LOCUS       NM_012497               1581 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus aldolase, fructose-bisphosphate C (Aldoc), mRNA.
ACCESSION   NM_012497
VERSION     NM_012497.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1581)
  AUTHORS   Martins-de-Souza,D., Alsaif,M., Ernst,A., Harris,L.W., Aerts,N.,
            Lenaerts,I., Peeters,P.J., Amess,B., Rahmoune,H., Bahn,S. and
            Guest,P.C.
  TITLE     The application of selective reaction monitoring confirms
            dysregulation of glycolysis in a preclinical model of schizophrenia
  JOURNAL   BMC Res Notes 5, 146 (2012)
   PUBMED   22420779
  REMARK    GeneRIF: Data show statistically significant altered levels of Tpi1
            and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline
            significance in phencyclidine (PCP) rats compared to controls.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1581)
  AUTHORS   Quy,P.N., Fujita,H., Sakamoto,Y., Na,J. and Sugihara,I.
  TITLE     Projection patterns of single mossy fiber axons originating from
            the dorsal column nuclei mapped on the aldolase C compartments in
            the rat cerebellar cortex
  JOURNAL   J Comp Neurol 519 (5), 874-899 (2011)
   PUBMED   21280042
  REMARK    GeneRIF: Dorsal column nuclei (DCN)-cerebellar axons project to
            multiple compartments with terminals clustered mainly in the
            conventional spinocerebellar region with a coarse topography, which
            relates to the cortical compartments defined by aldolase C.
REFERENCE   3  (bases 1 to 1581)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   4  (bases 1 to 1581)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 1581)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1581)
  AUTHORS   Mukai,T., Yatsuki,H., Masuko,S., Arai,Y., Joh,K. and Hori,K.
  TITLE     The structure of the brain-specific rat aldolase C gene and its
            regional expression
  JOURNAL   Biochem Biophys Res Commun 174 (2), 1035-1042 (1991)
   PUBMED   1993044
REFERENCE   7  (bases 1 to 1581)
  AUTHORS   Takasaki,Y. and Hori,K.
  TITLE     Construction of rat aldolase C expression plasmid and the hybrid
            formation between rat aldolase C and human aldolase A or B
            co-expressed in Escherichia coli
  JOURNAL   Protein Eng 3 (4), 273-277 (1990)
   PUBMED   2188264
REFERENCE   8  (bases 1 to 1581)
  AUTHORS   Kukita,A., Mukai,T., Miyata,T. and Hori,K.
  TITLE     The structure of brain-specific rat aldolase C mRNA and the
            evolution of aldolase isozyme genes
  JOURNAL   Eur J Biochem 171 (3), 471-478 (1988)
   PUBMED   2831050
REFERENCE   9  (bases 1 to 1581)
  AUTHORS   Hatzfeld,A., Feldmann,G., Guesnon,J., Frayssinet,C. and Schapira,F.
  TITLE     Location of adult and fetal aldolases A, B, and C by
            immunoperoxidase technique in LF fast-growing rat hepatomas
  JOURNAL   Cancer Res 38 (1), 16-22 (1978)
   PUBMED   201371
REFERENCE   10 (bases 1 to 1581)
  AUTHORS   Hatzfeld,A., Elion,J., Mennecier,F. and Schapira,F.
  TITLE     Purification of aldolase C from rat brain and hepatoma
  JOURNAL   Eur J Biochem 77 (1), 37-43 (1977)
   PUBMED   198211
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M63656.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X06984.1, FQ228893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132269
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1581
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..1581
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /note="aldolase, fructose-bisphosphate C"
                     /db_xref="GeneID:24191"
                     /db_xref="RGD:2091"
     exon            1..93
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /inference="alignment:Splign:2.1.0"
     exon            94..217
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1197
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /EC_number="4.1.2.13"
                     /note="brain-type aldolase; aldolase C,
                     fructose-biphosphate; aldolase C, fructose-bisphosphate"
                     /codon_start=1
                     /product="fructose-bisphosphate aldolase C"
                     /protein_id="NP_036629.1"
                     /db_xref="GeneID:24191"
                     /db_xref="RGD:2091"
                     /translation="MPHSYPALSAEQKKELSDIALRIVAPGKGILAADESVGSMAKRL
                     SQIGVENTEENRRLYRQVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQEKG
                     ILVGIKVDKGVVPLAGTDGETTTQGLDGLLERCAQYKKDGADFAKWRCVLKISDRTPS
                     ALAILENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQFVTEKVLAAVYKALS
                     DHHVYLEGTLLKPNMVTPGHACPIKYSPEEIAMATVTALRRTVPPAVPGVTFLSGGQS
                     EEEASLNLNAINRCSLPRPWALTFSYGRALQASALSAWRGQRDNAGAATEEFIKRAEM
                     NGLAAQGKYEGSGDGGAAAQSLYVANHAY"
     exon            218..429
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /inference="alignment:Splign:2.1.0"
     exon            430..484
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /inference="alignment:Splign:2.1.0"
     exon            485..645
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /inference="alignment:Splign:2.1.0"
     exon            646..729
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /inference="alignment:Splign:2.1.0"
     exon            730..904
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1104
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1581
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttactcca gcttggactg agctactgtc tgttgctaac cagaccaaag tgagctgtgc
       61 ctgtggctcc ggccgctgac tgactgagta tagacaactg tcaccatgcc ccactcatac
      121 ccagcccttt ctgctgagca gaagaaggag ttgtcggata ttgctctgag gattgtggcc
      181 ccaggcaagg gcattctggc tgcagatgag tccgtgggca gcatggccaa aaggctgagc
      241 caaattgggg tagagaacac tgaggagaat cgccgactgt accgccaggt cctgttcagt
      301 gctgatgacc gtgtgaaaaa gtgcattggg ggggtcatct tcttccacga gacactctac
      361 cagaaagatg acaatggtgt cccctttgtc cgcaccatcc aggagaaggg cattctcgta
      421 ggcatcaagg ttgacaaggg tgtagtgcct ctagctggga ctgatggaga aaccaccact
      481 caagggctgg atggactctt ggaacgctgt gctcagtata agaaggacgg tgctgatttt
      541 gccaaatggc gctgtgtgct gaaaatcagt gatcgcacac cctcggcact ggccatactg
      601 gagaatgcca atgtgctggc ccgctatgcc agcatctgcc agcagaatgg tatcgtgccc
      661 atcgtggagc ctgagatcct gcctgatgga gaccatgacc tcaaacgttg ccagtttgtt
      721 acagagaagg tcctggctgc tgtgtacaag gccttgagtg atcatcacgt atacctggaa
      781 gggactctcc tcaagcccaa catggtgacc cctggccatg cctgtcccat caaatatagc
      841 ccagaagaga tcgccatggc aactgtcact gccctgcgtc gaactgtgcc cccagctgtc
      901 ccaggggtga ctttcctgtc tgggggtcag agtgaagagg aggcatcact caacctcaat
      961 gccatcaacc gatgctcact tccccggccc tgggccctca ccttctccta cggacgtgcc
     1021 ctgcaggcat ctgcactcag tgcctggaga ggacaaaggg ataatgctgg ggctgctact
     1081 gaggagttta tcaagcgggc cgagatgaac gggcttgcag cccagggcaa atatgaaggc
     1141 agtggagatg gtggagcagc agcacagtcc ctctacgtgg ccaaccatgc ctactgaggc
     1201 acgcttacac gacctgtagc ccttggccta gcaatgcaca tcccattttg cctatagtca
     1261 cagccagggc caaatagccg tgctgaacag agatatcttc atccagcacc aagtcatctc
     1321 gcatcccaca atgcctcaca ttgctgcact ggagaccaca ggatgggagg gtagagaggc
     1381 ccgtccatgt ctgaggatgg agaaactatt tagaagtcag aacagaacct ttcccctgtc
     1441 tccaccagtc cttacagtgt cccttgatgg tgtagtttgt ccttgggctc tgcttgctga
     1501 ccttctctct tgggatcggg atgtgaaccc tggcccagac tcacgctctg agtacatagt
     1561 gaataaacgg gagcaaaaca c
//
