgaa ggaagctgac tggatcttgg agcggctttg tcaagatgtc ccctggaaac
      481 agaggatggg catcagagag gatataactt atccgcaacc aagacttaca gcatggtatg
      541 gagagcttcc ttacacttac tcaagagtca ctatggaacc aaatcctcac tggcttcctg
      601 tgctgtggac tctgaagagc cgcattgagg agaacactgg ccacaccttc aactccttgc
      661 tgtgtaattt ttaccgggac gagaaggaca gtgtggactg gcacagcgat gatgagccat
      721 ccctggggag ctgccctgtc attgcttcac tcagttttgg tgccactcgg acttttgaga
      781 tgaggaagaa acccccacct gaagagaatg gagactatac ttatgtggag agagtgaaga
      841 taccattgga tcacgggacc ttgctaatca tggaaggagc cacgcaagct gactggcagc
      901 accgagtgcc caaggaatac cactccagag aacggagagt aaacctaacc tttcggaccg
      961 tttatccaga cccaagagga gcccccggtg atacttctgc agagctgcca ctgaggtgag
     1021 ggctgtgcac ccagcagccc ctccccatct cccagaagca cttccagaag ctgctgcgtg
     1081 tacctccgtg atgtggctgt ttggaaattg tgtttgcttc tcaggtccta ttcctcctga
     1141 atgagagcta ccaacacttc atgctgtccg catgtctact atagggacag ttacttgaga
     1201 caactctcta aatcaagggt tgtccttagg caaattaaaa actgctctgg ctgtgcttac
     1261 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
