LOCUS       NM_031731               2977 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 3 family, member A2
            (Aldh3a2), mRNA.
ACCESSION   NM_031731 XM_346390
VERSION     NM_031731.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2977)
  AUTHORS   Kitamura,T., Takagi,S., Naganuma,T. and Kihara,A.
  TITLE     Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets
            via two C-terminal tryptophan residues and lipid modification
  JOURNAL   Biochem J 465 (1), 79-87 (2015)
   PUBMED   25286108
REFERENCE   2  (bases 1 to 2977)
  AUTHORS   Keller,M.A., Zander,U., Fuchs,J.E., Kreutz,C., Watschinger,K.,
            Mueller,T., Golderer,G., Liedl,K.R., Ralser,M., Krautler,B.,
            Werner,E.R. and Marquez,J.A.
  TITLE     A gatekeeper helix determines the substrate specificity of
            Sjogren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase
  JOURNAL   Nat Commun 5, 4439 (2014)
   PUBMED   25047030
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2977)
  AUTHORS   Lloyd,M.D., Boardman,K.D., Smith,A., van den Brink,D.M.,
            Wanders,R.J. and Threadgill,M.D.
  TITLE     Characterisation of recombinant human fatty aldehyde dehydrogenase:
            implications for Sjogren-Larsson syndrome
  JOURNAL   J Enzyme Inhib Med Chem 22 (5), 584-590 (2007)
   PUBMED   18035827
REFERENCE   4  (bases 1 to 2977)
  AUTHORS   Ashibe,B., Hirai,T., Higashi,K., Sekimizu,K. and Motojima,K.
  TITLE     Dual subcellular localization in the endoplasmic reticulum and
            peroxisomes and a vital role in protecting against oxidative stress
            of fatty aldehyde dehydrogenase are achieved by alternative
            splicing
  JOURNAL   J Biol Chem 282 (28), 20763-20773 (2007)
   PUBMED   17510064
REFERENCE   5  (bases 1 to 2977)
  AUTHORS   van den Brink,D.M., van Miert,J.N., Dacremont,G., Rontani,J.F.,
            Jansen,G.A. and Wanders,R.J.
  TITLE     Identification of fatty aldehyde dehydrogenase in the breakdown of
            phytol to phytanic acid
  JOURNAL   Mol Genet Metab 82 (1), 33-37 (2004)
   PUBMED   15110319
REFERENCE   6  (bases 1 to 2977)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 2977)
  AUTHORS   Kelson,T.L., Secor McVoy,J.R. and Rizzo,W.B.
  TITLE     Human liver fatty aldehyde dehydrogenase: microsomal localization,
            purification, and biochemical characterization
  JOURNAL   Biochim Biophys Acta 1335 (1-2), 99-110 (1997)
   PUBMED   9133646
REFERENCE   8  (bases 1 to 2977)
  AUTHORS   De Laurenzi,V., Rogers,G.R., Hamrock,D.J., Marekov,L.N.,
            Steinert,P.M., Compton,J.G., Markova,N. and Rizzo,W.B.
  TITLE     Sjogren-Larsson syndrome is caused by mutations in the fatty
            aldehyde dehydrogenase gene
  JOURNAL   Nat Genet 12 (1), 52-57 (1996)
   PUBMED   8528251
REFERENCE   9  (bases 1 to 2977)
  AUTHORS   Iborra,F.J., Renau-Piqueras,J., Portoles,M., Boleda,M.D., Guerri,C.
            and Pares,X.
  TITLE     Immunocytochemical and biochemical demonstration of formaldhyde
            dehydrogenase (class III alcohol dehydrogenase) in the nucleus
  JOURNAL   J Histochem Cytochem 40 (12), 1865-1878 (1992)
   PUBMED   1453005
REFERENCE   10 (bases 1 to 2977)
  AUTHORS   Miyauchi,K., Masaki,R., Taketani,S., Yamamoto,A., Akayama,M. and
            Tashiro,Y.
  TITLE     Molecular cloning, sequencing, and expression of cDNA for rat liver
            microsomal aldehyde dehydrogenase
  JOURNAL   J Biol Chem 266 (29), 19536-19542 (1991)
   PUBMED   1717467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M73714.1, CB727458.1, DW311997.1, EV780143.1 and CV109765.1.
            
            On Jan 26, 2008 this sequence version replaced NM_031731.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210485.1, M73714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-873               M73714.1           7-879
            874-875             CB727458.1         337-338
            876-1842            M73714.1           882-1848
            1843-1922           DW311997.1         230-309
            1923-1937           M73714.1           1927-1941
            1938-1938           DW311997.1         325-325
            1939-2196           M73714.1           1943-2200
            2197-2268           EV780143.1         561-632
            2269-2977           CV109765.1         31-739              c
FEATURES             Location/Qualifiers
     source          1..2977
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2977
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /note="aldehyde dehydrogenase 3 family, member A2"
                     /db_xref="GeneID:65183"
                     /db_xref="RGD:61866"
     exon            1..270
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1572
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /EC_number="1.2.1.3"
                     /EC_number="1.2.1.94"
                     /note="alcohol dehydrogenase family 3, subfamily A2;
                     aldehyde dehydrogenase 3A2; msALDH; aldehyde dehydrogenase
                     4; microsomal aldehyde dehydrogenase; fatty aldehyde
                     dehydrogenase; aldehyde dehydrogenase family 3, subfamily
                     A2"
                     /codon_start=1
                     /product="aldehyde dehydrogenase family 3 member A2"
                     /protein_id="NP_113919.2"
                     /db_xref="GeneID:65183"
                     /db_xref="RGD:61866"
                     /translation="MERQVQRLRQTFRSGRSRPLRFRLQQLEALRRMVQEREKDILAA
                     IAADLSKSELNAYSHEVITILGEIDFMLGNLPELASARPAKKNLLTMMDEAYVQPEPL
                     GVVLIIGAWNYPFVLTLQPLVGAIAAGNAAIVKPSELSENTAKILAELLPQYLDQDLY
                     MIVNGGVEETTELLRQRFDHILYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDR
                     DCDLDVACRRITWGKYMNCGQTCIAPDYILCEASLQDQIVQKIKDTVKDFYGENVKAS
                     PDYERIINLRHFKRIKSLLEGQKIAFGGETDEATRYIAPTILTDVDPNSKVMQEEIFG
                     PILPIVSVKNVEEAINFINDREKPLALYIFSHNNKLIKRVIDETSSGGVTGNDVIMHF
                     TVNSLPFGGVGASGMGAYHGKYSFDTFSHQRPCLLKGLKGESVNKLRYPPNSESKVSW
                     SKFFLLKQFNKGRLQLLLLVCLVAVAAVIVKDQL"
     exon            271..502
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            503..588
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            589..797
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            798..915
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1057
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1224
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1324
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1560
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..2977
                     /gene="Aldh3a2"
                     /gene_synonym="Aldh4; FALDH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggatgga agccagctgt cccgagaagc agtgaactgt ggcgtcatcc cgagcagtgc
       61 cttaccggta ttgtgctgct tcacctgcct cgctcggcgt tctcctcagg ccccgccatg
      121 gagcgacagg tccaacgact tcgccagacg ttccggtccg gccgatcgcg gccgctgcgt
      181 ttccgactgc agcagctcga ggccctccgg aggatggtgc aagagcgaga gaaggacatc
      241 ttggcagcca tcgcagcaga cctgagcaaa agtgaactca atgcatacag tcatgaagtc
      301 attaccatcc ttggggagat tgacttcatg ctggggaatc ttcctgaatt ggcctctgct
      361 cggccagcga agaagaacct gcttaccatg atggacgagg cctatgttca gccagagcct
      421 ctgggagtcg tgctgattat tggagcttgg aactatcctt ttgttctgac cctgcagcca
      481 ctggtgggag ccattgctgc aggaaatgct gccattgtta agccctcgga actcagtgaa
      541 aacacggcta agatcttggc tgaactcctc cctcagtatt tagaccagga cctgtacatg
      601 attgttaatg gcggcgttga agaaaccaca gagcttctga ggcagcggtt tgatcacatt
      661 ctctacacag gaaacaccgc agttggaaaa attgtcatgg aggctgctgc caagcacctg
      721 acccctgtga ccctggagct cgggggcaaa agcccatgct acattgacag agactgtgac
      781 ctggacgttg cttgcagacg gataacctgg ggaaagtaca tgaattgtgg tcagacctgt
      841 attgctcctg actatatcct gtgtgaagcc tccctccagg atcaaatcgt acagaagatt
      901 aaggatacgg tgaaggactt ttatggggaa aatgtaaaag cttctcctga ttatgaaagg
      961 atcatcaacc ttcgtcactt taagaggata aaaagtttgc ttgaaggaca gaaaatagct
     1021 tttggtgggg agactgatga agctacacgc tacatagccc caaccatact cactgatgtt
     1081 gaccctaact ccaaggtgat gcaagaagaa atttttggac caattctccc aatagtgtct
     1141 gtgaaaaatg tggaggaagc cataaatttc ataaatgatc gcgaaaagcc cctggcactc
     1201 tacatatttt ctcacaacaa taagctcatc aaacgggtga ttgatgagac atccagtggt
     1261 ggagtcacag gcaatgatgt catcatgcac ttcactgtta attctttgcc ctttggaggt
     1321 gtgggtgcca gtggaatggg ggcttatcat ggcaaataca gtttcgatac cttttctcat
     1381 cagcgcccct gcttgttaaa agggttaaag ggagagagtg ttaacaaact caggtaccct
     1441 cccaacagcg agtccaaggt cagctggtcg aaattcttcc tgctgaaaca gttcaacaaa
     1501 ggaaggctgc agctgctgct tctcgtgtgc ttggttgcgg ttgcagctgt gatcgtcaag
     1561 gatcagctgt gatgacttcc ttgtagcctc tactgaagta cccctcggcc aaatggttaa
     1621 cacaccaatg cttttaaaat tgtacccaaa ccaggaaatg aaattcacag gtgaactgca
     1681 gtcaaaccta agttgttgcc acaaaccact gatgaaactc agtgcttcag ccaaatccca
     1741 gcatttgtca gccgtgcagg tgctgagagg gtggagactg ggaggggcga cacctagtcc
     1801 atggcagcgg gatgtcaggg agactcgaca actgctcccg cagctctttg ctccaggaca
     1861 tagctctgcc cacccggtgt caacaccctc caggctttcc agctgtcctc tgattgctga
     1921 ggttcctgtt agggaccgag gtactaaacc tgggcgggtg gatttgtcgg cctcatccat
     1981 tgtggctcga gaccggcctt cgggagtcgg ctctcagtct aaacatcctt tctcattcat
     2041 agtgtgtcac ccgaagatgc ttgtttgtga cattgtgaca gtctgtcatg actgtcccgg
     2101 tgcctttgtg atgacttaaa ctacactgag gagcttgcca acttgtgaat gcccttcaga
     2161 gggtctggca gtcacagctg ttccagagcc cgagggcaga agattccgga gcccgggagt
     2221 ttgaggccaa cctaggcaac ataatgggac cctctcatta ttattcctcc ataacaatcc
     2281 cctcgagacc ctcgatttga atgttatata ggtcttcagg ataaatctgc ttattttcac
     2341 agcacaacac aaaaaaaatt tacttttgaa atcttagaga gattcctaca gatcttagca
     2401 tggagctgtt cctgtagtga aaggggggtt attagacatg aggcttcaga actcatgggg
     2461 cagggttgtt ggagactacc gtgagctgag ggggcacact gaagcgatgg gatggccaga
     2521 agcgcacctg agcaagcggg gcagcattct ctgtcagacc ctaacatggc tacacaggga
     2581 tgtggcagag agatctgtgt ggccctgctg ccagggcctg gttaggcctg aagctccaag
     2641 ctgcagaggt ctcattgcct tcccaggatc caaattaaga ctgcccactc aatgagaatg
     2701 tcacttgcgt atgtacaacc atgtttgctg agtaacctgt tccaccgttg aggctgtctg
     2761 aagtgtattg tatgaggtat caagaacgag tcattggccc atttggcaaa tagttgctta
     2821 tgtagcaatt gtcatggact aatcataaaa tattttgcac aaaatttcaa tgttgaactt
     2881 gcactcactg ttgttaaatt ataaatcaca gcttctagtt aggccaaaat atttacatac
     2941 tctactaatc ttcaaaataa atgtatccca tacctta
//
