LOCUS       NP_036629                363 aa            linear   ROD 02-JUN-2024
DEFINITION  fructose-bisphosphate aldolase C [Rattus norvegicus].
ACCESSION   NP_036629
VERSION     NP_036629.1
DBSOURCE    REFSEQ: accession NM_012497.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 363)
  AUTHORS   Martins-de-Souza,D., Alsaif,M., Ernst,A., Harris,L.W., Aerts,N.,
            Lenaerts,I., Peeters,P.J., Amess,B., Rahmoune,H., Bahn,S. and
            Guest,P.C.
  TITLE     The application of selective reaction monitoring confirms
            dysregulation of glycolysis in a preclinical model of schizophrenia
  JOURNAL   BMC Res Notes 5, 146 (2012)
   PUBMED   22420779
  REMARK    GeneRIF: Data show statistically significant altered levels of Tpi1
            and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline
            significance in phencyclidine (PCP) rats compared to controls.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 363)
  AUTHORS   Quy,P.N., Fujita,H., Sakamoto,Y., Na,J. and Sugihara,I.
  TITLE     Projection patterns of single mossy fiber axons originating from
            the dorsal column nuclei mapped on the aldolase C compartments in
            the rat cerebellar cortex
  JOURNAL   J Comp Neurol 519 (5), 874-899 (2011)
   PUBMED   21280042
  REMARK    GeneRIF: Dorsal column nuclei (DCN)-cerebellar axons project to
            multiple compartments with terminals clustered mainly in the
            conventional spinocerebellar region with a coarse topography, which
            relates to the cortical compartments defined by aldolase C.
REFERENCE   3  (residues 1 to 363)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   4  (residues 1 to 363)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (residues 1 to 363)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (residues 1 to 363)
  AUTHORS   Mukai,T., Yatsuki,H., Masuko,S., Arai,Y., Joh,K. and Hori,K.
  TITLE     The structure of the brain-specific rat aldolase C gene and its
            regional expression
  JOURNAL   Biochem Biophys Res Commun 174 (2), 1035-1042 (1991)
   PUBMED   1993044
REFERENCE   7  (residues 1 to 363)
  AUTHORS   Takasaki,Y. and Hori,K.
  TITLE     Construction of rat aldolase C expression plasmid and the hybrid
            formation between rat aldolase C and human aldolase A or B
            co-expressed in Escherichia coli
  JOURNAL   Protein Eng 3 (4), 273-277 (1990)
   PUBMED   2188264
REFERENCE   8  (residues 1 to 363)
  AUTHORS   Kukita,A., Mukai,T., Miyata,T. and Hori,K.
  TITLE     The structure of brain-specific rat aldolase C mRNA and the
            evolution of aldolase isozyme genes
  JOURNAL   Eur J Biochem 171 (3), 471-478 (1988)
   PUBMED   2831050
REFERENCE   9  (residues 1 to 363)
  AUTHORS   Hatzfeld,A., Feldmann,G., Guesnon,J., Frayssinet,C. and Schapira,F.
  TITLE     Location of adult and fetal aldolases A, B, and C by
            immunoperoxidase technique in LF fast-growing rat hepatomas
  JOURNAL   Cancer Res 38 (1), 16-22 (1978)
   PUBMED   201371
REFERENCE   10 (residues 1 to 363)
  AUTHORS   Hatzfeld,A., Elion,J., Mennecier,F. and Schapira,F.
  TITLE     Purification of aldolase C from rat brain and hepatoma
  JOURNAL   Eur J Biochem 77 (1), 37-43 (1977)
   PUBMED   198211
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M63656.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X06984.1, FQ228893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132269
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..363
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     Protein         1..363
                     /product="fructose-bisphosphate aldolase C"
                     /EC_number="4.1.2.13"
                     /note="brain-type aldolase; aldolase C,
                     fructose-biphosphate; aldolase C, fructose-bisphosphate"
                     /calculated_mol_wt=39153
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P05065; propagated from
                     UniProtKB/Swiss-Prot (P09117.3)"
     Region          15..363
                     /region_name="Glycolytic"
                     /note="Fructose-bisphosphate aldolase class-I; pfam00274"
                     /db_xref="CDD:459742"
     Site            36
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P09117.3)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P09117.3)"
     Site            45
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09972; propagated from
                     UniProtKB/Swiss-Prot (P09117.3)"
     Site            111
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P09972; propagated from
                     UniProtKB/Swiss-Prot (P09117.3)"
     Site            363
                     /site_type="other"
                     /note="Necessary for preference for fructose
                     1,6-bisphosphate over fructose 1-phosphate; propagated
                     from UniProtKB/Swiss-Prot (P09117.3)"
     CDS             1..363
                     /gene="Aldoc"
                     /gene_synonym="ALDCAA; F16dip7; RATALDCAA"
                     /coded_by="NM_012497.1:106..1197"
                     /db_xref="GeneID:24191"
                     /db_xref="RGD:2091"
ORIGIN      
        1 mphsypalsa eqkkelsdia lrivapgkgi laadesvgsm akrlsqigve nteenrrlyr
       61 qvlfsaddrv kkciggviff hetlyqkddn gvpfvrtiqe kgilvgikvd kgvvplagtd
      121 getttqgldg llercaqykk dgadfakwrc vlkisdrtps alailenanv laryasicqq
      181 ngivpivepe ilpdgdhdlk rcqfvtekvl aavykalsdh hvylegtllk pnmvtpghac
      241 pikyspeeia matvtalrrt vppavpgvtf lsggqseeea slnlnainrc slprpwaltf
      301 sygralqasa lsawrgqrdn agaateefik raemnglaaq gkyegsgdgg aaaqslyvan
      361 hay
//
