LOCUS       NM_031972               1715 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 3 family, member A1
            (Aldh3a1), mRNA.
ACCESSION   NM_031972
VERSION     NM_031972.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1715)
  AUTHORS   Kitamura,T., Takagi,S., Naganuma,T. and Kihara,A.
  TITLE     Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets
            via two C-terminal tryptophan residues and lipid modification
  JOURNAL   Biochem J 465 (1), 79-87 (2015)
   PUBMED   25286108
REFERENCE   2  (bases 1 to 1715)
  AUTHORS   Hlavacova,M., Gumulec,J., Stracina,T., Fojtu,M., Raudenska,M.,
            Masarik,M., Novakova,M. and Paulova,H.
  TITLE     Different doxorubicin formulations affect plasma
            4-hydroxy-2-nonenal and gene expression of aldehyde dehydrogenase
            3A1 and thioredoxin reductase 2 in rat
  JOURNAL   Physiol Res 64 (Suppl 5), S653-S660 (2015)
   PUBMED   26674287
  REMARK    GeneRIF: Different doxorubicin formulations decreased liver
            expression of ALDH3A1.
REFERENCE   3  (bases 1 to 1715)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   4  (bases 1 to 1715)
  AUTHORS   Kondraganti,S.R., Jiang,W., Jaiswal,A.K. and Moorthy,B.
  TITLE     Persistent induction of hepatic and pulmonary phase II enzymes by
            3-methylcholanthrene in rats
  JOURNAL   Toxicol Sci 102 (2), 337-344 (2008)
   PUBMED   18203689
REFERENCE   5  (bases 1 to 1715)
  AUTHORS   George,A.K., Balarama Kaimal,S. and Paulose,C.S.
  TITLE     Decreased dopamine D(2) receptor function in cerebral cortex and
            brain stem: their role in hepatic ALDH regulation in ethanol
            treated rats
  JOURNAL   Mol Cell Biochem 304 (1-2), 181-188 (2007)
   PUBMED   17530188
  REMARK    GeneRIF: Decreased function of dopamine mediated through DA D(2)
            receptor in the cerebral cortex and brain stem enhanced the brain,
            plasma and liver ALDH activity in ethanol treated rats.
REFERENCE   6  (bases 1 to 1715)
  AUTHORS   Hsu,L.C., Chang,W.C., Shibuya,A. and Yoshida,A.
  TITLE     Human stomach aldehyde dehydrogenase cDNA and genomic cloning,
            primary structure, and expression in Escherichia coli
  JOURNAL   J Biol Chem 267 (5), 3030-3037 (1992)
   PUBMED   1737758
REFERENCE   7  (bases 1 to 1715)
  AUTHORS   Rose,J.P., Hempel,J., Kuo,I., Lindahl,R. and Wang,B.C.
  TITLE     Preliminary crystallographic analysis of class 3 rat liver aldehyde
            dehydrogenase
  JOURNAL   Proteins 8 (4), 305-308 (1990)
   PUBMED   2091023
REFERENCE   8  (bases 1 to 1715)
  AUTHORS   Hempel,J., Harper,K. and Lindahl,R.
  TITLE     Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular
            carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver:
            distant relationship to the class 1 and 2 enzymes from mammalian
            liver cytosol/mitochondria
  JOURNAL   Biochemistry 28 (3), 1160-1167 (1989)
   PUBMED   2713359
REFERENCE   9  (bases 1 to 1715)
  AUTHORS   Jones,D.E. Jr., Brennan,M.D., Hempel,J. and Lindahl,R.
  TITLE     Cloning and complete nucleotide sequence of a full-length cDNA
            encoding a catalytically functional tumor-associated aldehyde
            dehydrogenase
  JOURNAL   Proc Natl Acad Sci U S A 85 (6), 1782-1786 (1988)
   PUBMED   2831537
REFERENCE   10 (bases 1 to 1715)
  AUTHORS   Lush,I.E.
  TITLE     Genetic variation of some aldehyde-oxidizing enzymes in the mouse
  JOURNAL   Anim Blood Groups Biochem Genet 9 (2), 85-96 (1978)
   PUBMED   742739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031972.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03637.1, BC070924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000010.1  46392464-46392624
            162-328             JAXUCZ010000010.1  46395830-46395996
            329-560             JAXUCZ010000010.1  46397207-46397438
            561-646             JAXUCZ010000010.1  46397927-46398012
            647-855             JAXUCZ010000010.1  46398261-46398469
            856-973             JAXUCZ010000010.1  46399193-46399310
            974-1115            JAXUCZ010000010.1  46400040-46400181
            1116-1282           JAXUCZ010000010.1  46400834-46401000
            1283-1382           JAXUCZ010000010.1  46401409-46401508
            1383-1513           JAXUCZ010000010.1  46401726-46401856
            1514-1715           JAXUCZ010000010.1  46401950-46402151
FEATURES             Location/Qualifiers
     source          1..1715
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1715
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /note="aldehyde dehydrogenase 3 family, member A1"
                     /db_xref="GeneID:25375"
                     /db_xref="RGD:2088"
     exon            1..161
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            162..328
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1528
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /EC_number="1.2.1.5"
                     /note="Aldehyde dehydrogenase (Ahd-c); aldehyde
                     dehydrogenase 3A1; HTC-ALDH; aldehyde dehydrogenase family
                     3 member A1; aldehyde dehydrogenase family 3 subfamily A1;
                     aldehyde dehydrogenase class 3; tumor-associated aldehyde
                     dehydrogenase tumor ALDH"
                     /codon_start=1
                     /product="aldehyde dehydrogenase, dimeric NADP-preferring"
                     /protein_id="NP_114178.1"
                     /db_xref="GeneID:25375"
                     /db_xref="RGD:2088"
                     /translation="MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSI
                     SGALASDLGKNEWTSYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHS
                     EPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQ
                     NLYLVVKGGVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCY
                     VDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDA
                     KQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEE
                     IFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVI
                     VHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAHKARYPPSPAKM
                     PRH"
     exon            329..560
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            561..646
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            647..855
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            856..973
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1115
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1282
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1382
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1513
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1715
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-c; AHDC; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctgcaccc atatttgaat attgttttat cctcatcacg cgaacttcct ggggaaggac
       61 tccaaggtcc aagtgggcgg gaaggagggt ccttaaatgt gccctctttc agctcttgct
      121 cattccagga gtcccagctg ctggagaagg ctgtgtagga gttgcaatga gcagtatcag
      181 tgacaccgtg aaacgggcca gggaggcctt taactccggc aagactcgat cgctgcagtt
      241 ccgaatccag cagttggagg cgctgcagcg catgatcaat gagaacctga aaagcatctc
      301 tggggcgctg gcctctgacc tgggcaagaa cgaatggacc tcctactatg aggaagtggc
      361 tcacgtactg gaggagcttg ataccacaat taaggagctc cctgattggg ctgaggatga
      421 gcctgtggcc aagactcgcc agacccagca ggatgacctt tacatccact cggagcccct
      481 gggtgtggtc cttgtcatag gtgcttggaa ctaccccttc aacctcacca tccagcccat
      541 ggtgggtgcc gttgctgcag gaaacgcagt gatcctcaag ccctcagaag tgagcgggca
      601 catggcagac ctgctagcga cactcatccc tcagtatatg gaccagaatc tgtacctagt
      661 ggtcaaaggg ggtgtccctg aaaccacgga gctgctcaaa gagaggtttg accacatcat
      721 gtacactggg agcacagccg tagggaagat tgttatggcc gctgccgcca agcatctgac
      781 tcctgtcacc ctggagcttg gagggaaaag cccttgttac gtggacaagg actgtgatct
      841 agatgtggct tgcaggcgta tcgcctgggg gaaatttatg aacagtggcc agacctgtgt
      901 ggccccagac tacatcctct gtgacccctc gattcagaac caaatcgtgg agaagctcaa
      961 gaagtcactc aaagatttct atggggaaga tgctaagcag tcccgtgatt atgggaggat
     1021 catcaatgac cgtcacttcc agcgggtcaa aggcctgatt gacaaccaga aagtagccca
     1081 tggaggcact tgggaccagt cctcacgata catagctcca accatcctgg tggatgtgga
     1141 cccccagtcc ccagtgatgc aggaggagat ctttgggccg gtgatgccca ttgtgtgtgt
     1201 tcgaagcttg gaggaggcca ttcaatttat caaccagcgt gagaagcccc tggcactcta
     1261 tgtgttctcc aacaatgaga aggtgatcaa gaaaatgatc gcagagacat ccagcggtgg
     1321 agtgacagcc aatgacgtca ttgttcacat caccgtgccc actttgccct ttggtggtgt
     1381 ggggaacagc ggcatggggg cctaccatgg caagaaaagc ttcgagacct tctcccaccg
     1441 ccgctcttgc ctggtgaagt ctctgttgaa tgaagaagct cacaaggcca ggtatccccc
     1501 aagcccagcc aagatgcccc ggcactgaga gtgctgctgc acctgacaca tgttttgctg
     1561 gctgtcttgt ccttgaggag ttgctcatgg agcctcatcc tggcttattc ccacctgctg
     1621 tcctgtgctt aactccccga aggctctcac ctcactcctc caaattccac tgtttgctgg
     1681 gcacagaaat caataaaagc ctctgaggaa aagtc
//
