LOCUS       NM_001395611            3910 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus alkB homolog 1, histone H2A dioxygenase (Alkbh1),
            transcript variant 1, mRNA.
ACCESSION   NM_001395611 XM_006240394
VERSION     NM_001395611.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3910)
  AUTHORS   Ma CJ, Ding JH, Ye TT, Yuan BF and Feng YQ.
  TITLE     AlkB Homologue 1 Demethylates N3-Methylcytidine in mRNA of Mammals
  JOURNAL   ACS Chem Biol 14 (7), 1418-1425 (2019)
   PUBMED   31188562
REFERENCE   2  (bases 1 to 3910)
  AUTHORS   Xiao CL, Zhu S, He M, Chen D, Zhang Q, Chen Y, Yu G, Liu J, Xie SQ,
            Luo F, Liang Z, Wang DP, Bo XC, Gu XF, Wang K and Yan GR.
  TITLE     N6-Methyladenine DNA Modification in the Human Genome
  JOURNAL   Mol Cell 71 (2), 306-318 (2018)
   PUBMED   30017583
REFERENCE   3  (bases 1 to 3910)
  AUTHORS   Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q,
            Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T and He C.
  TITLE     ALKBH1-Mediated tRNA Demethylation Regulates Translation
  JOURNAL   Cell 167 (3), 816-828 (2016)
   PUBMED   27745969
REFERENCE   4  (bases 1 to 3910)
  AUTHORS   Haag S, Sloan KE, Ranjan N, Warda AS, Kretschmer J, Blessing C,
            Hubner B, Seikowski J, Dennerlein S, Rehling P, Rodnina MV,
            Hobartner C and Bohnsack MT.
  TITLE     NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand
            codon recognition in mitochondrial translation
  JOURNAL   EMBO J 35 (19), 2104-2119 (2016)
   PUBMED   27497299
REFERENCE   5  (bases 1 to 3910)
  AUTHORS   Wu TP, Wang T, Seetin MG, Lai Y, Zhu S, Lin K, Liu Y, Byrum SD,
            Mackintosh SG, Zhong M, Tackett A, Wang G, Hon LS, Fang G, Swenberg
            JA and Xiao AZ.
  TITLE     DNA methylation on N(6)-adenine in mammalian embryonic stem cells
  JOURNAL   Nature 532 (7599), 329-333 (2016)
   PUBMED   27027282
REFERENCE   6  (bases 1 to 3910)
  AUTHORS   Muller TA, Meek K and Hausinger RP.
  TITLE     Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic
            sites
  JOURNAL   DNA Repair (Amst) 9 (1), 58-65 (2010)
   PUBMED   19959401
REFERENCE   7  (bases 1 to 3910)
  AUTHORS   Westbye MP, Feyzi E, Aas PA, Vagbo CB, Talstad VA, Kavli B, Hagen
            L, Sundheim O, Akbari M, Liabakk NB, Slupphaug G, Otterlei M and
            Krokan HE.
  TITLE     Human AlkB homolog 1 is a mitochondrial protein that demethylates
            3-methylcytosine in DNA and RNA
  JOURNAL   J Biol Chem 283 (36), 25046-25056 (2008)
   PUBMED   18603530
REFERENCE   8  (bases 1 to 3910)
  AUTHORS   Pan Z, Sikandar S, Witherspoon M, Dizon D, Nguyen T, Benirschke K,
            Wiley C, Vrana P and Lipkin SM.
  TITLE     Impaired placental trophoblast lineage differentiation in
            Alkbh1(-/-) mice
  JOURNAL   Dev Dyn 237 (2), 316-327 (2008)
   PUBMED   18163532
REFERENCE   9  (bases 1 to 3910)
  AUTHORS   Gorba T, Bradoo P, Antonic A, Marvin K, Liu DX, Lobie PE, Reymann
            KG, Gluckman PD and Sieg F.
  TITLE     Neural regeneration protein is a novel chemoattractive and neuronal
            survival-promoting factor
  JOURNAL   Exp Cell Res 312 (16), 3060-3074 (2006)
   PUBMED   16860792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000166.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001395611.2.
            
            On Jul 22, 2021 this sequence version replaced XM_006240394.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487230.7875.1,
                                           SRR8487226.15988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               JACYVU010000166.1  7088036-7088249     c
            215-323             JACYVU010000166.1  7084285-7084393     c
            324-486             JACYVU010000166.1  7081345-7081507     c
            487-577             JACYVU010000166.1  7075293-7075383     c
            578-771             JACYVU010000166.1  7072995-7073188     c
            772-3910            JACYVU010000166.1  7067766-7070904     c
FEATURES             Location/Qualifiers
     source          1..3910
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..3910
                     /gene="Alkbh1"
                     /gene_synonym="Alkbh"
                     /note="alkB homolog 1, histone H2A dioxygenase"
                     /db_xref="GeneID:362766"
                     /db_xref="RGD:1308327"
     exon            1..214
                     /gene="Alkbh1"
                     /gene_synonym="Alkbh"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1201
                     /gene="Alkbh1"
                     /gene_synonym="Alkbh"
                     /EC_number="4.2.99.18"
                     /note="alkylated DNA repair protein alkB homolog 1; alkB,
                     alkylation repair homolog 1; DNA demethylase ALKBH1"
                     /codon_start=1
                     /product="nucleic acid dioxygenase ALKBH1"
                     /protein_id="NP_001382540.1"
                     /db_xref="GeneID:362766"
                     /db_xref="RGD:1308327"
                     /translation="MGKMAAAVVSLTSLATEPKEDAFRKLFRFYRQSRRSTADLGAVI
                     DFSEAHVAQSPKPGVPKVVRFPLNVSSVTEHDTSRAGLQPVSKWQAYGLEGYPGFIFI
                     PNPFLPGCQWHWIKQCLKLYSQKPNVCNLDKHMTKEETQGLWEQSKEFLRSKDKTKRR
                     PRSLLERLRWVTLGYHYNWDSKKYSADHYTPFPSDLAFLSEQVATACGFQGFRAEAGI
                     LNYYRLDSTLGIHVDRSELDHSKPLLSFSFGQSAIFLLGGLKRDEAPTAMFMHSGDIM
                     VMSGFSRLLNHAVPRVLPHPDGECLPHCLETPLPAVLPSGSLLEPCSVEDWQVCATYL
                     KTARVNMTVRQVLATGQDFPLEPMEEPKRDITADGLCHLHDQKSPVKRKRLNTND"
     exon            215..323
                     /gene="Alkbh1"
                     /gene_synonym="Alkbh"
                     /inference="alignment:Splign:2.1.0"
     exon            324..486
                     /gene="Alkbh1"
                     /gene_synonym="Alkbh"
                     /inference="alignment:Splign:2.1.0"
     exon            487..577
                     /gene="Alkbh1"
                     /gene_synonym="Alkbh"
                     /inference="alignment:Splign:2.1.0"
     exon            578..771
                     /gene="Alkbh1"
                     /gene_synonym="Alkbh"
                     /inference="alignment:Splign:2.1.0"
     exon            772..3910
                     /gene="Alkbh1"
                     /gene_synonym="Alkbh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttccgggc caaactgttc gcaacatcga gatggggaag atggcggctg cggtcgtttc
       61 attaacctcg ctggcaacag aacccaaaga ggatgctttc cggaagcttt tccgcttcta
      121 caggcagagc cggcggagta cggcggacct aggagcggtc atcgacttct cagaggctca
      181 cgtggctcag agcccgaagc ccggcgtgcc caaggtggtc agattccctc tgaacgtgtc
      241 ctcagtgact gagcatgata cctctagggc aggacttcaa cctgtgagca agtggcaggc
      301 ttatggactg gaaggctatc ctggatttat ttttattcca aatcccttcc tcccgggatg
      361 ccaatggcac tggataaaac agtgccttaa gttgtattcc cagaaaccta atgtatgtaa
      421 cctggacaag cacatgacta aagaagagac ccaaggtctg tgggaacaga gcaaagagtt
      481 cctaaggtct aaagacaaga ctaagcggag accccgaagt ttactagaga gactgcgctg
      541 ggtcactctg ggctaccatt ataactggga cagtaagaaa tactcagcag atcattatac
      601 acctttccct tctgacctgg ctttcctctc agagcaagtc gccactgcct gtggatttca
      661 gggtttccga gcagaagcag gtatcctgaa ttactaccgc ctagactcca cactgggaat
      721 ccatgtggac agatcggaac tagatcactc caaacccttg ctgtccttca gctttggaca
      781 gtctgccatc tttctcctgg gtggcctcaa gagagatgaa gctcccacag ccatgtttat
      841 gcacagtggt gacatcatgg taatgtcagg tttcagccgc ctgttaaatc atgcagtccc
      901 tcgagtcctt ccacatcctg atggggagtg cctgcctcac tgcctggaga cacctctccc
      961 agctgtcctc cctagcggat cattgcttga gccctgttct gtggaagact ggcaggtgtg
     1021 tgccacctac ttgaaaactg cccgagttaa tatgactgtt cggcaggtac tggccacagg
     1081 ccaggacttt cctttagaac ccatggagga gccaaaaaga gacattactg cagatggttt
     1141 gtgccatctg catgaccaga aaagccctgt aaaacggaag aggttaaata ccaacgacta
     1201 aagcttaggg gactctctgg ttgcctcaca caggggcagg gaagaactca cctgtcatgc
     1261 ttctgccttg ggcccatctt agagcataaa ctgagtttgt ccagagaagt gtcctactcg
     1321 gcccagttct agctcttatt aggtgtgtgt gtgtttgtca taccacattg gtataatggt
     1381 ccacacagac gaaagcattt gaagtgagtt catatgtctg tgtcgagtca acacctcaca
     1441 gtttgctgat aggaaatagt gtctttctcc cagcactttg tgatctatga accagccacc
     1501 agaattccta acttctagcc gtcaaattct ttggctcttc actctttttt gctctcatag
     1561 aggaatctta agcagatgaa gacagtggaa ttaaaactgt gaccctcggg gctggggatt
     1621 tagctcagtg gtagagcgct tgcctaggaa gcgcaaggcc ctgggttcgg tccccagctc
     1681 cggaaaaaaa aagaaccaaa aaaaaaaaaa aaaactgtga ccctcaggag tcacagttgt
     1741 cacatgattg gtggagcaca tgcctgccat gcactaagcc ctgggttcaa taaccagtac
     1801 cacataagcc agatgcagtg catccctgtt tcccatgtac tctggggtac aggatcagac
     1861 ttgaaggtca tcctgcatct ctagactctt cctgataagt ttttaatttg cttaaaagtc
     1921 tctagggtgt tttgttagct gttttctcca tgaataaact tactctacat taaagatctc
     1981 tatctgtctt tgagattagt gtatcaggaa tttacttttc cctcatttta ttgtattgtt
     2041 catgctattg aagtctcaag ctgtctttcc tttcccctaa gtattgtgct gttgcaggaa
     2101 aaatgttcct tgaccatcca gtcatgatgt caaaagtgca atgtcgtctc cataggggaa
     2161 tttggtgctc ctttctagaa actgagtgtg cctgttaatt tgggagacag ggacaggctg
     2221 gaagccactg tgctgcctga agtgtgattt gttccatttc catctttctc tgccctgtcc
     2281 ccccaccccc tttatttatc tgcacttgat cattgagttt gtatgagaat agcaggtatg
     2341 gtattttttt ataaagaaaa attaatacat atcccttatt tttccttaac tttttcttga
     2401 taggttatta aacttgatcc acataaaacc aacaagctgg ggtttttttt gggggggggg
     2461 tggtgagccc aacagaaagt ttatcgatgc cattaaaaca ggcgagttag ctaggcaggg
     2521 gtggcacttg ccataatccc agcactcagg aggtagaggc aagtggggct ctgaatttga
     2581 gaccagcttg gtctacagga tgagttttag gacagccaag gctgttacac aaagaaaccc
     2641 tgtctcagga aggaaaaaac ctatagaaag tatcagataa ggcactctta gagccagcta
     2701 gaataagcta gccaggaaca cccggggtgg tgggcccctg tagggaacgc attcaaatag
     2761 actggattag aggtcagcac actgtggctc attttctttt cctgtgtgca agcctttcta
     2821 agtggctgtg gggagggttc ataagaatgt tctataaagt cccaacatcc agagttaatt
     2881 tcttgaatga gaggcaactg gagagatgac ccagaagaac cctatgttcc gttcccagca
     2941 cacatacatg acagctcatg agtatcgaac tccagttcag gggagccgac accctctctg
     3001 gcctctggta cccaagtgca catgtacata cataaagagg caaaacacaa acacatcaaa
     3061 aaaaaaaaaa acgtgtttag tgaggtttgt gtgtgtgtat tttaaagatt ttaggaacaa
     3121 atacctttga gtattttgag tacaaggtta gagaatccta cagaacctag aaaatctgat
     3181 cagcaccttg acagaacaag tttagcctcc taagaaactg catctgaagg aaaaagcctg
     3241 tcacctagga aggaaccgtg gaagtactgt ttttccaaga actaaattca agtgctgctc
     3301 ggagagtcca gttggtgttt tctcagtgca gaggtgcagg gaggtaggac cctgctagtc
     3361 tgctctgctg tgaggatgta aactagagtc ccctcttggg tgtttgcatt gtggaacgtg
     3421 gtcccacgct gtgtcctttt ttccgctcaa atcatttgag aaatcatgtg acatcctgtt
     3481 ttcagtagtg ttcttgggcc caataaattt cactactgag atttgagtct acaaaagtta
     3541 acagagccat gcagggaggt ttttgttcat gaatgtttat cagagtaaag atctagagca
     3601 agttcatgtc cagcatcagg aagcggctgc tcaaactctt atttctccac aaatggttct
     3661 ggagcacctt cagctaagca actggagtca tgctgacgtc acaccgaata cagaaaacaa
     3721 ctgctttttc aaggacagca ggggggtggg gagccatagt gtagaaagtg acaactatac
     3781 agagcaacat tctgtacaga atgtgaaata gttgttaatt tttatttaag ttatgtatgt
     3841 acttctgatt tatatttata accttttaaa aactttctta ataaaatttt atttttttaa
     3901 aaggtggtaa
//
