LOCUS       NM_032416               2034 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 2 family member (Aldh2),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_032416 XM_006249385 XM_346439
VERSION     NM_032416.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2034)
  AUTHORS   Ling,M., Huang,C., Hua,T., Li,H., Xiao,W., Lu,Z., Jia,D., Zhou,W.,
            Zhang,L. and Yang,M.
  TITLE     Acetaldehyde dehydrogenase 2 activation attenuates sepsis-induced
            brain injury through NLRP3 inflammasome regulation
  JOURNAL   Brain Res Bull 194, 128-138 (2023)
   PUBMED   36720319
  REMARK    GeneRIF: Acetaldehyde dehydrogenase 2 activation attenuates
            sepsis-induced brain injury through NLRP3 inflammasome regulation.
REFERENCE   2  (bases 1 to 2034)
  AUTHORS   Lin,X., Zhu,D., Wang,K., Luo,P., Rui,G., Gao,Y., Liu,F. and Yu,H.
  TITLE     Activation of aldehyde dehydrogenase 2 protects ethanol-induced
            osteonecrosis of the femoral head in rat model
  JOURNAL   Cell Prolif 55 (6), e13252 (2022)
   PUBMED   35567426
  REMARK    GeneRIF: Activation of aldehyde dehydrogenase 2 protects
            ethanol-induced osteonecrosis of the femoral head in rat model.
REFERENCE   3  (bases 1 to 2034)
  AUTHORS   Lin,L., Tao,J.P., Li,M., Peng,J., Zhou,C., Ouyang,J. and Si,Y.Y.
  TITLE     Mechanism of ALDH2 improves the neuronal damage caused by
            hypoxia/reoxygenation
  JOURNAL   Eur Rev Med Pharmacol Sci 26 (8), 2712-2720 (2022)
   PUBMED   35503616
  REMARK    GeneRIF: Mechanism of ALDH2 improves the neuronal damage caused by
            hypoxia/reoxygenation.
REFERENCE   4  (bases 1 to 2034)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 2034)
  AUTHORS   He,M., Long,P., Chen,T., Li,K., Wei,D., Zhang,Y., Wang,W., Hu,Y.,
            Ding,Y. and Wen,A.
  TITLE     ALDH2/SIRT1 Contributes to Type 1 and Type 2 Diabetes-Induced
            Retinopathy through Depressing Oxidative Stress
  JOURNAL   Oxid Med Cell Longev 2021, 1641717 (2021)
   PUBMED   34725563
  REMARK    GeneRIF: ALDH2/SIRT1 Contributes to Type 1 and Type 2
            Diabetes-Induced Retinopathy through Depressing Oxidative Stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2034)
  AUTHORS   Jeng,J.J. and Weiner,H.
  TITLE     Purification and characterization of catalytically active precursor
            of rat liver mitochondrial aldehyde dehydrogenase expressed in
            Escherichia coli
  JOURNAL   Arch Biochem Biophys 289 (2), 214-222 (1991)
   PUBMED   1898068
REFERENCE   7  (bases 1 to 2034)
  AUTHORS   Enomoto,N., Takada,A. and Date,T.
  TITLE     Genotyping of the aldehyde dehydrogenase 2 (ALDH2) gene using the
            polymerase chain reaction: evidence for single point mutation in
            the ALDH2 gene of ALDH2-deficiency
  JOURNAL   Gastroenterol Jpn 26 (4), 440-447 (1991)
   PUBMED   1916152
REFERENCE   8  (bases 1 to 2034)
  AUTHORS   Diwan,J.J., Paliwal,R., Kaftan,E. and Bawa,R.
  TITLE     A mitochondrial protein fraction catalyzing transport of the K+
            analog T1+
  JOURNAL   FEBS Lett 273 (1-2), 215-218 (1990)
   PUBMED   1699808
REFERENCE   9  (bases 1 to 2034)
  AUTHORS   Farres,J., Guan,K.L. and Weiner,H.
  TITLE     Primary structures of rat and bovine liver mitochondrial aldehyde
            dehydrogenases deduced from cDNA sequences
  JOURNAL   Eur J Biochem 180 (1), 67-74 (1989)
   PUBMED   2540003
REFERENCE   10 (bases 1 to 2034)
  AUTHORS   Greenfield,N.J. and Pietruszko,R.
  TITLE     Two aldehyde dehydrogenases from human liver. Isolation via
            affinity chromatography and characterization of the isozymes
  JOURNAL   Biochim Biophys Acta 483 (1), 35-45 (1977)
   PUBMED   18196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On or before Dec 5, 2020 this sequence version replaced
            XM_006249385.3, NM_032416.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY566468.1, SRR22582416.625338.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               JAXUCZ010000012.1  40610244-40610455
            213-317             JAXUCZ010000012.1  40621559-40621663
            318-458             JAXUCZ010000012.1  40629279-40629419
            459-538             JAXUCZ010000012.1  40630714-40630793
            539-650             JAXUCZ010000012.1  40632283-40632394
            651-779             JAXUCZ010000012.1  40632778-40632906
            780-893             JAXUCZ010000012.1  40634226-40634339
            894-996             JAXUCZ010000012.1  40636285-40636387
            997-1181            JAXUCZ010000012.1  40636755-40636939
            1182-1346           JAXUCZ010000012.1  40637526-40637690
            1347-1504           JAXUCZ010000012.1  40638989-40639146
            1505-1619           JAXUCZ010000012.1  40641457-40641571
            1620-2034           JAXUCZ010000012.1  40642806-40643220
FEATURES             Location/Qualifiers
     source          1..2034
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2034
                     /gene="Aldh2"
                     /note="aldehyde dehydrogenase 2 family member"
                     /db_xref="GeneID:29539"
                     /db_xref="RGD:69219"
     exon            1..212
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1652
                     /gene="Aldh2"
                     /EC_number="1.2.1.3"
                     /note="aldehyde dehydrogenase, mitochondrial;
                     mitochondrial aldehyde dehydrogenase; ALDH1; ALDH-E2; ALDH
                     class 2; aldehyde dehydrogenase 2, mitochondrial; aldehyde
                     dehydrogenase 2 family (mitochondrial)"
                     /codon_start=1
                     /product="aldehyde dehydrogenase, mitochondrial precursor"
                     /protein_id="NP_115792.2"
                     /db_xref="GeneID:29539"
                     /db_xref="RGD:69219"
                     /translation="MLRAALSTARRGPRLSRLLSAAATSAVPAPNQQPEVFCNQIFIN
                     NEWHDAVSKKTFPTVNPSTGEVICQVAEGNKEDVDKAVKAARAAFQLGSPWRRMDASD
                     RGRLLYRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHG
                     KTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPL
                     TALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEVGHLIQVAA
                     GSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDVY
                     DEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCGGGA
                     AADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSKYGLAAAV
                     FTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVK
                     TVTVKVPQKNS"
     exon            213..317
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            318..458
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            459..538
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..650
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            651..779
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            780..893
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..996
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1181
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1346
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1504
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1619
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..2034
                     /gene="Aldh2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgccggt tgctccgcta ggctcctctc tgctcggttc ggctcgccct gctcagctct
       61 gctcagttct gctaagctcc gctcagttca gcatgctgcg cgccgcactc agcaccgccc
      121 gccgtgggcc acgcctgagc cgcctgctgt ccgccgccgc caccagcgcg gtgccagccc
      181 ccaaccagca gcccgaggtc ttctgcaacc agatcttcat taacaatgag tggcatgatg
      241 ctgtcagcaa gaaaacattc cccaccgtca acccttccac gggggaggtc atctgccagg
      301 tagccgaagg gaacaaggag gacgtagaca aggcagtgaa ggccgctcgg gcagccttcc
      361 agctgggctc gccctggcgc cgcatggatg catctgacag gggccggctg ttgtaccgat
      421 tggctgatct catcgaacgg gaccggacct acctggcggc cttggagacc ctggacaacg
      481 gcaagcctta tgtcatctcc tacctggtgg atttggacat ggttctgaaa tgtctccgct
      541 attatgctgg ctgggctgac aagtaccacg ggaaaaccat tcccatcgat ggcgacttct
      601 tcagctacac ccgccacgag cctgtgggcg tgtgtggaca gatcattccg tggaacttcc
      661 cgctcctgat gcaagcctgg aagctgggcc ctgccttggc aactggaaac gtggtggtga
      721 tgaaagtggc cgagcagaca ccgctcactg cactctacgt ggccaacttg atcaaggagg
      781 caggcttccc ccctggtgtg gtcaatattg ttcctggatt cggccctacc gccggggctg
      841 ccatcgcgtc ccacgaggat gtggacaaag tggccttcac aggttccact gaggttggtc
      901 acctaatcca ggttgccgcc gggagcagca atctcaagag agtaaccctg gaactggggg
      961 gaaagagccc caatatcatc atgtcagacg ctgacatgga ctgggctgtg gaacaggccc
     1021 actttgccct gttcttcaac cagggccagt gctgttgtgc gggctcccgg accttcgtgc
     1081 aggaggatgt gtatgatgaa ttcgtggaac gcagtgtggc ccgggccaag tctcgggtgg
     1141 tcgggaaccc tttcgacagc cggacggagc aggggccgca ggtggatgag actcagttta
     1201 agaagatcct gggctatatc aagtcaggac aacaagaagg ggcgaagctg ctgtgcggtg
     1261 ggggcgccgc cgcagaccgt ggttacttca tccagcccac cgtgttcgga gacgtcaaag
     1321 atggcatgac catcgccaag gaggagatct tcggaccagt gatgcagatc ctcaaattca
     1381 agaccattga ggaggttgtg gggcgagcca ataattccaa gtacgggctg gctgccgctg
     1441 tcttcacaaa ggacctggac aaggccaatt acctgtccca agctctgcag gctgggactg
     1501 tgtggatcaa ctgctacgat gtgtttgggg cccagtcccc atttggtggc tataagatgt
     1561 cggggagtgg cagggagctg ggcgagtatg gcctgcaggc ctacacggaa gtgaagacgg
     1621 tcaccgtcaa agtgccacag aagaactcgt aaagtggtgt gcaggcttct tcagccagcg
     1681 cccgaaaacc caacaagatc ctgagaaaag ccaccaccaa gcacactgcg cctgccaaga
     1741 gaaaacccct tcaccaaagc ctgccaagag aaaacccctt caccaaagcg tcttgggcca
     1801 agaaagtcag gatttgataa acagggcagg gttggtgggc ggtgtttggg gagcgtcccc
     1861 agtaaactgg ggaagggagg agctctgtgc agaccaccca cacgcacgca cacgctcacg
     1921 ggtccttctg tgctggatgc tgggttccac cctcagtgct taaacaaatg agcaataaaa
     1981 atcagcagat aaagcctcag ggtcagttct ctgagcccta agttctgagt ctta
//
