LOCUS       NM_001100710            3049 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus ALG2, alpha-1,3/1,6-mannosyltransferase (Alg2),
            mRNA.
ACCESSION   NM_001100710 XM_001055088 XM_232987
VERSION     NM_001100710.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3049)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 3049)
  AUTHORS   Shibata H, Suzuki H, Yoshida H and Maki M.
  TITLE     ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum
            exit sites in a Ca2+-dependent manner
  JOURNAL   Biochem Biophys Res Commun 353 (3), 756-763 (2007)
   PUBMED   17196169
REFERENCE   3  (bases 1 to 3049)
  AUTHORS   Montaville P, Dai Y, Cheung CY, Giller K, Becker S, Michalak M,
            Webb SE, Miller AL and Krebs J.
  TITLE     Nuclear translocation of the calcium-binding protein ALG-2 induced
            by the RNA-binding protein RBM22
  JOURNAL   Biochim Biophys Acta 1763 (11), 1335-1343 (2006)
   PUBMED   17045351
REFERENCE   4  (bases 1 to 3049)
  AUTHORS   Wan M, Wu X, Guan KL, Han M, Zhuang Y and Xu T.
  TITLE     Muscle atrophy in transgenic mice expressing a human TSC1 transgene
  JOURNAL   FEBS Lett 580 (24), 5621-5627 (2006)
   PUBMED   16996505
REFERENCE   5  (bases 1 to 3049)
  AUTHORS   Shibata H, Yamada K, Mizuno T, Yorikawa C, Takahashi H, Satoh H,
            Kitaura Y and Maki M.
  TITLE     The penta-EF-hand protein ALG-2 interacts with a region containing
            PxY repeats in Alix/AIP1, which is required for the subcellular
            punctate distribution of the amino-terminal truncation form of
            Alix/AIP1
  JOURNAL   J Biochem 135 (1), 117-128 (2004)
   PUBMED   14999017
REFERENCE   6  (bases 1 to 3049)
  AUTHORS   Thiel C, Schwarz M, Peng J, Grzmil M, Hasilik M, Braulke T,
            Kohlschutter A, von Figura K, Lehle L and Korner C.
  TITLE     A new type of congenital disorders of glycosylation (CDG-Ii)
            provides new insights into the early steps of dolichol-linked
            oligosaccharide biosynthesis
  JOURNAL   J Biol Chem 278 (25), 22498-22505 (2003)
   PUBMED   12684507
REFERENCE   7  (bases 1 to 3049)
  AUTHORS   Satoh H, Nakano Y, Shibata H and Maki M.
  TITLE     The penta-EF-hand domain of ALG-2 interacts with amino-terminal
            domains of both annexin VII and annexin XI in a Ca2+-dependent
            manner
  JOURNAL   Biochim Biophys Acta 1600 (1-2), 61-67 (2002)
   PUBMED   12445460
REFERENCE   8  (bases 1 to 3049)
  AUTHORS   Kitaura Y, Matsumoto S, Satoh H, Hitomi K and Maki M.
  TITLE     Peflin and ALG-2, members of the penta-EF-hand protein family, form
            a heterodimer that dissociates in a Ca2+-dependent manner
  JOURNAL   J Biol Chem 276 (17), 14053-14058 (2001)
   PUBMED   11278427
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP504317.1 and BC105891.1.
            
            On or before Nov 21, 2008 this sequence version replaced
            XM_232987.4, XM_001055088.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP504317.1, FQ121739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-730               BP504317.1         7-736
            731-1453            BC105891.1         50-772
            1454-3049           BC105891.1         774-2369
FEATURES             Location/Qualifiers
     source          1..3049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..3049
                     /gene="Alg2"
                     /note="ALG2, alpha-1,3/1,6-mannosyltransferase"
                     /db_xref="GeneID:313231"
                     /db_xref="RGD:1309940"
     exon            1..413
                     /gene="Alg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1313
                     /gene="Alg2"
                     /note="asparagine-linked glycosylation 2 homolog (S.
                     cerevisiae, alpha-1,3-mannosyltransferase);
                     alpha-1,3-mannosyltransferase ALG2; asparagine-linked
                     glycosylation 2, alpha-1,3-mannosyltransferase homolog"
                     /codon_start=1
                     /product="alpha-1,3/1,6-mannosyltransferase ALG2"
                     /protein_id="NP_001094180.1"
                     /db_xref="GeneID:313231"
                     /db_xref="RGD:1309940"
                     /translation="MAENLYRTRSRVYSPSVLFLHPDMGIGGAERLVLDAALALQEYG
                     CQVKIWTAHYDPNHCFIETRELSVQCAGDWLPRSLGWGGRGAAICSYVRMVFLALYVL
                     FLSGEEFDVVVCDQVSACIPVFKLARRRKRVLFYCHFPDLLLTQRNSSLKKFYRAPID
                     WIEEYTTGMADRILVNSQYTASVFKETFKTLSHRNPDVLYPSLNIGSFDLAVPEKIDD
                     LVPKGKQFLFLSINRYERKKNLPLALSSLVQLRARLPPQEWEKVHLFMAGGYDDRVLE
                     NVEHYKELKKIVQESDLERHVTFLRSFSDRQKISLLHGCLCVLYTPSNEHFGIVPLEA
                     MYMQCPVIAVNSGGPLESIVHKVTGFLCEPDPVHFSEAMEKFIHKPSLKATMGLAGKA
                     RVAEKFSADAFADQLYQYVTKLV"
     exon            414..3025
                     /gene="Alg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggggcgga gcttgtagga gctagcagaa gctcgagcgg agagcgcagg cgcggctgat
       61 ctaccatggc cgaaaacctg taccgaaccc ggtcccgggt ttacagccca tccgtgctgt
      121 ttctgcaccc agatatgggt ataggcggtg ccgagcgcct agtgctggac gcggcgctgg
      181 cgctgcagga gtacggctgt caggtgaaga tatggaccgc gcactacgac ccaaaccact
      241 gtttcattga gacccgcgag ctctcggtgc agtgcgcagg ggactggctg cctcgcagcc
      301 tgggctgggg cggccgcggc gccgccatct gctcctacgt gcgcatggtc tttctggcgc
      361 tctacgtgct gtttctctcc ggcgaggagt tcgacgtggt ggtgtgcgac caggtgtctg
      421 cctgcatccc tgtgttcaaa ctggccagac ggcggaagag ggtcctcttt tactgtcact
      481 tcccagatct gctgcttact cagagaaatt catctctgaa gaagttctac agggccccca
      541 tcgactggat cgaggagtac accacgggca tggcagatcg catcttggtc aacagccagt
      601 acacagcttc cgtctttaag gaaaccttca agaccctgtc tcacagaaat cccgatgtgc
      661 tctacccatc tctgaacatc ggcagcttcg acttggccgt tcctgaaaag atagatgacc
      721 tagtccccaa ggggaaacag ttcctgttcc tctccatcaa ccggtacgag aggaagaaaa
      781 acctgccctt ggccctgagc tccctggtcc agcttcgcgc tcggttgccg cctcaagagt
      841 gggagaaggt tcatctgttc atggctggcg gctacgacga cagggtcctg gagaacgtgg
      901 agcactataa ggagttgaag aaaatagtcc aagagtcaga tctcgagcgg cacgtgacct
      961 tcctgcggtc cttctcagac agacagaaga tctcactcct ccacggctgc ttgtgtgtgc
     1021 tctacacgcc cagcaatgag cactttggca tcgtccctct ggaggccatg tacatgcagt
     1081 gcccggtcat cgctgtcaat tccggtgggc ccttggagtc tattgtccac aaggtcacgg
     1141 ggtttctgtg tgagcccgac ccagttcact tctcggaagc catggagaag ttcatccaca
     1201 aaccatcctt aaaggcaacg atgggcctgg ccggaaaagc cagggtggca gagaagtttt
     1261 ccgctgatgc atttgcagat cagctctacc agtatgtcac caaactggtg tagtcgggag
     1321 agtgtcaggt agggtctgta tgcctcgtgc actgcagtcc ctcttctggg ttgtagaagc
     1381 acctttgaaa ccaaaagagg agggggaaaa aaaggagcta gaatctagtg ctagtgagat
     1441 aatttttttt tttaagtaga cttgagtctt gagtgtgagc cacctgtcca ccacacccac
     1501 ctgtcatttt ctgaaaatac tctcaatgct gtaatcattc cgaatcacat cagtattgtg
     1561 gaaagtacgg tagaaatctg ctgctagcag acgattttaa ttctattttc ctggattatt
     1621 gttcctttat atataaaggt ttaatcatcc agtgccttaa ttggctttag tagtttaggt
     1681 cctaaccatt gccacagtca gttgatttga cttcagagtg taatgggaac ggagctactg
     1741 tggttcccat gctcagttta cttaaagggt tctctagtag ctgctcagaa attcttgttg
     1801 gaattttggc tggatccaca gcaagagtcc tcagtattat ttatttgttt tgttttgtgt
     1861 tctgttttgt ttttactgca acttgacaat aaaagatgtt tggcattgga agagaataga
     1921 acattaggtc tgggcccagc gctctgactc cgtcttgttt aatagtttaa cctgaagtcg
     1981 caagactggg ataaacagga gagctgacat gaaggacatc atcgcacatg tttcggctta
     2041 ctgtgtcaga actacacgtg cttggcctta tttctttgag cctgtggcag aagagtgtat
     2101 cgaggcagaa agcagaaagg tccaacctcc ctttctagaa aatgtccctt gatgtcctga
     2161 ttctcttcca ctagtcctca ctactaaagg tcctgtcacc tctcagtaac actgtgggcc
     2221 gggaaccaag cctcagggca caggcctttg ggagctgtat tagagttctc gagaagaata
     2281 aacagcactt acagaaggaa ttcccagaag aagaatgact tacaggcttc tgtccagcta
     2341 atccaacagt gagcagaaag tccaaaaatc cagcagttcg ggccatgagg ctgggtgtct
     2401 cggctggtct tcagtagact ctggaatccc aatgacgtag gctctaacgc cagtgaagga
     2461 atggacttgc caacaaggtg aggccaagca ggcaaagagc aaaagctccc ttcgtcctgt
     2521 cctcaagtag acttctagca gaaggcgtgg cccagactag aggtgtgtct tcccacctca
     2581 agatcaggat taaagaagat ctactgactt caaattaagc aaaactccct cccaggtgtg
     2641 ccctctgtca ttagatttta gttcattcaa gatggagtca agttgacaac caagaatggc
     2701 catcaccggg gacactccac atataaactg tataccaagc ttcatatttc agacatgttt
     2761 cttaatgtca tccacgtctc cagcccctgt agtgtgtatg tgttgtattc tctgcagaat
     2821 ttagcatgcc cgtgtttcct gtccttcaca taaacgcctt tgtgtgaagc ttgcttgatc
     2881 ctccactccc ctctccagcc cccacccctg tgacactgcc cagtaataac tgttcgttgt
     2941 ttacctgttg cttgtaagtg caagtattaa agcaatttga aagctaaact cacctgtaag
     3001 actataataa atacctgtaa tccaaaaaaa aaaaaaaaaa aaaaaaaaa
//
