LOCUS       NM_001033709            3007 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ALG6, alpha-1,3-glucosyltransferase (Alg6), mRNA.
ACCESSION   NM_001033709 XM_342868
VERSION     NM_001033709.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3007)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 3007)
  AUTHORS   Westphal,V., Schottstadt,C., Marquardt,T. and Freeze,H.H.
  TITLE     Analysis of multiple mutations in the hALG6 gene in a patient with
            congenital disorder of glycosylation Ic
  JOURNAL   Mol Genet Metab 70 (3), 219-223 (2000)
   PUBMED   10924277
REFERENCE   3  (bases 1 to 3007)
  AUTHORS   Imbach,T., Burda,P., Kuhnert,P., Wevers,R.A., Aebi,M., Berger,E.G.
            and Hennet,T.
  TITLE     A mutation in the human ortholog of the Saccharomyces cerevisiae
            ALG6 gene causes carbohydrate-deficient glycoprotein syndrome
            type-Ic
  JOURNAL   Proc Natl Acad Sci U S A 96 (12), 6982-6987 (1999)
   PUBMED   10359825
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC101850.1.
            
            On Sep 25, 2005 this sequence version replaced XM_342868.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101850.1, FQ210318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132296, SAMD00132299
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3007
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..3007
                     /gene="Alg6"
                     /note="ALG6, alpha-1,3-glucosyltransferase"
                     /db_xref="GeneID:362547"
                     /db_xref="RGD:1308815"
     exon            1..23
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            24..277
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1719
                     /gene="Alg6"
                     /EC_number="2.4.1.267"
                     /note="dolichyl pyrophosphate Man9GlcNAc2
                     alpha-1,3-glucosyltransferase;
                     dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl
                     glucosyltransferase; asparagine-linked glycosylation
                     protein 6 homolog; asparagine-linked glycosylation 6
                     homolog (yeast, alpha-1,3,-glucosyltransferase);
                     asparagine-linked glycosylation 6 homolog (S. cerevisiae,
                     alpha-1,3-glucosyltransferase);
                     dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol
                     alpha-1,3-glucosyltransferase; asparagine-linked
                     glycosylation 6, alpha-1,3-glucosyltransferase homolog"
                     /codon_start=1
                     /product="dolichyl pyrophosphate Man9GlcNAc2
                     alpha-1,3-glucosyltransferase precursor"
                     /protein_id="NP_001028881.1"
                     /db_xref="GeneID:362547"
                     /db_xref="RGD:1308815"
                     /translation="MESWTWMTVVVLLGLTVRWTVSLNSYSGAGKPPMFGDYEAQRHW
                     QEITLNLPVKQWYFNSSDNNLQYWGLDYPPLTAYHSLLCAYVAKFINPDWVALHTSRG
                     YESQAHKLFMRTTVLAADLLIYIPAVLLYCYSLKEISPKRKIASALCILLYPGLILID
                     YGHFQYNSVSLGFALWGVLGVSCDWDLLGSLAFCLALNYKQMELYHSLPFFCFLLGKC
                     FKKGLRGKGSALFIRIACTVVASFLLCWLPFLTEREHALQVVRRLFPVDRGLFEDKVA
                     NIWCSLNVFLKIKDILPRHIQIAISFCFTFLSLLPACIKLTVQPSAKGFRFTLVSCAL
                     SFFLFSFQVHEKSILLVSLPVCLVLTEIPFMSTWFLLVSTFSMLPLLLKDQLLLPSVV
                     TVMAFLIACSTFFPMFENTSEEQLQLKSFAVSVRRHLPGFTFLPRIIQCLFLSSVITM
                     ILLTILSVTLDPPQKLPDLFSVLICFVSCVNFVFFLVYFNIVIMWDSKNGRNRKKID"
     exon            278..362
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            363..452
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            453..541
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            542..624
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            625..689
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            690..875
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1011
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1097
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1182
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1253
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1322
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1521
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..2977
                     /gene="Alg6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaattctgg agaccagagg ctggctacaa agacatagtc aagttttcat tgttttgaag
       61 ccaagtatca gtaaaatcct ctcaagctcc caactgcagg gatgtggcat tgctctgaag
      121 aaggagacaa gtgactgact ttggaggaag cactgtagcc ctggcttttg ttttcctccc
      181 tgagtttgaa gagctatgga gagctggacc tggatgacag tcgtggtctt acttggactc
      241 acggtgcggt ggacggtttc tctcaattct tactcaggtg ctggaaaacc gcctatgttt
      301 ggtgattatg aagctcagag acactggcaa gaaattaccc ttaacttacc agtcaaacaa
      361 tggtatttta acagtagtga taacaattta cagtactggg gattggatta cccacctctt
      421 acggcctatc acagtctctt atgtgcatat gtggcaaagt ttataaaccc agactgggtt
      481 gctctccaca catcacgagg ctatgagagt caggcacaca agctcttcat gcgtaccaca
      541 gttctcgctg ctgatttgct catttatata cccgcagtgc ttttgtactg ttactcctta
      601 aaagaaatct cacctaagag aaagatcgcc agcgcgctat gcatattgct gtacccaggt
      661 ctcattctta tcgactatgg acattttcag tataattctg tgagtcttgg ctttgctctg
      721 tggggtgttc ttggagtgtc ttgtgactgg gacctgctag ggtcattggc cttttgctta
      781 gctctaaatt ataaacagat ggagctttac cactccctac catttttttg ctttttactt
      841 ggcaaatgtt ttaaaaaagg cctcagagga aaggggtctg cattgttcat taggatagcc
      901 tgtactgtcg tggcctcctt ccttctgtgt tggctgccgt tcttgacaga aagggagcat
      961 gccctgcagg tcgtgagaag actcttccct gttgatcgcg gattgtttga ggataaagta
     1021 gccaatattt ggtgcagcct taatgttttt ctgaagatta aagacatttt gcctcgtcac
     1081 atccagatag caatcagctt ttgcttcaca tttttgagct tgcttcctgc atgcataaag
     1141 ttgacagttc agccctctgc taaaggattc agattcactc tggttagctg tgcactatca
     1201 ttctttctgt tttctttcca agtacacgag aagtccattc tcttggtatc actaccagtc
     1261 tgcttagttt taactgaaat tcctttcatg tcaacttggt ttttactagt ttcaacgttt
     1321 agcatgctgc ctcttctatt aaaggaccaa ctcctgctgc cctcggttgt gacagtgatg
     1381 gcgtttttaa tagcttgttc caccttcttc ccaatgtttg aaaacacttc tgaggaacaa
     1441 ctgcagctga agtcctttgc cgtctctgtg aggaggcacc ttccgggctt cacgtttctt
     1501 cccagaatta tacagtgttt gtttctttct tcagtcatca ccatgatcct tctgacgatt
     1561 ttgagtgtaa cactggaccc tcctcagaaa ttaccagact tgttttctgt acttatatgt
     1621 tttgtgtcct gtgtaaactt tgtattcttc ttggtatatt ttaacattgt aatcatgtgg
     1681 gattccaaaa atggaagaaa tcgtaagaaa attgactagc tatattccca agcaaatgca
     1741 atctttttgt ttatgtataa ttgaacaaca tatctttaga atcatggaat taaaggaaga
     1801 gaaatggtga aaggcattgt tatttacaga aaatgtacac aggaccaaag catttgtttt
     1861 ccaagtatgt ttttggttag tatattttgg taatattcac agatatttaa atagtaaaat
     1921 aagagcaaaa aatgtcccag ctggttgtag tagctcacat ttgcaatccc aggggtgcct
     1981 cgagttcaag gtcatccttg gttatacata gcaagtttga ggctatctta ggcttcgtga
     2041 gacccctgtc tcaacacaag gggaagagaa aaaaaatgtc cttaacgcca atatttagta
     2101 atggaatgta ttctaaaaat tgtaacttta aaaaactata tattttatat ataggctagc
     2161 ctgagctaca tgaaatcctg ttttaaaaaa caaaacaaag tcagacaaag tatgctttaa
     2221 taaatttaaa atgaatttat tggaagaatt aagcacctga cttgtttgga tacaagtgat
     2281 aagcatctcg tttagaagtc gcatctctgg gctggagaga tggctcagtg gttaagagca
     2341 ccagctgttc ttccagagga cctgagttca attcccagca accacatggt ggctcataac
     2401 cagctgtaat gggatctggt gccctcttct ggtgtgcatg aagatgtcat actgatatgc
     2461 acaaaatata tgtatatatg tgtttgtata cataaaatag atctttagaa gtatctcagg
     2521 gaattaccat ttttcttaat tactgagaag gcacgttatg ctgtttgaaa tttgaattgc
     2581 attattgcat attcaaaatt gggtgcttat agattaagtg gtatttttat ttctaagaat
     2641 gtagaccctc ttgatgccat tttttaaaaa gaacttttat tgaataaatt aaaaagtttg
     2701 aagtcttttt aggtactcat ggtaattagt tctaaatttc tagagtcatt ctaaattaaa
     2761 actatcttat caaggactcc atttcccttt ctgatacctt gtttcaggtt tccactgatg
     2821 taactgtgta ttcagatcat gtcgaacaca ggctttgtcc tattgtaggg ttatcccttc
     2881 acccatatca gctggtaaaa tgaatgcatt gtgttttact ttcacaggaa agctacttct
     2941 ttagtctctg acaaaaatta aagtcacttt accactaaaa aaaaaaaaaa aaaaaaaaaa
     3001 aaaaaaa
//
