LOCUS       NM_022273               2360 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 9 family, member A1
            (Aldh9a1), mRNA.
ACCESSION   NM_022273
VERSION     NM_022273.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Koncitikova,R., Vigouroux,A., Kopecna,M., Sebela,M., Morera,S. and
            Kopecny,D.
  TITLE     Kinetic and structural analysis of human ALDH9A1
  JOURNAL   Biosci Rep 39 (4) (2019)
   PUBMED   30914451
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2360)
  AUTHORS   Matsunaga,A., Harita,Y., Shibagaki,Y., Shimizu,N., Shibuya,K.,
            Ono,H., Kato,H., Sekine,T., Sakamoto,N., Igarashi,T. and Hattori,S.
  TITLE     Identification of 4-Trimethylaminobutyraldehyde Dehydrogenase
            (TMABA-DH) as a Candidate Serum Autoantibody Target for Kawasaki
            Disease
  JOURNAL   PLoS One 10 (5), e0128189 (2015)
   PUBMED   26010099
  REMARK    GeneRIF: TMABA-DH colocalized with myosin light chains in cardiac
            myocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2360)
  AUTHORS   Garcia-Delgado,M., Peral,M.J., Duran,J.M., Garcia-Miranda,P.,
            Calonge,M.L. and Ilundain,A.A.
  TITLE     Ontogeny of Na(+)/L-carnitine transporter and of
            gamma-trimethylaminobutyraldehyde dehydrogenase and
            gamma-butyrobetaine hydroxylase genes expression in rat kidney
  JOURNAL   Mech Ageing Dev 130 (4), 227-233 (2009)
   PUBMED   19150623
  REMARK    GeneRIF: Foetuses express TMABA-DH mRNA and this expression
            increased during postnatal life
REFERENCE   5  (bases 1 to 2360)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2360)
  AUTHORS   Vaz,F.M., Fouchier,S.W., Ofman,R., Sommer,M. and Wanders,R.J.
  TITLE     Molecular and biochemical characterization of rat
            gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for
            the involvement of human aldehyde dehydrogenase 9 in carnitine
            biosynthesis
  JOURNAL   J Biol Chem 275 (10), 7390-7394 (2000)
   PUBMED   10702312
REFERENCE   7  (bases 1 to 2360)
  AUTHORS   Testore,G., Cravanzola,C. and Bedino,S.
  TITLE     Aldehyde dehydrogenase from rat intestinal mucosa: purification and
            characterization of an isozyme with high affinity for
            gamma-aminobutyraldehyde
  JOURNAL   Int J Biochem Cell Biol 31 (7), 777-786 (1999)
   PUBMED   10467734
REFERENCE   8  (bases 1 to 2360)
  AUTHORS   Kikonyogo,A. and Pietruszko,R.
  TITLE     Aldehyde dehydrogenase from adult human brain that dehydrogenates
            gamma-aminobutyraldehyde: purification, characterization, cloning
            and distribution
  JOURNAL   Biochem J 316 (Pt 1) (Pt 1), 317-324 (1996)
   PUBMED   8645224
REFERENCE   9  (bases 1 to 2360)
  AUTHORS   Ambroziak,W., Kurys,G. and Pietruszko,R.
  TITLE     Aldehyde dehydrogenase (EC 1.2.1.3): comparison of subcellular
            localization of the third isozyme that dehydrogenates
            gamma-aminobutyraldehyde in rat, guinea pig and human liver
  JOURNAL   Comp Biochem Physiol B 100 (2), 321-327 (1991)
   PUBMED   1799975
REFERENCE   10 (bases 1 to 2360)
  AUTHORS   Kurys,G., Ambroziak,W. and Pietruszko,R.
  TITLE     Human aldehyde dehydrogenase. Purification and characterization of
            a third isozyme with low Km for gamma-aminobutyraldehyde
  JOURNAL   J Biol Chem 264 (8), 4715-4721 (1989)
   PUBMED   2925663
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC074019.1.
            
            On Sep 20, 2005 this sequence version replaced NM_022273.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC074019.1, AF170918.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..2360
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /note="aldehyde dehydrogenase 9 family, member A1"
                     /db_xref="GeneID:64040"
                     /db_xref="RGD:68409"
     exon            1..179
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1564
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /EC_number="1.2.1.3"
                     /EC_number="1.2.1.19"
                     /EC_number="1.2.1.47"
                     /EC_number="1.2.1.46"
                     /note="aldehyde dehydrogenase family 9, subfamily A1;
                     TMABADH; aldehyde dehydrogenase family 9 member A1;
                     gamma-trimethylaminobutyraldehyde dehydrogenase; aldehyde
                     dehydrogenase 9A1; gamma-aminobutyraldehyde dehydrogenase;
                     4-trimethylaminobutyraldehyde dehydrogenase-like;
                     formaldehyde dehydrogenase"
                     /codon_start=1
                     /product="4-trimethylaminobutyraldehyde dehydrogenase"
                     /protein_id="NP_071609.2"
                     /db_xref="GeneID:64040"
                     /db_xref="RGD:68409"
                     /translation="MSTGTFVVSQPLNYRGGARVEPVDASGTEKAFEPATGREIATFK
                     CSGEKEVNLAVENAKAAFKIWSKKSGLERCQVLLEAARIIKERRDEIAIMETINNGKS
                     IFEARLDVDTSWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCLGIGAWNYPF
                     QIACWKSAPALACGNAMIFKPSPFTPVSALLLAEIYTKAGAPNGLFNVVQGGAATGQF
                     LCQHRDVAKVSFTGSVPTGMKIMEMAAKGIKPITLELGGKSPLIIFSDCNMKNAVKGA
                     LLANFLTQGQVCCNGTRVFVQKEIADAFTKEVVRQTQRIKIGDPLLEDTRMGPLINAP
                     HLERVLGFVRSAKEQGATVLCGGEPYAPEDPKLKHGYYMTPCILTNCTDDMTCVKEEI
                     FGPVMSILTFETEAEVLERANDTTFGLAAGVFTRDIQRAHRVAAELQAGTCYINNYNV
                     SPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESPFENQ"
     exon            180..325
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /inference="alignment:Splign:2.1.0"
     exon            326..455
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /inference="alignment:Splign:2.1.0"
     exon            456..590
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /inference="alignment:Splign:2.1.0"
     exon            591..787
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /inference="alignment:Splign:2.1.0"
     exon            788..928
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1117
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1205
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1347
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1460
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..2340
                     /gene="Aldh9a1"
                     /gene_synonym="Tmaba-dh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttctcagt gcagtcggac ctgtgctgac ctcgctcctc cgcgtacccc ggcctgcagc
       61 agtcgccgcc atgagcactg gcaccttcgt cgtgtcgcag ccgctcaact accgcggcgg
      121 ggcccgcgtg gagccggtgg atgcctccgg cacggagaaa gcgttcgagc cagccaccgg
      181 ccgagagata gctactttca agtgttcggg agaaaaggaa gtaaatttgg ctgttgaaaa
      241 tgcaaaagct gcctttaaaa tctggagtaa gaaaagcggc ttggagcgtt gtcaagtcct
      301 cttagaggct gcccggataa taaaggaacg gagggatgaa attgccatta tggagaccat
      361 caacaacggg aagtccatat ttgaggctcg cctggatgtt gacacttcct ggcagtgcct
      421 ggaatactat gcaggcctgg ctgcgtccat ggcgggagag cacatccagc tcccaggagg
      481 gtcctttggc tacaccagaa gagaaccact tggggtgtgt ttggggatag gagcatggaa
      541 ctaccccttc cagattgcct gttggaagtc tgctccggct ttggcttgtg gtaatgccat
      601 gatctttaag ccctctccct tcacgcctgt gtctgctctg ctcctggctg agatctacac
      661 caaagccggt gcgcctaacg gcctcttcaa cgtggtgcaa ggtggggctg ccacaggcca
      721 gtttctgtgt cagcatcgtg atgtggccaa agtctccttc actggaagcg tgcccactgg
      781 catgaagatc atggagatgg ccgctaaagg aatcaaaccc attactttgg aacttggggg
      841 caaatctcct ctgatcattt tctctgactg taatatgaag aatgctgtga agggggcctt
      901 gctggccaac ttcctcacac aaggacaggt gtgctgcaac ggcactagag tgtttgtgca
      961 aaaggaaatt gctgacgcat ttacaaagga agttgtgagg cagactcaga ggataaagat
     1021 tggggaccca cttctggaag atacaaggat gggcccactc atcaatgccc cgcacctgga
     1081 gcgagtcctc gggtttgtca ggtctgcaaa ggagcagggt gccactgtgc tgtgtggtgg
     1141 agagccgtat gccccggagg atcctaagtt aaaacatgga tattacatga caccttgcat
     1201 tttaactaat tgcacagatg acatgacttg tgtaaaagaa gagatctttg ggccagttat
     1261 gtccattcta acatttgaga ctgaagccga ggttctggag cgggccaatg acaccacgtt
     1321 tggactagca gctggggtct ttaccaggga cattcagagg gcgcacaggg tggcggctga
     1381 gctgcaggcc ggaacgtgct acattaacaa ctataacgtc agcccggtgg agttgccctt
     1441 tggtggatac aagaagtcag gatttggcag agagaacggc cgagtgacga ttgagtacta
     1501 ttcacagctg aagacggtgt gtgtggagat gggggacgtg gagtcgcctt ttgaaaacca
     1561 gtgacgtaca tggccaagct gtgcaatgag tcggctgcct tgattgacag gcagtgtaac
     1621 tgaatagctt cttacatcca ggctttgggt cattagtgtg ataatgggtc agtattgtcc
     1681 tctgtcttgc agtcaccttc ccaattgaaa atgtgcacaa gtgcctttcc gatggtagcc
     1741 agggaacctg ttcttccagg aagttccgga gaaaccggta aacctcagca acactgttca
     1801 gacatgggca ggccacagct ctgctcatac acattcgtcc caccaacaat ggcagttttc
     1861 tagtttgatt taaaggcctt ccttcctggt ttcctggtga atcagatata tgttctttgt
     1921 tcattgacaa ctaaaacaca aattcttaaa ttagaggcag tggtgtggtg catgcctcta
     1981 atcccagcac ttgggaggca gaggcaggta catatctgag ttcgaggcca gcctggtcta
     2041 cagagtgagt tccagtacaa ccagggctac acaaattaac cctgtcttga aaaaccaaaa
     2101 ataaataaga agtgcatttt aaaaagttgt tattcggaga cattaaagtc ttaatacttg
     2161 tggaaaatgt gattcattgg catttaaaaa gctatgttct tcttggctag caagacagct
     2221 cagtgggtaa ggtcttagca cataagcccc gtgacctcag ttttatcccc agaactcaca
     2281 tcaaggtggt agcccctccc ccaatccata taatgcacaa taattaaatc tttctcaaaa
     2341 aaaaaaaaaa aaaaaaaaaa
//
