LOCUS       NM_031057               3333 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 6 family, member A1
            (Aldh6a1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_031057 XM_346778
VERSION     NM_031057.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3333)
  AUTHORS   Marcadier,J.L., Smith,A.M., Pohl,D., Schwartzentruber,J.,
            Al-Dirbashi,O.Y., Majewski,J., Ferdinandusse,S., Wanders,R.J.,
            Bulman,D.E., Boycott,K.M., Chakraborty,P. and Geraghty,M.T.
  CONSRTM   FORGE Canada Consortium
  TITLE     Mutations in ALDH6A1 encoding methylmalonate semialdehyde
            dehydrogenase are associated with dysmyelination and transient
            methylmalonic aciduria
  JOURNAL   Orphanet J Rare Dis 8, 98 (2013)
   PUBMED   23835272
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3333)
  AUTHORS   Suryawanshi,A.R., Khan,S.A., Joshi,C.S. and Khole,V.V.
  TITLE     Epididymosome-mediated acquisition of MMSDH, an androgen-dependent
            and developmentally regulated epididymal sperm protein
  JOURNAL   J Androl 33 (5), 963-974 (2012)
   PUBMED   22207704
  REMARK    GeneRIF: Suggest that MMSDH protein is present in the entire
            epididymis; its expression is regulated by androgen and the
            developmental status of the epididymis.
REFERENCE   3  (bases 1 to 3333)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3333)
  AUTHORS   Wu,Y. and Smas,C.M.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   5  (bases 1 to 3333)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 3333)
  AUTHORS   Kedishvili,N.Y., Popov,K.M., Rougraff,P.M., Zhao,Y., Crabb,D.W. and
            Harris,R.A.
  TITLE     CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique
            member of the aldehyde dehydrogenase superfamily. cDNA cloning,
            evolutionary relationships, and tissue distribution
  JOURNAL   J Biol Chem 267 (27), 19724-19729 (1992)
   PUBMED   1527093
REFERENCE   7  (bases 1 to 3333)
  AUTHORS   Popov,K.M., Kedishvili,N.Y. and Harris,R.A.
  TITLE     Coenzyme A- and NADH-dependent esterase activity of methylmalonate
            semialdehyde dehydrogenase
  JOURNAL   Biochim Biophys Acta 1119 (1), 69-73 (1992)
   PUBMED   1540637
REFERENCE   8  (bases 1 to 3333)
  AUTHORS   Kedishvili,N.Y., Popov,K.M. and Harris,R.A.
  TITLE     The effect of ligand binding on the proteolytic pattern of
            methylmalonate semialdehyde dehydrogenase
  JOURNAL   Arch Biochem Biophys 290 (1), 21-26 (1991)
   PUBMED   1898092
REFERENCE   9  (bases 1 to 3333)
  AUTHORS   Goodwin,G.W., Rougraff,P.M., Davis,E.J. and Harris,R.A.
  TITLE     Purification and characterization of methylmalonate-semialdehyde
            dehydrogenase from rat liver. Identity to malonate-semialdehyde
            dehydrogenase
  JOURNAL   J Biol Chem 264 (25), 14965-14971 (1989)
   PUBMED   2768248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB760062.1, DN948946.1, M93401.1, CK476335.1, CK474421.1,
            CV797088.1 and AA819519.1.
            
            On Apr 24, 2007 this sequence version replaced NM_031057.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760400,
                              SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               CB760062.1         58-180
            124-784             DN948946.1         121-781
            785-1498            M93401.1           822-1535
            1499-2144           CK476335.1         66-711
            2145-2750           CK474421.1         52-657
            2751-3315           CV797088.1         13-577              c
            3316-3333           AA819519.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..3333
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..3333
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /note="aldehyde dehydrogenase 6 family, member A1"
                     /db_xref="GeneID:81708"
                     /db_xref="RGD:621556"
     exon            1..95
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1652
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /EC_number="1.2.1.27"
                     /note="methylmalonate-semialdehyde dehydrogenase
                     [acylating], mitochondrial; aldehyde dehydrogenase family
                     6 member A1; malonate-semialdehyde dehydrogenase;
                     methylmalonate semialdehyde dehydrogenase; aldehyde
                     dehydrogenase family 6, subfamily A1;
                     methylmalonate-semialdehyde/malonate-semialdehyde
                     dehydrogenase [acylating], mitochondrial"
                     /codon_start=1
                     /product="methylmalonate-semialdehyde/malonate-
                     semialdehyde dehydrogenase [acylating], mitochondrial
                     precursor"
                     /protein_id="NP_112319.2"
                     /db_xref="GeneID:81708"
                     /db_xref="RGD:621556"
                     /translation="MAAAVAAAAAVRSRILQVSSKVNSTWCPASSFSSSSVPTVKLFI
                     DGKFVESKSDKWIDIHNPATNEVVGRVPQSTKAEMEAAVAACKRAFPAWADTSILSRQ
                     QVLLRYQQLIKENLKEIARLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGETM
                     PSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGAT
                     MLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRN
                     GKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLP
                     ELVERAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGAKEGASILLDGRKIKVKG
                     YENGNFVGPTIISNVKPSMTCYKEEIFGPVLVVLETETLDEAIKIVNDNPYGNGTAIF
                     TTNGAIARKYAHMVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQ
                     LKTITSQWKEEDATLSSPAVVMPTMGR"
     exon            96..155
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
     exon            156..230
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
     exon            231..392
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
     exon            393..471
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
     exon            472..774
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
     exon            775..896
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1086
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1268
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1448
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1547
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..3319
                     /gene="Aldh6a1"
                     /gene_synonym="Mmsdh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actggcagcg gaggcgcggg gagctgggca gagtctggtg agccatggcg gcggcagtgg
       61 cggcagcagc agcagtgcgg tcccggatcc tgcaggtttc ttctaaagta aactccacat
      121 ggtgtccagc atcttccttc tcttcatcat cagtgccaac tgtaaagctc ttcattgatg
      181 ggaaattcgt tgaatccaaa agtgacaaat ggattgacat ccacaaccca gccaccaatg
      241 aggttgttgg tcgggttcct cagtccacca aagctgaaat ggaggcagcc gtagccgcct
      301 gcaaacgtgc tttccctgcg tgggcagaca catctatttt aagccggcag caggtcctgc
      361 ttcgttatca gcaactcatt aaagaaaacc tgaaagaaat cgccaggtta atcacattgg
      421 aacaagggaa gactctggct gatgctgaag gagatgtgtt ccgaggcctt caggtggttg
      481 agcatgcctg cagtgtgacg tccctcatgc tgggagagac catgccatct atcaccaaag
      541 acatggacct ttattcctac cgcctgcctc tgggggtgtg tgcaggcatc gcaccattta
      601 attttcctgc catgatcccc ctttggatgt ttcccatggc tatggtttgt ggaaatactt
      661 tcctaatgaa accatcagag cgagtacctg gagcaaccat gcttcttgct aagttgcttc
      721 aggattctgg tgccccggac ggaacactga acatcatcca tggacaacat gaagctgtaa
      781 attttatttg cgatcatcca gacatcaagg caatcagctt tgtgggatcc aaccaggcgg
      841 gagagtacat cttcgaaaga gggtcaagaa atggcaagag ggttcaagcc aatatgggag
      901 ccaagaacca tggggtagtc atgccagatg ccaataagga aaataccctc aaccagctgg
      961 ttggggcagc atttggagct gctgggcagc gctgcatggc tctttcaaca gccgtccttg
     1021 tgggagaagc taagaagtgg ctgccagaac tggtagagcg tgccaagaat ctccgcgtca
     1081 atgcaggaga tcagcctgga gctgatcttg gtcccctgat caccccccag gccaaagaga
     1141 gagtctgcaa tctgattgat agtggagcaa aagagggggc ttccatcctt ctggatgggc
     1201 ggaaaattaa agttaagggc tacgaaaacg gtaactttgt tggaccaacc atcatctcca
     1261 atgttaagcc aagtatgact tgttacaaag aggagatttt tggtccagtt cttgtggtct
     1321 tagagacaga aaccctggat gaagccatca agattgttaa tgacaaccca tatggaaacg
     1381 ggactgctat ctttaccacc aacggagcca tagctcggaa atacgctcac atggtggatg
     1441 tgggacaggt gggcgtgaat gtccccattc cagtgccttt gccaatgttt tccttcactg
     1501 gctctcgatc ttccttcagg ggagacacca atttctatgg caaacagggc atccagtttt
     1561 acactcagtt aaagactatc acatctcagt ggaaggaaga agatgctact ctttcctcac
     1621 ctgcagtggt catgcctacc atggggcgtt agaacgttca agactccatc cagcctgagt
     1681 aacttcccac tgtccttggc aatcttcatc tgccatcttt gctccaaaca gatccatgag
     1741 gatggagtat attgcaatga aattctttct cagaactcgc aatcccttca aagttatagg
     1801 gagtacagga taacaccaac gccaggcctt cacttgttct ccatacttct ctacggtttt
     1861 tgaggttaac tgttgttaag tgtgaagtgt ttgcctagaa taagagctta gaactgtctt
     1921 ctaacaattc ttttctgatg acttggaggg acaacgtagg ggcagatctt gcaatcactg
     1981 aaactgttca tcctctgagc ctcaattata gccctccacc agtccccaca ctatcaaaca
     2041 tgtaacctag ttttacttat cccagcatgg tgatgactgc ttttctgctc aataccactt
     2101 tcttcatggc cactatttaa ttctatccat ttcttgcttc ttaaaatact tctcaaggta
     2161 cctcaggatg aagtgataag ttagcttttt gttacatgtg ccattcttca tggtttgcct
     2221 caacaatcat taaaccaata ctctagccat taattcagat acaaataaat ccttagacaa
     2281 aatatttcac aaatggtttt tgacccagaa atcaaaggat ctccaatcct gaaagtgaat
     2341 agactcttgc cttaagtagc cttacctatt atttgccaaa atatgttatt ctttcttttg
     2401 acagcatttc tctttagttg atacttttta atgaacaaaa ctcttcatat agaataattg
     2461 attaggctac tagaaacttc aaagtttcat gctttgacaa tattcagtca ccttattcaa
     2521 cttagccagt tactcagctg cctttaagct tgcttctctg ataatctgaa ccttaagtca
     2581 gaagaggctg atgtgctgaa cagaacagtt tgtccatctg acctgaagcc ttggctttct
     2641 gaactaggct atgggttctg cttagtcttt agtgcttagt gaggtgtggc gctggccatt
     2701 tatttccctc tgttctgtac agccatgtgt ggacagtgct gctccagtcc atgtgggctt
     2761 tggtgagttg agataaaggt ggtgaaaacc ttgacatttc ctactctttg gatatagatt
     2821 ttagagcaac cggcttcggt agaattcaga gcttcggtca ctttaacaaa ccacaactct
     2881 gatttctttt gttttccacc ctaaagcaaa gtagacattt atacttcgtg actgcataaa
     2941 atacagttca tacttaattt aatccaacaa ttttgggctg ggttgaaaag tggttattat
     3001 ctaaattcca aatacaattt aatctagact cctaatattt tccttagata tgaaggaagt
     3061 ttcttttaaa aaattatgac taatcagaat tgtattgctt ctaattataa tcaacagata
     3121 cgagcagcta ctagtgctca aaagaatttc ttgtttctta gatgaaattt atatttggct
     3181 atattaaggt taatatcact aaaacagaaa accagcattt ttcctttttg tttttatatg
     3241 gcctcatcaa gtttttgtga gcttctatac tgatcatgaa taataaaata caaataaaaa
     3301 agccttagga aaaaatacaa aaaaaaaaaa aaa
//
