LOCUS       NM_001034127            2013 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ALG8, alpha-1,3-glucosyltransferase (Alg8), mRNA.
ACCESSION   NM_001034127 XM_214992
VERSION     NM_001034127.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   Besse,W., Dong,K., Choi,J., Punia,S., Fedeles,S.V., Choi,M.,
            Gallagher,A.R., Huang,E.B., Gulati,A., Knight,J., Mane,S.,
            Tahvanainen,E., Tahvanainen,P., Sanna-Cherchi,S., Lifton,R.P.,
            Watnick,T., Pei,Y.P., Torres,V.E. and Somlo,S.
  TITLE     Isolated polycystic liver disease genes define effectors of
            polycystin-1 function
  JOURNAL   J Clin Invest 127 (5), 1772-1785 (2017)
   PUBMED   28375157
  REMARK    Erratum:[J Clin Invest. 2017 Sep 1;127(9):3558. PMID: 28862642]
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Chantret I, Dancourt J, Dupre T, Delenda C, Bucher S,
            Vuillaumier-Barrot S, Ogier de Baulny H, Peletan C, Danos O, Seta
            N, Durand G, Oriol R, Codogno P and Moore SE.
  TITLE     A deficiency in dolichyl-P-glucose:Glc1Man9GlcNAc2-PP-dolichyl
            alpha3-glucosyltransferase defines a new subtype of congenital
            disorders of glycosylation
  JOURNAL   J Biol Chem 278 (11), 9962-9971 (2003)
   PUBMED   12480927
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100614.1.
            
            On Oct 14, 2005 this sequence version replaced XM_214992.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132269, SAMD00132277
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2013
                     /gene="Alg8"
                     /note="ALG8, alpha-1,3-glucosyltransferase"
                     /db_xref="GeneID:293129"
                     /db_xref="RGD:1305468"
     exon            1..107
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1593
                     /gene="Alg8"
                     /EC_number="2.4.1.265"
                     /note="dolichyl pyrophosphate Glc1Man9GlcNAc2
                     alpha-1,3-glucosyltransferase; asparagine-linked
                     glycosylation 8 homolog (yeast,
                     alpha-1,3-glucosyltransferase); asparagine-linked
                     glycosylation 8 homolog (S. cerevisiae,
                     alpha-1,3-glucosyltransferase); probable dolichyl
                     pyrophosphate Glc1Man9GlcNAc2
                     alpha-1,3-glucosyltransferase; asparagine-linked
                     glycosylation 8, alpha-1,3-glucosyltransferase homolog"
                     /codon_start=1
                     /product="probable dolichyl pyrophosphate Glc1Man9GlcNAc2
                     alpha-1,3-glucosyltransferase precursor"
                     /protein_id="NP_001029299.1"
                     /db_xref="GeneID:293129"
                     /db_xref="RGD:1305468"
                     /translation="MAAFGLAAGSGHWFSALALGVTLLKCLLIPTYHSTDFEVHRNWL
                     AITHNLPISQWYYEATSEWTLDYPPFFAWFEYALSHIAKYFDQEMLDIHNLNYYSSRT
                     LLFQRFSVILTDALFVYAVHECCKCIDGKRTGKDPTEKPKFVLSVLLLWNFGLLIVDH
                     IHFQYNGLLSGLLLLSIARLFQKRHIEGAFLFAVLLHFKHIYLYVAPAYGIYLLRSYC
                     FTASKPDGSVRWDSFSIVRVTALALIVFLVSALSLGPFLALNQLPQVFSRLFPFKRGL
                     CHAYWAPNFWALYSALDKALCVTGLELKLLDPSQIPRASMTSGLVQQSQHTVLPSVSP
                     SATLICTLIAILPSVFCLWFKPQGPRGFLRCLVLCALSSFMFGWHVHEKAILLAILPM
                     SLLAVEKAGDATIFLILTTTGHYSLFPLLFTAPELPIKILLMSLFTVYSISSLRTLFR
                     KEKPLFNWMETLYLLGLGPLEVCCEFLFPFTSWKLKYPFIPLLLTSVYCAVGITYAWI
                     RLYASVLTGCLVSKTKKH"
     exon            108..186
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     exon            187..380
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     exon            381..490
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     exon            491..558
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     exon            559..685
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     exon            686..789
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     exon            790..910
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1050
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1190
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1288
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1361
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1984
                     /gene="Alg8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggactccag gaatggcggc gtttgggctt gcagccggta gtggccattg gttctcggct
       61 ttggctcttg gggtgacact ccttaagtgc cttctcatcc ccacctacca ttccacagat
      121 tttgaagtgc accgaaattg gcttgctatc actcacaacc tcccaatatc tcagtggtat
      181 tatgaggcaa cttcagagtg gaccttggat tatcccccct tttttgcatg gttcgagtac
      241 gccttatcac atattgccaa atactttgat caagagatgc ttgatatcca taacctgaac
      301 tattacagct caaggacact gcttttccag aggttttctg tcatcttgac agatgcgctc
      361 tttgtgtatg ctgttcacga gtgctgtaaa tgcatcgacg gaaaaagaac agggaaagac
      421 cccacagaga aaccgaagtt tgttctgtcc gtgctattgc tgtggaactt cgggttgtta
      481 attgtggacc acattcattt ccagtacaat ggcttgctct ctggcttgct gctgctgtcc
      541 attgcccgtc tgtttcagaa gaggcatatt gaaggggcat ttctctttgc tgtcctcctc
      601 catttcaagc acatctacct ctatgtagcc ccagcctatg gtatctatct gctgcgatct
      661 tactgtttca cggcaagtaa accagatggc tctgtccgat gggacagctt cagcattgtc
      721 cgagttactg ccctggcact gatcgttttc ctagtttccg ctctttcgct aggtcctttc
      781 ctagccttga accagctgcc acaagtcttc tcccgactct ttcctttcaa gaggggcctt
      841 tgccatgcct actgggctcc aaacttctgg gccttgtaca gtgctttgga caaagcactg
      901 tgtgtaactg gtttggaact gaagcttctt gatcccagcc agatccccag ggcctcaatg
      961 acaagtggtt tggtccagca gtcccagcac actgtcctcc cctcagtctc cccctcggca
     1021 accctcatct gcacactgat agccatattg ccctctgttt tctgtctttg gtttaaaccc
     1081 caagggccca gaggctttct ccgatgcttg gttctttgtg ccttaagttc cttcatgttt
     1141 gggtggcatg tccatgaaaa agccatactc cttgcgattc tcccaatgag cctactggct
     1201 gtggaaaaag caggagatgc gacaattttt ctgattctga cgacaaccgg acactattcc
     1261 ctcttccctc tgctcttcac tgcaccagaa ctccccatta aaatcttgct catgtccctg
     1321 ttcactgtgt acagtatctc ctcgctgagg acgctgttca gaaaagaaaa acctcttttt
     1381 aattggatgg aaactctgta cctccttggc ctggggcctc tggaagtctg ctgtgagttt
     1441 ctattccctt ttacctcgtg gaagctgaag taccccttca tccctttgct gctgacctcg
     1501 gtgtactgtg cagtgggcat cacgtacgcc tggatcaggc tgtatgcttc agtgttgact
     1561 ggctgtcttg tcagcaagac aaagaagcat tgaagaaaga agtgtttgga taaaggccaa
     1621 gcagttactt catgggtatt gatcagaact tgaagaaagt tgccagtcgc aggatctatt
     1681 tatttagtag atctgtttaa ggaccattct tccacacttg gccttgtcct gcctagcaac
     1741 ctgattgttt ccatggggag aagctgcttg ccctctctaa gcaacaaaac acatttgaga
     1801 aagctctcac cttcctctgt aaaaatagtc tgtgatcgtt gtgactgccg tgcccactaa
     1861 ggtgaactgg gagatgaaaa gcagcataat gttctgtagc tggtactgac cattgctagg
     1921 atgtaatgca taattagatt ctgttcctaa ggagatataa ataaaatgtc attttatatt
     1981 tgcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
