LOCUS       NM_022851               5435 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 5 family, member A1
            (Aldh5a1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_022851 XM_001062926 XM_214478
VERSION     NM_022851.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5435)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   2  (bases 1 to 5435)
  AUTHORS   Swenby,N.P. and Picklo,M.J. Sr.
  TITLE     The conserved R166 residue of ALDH5A (succinic semialdehyde
            dehydrogenase) has multiple functional roles
  JOURNAL   Chem Biol Interact 178 (1-3), 70-74 (2009)
   PUBMED   18926807
  REMARK    GeneRIF: data using R166K and R166H mutants demonstrate that
            inhibition of enzyme activity by low pH is regulated in part by the
            R166 residue. Our data indicate that the R166 residue of ALDH5A
            regulates multiple enzymatic functions
REFERENCE   3  (bases 1 to 5435)
  AUTHORS   Chowdhury,G.M., Gupta,M., Gibson,K.M., Patel,A.B. and Behar,K.L.
  TITLE     Altered cerebral glucose and acetate metabolism in succinic
            semialdehyde dehydrogenase-deficient mice: evidence for glial
            dysfunction and reduced glutamate/glutamine cycling
  JOURNAL   J Neurochem 103 (5), 2077-2091 (2007)
   PUBMED   17854388
REFERENCE   4  (bases 1 to 5435)
  AUTHORS   Barcelo-Coblijn,G., Murphy,E.J., Mills,K., Winchester,B.,
            Jakobs,C., Snead,O.C. 3rd and Gibson,K.M.
  TITLE     Lipid abnormalities in succinate semialdehyde dehydrogenase
            (Aldh5a1-/-) deficient mouse brain provide additional evidence for
            myelin alterations
  JOURNAL   Biochim Biophys Acta 1772 (5), 556-562 (2007)
   PUBMED   17300923
REFERENCE   5  (bases 1 to 5435)
  AUTHORS   Sauer,S.W., Kolker,S., Hoffmann,G.F., Ten Brink,H.J., Jakobs,C.,
            Gibson,K.M. and Okun,J.G.
  TITLE     Enzymatic and metabolic evidence for a region specific
            mitochondrial dysfunction in brains of murine succinic semialdehyde
            dehydrogenase deficiency (Aldh5a1-/- mice)
  JOURNAL   Neurochem Int 50 (4), 653-659 (2007)
   PUBMED   17303287
REFERENCE   6  (bases 1 to 5435)
  AUTHORS   Gupta,M., Greven,R., Jansen,E.E., Jakobs,C., Hogema,B.M.,
            Froestl,W., Snead,O.C., Bartels,H., Grompe,M. and Gibson,K.M.
  TITLE     Therapeutic intervention in mice deficient for succinate
            semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria)
  JOURNAL   J Pharmacol Exp Ther 302 (1), 180-187 (2002)
   PUBMED   12065715
REFERENCE   7  (bases 1 to 5435)
  AUTHORS   Hogema,B.M., Gupta,M., Senephansiri,H., Burlingame,T.G., Taylor,M.,
            Jakobs,C., Schutgens,R.B., Froestl,W., Snead,O.C.,
            Diaz-Arrastia,R., Bottiglieri,T., Grompe,M. and Gibson,K.M.
  TITLE     Pharmacologic rescue of lethal seizures in mice deficient in
            succinate semialdehyde dehydrogenase
  JOURNAL   Nat Genet 29 (2), 212-216 (2001)
   PUBMED   11544478
REFERENCE   8  (bases 1 to 5435)
  AUTHORS   Chambliss,K.L., Hinson,D.D., Trettel,F., Malaspina,P.,
            Novelletto,A., Jakobs,C. and Gibson,K.M.
  TITLE     Two exon-skipping mutations as the molecular basis of succinic
            semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria)
  JOURNAL   Am J Hum Genet 63 (2), 399-408 (1998)
   PUBMED   9683595
REFERENCE   9  (bases 1 to 5435)
  AUTHORS   Chambliss,K.L., Caudle,D.L., Hinson,D.D., Moomaw,C.R.,
            Slaughter,C.A., Jakobs,C. and Gibson,K.M.
  TITLE     Molecular cloning of the mature NAD(+)-dependent succinic
            semialdehyde dehydrogenase from rat and human. cDNA isolation,
            evolutionary homology, and tissue expression
  JOURNAL   J Biol Chem 270 (1), 461-467 (1995)
   PUBMED   7814412
REFERENCE   10 (bases 1 to 5435)
  AUTHORS   Rivett,A.J. and Tipton,K.F.
  TITLE     Kinetic studies with rat-brain succinic-semialdehyde dehydrogenase
  JOURNAL   Eur J Biochem 117 (1), 187-193 (1981)
   PUBMED   7262085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM032642.1 and JAXUCZ010000017.1.
            
            On or before Feb 14, 2013 this sequence version replaced
            XM_214478.6, XM_001062926.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1623373.1,
                                           SRR26643296.36669.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               FM032642.1         1-600
            601-706             JAXUCZ010000017.1  40571164-40571269
            707-850             JAXUCZ010000017.1  40575322-40575465
            851-994             JAXUCZ010000017.1  40576470-40576613
            995-1153            JAXUCZ010000017.1  40578986-40579144
            1154-1323           JAXUCZ010000017.1  40580383-40580552
            1324-1382           JAXUCZ010000017.1  40581793-40581851
            1383-5435           JAXUCZ010000017.1  40582659-40586711
FEATURES             Location/Qualifiers
     source          1..5435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p11"
     gene            1..5435
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /note="aldehyde dehydrogenase 5 family, member A1"
                     /db_xref="GeneID:291133"
                     /db_xref="RGD:621422"
     exon            1..334
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1588
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /EC_number="1.2.1.24"
                     /note="succinate-semialdehyde dehydrogenase,
                     mitochondrial; succinic semialdehyde dehydrogenase;
                     aldehyde dehydrogenase family 5, subfamily A1;
                     NAD(+)-dependent succinic semialdehyde dehydrogenase;
                     aldehyde dehydrogenase 5 family, member A1
                     (succinate-semialdehyde dehydrogenase)"
                     /codon_start=1
                     /product="succinate-semialdehyde dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_074042.1"
                     /db_xref="GeneID:291133"
                     /db_xref="RGD:621422"
                     /translation="MATCFLLRNFCAARPALRPPGRLLREPAGAQRRSYVGGPADLHA
                     DLLRGDSFVGGRWLPTPATFPVYDPASGAKLGTVADCGVPEARAAVRAAYDAFSSWKE
                     ISVKERSSLLRKWYDLMIQNKDELAKIITAESGKPLKEAQGEILYSAFFLEWFSEEAR
                     RVYGDIIYTSAKDKRGLVLKQPVGVASIITPWNFPSAMITRKVGAALAAGCTVVVKPA
                     EDTPYSALALAQLANQAGIPPGVYNVIPCSRTKAKEVGEVLCTDPLVSKISFTGSTAT
                     GKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNAGQTCVCSNRF
                     LVQRGIHDSFVTKFAEAMKKSLRVGNGFEEGTTQGPLINEKAVEKVEKHVNDAVAKGA
                     TVVTGGKRHQSGGNFFEPTLLSNVTRDMLCITEETFGPLAPVIKFDKEEEAVAIANAA
                     DVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYG
                     IDEYLEVKYVCYGGL"
     exon            335..418
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /inference="alignment:Splign:2.1.0"
     exon            419..589
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /inference="alignment:Splign:2.1.0"
     exon            590..706
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /inference="alignment:Splign:2.1.0"
     exon            707..850
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /inference="alignment:Splign:2.1.0"
     exon            851..994
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1153
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1323
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1382
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..5435
                     /gene="Aldh5a1"
                     /gene_synonym="Ssadh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgctgctgc cgggccatgg cgacctgctt tctgctgcgg aacttctgcg ccgcgcgtcc
       61 cgcgctgcgg cctccgggcc gactcctccg ggagcccgca ggggcccagc ggcgcagcta
      121 cgtcggcggc ccggctgacc tccacgccga cctgctccgc ggggacagct ttgtgggcgg
      181 ccgctggctt ccaacccctg ccaccttccc tgtgtatgac ccggccagcg gcgccaagct
      241 gggcaccgtg gccgactgcg gggtaccgga ggcccgcgct gctgtgcgcg ccgcctacga
      301 tgccttcagc agctggaaag agatctcggt caaggagagg agctcattgc tccgtaaatg
      361 gtacgactta atgatacaaa acaaggacga gcttgccaag atcataacag ctgagagtgg
      421 aaagccactg aaagaggccc agggagagat cctgtattca gcgtttttcc tggagtggtt
      481 ctcagaggaa gctcgccgtg tttatggaga catcatctat acctctgcca aagataagcg
      541 aggactggtc ctcaagcagc ccgttggtgt ggcgtccatc atcacaccgt ggaattttcc
      601 cagtgccatg atcacccgga aagtgggggc tgccctggca gctggctgca ctgtggtggt
      661 aaaacctgct gaagatacac cctattctgc cctggccctg gctcagcttg caaaccaggc
      721 aggaatccct ccaggtgtct ataatgtcat tccctgctct agaaccaagg ccaaggaagt
      781 gggagaggtg ctgtgtactg atcccctcgt gtccaaaatc tcctttactg gctcaacggc
      841 aacgggaaag atcctgctgc atcatgcagc aaattctgtg aagcgtgtct ccatggagct
      901 gggtggcctc gccccattca ttgtctttga cagtgccaac gtggaccagg ctgtcgcagg
      961 agcaatggca tctaaattta ggaatgctgg gcagacttgc gtttgctcaa acagattctt
     1021 ggtacaacgg ggtatccacg attcctttgt aacgaagttt gcagaagcga tgaagaaaag
     1081 cctgcgtgta ggtaacggat ttgaggaagg aacaactcaa gggccattaa ttaatgagaa
     1141 agctgtagaa aaggtagaga agcatgtgaa tgacgcagtt gccaaagggg ccacggttgt
     1201 gacaggcggg aagcgacacc agagcggagg gaatttcttc gaacccaccc tgctcagcaa
     1261 cgtcaccagg gacatgctct gcatcaccga ggagaccttt gggccgctgg cgccagtcat
     1321 caagttcgat aaagaggaag aggctgtcgc catcgcaaat gcagctgatg ttggattggc
     1381 aggttacttt tactctcaag acccagccca gatctggaga gtggcggagc agctggaggt
     1441 gggcatggtt ggcgtgaacg aaggactgat ctcttcagtg gagtgccctt ttggtggggt
     1501 gaaacagtcc ggccttgggc gagaagggtc caagtatggc attgacgaat atctagaggt
     1561 caaatatgtg tgttatggag gcttgtaggg ttctcacttc tttaataaat tacctagatc
     1621 catagggaca ttccatccat ttttttacaa tgaacaagta ggttatcaga gttatgaatt
     1681 tttaaaaatt cagccggtcc tgtcttagat gtacacccta acccttccct tatctaacta
     1741 gggaccaatg gacaccatat acctgtggct gtgggtccca gccagtgctg agaccccagc
     1801 acaaccccac tgcctccaga caaagtacag tgtgagtgtt cacatgccct ctggcacctc
     1861 acgaagtgta gtcactgtgt gggcagtggg tccgcccagg cctgtcagct ttgaggaaca
     1921 gctggctgcc tgtccggggg ttggggtggg gatggaggtg ggggcgttgg ttggcaaagg
     1981 ctttggtttc ctaagacttc tttctaaacc tcacagattg cctgcactat atggaatgaa
     2041 ggggtgtttc tccttgtttc tgggctgctg tttattactg ggagcagggt tattttgggt
     2101 tttttgtttt gtttttgctt tctttggttc atcctggttt ggtttgactt tatccgacag
     2161 ggtcttgcta agtagcctac ctggcttcag actcacaggt ctcctgtttc agcctccgaa
     2221 gggttagggt cacaggcatg ctctcctaca gctgggtaaa ggaagtctct attgccctaa
     2281 acttacagct catgtttaat tttgttcctc ttagaaaatc aacccaaact gggggcaaaa
     2341 atcagcagag tcgggttggt aggacagaca acatggcttt tgtgtctttt ccagtgcttg
     2401 gtgttggatc catggccttg tcataccagc atgtgttcta ccaccgaact atccctagct
     2461 ttttttcttt ctttcctttt aatttttgag acagagtctt gataagttgc actggctggc
     2521 cttgagctgc ttggtctcag tagcctacgt agctggggag acaggcctgc attgctggcc
     2581 aggccagtgg agagtctcaa ctgccgcctg ctgtcttggg catgctcttt agggcaccat
     2641 ggtcccactt acagagattc atgcttggct taaaggacag tgtgggcctg gaagaaaaaa
     2701 ttgctttaca aaatggtgga aatgcagctc aagtacagga accattttcg atgaccaccc
     2761 tgcccctcct tgagctcagg aggtgacttc gtggaggaaa gaaaccaggc acctagttgc
     2821 tcacctgcct aagtctgacc caggttttct gtatctgggt gtggctgctg ctaaacttgc
     2881 agaagagcaa atacacttta ctgctatgaa aaaagttatt cccaccatgg ccagtctgct
     2941 gtggaagaga gctgaagcca tgaatctcag gcacctttgc cctaagtaaa gcgtttatgg
     3001 ttcatgattc aaaaacaaag caccacacag ggacctgcaa gataacttgg gtaaggcttt
     3061 gctggacaag cctggtgacc tgagacctga gttctatccc tggaacctac agaaagacag
     3121 agaaccaaca tgacagtgtt gacctctgac ctccacaaat gcatcagagc attcaccaca
     3181 cacacacaca ccccaaaatt ccctgcaact ggtgttggtc ttgctttgaa acagtttaag
     3241 tgagggagag cctatgttct tgtaggcatg cctcccatct acctagaagc tatttattcc
     3301 caacaggcaa cgatgaagct ccctgctccc tccccctctc tgtgcagaga gcccactggc
     3361 acactctgtg gatgctctgt aacacatcaa cgggaatgac agtagcacta gctgcagtgg
     3421 ttcctaaaca ctaagcccca tgccactggg aatgttgaat gaggaagtca tgattcttaa
     3481 aatctctgtg cacaagaaga aagtagaaat ctgcctccta gggaccccgc ccaaatggca
     3541 agggtcacaa ctcaggatgc tcatagtctg tttatgccat tcttttgtat agtgtgtata
     3601 gtcggtttct attacatttt ctaatttaaa ttttaatttt tttatggacg tgggtgtttt
     3661 gcctacatgt atatctgtgc accacatgta tgctggtgcc ctcaagaggc cagaaagggg
     3721 catcagaaca cctagaaata gagttacaga tgattgtaag ccgccttgtg ggttctggga
     3781 atcgacccct ggccctctga aaataagcat ttttctgaaa ataagcattt ttctgaaaat
     3841 aagcattttt ctgaaaatga gccttcttga cagcccgaca tttctaattt cttaataatt
     3901 gtgccatctt ttttttttaa ttaaaaatac aaaatgttct gctggttatt ttgtagaaaa
     3961 tgaatacacc cactgagatg tgaattcctt tcaaatatac tttaaactgt gtcaaccagt
     4021 gggttcccgg actgtgtggc aagtttgtac tttttgtgtg tgcatgtttg attcactggg
     4081 tagatcgccg gcccatacat ttgttacaat aagtgtaatc aatttctgta attaaaacaa
     4141 ggtggggggc tattggtggt gaagtatata cttagcacac tggagaccat ggaattaatc
     4201 atcaccaaag agtgaacatt gggattttat attgttttta aacacgatct cctgttggcc
     4261 ttaaattctg ggctcaaatg atccttagtt cgccaaatat ctataactat aggcatgttg
     4321 tcaccaagtc aactaagtag atttattatt tttaggggtt tttgagtctg ggtctcatgt
     4381 agttggggct caccttggaa ctctcctgcc cctacttcct gtactggaac taccacacct
     4441 aactaaggag tgtttgctgg tgaatctctg ttgctgttcc ttaagatatg tgacagatgg
     4501 gagttttgaa gctgtctata caggcatgca aggacaaggg ctaatgaccc acaacctgtg
     4561 agtcagatct gacctgccac ctgattttgt ctaacttggg actttagttt gttttttttt
     4621 taatctattc aaatggattg gggtgggtga caactgttat ttcatgaaac ctgtggatga
     4681 ccacagccac agtgccctgt gcctgagtgg ctgtggtgtg acagtatggc ctgcagagcc
     4741 taaaggatta actgcaaagc tgctaaaaaa aaggtttaca gcccctcacc tagatcaagc
     4801 cggagacact ggccttctcc cggcccccac cccaccccac ccccgtgttt atgagtcatc
     4861 attttatcct attaaacacc ctctgtgaaa actgcacatt ttctgggcat tggttagcag
     4921 gacttcttgg cagtaattat caactcaaat gacataagcc tgatagtcat gtctcccagg
     4981 tagtggggct cactgaagta ccagagttcg tctgtttttc catctgaggg accttgaagc
     5041 agggcctcgt agcaagtgat tcttctttct ctatctttgt tcttcaggac tgggggggag
     5101 gggtgtagga gaataaagat cagacgcaca atgtaagcaa gcctattctg tgatgtaaca
     5161 accttcaaat ggggtcccat gggttgtcct ctctgaaggc cagatcccag tgtttattac
     5221 ccctgtgcac ctattttaac acacaacttt acttgaatac ttaatactgt gactgttcta
     5281 tgccatactt tgtgagacaa atttcatgag ttgttgagaa atatattttg ctctatcaac
     5341 atgtattgct tcgtttttct agtgtttgac attgtgtgat caacagagtt gaatctcaat
     5401 aaatgtttaa caggatttct tattcctgtg tgaaa
//
