LOCUS       NM_001177305            1363 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus aldolase, fructose-bisphosphate A (Aldoa),
            transcript variant 2, mRNA.
ACCESSION   NM_001177305
VERSION     NM_001177305.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Oppelt,S.A., Sennott,E.M. and Tolan,D.R.
  TITLE     Aldolase-B knockout in mice phenocopies hereditary fructose
            intolerance in humans
  JOURNAL   Mol Genet Metab 114 (3), 445-450 (2015)
   PUBMED   25637246
REFERENCE   2  (bases 1 to 1363)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1363)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 1363)
  AUTHORS   Ritterson Lew,C. and Tolan,D.R.
  TITLE     Aldolase sequesters WASP and affects WASP/Arp2/3-stimulated actin
            dynamics
  JOURNAL   J Cell Biochem 114 (8), 1928-1939 (2013)
   PUBMED   23495010
REFERENCE   5  (bases 1 to 1363)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   6  (bases 1 to 1363)
  AUTHORS   Joh,K., Arai,Y., Mukai,T. and Hori,K.
  TITLE     Expression of three mRNA species from a single rat aldolase A gene,
            differing in their 5' non-coding regions
  JOURNAL   J Mol Biol 190 (3), 401-410 (1986)
   PUBMED   3783705
REFERENCE   7  (bases 1 to 1363)
  AUTHORS   Mukai,T., Joh,K., Arai,Y., Yatsuki,H. and Hori,K.
  TITLE     Tissue-specific expression of rat aldolase A mRNAs. Three molecular
            species differing only in the 5'-terminal sequences
  JOURNAL   J Biol Chem 261 (7), 3347-3354 (1986)
   PUBMED   3753977
REFERENCE   8  (bases 1 to 1363)
  AUTHORS   Joh,K., Mukai,T., Yatsuki,H. and Hori,K.
  TITLE     Rat aldolase A messenger RNA: the nucleotide sequence and multiple
            mRNA species with different 5'-terminal regions
  JOURNAL   Gene 39 (1), 17-24 (1985)
   PUBMED   2416636
REFERENCE   9  (bases 1 to 1363)
  AUTHORS   Tsutsumi,R., Tsutsumi,K., Numazaki,M. and Ishikawa,K.
  TITLE     Two different aldolase A mRNA species in rat tissues
  JOURNAL   Eur J Biochem 142 (1), 161-164 (1984)
   PUBMED   6086339
REFERENCE   10 (bases 1 to 1363)
  AUTHORS   Rutter,W.J., Rajkumar,T., Penhoet,E., Kochman,M. and Valentine,R.
  TITLE     Aldolase variants: structure and physiological significance
  JOURNAL   Ann N Y Acad Sci 151 (1), 102-117 (1968)
   PUBMED   5251864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M14420.1, CO398643.1 and CO383722.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216820.1, FQ216189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132294
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               M14420.1           1-441
            442-686             CO398643.1         435-679
            687-1339            M14420.1           687-1339
            1340-1363           CO383722.1         447-470
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..1363
                     /gene="Aldoa"
                     /gene_synonym="Aldo1; RNALDOG5"
                     /note="aldolase, fructose-bisphosphate A"
                     /db_xref="GeneID:24189"
                     /db_xref="RGD:2089"
     exon            1..41
                     /gene="Aldoa"
                     /gene_synonym="Aldo1; RNALDOG5"
                     /inference="alignment:Splign:2.1.0"
     exon            42..174
                     /gene="Aldoa"
                     /gene_synonym="Aldo1; RNALDOG5"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1157
                     /gene="Aldoa"
                     /gene_synonym="Aldo1; RNALDOG5"
                     /EC_number="4.1.2.13"
                     /note="muscle-type aldolase; aldolase A,
                     fructose-bisphosphate"
                     /codon_start=1
                     /product="fructose-bisphosphate aldolase A"
                     /protein_id="NP_001170776.1"
                     /db_xref="GeneID:24189"
                     /db_xref="RGD:2089"
                     /translation="MPHPYPALTPEQKKELADIAHRIVAPGKGILAADESTGSIAKRL
                     QSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKG
                     GVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPS
                     SLAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALS
                     DHHVYLEGTLLKPNMVTPGHACTQKFSNEEIAMATVTALRRTVPPAVPGVTFLSGGQS
                     EEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYIKRALA
                     NSLACQGKYTPSGQSGAAASESLFISNHAY"
     exon            175..386
                     /gene="Aldoa"
                     /gene_synonym="Aldo1; RNALDOG5"
                     /inference="alignment:Splign:2.1.0"
     exon            387..441
                     /gene="Aldoa"
                     /gene_synonym="Aldo1; RNALDOG5"
                     /inference="alignment:Splign:2.1.0"
     exon            442..602
                     /gene="Aldoa"
                     /gene_synonym="Aldo1; RNALDOG5"
                     /inference="alignment:Splign:2.1.0"
     exon            603..686
                     /gene="Aldoa"
                     /gene_synonym="Aldo1; RNALDOG5"
                     /inference="alignment:Splign:2.1.0"
     exon            687..861
                     /gene="Aldoa"
                     /gene_synonym="Aldo1; RNALDOG5"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1061
                     /gene="Aldoa"
                     /gene_synonym="Aldo1; RNALDOG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1340
                     /gene="Aldoa"
                     /gene_synonym="Aldo1; RNALDOG5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctgacc aggctctgcg gcttctttca ctgcaccaca ggaaagcgct gccaccggca
       61 ccatgcccca cccataccca gcactgaccc cggagcagaa gaaggagctg gctgacatcg
      121 ctcaccgaat tgtagctccg ggcaagggca tcctggctgc agacgagtcc actggaagca
      181 ttgccaagcg cctgcagtcc attggcaccg agaacaccga ggagaacagg cgcttctacc
      241 gccaactgct gctgactgcc gatgaccgtg tgaatccctg cattggaggg gtgatccttt
      301 tccacgagac actgtaccag aaggcagatg atggccgtcc cttcccccaa gttatcaagt
      361 ccaagggtgg tgttgtgggc attaaggtag ataagggtgt agtgcccctg gctggaacca
      421 atggcgagac cactactcaa gggctggacg ggctgtctga gcgctgtgcc cagtataaga
      481 aggatggagc cgactttgcc aagtggcgct gtgtgctaaa gattggggag catactccct
      541 cgtccctcgc catcatggaa aatgccaatg ttctggcccg ttacgccagc atctgccagc
      601 agaatggcat tgtacccatt gtggagcctg aaattctccc tgatggggac catgacttga
      661 agcgctgcca gtatgtaact gagaaggtac tggcagctgt ctacaaggct ctgagtgacc
      721 accatgtcta tctggaaggc acactgctga agcccaacat ggtcacccct ggccatgctt
      781 gcacccagaa attttccaat gaggaaattg ccatggcaac cgtcacagca cttcgtcgaa
      841 cagtgccccc tgccgtccct ggggtcactt tcctgtctgg agggcagagt gaggaagagg
      901 catccatcaa cctcaatgct atcaacaagt gtcccctgct gaagccatgg gccttgactt
      961 tctcctatgg ccgagccctg caggcctctg ctctaaaggc ttggggtggg aagaaggaga
     1021 acctgaaggc agcccaggag gagtacatca agcgagccct ggccaacagc ctcgcttgtc
     1081 aaggaaagta cactccaagt ggccagtctg gagccgcagc cagtgaatct ctcttcatct
     1141 ctaaccatgc ctactaacca gagctgatct aaggctgctc catcgacact ccaggcccct
     1201 gcctacccac ttgctattga agaggggcct tcaggctctt tcccatcact cttgctgccc
     1261 tcgtgtgtgc agtgttgtct gtgaatgcta aatctgccat cccttccagc ccactgccaa
     1321 taaacagcta tttaaggggg aaaaaaaaaa aaaaaaaaaa aaa
//
