LOCUS       NM_001134698            3171 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 4 family, member A1
            (Aldh4a1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001134698
VERSION     NM_001134698.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3171)
  AUTHORS   Pemberton,T.A. and Tanner,J.J.
  TITLE     Structural basis of substrate selectivity of
            Delta(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1):
            semialdehyde chain length
  JOURNAL   Arch Biochem Biophys 538 (1), 34-40 (2013)
   PUBMED   23928095
REFERENCE   2  (bases 1 to 3171)
  AUTHORS   Srivastava,D., Singh,R.K., Moxley,M.A., Henzl,M.T., Becker,D.F. and
            Tanner,J.J.
  TITLE     The three-dimensional structural basis of type II hyperprolinemia
  JOURNAL   J Mol Biol 420 (3), 176-189 (2012)
   PUBMED   22516612
REFERENCE   3  (bases 1 to 3171)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 3171)
  AUTHORS   Hu,C.A., Lin,W.W. and Valle,D.
  TITLE     Cloning, characterization, and expression of cDNAs encoding human
            delta 1-pyrroline-5-carboxylate dehydrogenase
  JOURNAL   J Biol Chem 271 (16), 9795-9800 (1996)
   PUBMED   8621661
REFERENCE   5  (bases 1 to 3171)
  AUTHORS   Hopkinson,D.A., Santisteban,I., Povey,S. and Smith,M.
  TITLE     Biochemical genetic analysis of human and rodent aldehyde
            dehydrogenase (ALDH)
  JOURNAL   Alcohol 2 (1), 73-78 (1985)
   PUBMED   4015840
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168153.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3171
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3171
                     /gene="Aldh4a1"
                     /note="aldehyde dehydrogenase 4 family, member A1"
                     /db_xref="GeneID:641316"
                     /db_xref="RGD:1624206"
     exon            1..89
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1719
                     /gene="Aldh4a1"
                     /EC_number="1.2.1.88"
                     /note="P5C dehydrogenase; aldehyde dehydrogenase family 4
                     member A1; L-glutamate gamma-semialdehyde dehydrogenase"
                     /codon_start=1
                     /product="delta-1-pyrroline-5-carboxylate dehydrogenase,
                     mitochondrial"
                     /protein_id="NP_001128170.1"
                     /db_xref="GeneID:641316"
                     /db_xref="RGD:1624206"
                     /translation="MLPPALLRRSLLSYAWRGSGLRWKHASSLKVANEPILAFTQGSP
                     ERDALQKALNDLKDQTEAIPCVVGDEEVWTSDVRYQLSPFNHGHKVAKFCYADKALLN
                     KAIEAAVLARKEWDLKPVADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEID
                     AAAELIDFFRFNAKFAVELEGEQPISVPPSTNHVVYRGLEGFVAAISPFNFTAIGGNL
                     AGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNVIQFVPADGPTFGDTVTSSE
                     HLCGINFTGSVPTFKHLWKQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSG
                     TLRSAFEYGGQKCSACSRLYVPQSLWPQIKGRLLEEHSRIKVGNPAEDFGTFFSAVID
                     AKAFARIKKWLEHARSSPSLSILAGGQCNESVGYFVEPCIIESKDPQEPIMKEEIFGP
                     VLTVYVYPDEKYRETLQLVDSTTSYGLTGAVFAQDKTIVQEATRMLRNAAGNFYINDK
                     STGSVVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYMQ"
     exon            90..183
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..276
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..324
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..480
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..630
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..705
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..893
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..967
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1164
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1212
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1365
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1487
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1606
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..3138
                     /gene="Aldh4a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaccgctca agactcttag aacctctgtg atgctgccgc cggctttgct tcgccgatcc
       61 ctgctgtcct acgcctggag gggctctggg ctgcggtgga aacatgcctc ctctctgaag
      121 gtggccaatg agcccatctt agcgtttact cagggcagcc ccgaacggga cgcactgcag
      181 aaggctctga acgacctgaa ggaccagaca gaagccatcc cctgcgttgt tggggacgag
      241 gaggtgtgga cctctgatgt gcggtaccag ctgtcgcctt ttaaccatgg acacaaggtg
      301 gccaagttct gttatgccga caaggccttg ctcaacaaag ccatcgaagc tgccgtgctt
      361 gccaggaaag agtgggacct gaagcccgtg gcagaccggg cccagatctt cctgaaggcg
      421 gcagatatgc tgagcgggcc ccgaagggct gaaatccttg ccaagaccat ggtgggacag
      481 ggcaagaccg taatccaagc agagattgac gccgcagccg aactcatcga cttcttcagg
      541 ttcaatgcca agttcgccgt ggaactggag ggggaacaac ccatcagcgt gccacccagt
      601 accaaccacg tggtgtaccg gggactggag ggcttcgtgg cggccatctc tcccttcaac
      661 ttcaccgcga tcggaggcaa cctggcaggc gcaccggcct taatgggcaa cgtggttctc
      721 tggaagccca gtgacactgc catgttggct agctatgctg tctaccgcat cctccgggag
      781 gccggcttgc cccccaacgt aatccagttt gtgccagctg atgggccgac attcggggac
      841 acagtcacca gctcagagca cctctgtggt atcaacttca caggcagtgt gcccaccttt
      901 aaacacctgt ggaagcaggt ggcccagaat ctggaccggt tccgtacctt cccacgcctg
      961 gctggagagt gtggcgggaa gaatttccat ttcgtgcaca gctcggccga cgtggacagc
     1021 gtggtgagcg ggacgctgcg ctcggccttc gagtatggcg gtcagaagtg ctcagcctgc
     1081 tcgcgcctct acgtgccaca gtctctgtgg ccacagatca aagggcgact gctggaggag
     1141 cacagcagga tcaaagtggg caaccctgca gaggactttg ggaccttctt ctctgcagtg
     1201 attgatgcca aggccttcgc ccgcataaag aagtggctgg agcatgcgcg ttcctcgccc
     1261 agcctcagca tcctggcagg cggccagtgt aacgagtcgg tgggttactt cgtggagccg
     1321 tgtatcattg agagcaagga cccacaggag cccatcatga aggaggagat cttcggccct
     1381 gtgctgacag tgtatgtgta cccggatgag aaatacagag agacgctgca actggtcgac
     1441 agcaccacca gctatggcct cacgggggca gtgtttgccc aggataaaac aattgtccaa
     1501 gaagccacga ggatgctgag gaacgctgct ggcaacttct acatcaacga caagtctact
     1561 ggatctgtgg tgggccagca gccctttggg ggcgcccggg cctcaggaac caatgacaaa
     1621 ccaggaggcc cccactacat cttacgctgg acctcacccc aggtcatcaa ggagactcat
     1681 aagcccctgg gggactggcg atactcctac atgcagtaac ccggcccagc acctctgttg
     1741 tcaaaccatc tgtccatcca aatgacagac atctctgcac tgacccccct gctccccaac
     1801 cagctcctcc tggactctct acagctgagc tggaccctgc cctggccact gggtaccttt
     1861 ccttggaatc aggtgcccag tcattggctt tggtcatatt ggagaggatg agccaatcta
     1921 cccagaaatc tcatctgctg gggaacaccc tggtacctgg caggttcttc ccctgactgc
     1981 ttttcttgcc tcatcctgga ccgggtgact cagaggcccc gagaacagag agggatattt
     2041 tcaggatctt gtcagggaag gagacaacgc tggtgtcctg tagcctcacc actcaaagac
     2101 tcctgacctt agccttgtcc cctacacatg tccactgaga taagacctta gccagatgtc
     2161 tgtccgggca ccagctggct ttgcccttgg tctgtgctag ctcctcctgc aggtacttgt
     2221 gtccagccat atgccttaga cccatgtgcc ttcctccagg gtgcctgtgc atccctgaga
     2281 cttcatccct cctggccacc ttctgggagt gaccagtcat ggtcacccca tacagtctga
     2341 atctgggaag cctcgagatg ggcctccatt ccatactctt gtgcgatgca gccagcccag
     2401 aggtagccag ggtgagctcc tgcttgggtc cctgataatc aaatgtttcc agtggcttga
     2461 gagcatgtgg ggtttccttt caaggacatt tgccaggggt ccgcatggag ctggtatagc
     2521 tgtcaccaag ggctaccctc atcactctca ggggcaggca ccagtaccag gccggctctg
     2581 tcctgcttcc tttcagggtc catgttgctt cccagggagc agggctagac tgcaaatgtc
     2641 ccgattctgc tggttctata ctgtgaggcg catttactgc cacctgagaa aatgccagat
     2701 acctactcaa agtggccacg gagggaggtg aggggcgcac tggattctca ttcctaatct
     2761 aacgaactgc cagcgacttg tcgcatggtt ctgtgtgatg ccactggagg gagtagtgac
     2821 tccggtgccc agtggttggg tttaaatggc tttttgtctc ccccaccccc caaggtggtc
     2881 acccaaaaaa accatgtaaa ttctctaacc tttcatgtct aaaatggtga cgattccctc
     2941 atgtacccgg aggatcattg agctaatccc tgtggatttc agataaacga ttggaaatgt
     3001 cacctgtttg tttctcaacc ctgtgtgctg atcttatgtg tcagctttgc tgggccacag
     3061 tacccagaga cctggtcaac cattgtggaa ggtgccttga atgagagtaa agtttaaata
     3121 aatgagctct taaattttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
