LOCUS       NM_001191088            1734 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 8 family, member A1
            (Aldh8a1), mRNA.
ACCESSION   NM_001191088 XM_001065122 XM_006227674
VERSION     NM_001191088.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1734)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 1734)
  AUTHORS   Lin,M., Zhang,M., Abraham,M., Smith,S.M. and Napoli,J.L.
  TITLE     Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular
            expression, and activity in 9-cis-retinoic acid biosynthesis in
            intact cells
  JOURNAL   J Biol Chem 278 (11), 9856-9861 (2003)
   PUBMED   12519776
REFERENCE   3  (bases 1 to 1734)
  AUTHORS   Zhuang,R., Lin,M. and Napoli,J.L.
  TITLE     cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a
            short-chain dehydrogenase active in a reconstituted path of
            9-cis-retinoic acid biosynthesis in intact cells
  JOURNAL   Biochemistry 41 (10), 3477-3483 (2002)
   PUBMED   11876656
REFERENCE   4  (bases 1 to 1734)
  AUTHORS   Lin,M. and Napoli,J.L.
  TITLE     cDNA cloning and expression of a human aldehyde dehydrogenase
            (ALDH) active with 9-cis-retinal and identification of a rat
            ortholog, ALDH12
  JOURNAL   J Biol Chem 275 (51), 40106-40112 (2000)
   PUBMED   11007799
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Aug 9, 2017 this sequence version replaced
            XM_006227674.3, NM_001191088.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.82.1, SRR26643287.131.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               JAXUCZ010000001.1  18003507-18003679
            174-321             JAXUCZ010000001.1  18006711-18006858
            322-477             JAXUCZ010000001.1  18008161-18008316
            478-627             JAXUCZ010000001.1  18009520-18009669
            628-884             JAXUCZ010000001.1  18015094-18015350
            885-1046            JAXUCZ010000001.1  18018908-18019069
            1047-1734           JAXUCZ010000001.1  18022265-18022952
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..1734
                     /gene="Aldh8a1"
                     /note="aldehyde dehydrogenase 8 family, member A1"
                     /db_xref="GeneID:685750"
                     /db_xref="RGD:1590218"
     exon            1..173
                     /gene="Aldh8a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1499
                     /gene="Aldh8a1"
                     /EC_number="1.2.1.-"
                     /note="aldehyde dehydrogenase family 8 member A1"
                     /codon_start=1
                     /product="2-aminomuconic semialdehyde dehydrogenase"
                     /protein_id="NP_001178017.2"
                     /db_xref="GeneID:685750"
                     /db_xref="RGD:1590218"
                     /translation="MAGKRELLMLENFIGGKFLPCNSYIDSYDPSTGEVYCKVPNSGK
                     EEIEVAVQAAREAFPAWSSRSPQERSLILNRVADVLEQSLEELAQAESKDQGKTLTLA
                     RTMDIPRSVLNFRFFASSIQHHVSDCTEMSHLGCMHYTVRTPVGIAGLISPWNLPLYL
                     LTWKIAPAIAAGNTVIAKPSELTSVTAWMFCKLLDKAGVPPGVINVVFGTGPRVGEAL
                     VSHPEVPVISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLEECIPATV
                     RSSFANQGEICLCTSRIFVQRSIYNEFLKRFVEATRKWKVGIPSDPSANMGALISKAH
                     LEKVRSYVTKAHAEGAKILCGEGVDQLSLPLRNQAGYFMLPTVITDIKDESCCMTEEI
                     FGPVTCVVPFDSEEEVIARANGVKYGLGATVWSKDVGRIHRVAKRLQSGLVWTNCWLI
                     RELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITIKY"
     exon            174..321
                     /gene="Aldh8a1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..477
                     /gene="Aldh8a1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..627
                     /gene="Aldh8a1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..884
                     /gene="Aldh8a1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1046
                     /gene="Aldh8a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1734
                     /gene="Aldh8a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagctgag tacaggctga gagcattctc ctaacatggc cggaaaaagg gaacttttga
       61 tgttggagaa ctttataggt ggaaaatttt taccctgtaa ctcgtatata gattcttatg
      121 atccgtcgac aggggaagtg tactgcaaag taccaaacag tgggaaggag gagatcgaag
      181 ttgctgtgca ggctgccaga gaggccttcc cggcctggtc atcccggagt ccccaggaac
      241 gttctctcat cctgaacagg gtggctgatg tgctggagca gtccctggag gagttagccc
      301 aggcagaatc taaagaccaa gggaaaaccc tcacgctggc aaggaccatg gacattcctc
      361 ggtctgtcct gaacttccgg ttcttcgctt cctccatcca gcaccacgta tcggattgca
      421 cagagatgag ccacctgggc tgtatgcact acaccgttcg tacccccgtg ggaattgctg
      481 gtttgatcag cccttggaat ttaccgctct acctgttgac ctggaaaata gctccggcca
      541 tcgctgctgg gaataccgtg atagccaagc ccagcgagct gacttctgtg actgcttgga
      601 tgttttgtaa actcctagat aaagcaggtg tgccaccagg tgtgatcaat gttgtgttcg
      661 gaacagggcc gagggttggt gaggccctcg tgtcccaccc agaggtcccc gtgatctcct
      721 tcacggggag ccagcccaca gctgaacgga ttacccagct aagtgccccc cactgcaaga
      781 agctctccct ggagctagga ggcaagaacc ctgccatcat ttttgaggat gccaacctgg
      841 aggagtgcat cccagcaacc gtgagatcca gcttcgccaa ccagggggag atctgccttt
      901 gtaccagcag gatctttgtc cagaggagca tctataatga atttctgaag aggtttgtgg
      961 aagctaccag aaagtggaaa gttggcattc cttccgatcc atcagccaac atgggtgctt
     1021 taataagtaa agcacatttg gagaaagtca gaagttatgt aacaaaagct catgctgagg
     1081 gtgccaagat tctgtgtggt gagggcgtgg accagctgag ccttccactc aggaaccagg
     1141 caggctactt catgcttccc acagtgataa cggacattaa ggatgagtcc tgctgcatga
     1201 cagaagagat ctttggcccc gtgacgtgcg tcgtcccttt tgatagcgaa gaggaagtga
     1261 ttgcaagagc taacggcgtt aagtatgggc tgggggccac agtatggtca aaggatgtgg
     1321 ggcgcatcca cagggtagct aagaggcttc agtcagggct tgtctggacc aactgctggc
     1381 tcatcaggga gctgaacctg cccttcggag ggatgaaaag ctctggaata ggaagagagg
     1441 gagccaagga ctcatatgat ttctttactg aaataaaaac catcaccatt aaatactgac
     1501 cttccctgcg ggcacatcag ttgtcagcca tggcagagaa tcactagtca gagcagtcaa
     1561 cagaaatcct tctatgttca gtcacgtcat gacctgccag gagactggct cttgctcacc
     1621 ttggctagtt ggtgttctta ccagcttgtg aaaaaaaaaa ggcagttttt atgaattctt
     1681 gaaaatccgc caaaataggg tatttttatt tgcaaatata tggtaaaacc aaaa
//
