LOCUS       NM_139101               7573 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus ALG10, alpha-1,2-glucosyltransferase (Alg10),
            mRNA.
ACCESSION   NM_139101 XM_343317
VERSION     NM_139101.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7573)
  AUTHORS   Probst,F.J., Corrigan,R.R., Del Gaudio,D., Salinger,A.P.,
            Lorenzo,I., Gao,S.S., Chiu,I., Xia,A., Oghalai,J.S. and
            Justice,M.J.
  TITLE     A point mutation in the gene for asparagine-linked glycosylation
            10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus
            musculus)
  JOURNAL   PLoS One 8 (11), e80408 (2013)
   PUBMED   24303013
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7573)
  AUTHORS   Michels,G., Er,F., Khan,I.F., Endres-Becker,J., Brandt,M.C.,
            Gassanov,N., Johns,D.C. and Hoppe,U.C.
  TITLE     K+ channel regulator KCR1 suppresses heart rhythm by modulating the
            pacemaker current If
  JOURNAL   PLoS One 3 (1), e1511 (2008)
   PUBMED   18231597
  REMARK    GeneRIF: observations demonstrate for the first time that KCR1
            modulates I(HCN2)/I(f) channel gating and indicate that KCR1 serves
            as a regulator of cardiac automaticity
            Erratum:[PLoS One. 2012;7(8):
            doi/10.1371/annotation/ff27c2a4-7732-4c32-88da-c412f1cced0c]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7573)
  AUTHORS   Kupershmidt,S., Yang,I.C., Hayashi,K., Wei,J., Chanthaphaychith,S.,
            Petersen,C.I., Johns,D.C., George,A.L. Jr., Roden,D.M. and
            Balser,J.R.
  TITLE     The IKr drug response is modulated by KCR1 in transfected cardiac
            and noncardiac cell lines
  JOURNAL   FASEB J 17 (15), 2263-2265 (2003)
   PUBMED   14525949
REFERENCE   4  (bases 1 to 7573)
  AUTHORS   Hoshi,N., Takahashi,H., Shahidullah,M., Yokoyama,S. and
            Higashida,H.
  TITLE     KCR1, a membrane protein that facilitates functional expression of
            non-inactivating K+ currents associates with rat EAG
            voltage-dependent K+ channels
  JOURNAL   J Biol Chem 273 (36), 23080-23085 (1998)
   PUBMED   9722534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 17, 2023 this sequence version replaced NM_139101.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.19069.1,
                                           SRR26643298.41766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000007.1  123214636-123214900
            266-463             JAXUCZ010000007.1  123216266-123216463
            464-7573            JAXUCZ010000007.1  123217995-123225104
FEATURES             Location/Qualifiers
     source          1..7573
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q35"
     gene            1..7573
                     /gene="Alg10"
                     /gene_synonym="Alg10b; KCR1"
                     /note="ALG10, alpha-1,2-glucosyltransferase"
                     /db_xref="GeneID:245960"
                     /db_xref="RGD:708500"
     exon            1..265
                     /gene="Alg10"
                     /gene_synonym="Alg10b; KCR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1519
                     /gene="Alg10"
                     /gene_synonym="Alg10b; KCR1"
                     /EC_number="2.4.1.256"
                     /note="potassium channel regulator 1;
                     alpha-1,2-glucosyltransferase ALG10-A; asparagine-linked
                     glycosylation 10 homolog B (yeast,
                     alpha-1,2-glucosyltransferase); putative
                     Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol
                     alpha-1,2-glucosyltransferase; alpha-2-glucosyltransferase
                     ALG10-B; asparagine-linked glycosylation 10,
                     alpha-1,2-glucosyltransferase homolog; asparagine-linked
                     glycosylation 10, alpha-1,2-glucosyltransferase homolog B;
                     asparagine-linked glycosylation protein 10 homolog B;
                     putative alpha-1,2-glucosyltransferase ALG10-B"
                     /codon_start=1
                     /product="dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol
                     alpha-1,2-glucosyltransferase"
                     /protein_id="NP_620801.1"
                     /db_xref="GeneID:245960"
                     /db_xref="RGD:708500"
                     /translation="MAQLEGYYFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQ
                     AQRYCEGRFSLSQWDPMITTLPGLYLVSVGVVKPASWILGWSEHVVCSIGMLRFVNLL
                     FSVGNFYLLYLLFRKIQPRNKASSSIQRILSTLTLAVFPTLYFFNFLYYTEAGSVFFT
                     LFAYLMCLYGNHRTSALLGFCGFMFRQTNIIWAAFCAGHIIAQKCSEAWKTELQKKKE
                     ERLPPAKGPLSELRRVLQFLLMYSMSLKNLSMLFLLTWPYMLLLLAFFVFVVVNGGIV
                     VGDRSSHEACLHFPQLFYFFSFTAFFSFPHLLSPTKVKTFLSLVWKRRVQFSVITLVS
                     VFLVWKFTYVHKYLLADNRHYTFYVWKRVFQRHEIVKYLLVPAYMFAGWAVADSLKSK
                     SIFWNLMFFVCLVASTVPQKLLEFRYFILPYIIYRLNMPLPPISRLVCELGCYAVVNF
                     LTFYIFLNKTFQWSDSHDIQRFMW"
     exon            266..463
                     /gene="Alg10"
                     /gene_synonym="Alg10b; KCR1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..7573
                     /gene="Alg10"
                     /gene_synonym="Alg10b; KCR1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacttcacc aggcagtact aggccataga tcccgtgttc cgggctcggc gctccgggct
       61 tcccagggct gggcccggga cgcggcctcc cgccatggcg cagctggagg gttattactt
      121 ctcggccgcc ttgagctgca ccttcctggt gtcctgcctg ctcttctccg ccttcagccg
      181 cgctctgcgt gagccttaca tggacgagat cttccacctg ccgcaggcgc agcgctactg
      241 cgagggccgc ttctcactgt cacagtggga tcctatgatt actacattac ctggcctgta
      301 cctggtgtcg gtcggagtgg tcaaacctgc cagctggatc cttggctggt ctgagcatgt
      361 cgtctgctcc atcggaatgc tcagatttgt caatcttctc ttcagtgttg gcaacttcta
      421 tttgctgtat ttgctcttca ggaagataca gcccagaaac aaggcttctt caagtatcca
      481 gagaatcttg tcaacattaa ccctagcagt atttccaacc ctctattttt ttaactttct
      541 ttactataca gaagccggct ctgtattctt tactcttttt gcttatttga tgtgtcttta
      601 cggcaaccat aggacttcgg ccttgcttgg gttttgtggc ttcatgtttc gtcagaccaa
      661 tatcatctgg gctgccttct gtgcaggaca catcattgca cagaagtgca gtgaagcctg
      721 gaagactgaa ctacagaaga agaaggaaga gaggcttccc ccggctaaag gaccgctctc
      781 ggaactcaga agagttcttc agtttctgct gatgtactcc atgtccctta agaacctgag
      841 tatgcttttc cttttgacct ggccctacat gcttctgctg ttggcatttt tcgtttttgt
      901 ggtggttaat ggtgggattg tcgtgggtga tcggagtagt catgaggcct gcctccattt
      961 tcctcagttg ttctacttct tctcctttac tgcctttttt tcctttcctc acctactttc
     1021 tccgaccaaa gtcaagactt ttcttagctt agtttggaaa cgtagagttc agttctctgt
     1081 gattacttta gtctcggtat ttttggtttg gaaattcact tacgtccata agtatttact
     1141 ggcagacaat aggcattaca cgttttatgt gtggaaaaga gtatttcaga gacatgaaat
     1201 tgtcaagtat ttattagttc cagcctacat gtttgctggt tgggctgtag ctgactcttt
     1261 aaaatcaaag tcaattttct ggaatttaat gttttttgta tgcttggttg cttctacggt
     1321 tcctcagaaa ctactagaat tccgttactt cattttacca tacattattt ataggctcaa
     1381 catgcctctg ccacccatat ctagacttgt ttgtgaactg ggttgctatg cagttgtcaa
     1441 ttttctaact ttttacatct ttctgaacaa gacttttcag tggtcggata gtcatgacat
     1501 ccaaaggttt atgtggtagt ggcagggcta ttttgaactc taagagccta tttctacaac
     1561 agatgactgg gtaaaggagt gtggatttct tttaagtaaa ttcagggaga cgaaaagaat
     1621 tacatttgag gctagcctaa aagcttagat aatgctaata aatttgcttg cagttgtctt
     1681 gagaatcttt tcagaagttt ggggattttc cgtgtatgta ggggactggg tgagctccgt
     1741 agcaccagaa cctgtcaacc aacttccttt gtaaagaaca gtgaagaatg tgaaaactgt
     1801 ttacaaataa atgacctagt ggtatttctg agcaaaattg ccagatattg cagtaaatat
     1861 agctctggtc ttagtaactt atgaacgaga ttctgggatg tctatctagg aattgggtat
     1921 tttaactaag aatatagaag tgatgaagcc atttgaacta actccttatt tgaaggtttt
     1981 gcaggccgaa ggtaagctgt gctgattatg acacctttta tagataatct ttctgaaata
     2041 ctgctctgtt agttgtccag ggctcctgca caaaactgac cataaacctt gtggcttcag
     2101 agttttttct cacatacgaa taagcagcac ctaaactcga gtgctggcag agctcctaaa
     2161 ctcgagtgct ggcagagctc gctccttcag gagacaagag ttcattgttc ctgttcagct
     2221 cactccttag aggggcctta cttttagaca ggtccctcca gtctgtctgt gtctgcacag
     2281 gactgtctcc accggcttct tgtgcagtta atgccattgg ctttagggat cctctgattc
     2341 agggtaacgg tacctggaga ccctggatta tatctatcac atttttaaag taagttccct
     2401 ttcagaggtc ccacatcatt ttggggtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2461 tgtgtgtgta agtaagatga ccttgatgag agcttttaag taaaagttag tttttaaaag
     2521 agaggccaaa aaacaacaac aacaaacccc agatggccaa ggtcatgtaa tttacatttg
     2581 tccctattat ccaaacaaac cagaactcag aaggtgagag gtcattggtt tagtttcatt
     2641 ttataattta ggaagcacta ctaggctctg gggtttgctt tgtctgggtt ccggttctgt
     2701 gctgctgttt aaagtttgtt tattgattgt caccattgtt acagacactg ttgcttagtc
     2761 ctgtgctgag agtgtaaaca cggaagtgtg acttgagctt acttagccca cttcctgagc
     2821 tttacacacg cacacacaca cacacacaca cactccccaa aggaacagaa ccttttattt
     2881 tattggataa tgttttcttt gagttttaaa tatgtagtaa actttataca actttaaaaa
     2941 ctacttggat aaaagttaca agcatagccc tgggtggtca gcccacacgg accactctga
     3001 tgcttcggag gtttgctcaa gtgtaacagt gactggtgtg ttagcacatc agaaagcttc
     3061 atgacacttt attatgatag aagctaagtc caggaagcaa acacttgcaa ttgaataaag
     3121 caagtgctgt ctgatgctta gtccctggct tttgtgtctg gggacacaga gggatggagt
     3181 gcttcatccc agtagtctgc tgtaaggagg gaagcacttt gtcccatgta atggaaggag
     3241 gctgctttca gatatgttga gtcccttcag aattaggaga catcgtaggg gtctacagag
     3301 agagagagag agagagagag agagagagag agagaaagta ctggtattct acaccacttc
     3361 ccattatgta ttggaagtag gacttggcat ttcagactgc agcgccatgg actaaaaggt
     3421 gctatttagt tgttactgtg atcttaaaaa tggatgcatg ttgatacatt tgaggtaggg
     3481 gtttggttaa tgttgcttgg gcagttgaca agttaatggt catttgctga taaatttctc
     3541 agtcttttaa ctcagtatgt gagagaaaaa ggcttcaccc ggcggttcac ttttggttgt
     3601 tcaaattaac agccccatct ctgaagtcat ttcacttggg aaaaaaatcc ttgcttttgc
     3661 aaatgtagat tgtatttcta ctttaatttt taaaaagaat tatcaagtag ttttcattag
     3721 acttaattga tttattgatc ataagaggct cagtggttaa aagcttgagc ccccattgca
     3781 gggaccccgt gtggttcctc gcccctaggg cagcctctag ggcactgact gcaggcgtcc
     3841 agctctgcag cctcctgaac tcatctgctg taaacacact gcccaccgcc tacttcagtt
     3901 aaaaactcta aatggtcagt gtagaaaatg tcagctgctg aaggggtgtg gagtgcgagt
     3961 tctccatcac tcttccagtg gacattttag agcctttatg aagaggccca ggcttgcctg
     4021 agctgctcta ggctcagtgg tcagttttag cagctctgct ttctgtgaca atccacaggc
     4081 atagactcac ttcccagaca cattagaacg agtgtgtgca ctgtacctgc ttatatttac
     4141 gcttccttgg acagccttcc cacggctgcg tctcaccaaa cgttgtggac atagtgtgtt
     4201 gtactttaca catagtacat aatcttgtac gaggaatttc tgtgctcatg gaccatctgt
     4261 gtttgtcgct gtaaaacacc cactgtaaac agtgtgattt acttacaggg aatagcttag
     4321 gatatccgtg atgtatttct ggtgtgaact tacctgactt gacattgtgc tcatctcctt
     4381 tgtctggaga ggagagaagg gagtcccagc tttcatttat aactcctaga gagtggacat
     4441 atattttagg tcaagttcaa actgtattca ggtaaaatca tatcttagag cagttagaaa
     4501 gcctttaaat gttaagacaa gtgtaatttt aatgtataca atattttgca tagatgaact
     4561 taagatgtag aaaagaatgc ccttgatttt ggttccacat aaaaaagaca gattgttgaa
     4621 agaccaggtg cttgttcctg atctcagatg agaatgttat gtctgaactc ttgttagtac
     4681 ctggggtgag tcctaccgca tttcaacagg attcatgctg tagtacatat ctgtatgctc
     4741 ataaacatgc tgtttgatgt atatcgagta aatttgtatt gaatggagtt ttcaatatag
     4801 aaggaagcag atattctaga aaagtatcat ataaccaact taatcttagg aagcaaatgt
     4861 gttttatact aagccatcct gacccatcct ctgcctgttt tctaaatgtt attttctata
     4921 gtaatgaatt cagtcatgcc cgtttagtat gcgccgtgtg caataggctt gattctaaca
     4981 atgccattta aatatgaagt cattcagtaa ttacagtaag tttgatgact tgtcttttac
     5041 atttcaatca gttagaaaca tcttctgttt ggttttagct ctctgattta cttttctttg
     5101 ggtgcatttt aggtatttga agtcaatggc aaaatgttgc tgagaaatat aaacaactta
     5161 agttaatgat gacataattt taatatatcg aaatgattcc agcactaaat tccataatgt
     5221 ttggaagtta tttctaaagt aaatttggtg ataataggta tctaataatc tctttttatt
     5281 atttaaaatg agatattgat tagtggcatt ctccatacct tagacactgt taaagcaaaa
     5341 gtaggtaggg tatatttttc tttcaaaaaa gtaaatatat ggaatttgca ttcagaaatt
     5401 tgatcagttc aatttatttg agccctgtac ttatcactgt cttgctcaag atgaataaga
     5461 atgaaaagaa ttacagtagt tgtctttctc aatagtgttt tgctggttca cacacacaca
     5521 cgcactcaca ctcacactca cactcagaca catcataaag ctgacctttt gctattttgt
     5581 ttcgctatca aagctgtact ggtctgacct ctcatgttat tgtgtgagtt acaggttttt
     5641 aaaatcctta ggagcctttt agaggaacat gtataaaatg ataaacgctt aggttttatt
     5701 acaagatgaa ttgttgaaca aattgttgat gtttaattgg aaaaacatag ctcccataac
     5761 aacaagttct tacggttatt tgaaagcata atacattgct ttaaatgtag atcagtggtc
     5821 aacaaatagg ttttaactca caaaaacacc ctttcttaat tatgttgtct ctttaggggc
     5881 atagagctcc cctaaataag ttttgtattt actgaaaaca tttcactggg aaagcgtcag
     5941 tggcttgaga gagtagatat gggatagtgt cttttcaagg gtctcaaaac ctgccatttt
     6001 aaacgtgagt ttattgtagt tcatgttctt tatattcttc ggtaagtcag gttcaagaat
     6061 ctcttgaagt attctgcctt tcatatattt tgtttctgaa ataaagtgga tgtttagctt
     6121 tcgttaagct ggtttttaaa ttgtgtccta cacccagcca caggtggtgt aaagtctcag
     6181 cgcaccagta atgcagtgtt tacctcacat acgtttgtgt tcctttgtca ggagagaagt
     6241 gtatttgggt ttcccctgta gtgaggaata ggaaagtact gtgtaatcaa atttgtactg
     6301 aaatgtttac taggtgatga cagtgggcta cattttaacg tattcttgta atttaacttt
     6361 ttctactaat ctggattaaa ctttttatag ttttgtattg ttttgaacca caaagattta
     6421 gaattctcca ccttcattaa tgattatttg ttgttcagga agggtctcat aatccaggct
     6481 agcctggaat ttacaatgta gccaagaaag accttgaact cctgattctt ttgcctctac
     6541 ctctggactg ctgggttccc ggcatgccgc accatgccca gtgtatgcag tgctggggat
     6601 caaacacaga acttagggca gccggcaagc agtctgccag ctgggctgtt tcctcagccc
     6661 tgctgcttct actgtggccg aaaatgttcc ctgggttcca tgaagtgaag gtaaatgtga
     6721 aaccaaaagt catttgttcc atgattaatt gtgtctcaga tgacggaacc taatgcaccc
     6781 ggccatgaaa ctgtttacct cacagactgg gggatgtttc tgatagtgat aataggtttg
     6841 gaaacaacct gaactgtcta cttctgtctc gctggttctc aggcctcttg tgttaactgt
     6901 accacataca cggagagact gaggagaggg tgggtttttg tctcatatta gaataagcag
     6961 aatgagtatt tgtctaatgt tacaaagtag ctgtgtgagc tgcctttatg agtgggcagc
     7021 ctgacgagaa tcgggctctt agctgcagct gagatggagt agtaggaagg acactgagtc
     7081 taccttcctt tttgtaacat tttggaaaac aaattccatg ggaaatagaa ctccactact
     7141 tttctagatc agacagttga ggcgcataca gactgtctct tccagagcag gcagtctctc
     7201 ccattgtgtc atcacggcct cagcttgttg tgtgaacaca aaatctacag cacgggctga
     7261 agttgtcagc ccgattaaca aggaagtaaa gatctttgat atccaataga gatgtagttg
     7321 cctaagactt aatttctcaa aagaactttg gaaataaatg gttgttttaa actgatctgt
     7381 gatttttaaa taatcttttc tgaaagaatt tgatgtttat tttaaatacg tgaatatatg
     7441 ttttaaccgt tttttaaggt tttacatttt gttacattca aaacttaaga tgtttgactc
     7501 taaaattgtg attcatgtca tttaaactct tgaataaacc tatttataag aataaaagcg
     7561 ttttaaatag tta
//
