LOCUS       NM_001271105            1894 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 7 family, member A1
            (Aldh7a1), mRNA.
ACCESSION   NM_001271105 XM_214535
VERSION     NM_001271105.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1894)
  AUTHORS   Cao,Y., Ding,W., Zhang,J., Gao,Q., Yang,H., Cao,W., Wang,Z.,
            Fang,L. and Du,R.
  TITLE     Significant Down-Regulation of Urea Cycle Generates Clinically
            Relevant Proteomic Signature in Hepatocellular Carcinoma Patients
            with Macrovascular Invasion
  JOURNAL   J Proteome Res 18 (5), 2032-2044 (2019)
   PUBMED   30901224
REFERENCE   2  (bases 1 to 1894)
  AUTHORS   Mills,P.B., Struys,E., Jakobs,C., Plecko,B., Baxter,P.,
            Baumgartner,M., Willemsen,M.A., Omran,H., Tacke,U., Uhlenberg,B.,
            Weschke,B. and Clayton,P.T.
  TITLE     Mutations in antiquitin in individuals with pyridoxine-dependent
            seizures
  JOURNAL   Nat Med 12 (3), 307-309 (2006)
   PUBMED   16491085
REFERENCE   3  (bases 1 to 1894)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 1894)
  AUTHORS   Skvorak,A.B., Robertson,N.G., Yin,Y., Weremowicz,S., Her,H.,
            Bieber,F.R., Beisel,K.W., Lynch,E.D., Beier,D.R. and Morton,C.C.
  TITLE     An ancient conserved gene expressed in the human inner ear:
            identification, expression analysis, and chromosomal mapping of
            human and mouse antiquitin (ATQ1)
  JOURNAL   Genomics 46 (2), 191-199 (1997)
   PUBMED   9417906
REFERENCE   5  (bases 1 to 1894)
  AUTHORS   Lee,P., Kuhl,W., Gelbart,T., Kamimura,T., West,C. and Beutler,E.
  TITLE     Homology between a human protein and a protein of the green garden
            pea
  JOURNAL   Genomics 21 (2), 371-378 (1994)
   PUBMED   8088832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Aug 31, 2012 this sequence version replaced XM_214535.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.44464.1,
                                           SRR26643293.77426.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JAXUCZ010000018.1  52240025-52240293   c
            270-323             JAXUCZ010000018.1  52238729-52238782   c
            324-389             JAXUCZ010000018.1  52237178-52237243   c
            390-470             JAXUCZ010000018.1  52232477-52232557   c
            471-594             JAXUCZ010000018.1  52231495-52231618   c
            595-727             JAXUCZ010000018.1  52229925-52230057   c
            728-772             JAXUCZ010000018.1  52228256-52228300   c
            773-850             JAXUCZ010000018.1  52226435-52226512   c
            851-948             JAXUCZ010000018.1  52223677-52223774   c
            949-990             JAXUCZ010000018.1  52219927-52219968   c
            991-1085            JAXUCZ010000018.1  52218396-52218490   c
            1086-1170           JAXUCZ010000018.1  52214921-52215005   c
            1171-1277           JAXUCZ010000018.1  52213165-52213271   c
            1278-1394           JAXUCZ010000018.1  52212630-52212746   c
            1395-1492           JAXUCZ010000018.1  52212366-52212463   c
            1493-1566           JAXUCZ010000018.1  52212150-52212223   c
            1567-1642           JAXUCZ010000018.1  52209432-52209507   c
            1643-1894           JAXUCZ010000018.1  52208035-52208286   c
FEATURES             Location/Qualifiers
     source          1..1894
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1894
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /note="aldehyde dehydrogenase 7 family, member A1"
                     /db_xref="GeneID:291450"
                     /db_xref="RGD:1308614"
     exon            1..269
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1697
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /EC_number="1.2.1.3"
                     /EC_number="1.2.1.8"
                     /EC_number="1.2.1.31"
                     /note="antiquitin-1; P6c dehydrogenase; alpha-AASA
                     dehydrogenase; aldehyde dehydrogenase family 7 member A1;
                     delta1-piperideine-6-carboxylate dehydrogenease; betaine
                     aldehyde dehydrogenase; delta1-piperideine-6-carboxylate
                     dehydrogenase"
                     /codon_start=1
                     /product="alpha-aminoadipic semialdehyde dehydrogenase"
                     /protein_id="NP_001258034.1"
                     /db_xref="GeneID:291450"
                     /db_xref="RGD:1308614"
                     /translation="MLRLARPLCVQTVKASKLSRLWSRPAALMSTLLIHHPQYAWLQD
                     LGLREDNEGVFNGSWGGRGEVITTYCPANNEPIARVRQASMKDYEETIGKAKKAWNIW
                     ADIPAPKRGEIVRKIGDALREKIQLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGL
                     SRMIGGPTLPSERPGHALMEQWNPLGLVGIITAFNFPVAVFGWNNAIALITGNVCLWK
                     GAPTTSLVSIAVTKIIAKVLEDNLLPGAICSLTCGGADMGTAMARDERVNLLSFTGST
                     QVGKQVALMVQERFGKSLLELGGNNAIIAFEDADLSLVLPSALFAAVGTAGQRCTTVR
                     RLFLHESIHDEVVDRLKNAYSQIRVGNPWDPNILYGPLHTKQAVSMFVQAVEEAKKEG
                     GTVVYGGKVMDHPGNYVEPTIVTGLVHDAPIVHKETFAPILYVFKFKNEEEVFEWNNE
                     VKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
                     GSDAWKQYMRRSTCTINYSTALPLAQGIKFQ"
     exon            270..323
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            324..389
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            390..470
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            471..594
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            595..727
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            728..772
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            773..850
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            851..948
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            949..990
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1085
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1170
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1277
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1394
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1492
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1566
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1642
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1894
                     /gene="Aldh7a1"
                     /gene_synonym="antiquitin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggactctccg agggcagggg gcggggctgt atttcccgac tgccctgcgg taggggcttc
       61 tagcgtgcga gctcgttatg ttgcgtctgg ctcgcccgct ctgcgtgcag actgtgaagg
      121 ccagcaaact ttcccgcctt tggagtaggc ctgccgccct tatgtctact ctgctgatcc
      181 atcatcccca gtatgcctgg ctgcaagacc tgggtctccg cgaagataac gagggcgtgt
      241 ttaatggaag ctggggcggc cggggagagg taattacgac ctattgtcct gctaacaatg
      301 agccaatagc aagagtccga caggccagca tgaaagacta tgaagagact atagggaaag
      361 ccaagaaagc ttggaacatc tgggcagata ttcctgcccc aaagcgagga gaaatagtca
      421 gaaagattgg cgatgccttg cgggagaaga tccaattact gggaagactg gtgtctttgg
      481 agatggggaa aatcttagtg gaaggaatag gggaggttca ggagtacgtg gacgtctgcg
      541 attatgctgc cggcttgtcg aggatgatcg ggggacccac cttgccctct gaaagacccg
      601 gccatgctct catggaacag tggaatccgt taggcctggt gggaatcatc actgccttca
      661 acttccctgt ggctgtgttt ggctggaaca atgccatagc tctgatcaca ggcaacgtct
      721 gcctttggaa aggagcacca acaacttccc tcgttagtat agctgtcaca aagatcatag
      781 ccaaggtttt ggaggacaac ctgctgcctg gtgccatttg ctccctgacc tgtggtggag
      841 cagatatggg cacagcaatg gccagagatg agcgtgtgaa cctgctgtcg ttcactggga
      901 gcactcaggt ggggaagcag gtggccctca tggtgcagga gaggtttggg aaaagcttgt
      961 tggagctcgg aggaaacaat gccatcattg ctttcgagga cgccgacctc agcttggttc
     1021 ttccctccgc tctgtttgcc gccgtgggaa cagccggcca gaggtgtacc actgtgaggc
     1081 gactgttttt gcacgaaagc atccatgatg aagttgtaga cagactgaaa aatgcctact
     1141 cacagatccg tgtcgggaac ccctgggacc ccaatatcct ctatggaccg ctccacacca
     1201 aacaggcggt gagcatgttt gtgcaagccg tggaagaagc aaagaaagaa ggaggcacgg
     1261 tggtctatgg gggcaaggtc atggaccacc ctggcaatta tgtggaaccc accattgtga
     1321 ctggtcttgt ccatgatgcg cccattgttc acaaggagac ttttgcccca attctctatg
     1381 tcttcaaatt caagaatgaa gaagaggtct ttgaatggaa caatgaagta aaacagggac
     1441 tttcgagtag tatctttacc aaggatctgg gcagaatctt ccgctggctt ggacctaagg
     1501 gttcagactg tggcattgtg aacgtcaata ttcctaccag cggggctgag atcggcggtg
     1561 cgtttggagg cgagaagcac acgggcggtg gcagggaatc tggcagcgat gcctggaagc
     1621 agtacatgcg gagatctacg tgtaccatca actacagcac ggccctccct ctggctcaag
     1681 gtatcaagtt tcagtgatac tggttggtca cttagccatt cctgtgactg ctctgaagac
     1741 gcccaagagg actctgactt tcccggaata aatgatcgat ttgagtacag cagtgcctac
     1801 tctccagtga tcaaacccct gactaaatca agatatatcc atttatcaag aattgaaaat
     1861 taaatattta caacctagct acatttagca aaag
//
