LOCUS       NM_012496               1589 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus aldolase, fructose-bisphosphate B (Aldob), mRNA.
ACCESSION   NM_012496
VERSION     NM_012496.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1589)
  AUTHORS   Sanguesa,G., Shaligram,S., Akther,F., Roglans,N., Laguna,J.C.,
            Rahimian,R. and Alegret,M.
  TITLE     Type of supplemented simple sugar, not merely calorie intake,
            determines adverse effects on metabolism and aortic function in
            female rats
  JOURNAL   Am J Physiol Heart Circ Physiol 312 (2), H289-H304 (2017)
   PUBMED   27923787
REFERENCE   2  (bases 1 to 1589)
  AUTHORS   Droppelmann,C.A., Saez,D.E., Asenjo,J.L., Yanez,A.J.,
            Garcia-Rocha,M., Concha,I.I., Grez,M., Guinovart,J.J. and
            Slebe,J.C.
  TITLE     A new level of regulation in gluconeogenesis: metabolic state
            modulates the intracellular localization of aldolase B and its
            interaction with liver fructose-1,6-bisphosphatase
  JOURNAL   Biochem J 472 (2), 225-237 (2015)
   PUBMED   26417114
  REMARK    GeneRIF: Data suggest energy metabolism (gluconeogenesis versus
            glycolysis) modulates aldolase B and fructose-1,6-bisphosphatase-1
            activities in hepatocytes via their interaction suggesting their
            association confers catalytic advantage for both enzymes.
REFERENCE   3  (bases 1 to 1589)
  AUTHORS   Oppelt,S.A., Sennott,E.M. and Tolan,D.R.
  TITLE     Aldolase-B knockout in mice phenocopies hereditary fructose
            intolerance in humans
  JOURNAL   Mol Genet Metab 114 (3), 445-450 (2015)
   PUBMED   25637246
REFERENCE   4  (bases 1 to 1589)
  AUTHORS   Liu,J., Wang,R., Desai,K. and Wu,L.
  TITLE     Upregulation of aldolase B and overproduction of methylglyoxal in
            vascular tissues from rats with metabolic syndrome
  JOURNAL   Cardiovasc Res 92 (3), 494-503 (2011)
   PUBMED   21890532
  REMARK    GeneRIF: Upregulation of aldolase B by accumulated fructose is a
            common mechanism for methylglyoxal overproduction in vascular
            smooth muscle cella and aorta in different models of metabolic
            syndrome.
REFERENCE   5  (bases 1 to 1589)
  AUTHORS   Ndisang,J.F., Lane,N. and Jadhav,A.
  TITLE     The heme oxygenase system abates hyperglycemia in Zucker diabetic
            fatty rats by potentiating insulin-sensitizing pathways
  JOURNAL   Endocrinology 150 (5), 2098-2108 (2009)
   PUBMED   19106228
REFERENCE   6  (bases 1 to 1589)
  AUTHORS   Brand,I.A. and Heinickel,A.
  TITLE     Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa
            Zn(2+)-binding protein (parathymosin)
  JOURNAL   J Biol Chem 266 (31), 20984-20989 (1991)
   PUBMED   1834654
REFERENCE   7  (bases 1 to 1589)
  AUTHORS   Tsutsumi,K., Mukai,T., Tsutsumi,R., Hidaka,S., Arai,Y., Hori,K. and
            Ishikawa,K.
  TITLE     Structure and genomic organization of the rat aldolase B gene
  JOURNAL   J Mol Biol 181 (2), 153-160 (1985)
   PUBMED   2580098
REFERENCE   8  (bases 1 to 1589)
  AUTHORS   Hatzfeld,A., Feldmann,G., Guesnon,J., Frayssinet,C. and Schapira,F.
  TITLE     Location of adult and fetal aldolases A, B, and C by
            immunoperoxidase technique in LF fast-growing rat hepatomas
  JOURNAL   Cancer Res 38 (1), 16-22 (1978)
   PUBMED   201371
REFERENCE   9  (bases 1 to 1589)
  AUTHORS   Stoltzner,G.
  TITLE     Effects of life-long dietary protein restriction on mortality,
            growth, organ weights, blood counts, liver aldolase and kidney
            catalase in Balb/C mice
  JOURNAL   Growth 41 (4), 337-348 (1977)
   PUBMED   604178
REFERENCE   10 (bases 1 to 1589)
  AUTHORS   Foemmel,R.S., Gray,R.H. and Bernstein,I.A.
  TITLE     Intracellular localization of fructose 1,6-bisphosphate aldolase
  JOURNAL   J Biol Chem 250 (5), 1892-1897 (1975)
   PUBMED   234468
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081697.1.
            
            On Oct 10, 2007 this sequence version replaced NM_012496.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081697.1, FQ218551.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1589
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1589
                     /gene="Aldob"
                     /gene_synonym="Aldo2; LIV10"
                     /note="aldolase, fructose-bisphosphate B"
                     /db_xref="GeneID:24190"
                     /db_xref="RGD:2090"
     exon            1..47
                     /gene="Aldob"
                     /gene_synonym="Aldo2; LIV10"
                     /inference="alignment:Splign:2.1.0"
     exon            48..169
                     /gene="Aldob"
                     /gene_synonym="Aldo2; LIV10"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1152
                     /gene="Aldob"
                     /gene_synonym="Aldo2; LIV10"
                     /EC_number="4.1.2.13"
                     /note="liver-type aldolase; Aldolase B,
                     fructose-biphosphate; aldolase B, fructose-bisphosphate"
                     /codon_start=1
                     /product="fructose-bisphosphate aldolase B"
                     /protein_id="NP_036628.2"
                     /db_xref="GeneID:24190"
                     /db_xref="RGD:2090"
                     /translation="MAHRFPALTSEQKKELSEIAQRIVANGKGILAADESVGTMGNRL
                     QRIKVENTEENRRQFRELLFSVDNSISQSIGGVILFHETLYQKDSQGKLFRNILKEKG
                     IVVGIKLDQGGAPLAGTNKETTIQGLDGLSERCAQYKKDGVDFGKWRAVLRISDQCPS
                     SLAIQENANALARYASICQQNGLVPIVEPEVLPDGDHDLEHCQYVSEKVLAAVYKALN
                     DHHVYLEGTLLKPNMVTAGHACTKKYTPEQVAMATVTALHRTVPAAVPGICFLSGGMS
                     EEDATLNLNAINRCPLPRPWKLSFSYGRALQASALAAWGGKAANKKATQEAFMKRAVA
                     NCQAAQGQYVHTGSSGAASTQSLFTASYTY"
     exon            170..381
                     /gene="Aldob"
                     /gene_synonym="Aldo2; LIV10"
                     /inference="alignment:Splign:2.1.0"
     exon            382..436
                     /gene="Aldob"
                     /gene_synonym="Aldo2; LIV10"
                     /inference="alignment:Splign:2.1.0"
     exon            437..597
                     /gene="Aldob"
                     /gene_synonym="Aldo2; LIV10"
                     /inference="alignment:Splign:2.1.0"
     exon            598..681
                     /gene="Aldob"
                     /gene_synonym="Aldo2; LIV10"
                     /inference="alignment:Splign:2.1.0"
     exon            682..856
                     /gene="Aldob"
                     /gene_synonym="Aldo2; LIV10"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1056
                     /gene="Aldob"
                     /gene_synonym="Aldo2; LIV10"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1562
                     /gene="Aldob"
                     /gene_synonym="Aldo2; LIV10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcacacag cttctgatac cttggagcac tcttctccct tggctgtacc tgtcatcatg
       61 gctcaccgat ttccagccct cacctcagag cagaagaagg agctctccga gattgcgcag
      121 cgcattgttg ccaatgggaa gggtatcctg gctgcagatg agtctgtggg caccatggga
      181 aaccgcctac agaggataaa ggtggaaaac actgaagaga accgaaggca gttccgagag
      241 ctcctcttta gtgtggacaa ttctatcagc cagagcatcg gcggagtgat ccttttccat
      301 gagacgctct accagaagga cagccaggga aagctgttca gaaacattct caaggagaag
      361 ggaattgtgg tgggcatcaa gctggaccaa ggaggtgccc cgcttgcagg aacaaacaaa
      421 gaaaccacca ttcaagggct tgacggcctc tccgaacgct gtgctcagta caagaaagac
      481 ggagtcgact ttgggaagtg gcgtgctgtg ctgaggatct cggaccagtg cccttccagc
      541 cttgctatcc aagaaaacgc caacgctctg gctcgctacg ccagcatctg ccagcagaat
      601 gggctggtac ctattgttga gccagaggtt cttcctgatg gagaccatga cctagagcac
      661 tgccagtatg tttctgagaa ggtcctggct gctgtctaca aggctctcaa tgatcatcat
      721 gtttaccttg agggcaccct gctaaagcca aacatggtga ctgctggaca tgcctgcacc
      781 aagaagtaca cacctgagca agtggctatg gccaccgtca cggctctcca cagaactgtt
      841 cctgcagctg tgcctggtat ctgctttttg tctggaggca tgagtgagga ggatgctaca
      901 cttaacctca atgctatcaa ccgttgccct ctacctaggc cctggaaact aagcttttca
      961 tacggcagag ccctccaggc cagtgcattg gctgcctggg gcggcaaggc tgcaaacaag
     1021 aaggcaaccc aggaagcttt catgaagcgg gctgtggcca actgccaggc agcccaagga
     1081 cagtatgttc acacgggctc gtcaggcgct gcttccacgc agtcactctt cacagcctcc
     1141 tacacctact agataccgtc acctaccagc caggctccag ttgtcctaaa tattttggtt
     1201 ggagacctga aaggcttcag tcagccctgg aaattagatc acatttgatt gaacttttga
     1261 aaacaccaca tatgcgaatc ataaacacag gagaaaagca gaatcagctg ttgaagtgcg
     1321 agtatgagca cgtcacccag tagtctccga acacctccag ttccccgtgt tccagaacat
     1381 ccatccaaga gaagaacggg ctttacatgg aaggtcagtc ttccatgcat acagccacta
     1441 ctgagcaaag cagctcggaa gggaaggatg gagaagggca ttttaacaaa catacttacc
     1501 gggggttggt tagagaagag gcacagcagc agaaaaagaa ataaaaagtc tatgaacctt
     1561 caaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
