LOCUS       NM_001169101            6375 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Rattus norvegicus ALK receptor tyrosine kinase (Alk), mRNA.
ACCESSION   NM_001169101 XM_001067235
VERSION     NM_001169101.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6375)
  AUTHORS   Tang,C., Wang,M., Wang,P., Wang,L., Wu,Q. and Guo,W.
  TITLE     Neural Stem Cells Behave as a Functional Niche for the Maturation
            of Newborn Neurons through the Secretion of PTN
  JOURNAL   Neuron 101 (1), 32-44 (2019)
   PUBMED   30497772
REFERENCE   2  (bases 1 to 6375)
  AUTHORS   Liu,C.N., Mathialagan,N., Lappin,P., Fortner,J., Somps,C.,
            Seitis,G., Johnson,T.R., Hu,W. and Matsumoto,D.
  TITLE     Crizotinib reduces the rate of dark adaptation in the rat retina
            independent of ALK inhibition
  JOURNAL   Toxicol Sci 143 (1), 116-125 (2015)
   PUBMED   25326243
  REMARK    GeneRIF: Electroretinography b-wave amplitude decreases during dark
            adaption following crizotinib administration may be related to
            signaling changes within the retina in rats, likely independent of
            ALK inhibition.
REFERENCE   3  (bases 1 to 6375)
  AUTHORS   Bresler,S.C., Weiser,D.A., Huwe,P.J., Park,J.H., Krytska,K.,
            Ryles,H., Laudenslager,M., Rappaport,E.F., Wood,A.C., McGrady,P.W.,
            Hogarty,M.D., London,W.B., Radhakrishnan,R., Lemmon,M.A. and
            Mosse,Y.P.
  TITLE     ALK mutations confer differential oncogenic activation and
            sensitivity to ALK inhibition therapy in neuroblastoma
  JOURNAL   Cancer Cell 26 (5), 682-694 (2014)
   PUBMED   25517749
REFERENCE   4  (bases 1 to 6375)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   5  (bases 1 to 6375)
  AUTHORS   Wang,K.S., Liu,X., Zhang,Q., Pan,Y., Aragam,N. and Zeng,M.
  TITLE     A meta-analysis of two genome-wide association studies identifies 3
            new loci for alcohol dependence
  JOURNAL   J Psychiatr Res 45 (11), 1419-1425 (2011)
   PUBMED   21703634
REFERENCE   6  (bases 1 to 6375)
  AUTHORS   Mourali,J., Benard,A., Lourenco,F.C., Monnet,C., Greenland,C.,
            Moog-Lutz,C., Racaud-Sultan,C., Gonzalez-Dunia,D., Vigny,M.,
            Mehlen,P., Delsol,G. and Allouche,M.
  TITLE     Anaplastic lymphoma kinase is a dependence receptor whose
            proapoptotic functions are activated by caspase cleavage
  JOURNAL   Mol Cell Biol 26 (16), 6209-6222 (2006)
   PUBMED   16880530
  REMARK    GeneRIF: ALK has a proapoptotic activity in the absence of ligand,
            whereas it is antiapoptotic in the presence of its ligand and when
            the kinase is intrinsically activated.
REFERENCE   7  (bases 1 to 6375)
  AUTHORS   Moog-Lutz,C., Degoutin,J., Gouzi,J.Y., Frobert,Y., Brunet-de
            Carvalho,N., Bureau,J., Creminon,C. and Vigny,M.
  TITLE     Activation and inhibition of anaplastic lymphoma kinase receptor
            tyrosine kinase by monoclonal antibodies and absence of agonist
            activity of pleiotrophin
  JOURNAL   J Biol Chem 280 (28), 26039-26048 (2005)
   PUBMED   15886198
  REMARK    GeneRIF: analysis of differentiation of PC12 cells and human
            embryonic kidney 293 cells transfected with ALK shows absence of
            agonist activity of pleiotrophin
REFERENCE   8  (bases 1 to 6375)
  AUTHORS   Grisendi,S. and Pandolfi,P.P.
  TITLE     NPM mutations in acute myelogenous leukemia
  JOURNAL   N Engl J Med 352 (3), 291-292 (2005)
   PUBMED   15659732
REFERENCE   9  (bases 1 to 6375)
  AUTHORS   Souttou,B., Carvalho,N.B., Raulais,D. and Vigny,M.
  TITLE     Activation of anaplastic lymphoma kinase receptor tyrosine kinase
            induces neuronal differentiation through the mitogen-activated
            protein kinase pathway
  JOURNAL   J Biol Chem 276 (12), 9526-9531 (2001)
   PUBMED   11121404
REFERENCE   10 (bases 1 to 6375)
  AUTHORS   Morris,S.W., Naeve,C., Mathew,P., James,P.L., Kirstein,M.N., Cui,X.
            and Witte,D.P.
  TITLE     ALK, the chromosome 2 gene locus altered by the t(2;5) in
            non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine
            kinase that is highly related to leukocyte tyrosine kinase (LTK)
  JOURNAL   Oncogene 14 (18), 2175-2188 (1997)
   PUBMED   9174053
  REMARK    Erratum:[Oncogene 1997 Dec 4;15(23):2883]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001169101.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840116,
                              SAMN12840117 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1601              JAXUCZ010000006.1  28631477-28633077
            1602-1718           JAXUCZ010000006.1  28844600-28844716
            1719-1883           JAXUCZ010000006.1  28862934-28863098
            1884-2085           JAXUCZ010000006.1  29023352-29023553
            2086-2213           JAXUCZ010000006.1  29163020-29163147
            2214-2345           JAXUCZ010000006.1  29223355-29223486
            2346-2477           JAXUCZ010000006.1  29230232-29230363
            2478-2578           JAXUCZ010000006.1  29231026-29231126
            2579-2748           JAXUCZ010000006.1  29247915-29248084
            2749-2843           JAXUCZ010000006.1  29266614-29266708
            2844-2972           JAXUCZ010000006.1  29266906-29267034
            2973-3135           JAXUCZ010000006.1  29296895-29297057
            3136-3286           JAXUCZ010000006.1  29305441-29305591
            3287-3418           JAXUCZ010000006.1  29312062-29312193
            3419-3563           JAXUCZ010000006.1  29312887-29313031
            3564-3746           JAXUCZ010000006.1  29314504-29314686
            3747-3845           JAXUCZ010000006.1  29315904-29316002
            3846-3998           JAXUCZ010000006.1  29316482-29316634
            3999-4103           JAXUCZ010000006.1  29318256-29318360
            4104-4290           JAXUCZ010000006.1  29319708-29319894
            4291-4381           JAXUCZ010000006.1  29321478-29321568
            4382-4446           JAXUCZ010000006.1  29321668-29321732
            4447-4576           JAXUCZ010000006.1  29323373-29323502
            4577-4674           JAXUCZ010000006.1  29326586-29326683
            4675-4767           JAXUCZ010000006.1  29332869-29332961
            4768-4869           JAXUCZ010000006.1  29336153-29336254
            4870-5004           JAXUCZ010000006.1  29343643-29343777
            5005-5095           JAXUCZ010000006.1  29344355-29344445
            5096-6375           JAXUCZ010000006.1  29348458-29349737
FEATURES             Location/Qualifiers
     source          1..6375
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..6375
                     /gene="Alk"
                     /note="ALK receptor tyrosine kinase"
                     /db_xref="GeneID:266802"
                     /db_xref="RGD:628622"
     exon            1..1601
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     CDS             920..5773
                     /gene="Alk"
                     /EC_number="2.7.10.1"
                     /note="ALK tyrosine kinase receptor; anaplastic lymphoma
                     receptor tyrosine kinase; anaplastic lymphoma kinase; ALK
                     tyrosine kinase receptor-like"
                     /codon_start=1
                     /product="ALK tyrosine kinase receptor precursor"
                     /protein_id="NP_001162572.1"
                     /db_xref="GeneID:266802"
                     /db_xref="RGD:628622"
                     /translation="MGALGFLWLLPPLLLTAASYSGAATDQRAGSPASGPPLQPREPL
                     SYSRLQRKSLAVDFVVPSLFRVYARDLLLPQPPSPSEPGAGGLEARGSLALDCDPLLR
                     LLGPSPGISWAEGASSPSPEAAPTLSRVLKGGSVRKLRRAKQLVLELGEETILEGCIG
                     PPEEAAAVGILQFNLSELFSWWILHGEGRLRIRLMPEKKASEVGREGRLSTAIRASQP
                     RLLFQIFGTGHSSLESPSEMPSPPGNFLWNLTWTMKDSFPFLSHRSRYGLECSFDFPC
                     ELEYSPPLHTHGNQSWSWRRVPSEEASRMNLLDGPEAEHLKEMPRGSFLLLNTSADSK
                     HTILSPWMRSSSEHCTLAVSVHRHLQPSGRYVAQLLPHNEAGREILLVPTPGKHGWTV
                     LHGRVGRPENPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNG
                     TVLQLGQACDFHQNCAQGEDEGQLCSKLPAGFYCNFEDGFCGWTQSPLSPRVPRWQVK
                     TLKDTHSQGHQGHALLLSTTDDPTSESATVTSATFPAPMKSSPCELRMSWLIRGVLKG
                     NVSLVLVENKTGKEQSRTVWHVATNEGLSLWQWTVLSLLDVTDRFWLQIVTWWGPGSR
                     ATVAFDNISISLDCYLTISGEEKMSLNAVPKSRNLFEKNPNKEPKPWANISGPTPIFD
                     PTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVVVGSEGPLRGIQIWKVPATDTYSI
                     SGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDTLYILVGQQGEDACPRANQLIQKVC
                     VGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAK
                     TETFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLLEGAAGGHSCPQAM
                     KKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTP
                     ALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLADDGVSCIVSPT
                     PEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLR
                     TSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDP
                     SPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMA
                     GGDLKSFLRETRPRPNQPTSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLT
                     CPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFG
                     VLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRP
                     NFAIILERIEYCTQDPDVINTALPIEYGPVVEEEEKVPMRPKDPEGMPPLLVSPQSAK
                     HEEASSAPQPSALAAPGPLVKKPSGAGAGAGAGPVPRGAADRGHVNMAFSQPNPPPEL
                     HKGPGSRNKPTSLWNPTYGSWFTEKPAKKTHPPPGAEPQARAGAAEGGWTGPGAGPRR
                     AEAALLLEPSALSATMKEVPLFRLRHFPCGNVNYGYQQQGLPLEATAAPGDTVLKSKT
                     KVTQPGP"
     exon            1602..1718
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1883
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2085
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2213
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2345
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            2346..2477
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2578
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2748
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2843
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..2972
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3135
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3286
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3418
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3563
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            3564..3746
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            3747..3845
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..3998
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..4103
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            4104..4290
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..4381
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            4382..4446
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            4447..4576
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            4577..4674
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..4767
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            4768..4869
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            4870..5004
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            5005..5095
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
     exon            5096..6375
                     /gene="Alk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagctctgg gggcggcagc ggcggtggca actggctcct cccgcttctt ctgtccaggg
       61 gttctcgggg cagtaagacg ctttccgttc gccccctggc cagtcaacaa aaccgcgggc
      121 gctgctggta ggtaaggagg gagctggcta cgttgcgggc tcctctgccc cgaatgtttt
      181 cactcggcgg cagcggccgg ggccgctctg gtgcttggga gtgaactccg aggaacgaag
      241 acgtcggtga cagcaaggac gctgcaaact tgtgcgcgtg gaggcagcgg gagcctcctc
      301 tccgcaacgc agagctcgcg ttcacgccca gaagttcagc gggcagggtg atcgatccga
      361 agacttcctg cagcggaggt cacttgaggg ggcgctagaa agcagccccc tccggtggtc
      421 cttgcctaga cctgggaagg agcgcagagg aggtgacagg aacggaggac gtgggcaaga
      481 cagtgaccga ctcagaaccg cggctcgcag cctggaaagt tgcagaagat tggaggcgaa
      541 gaggagagct ctggtcaccg agggctcctt gaacggtacc taattgccac ctccctcaac
      601 catagtgatt tctctggtcc ctgagcaaat ggggcgcagc atggcgagag gcgcaggatc
      661 cagctgttga acccaaggtg tctcactgtc tccgaactcc cccctgactt tctcatccgt
      721 tttgctgaga accctttttg cctccttgta gactggggaa agcagggcgc tctatagtgt
      781 acacagtcct tgagaccaag tggaaggagc cgttcaggac caaggactat ttggagcccc
      841 tttctgttta ggggagagtg aaaggtgagg ctggaccagg cagggaaggg agtctagtgt
      901 aaactcgccc tccggaggga tgggagccct tgggttcctg tggctgctgc cgccgctgct
      961 tttgacagca gcctcgtact ccggagctgc aaccgatcag cgcgcgggtt ctccagcctc
     1021 agggccgcct ctgcagcccc gggagccgct cagctattcg cgcctgcaga ggaagagtct
     1081 ggcggtggac ttcgtggtgc cctcactctt ccgcgtctat gcccgagacc tgctgctgcc
     1141 gcagccaccg tccccctcgg agcccggggc tggcgggctg gaggcgcggg gatcactggc
     1201 tctggactgc gaccctctgc tcaggttgct ggggccatcg cctggaatct cctgggcaga
     1261 gggagccagt tctcctagtc cggaggcggc tccgacgctg tccagggtgc tgaagggcgg
     1321 ctcggtgcgc aagctcaggc gtgccaaaca gctggtgctg gagctgggcg aggagacgat
     1381 ccttgaaggc tgcattggtc ccccagagga ggcggcggct gtggggatac tccagttcaa
     1441 ccttagcgag ctgttcagct ggtggattct acacggcgaa gggcggctga ggatccgcct
     1501 gatgcctgag aagaaggcat cggaagtggg cagggaggga aggctatcca ctgcgatccg
     1561 agcctcccag ccccgccttc tcttccagat cttcgggacc ggtcacagct ccttggaatc
     1621 accctcagaa atgccttctc ctcctggtaa ctttctatgg aatctcacct ggacaatgaa
     1681 agactccttc cctttccttt cccaccgcag tcgatatggt ctggagtgca gcttcgattt
     1741 tccctgtgag ctagaatact cccctcccct ccacacccat gggaaccaga gctggtcctg
     1801 gcgccgtgtg ccctctgagg aggcctcgag gatgaacttg ttggatgggc cagaggcaga
     1861 gcatttgaaa gagatgccca gaggctcctt cctcctcctg aacacctctg cagattccaa
     1921 gcataccatc ctgagcccct ggatgaggag cagtagtgag cactgcacgc tggctgtctc
     1981 agtgcacaga catctacagc cttctgggag atatgttgcc cagctcctac cccacaatga
     2041 agctggaaga gagattcttc tggtgcctac cccggggaaa catggctgga cagtgctgca
     2101 tgggagagtc gggcgcccag agaacccatt ccgagtggcc ctggaataca tctcgagtgg
     2161 aaaccggagc ttgtctgcgg tggatttctt tgccctgaag aactgcagtg aaggaacatc
     2221 cccaggctcc aagatggcct tgcagagttc cttcacttgt tggaacggga cagtcctcca
     2281 gctcgggcaa gcctgtgact tccaccagaa ctgtgcccaa ggagaagatg agggtcagct
     2341 atgcagtaaa cttcctgctg ggttttactg taacttcgag gatggcttct gtggctggac
     2401 ccaaagtcca ctctcacccc gtgtgccccg atggcaagtg aagaccctga aagataccca
     2461 ttcccagggc caccaaggcc atgccctgtt gctcagcacc actgacgacc ccacttcaga
     2521 aagtgcaaca gtgaccagtg ctacattccc cgcaccaatg aagagctctc cttgtgagct
     2581 ccggatgtcc tggctcatcc gtggggttct gaaaggaaat gtatctttgg tgctggtgga
     2641 gaacaaaact ggaaaggagc aaagccggac cgtctggcat gttgccacca atgaaggcct
     2701 aagcctgtgg cagtggacag tgttgtcgct cctcgatgtg actgacaggt tctggctgca
     2761 aatagtcaca tggtggggcc caggatccag ggcaaccgtg gcatttgaca acatttccat
     2821 cagcctcgac tgctacctca ccatcagtgg ggaggagaaa atgtccctga atgcagtacc
     2881 caaatccaga aatctgtttg agaaaaaccc aaacaaggag ccaaaaccct gggcaaacat
     2941 atcaggacca actcccatct tcgaccctac agttcactgg ctgttcacca catgtggggc
     3001 cagtggccct catggcccca cacaggcaca gtgcaacaac gcctaccaga actccaacct
     3061 gagcgtggtg gtgggaagtg aagggccctt gaggggcatc cagatttgga aagtgccagc
     3121 tactgacacc tacagtatct caggctatgg agcagctggc ggaaaaggtg ggaagaacac
     3181 catgatgcgg tcccatggcg tgtctgtcct gggcatcttc aatctggaga aagatgacac
     3241 gctctacatc cttgtcggtc aacaagggga agatgcctgt cccagggcaa accaactaat
     3301 ccagaaagta tgtgtcggcg agaacaatgt gatagaagaa gagatccgag tgaacagaag
     3361 cgttcacgag tgggcaggag gaggaggagg tgggggtgga gccacctacg tgtttaagat
     3421 gaaagacggc gtgcccgtgc ccctgattat tgcggccggc ggtggtggca gggcctatgg
     3481 ggccaagaca gaaacgttcc acccagagag actggagaat aactcctcag ttctagggct
     3541 gaacggcaat tccggagccg caggtggtgg aggcggctgg aatgataaca cttccttgct
     3601 ctgggccgga aagtctttgt tggagggcgc cgccggagga cattcctgcc cccaggccat
     3661 gaagaagtgg gggtgggaga caagaggggg tttcggaggg ggtggagggg ggtgctcctc
     3721 aggtggagga ggcggaggat atataggtgg caacgcagca tcaaacaatg accccgaaat
     3781 ggatggggaa gatggggttt ccttcatcag tccattgggt atcctgtata ccccggcctt
     3841 aaaagtgatg gagggccatg gggaagtgaa tatcaagcac tatctaaact gcagccactg
     3901 tgaggtagac gaatgtcaca tggaccccga gagccacaaa gtcatctgct tctgtgacca
     3961 tgggaccgtg ctggctgacg atggtgtctc ctgcattgtg tcgcccaccc cggaacccca
     4021 cctgccgctc tcattgatcc tctccgtcgt gacctctgcc ctggtggccg ctctcgttct
     4081 ggcattctcc ggcatcatga ttgtgtaccg ccggaagcac caggagttgc aagctatgca
     4141 gatggagctg cagagccctg agtataagct gagcaagcta cggacctcga ccatcatgac
     4201 agactacaac cccaactact gctttgctgg caagacttca tccatcagtg acctgaagga
     4261 ggtgcctcgg aaaaacatca ccctcatccg gggcctaggc catggcgcat ttggggaggt
     4321 gtatgaaggc caggtatctg gaatgcccaa tgacccaagc cctctacaag tggctgtaaa
     4381 gacgctgccg gaagtgtgtt cagagcaaga tgagctggac ttcctcatgg aagctctgat
     4441 catcagtaaa ttcaaccacc agaacattgt ccgctgcatc ggggtgagtc tgcaagccct
     4501 gccccgcttc atcctgctgg agctcatggc tggtggagac ctcaagtcct tcctcaggga
     4561 gacacgtcct cgcccgaacc agcccacctc cctggccatg ttggatcttc tgcacgtagc
     4621 tcgggacatt gcctgtggct gtcagtacct ggaggaaaat cactttatcc accgcgatat
     4681 tgctgctaga aactgtctgc tgacctgtcc gggagctggg aggatagcga agatcggaga
     4741 cttcgggatg gcccgagata tctacagggc cagctactac agaaagggag gctgtgccat
     4801 gctgccagtg aagtggatgc ccccggaggc cttcatggaa ggaatattta cttctaaaac
     4861 agatacatgg tcttttggag tgttgctgtg ggaaatattt tctcttggat atatgccata
     4921 ccccagcaag agcaaccagg aagttctgga gtttgtcacc agtggaggac ggatggaccc
     4981 acctaagaac tgccccggac ctgtataccg gataatgact cagtgctggc agcatcagcc
     5041 tgaggacaga cccaactttg ccatcattct ggagaggatc gaatactgca cccaggaccc
     5101 cgatgtcatc aatacagctc tgcccatcga atatggcccc gtagtagagg aggaggagaa
     5161 agtgcccatg cgccccaaag accctgaggg gatgcctcct ctgctggtgt ctccccagtc
     5221 tgcgaagcac gaggaggcgt cctcagcccc ccaaccctca gccctggcag cgccaggccc
     5281 gctggtgaag aagccctcgg gtgcaggcgc gggagcgggt gccggtccgg tgccccgagg
     5341 tgcagccgat cggggccacg tgaacatggc gttctctcag cccaaccctc ccccagagct
     5401 gcacaaaggc ccgggctcca gaaacaagcc gaccagcctg tggaacccca cctacggctc
     5461 gtggttcacc gagaagccag ccaaaaagac ccatccccca ccgggcgcgg agccgcaggc
     5521 ccgggcagga gcggcggagg gtggctggac cgggccgggt gcggggcccc gcagagccga
     5581 ggctgcgctg ctgctcgagc cgtcggcgct cagcgccacc atgaaggagg tgcccctgtt
     5641 caggctgcgc cacttcccct gcggcaacgt caactatggt taccagcaac agggtctccc
     5701 cttggaagcc actgctgccc cgggggacac cgtgctgaaa agcaagacta aggtcaccca
     5761 gccagggccc tgagcccggc gtcccactag cttttctccc tggctggagc tgaagcccac
     5821 cgggagggag acggacagaa tgactccacc acaattccga gaccaaatgt cactcacttt
     5881 catttttgtg ccaacttgtt ttgaagtgcc acatttaaaa gagaaaaaga agaaaaaaaa
     5941 aagaggaaaa cttgttttca agatgtgtta gaaaggtttt tgagcatggg ttcatccatc
     6001 ctcaaagaag aaaatgccgt tcttaagaaa gcgatcagta caaggcccag attggttgcg
     6061 tagttttggt gcatgatctg ctgtacagtc ccctcaggct tctttccgat ttgtgtgtgc
     6121 tctctgcttc cgtgtagtca gaaatagctg cctccatgtc tcataggggg agtcgtaggt
     6181 gtttccttgc cttgtggata tgaaccattc gaggggcgag ggaacagaaa taaaggaatt
     6241 aatttcaatg actcagcatg aggagagacg ttatttacgt ggaaaagaaa tatcatacac
     6301 tgtcatcgct gtgggtggtg gttagaggct tttaattgtt ctaactcatt gcctattgta
     6361 aaaaaaaaaa aaaaa
//
