LOCUS       NM_001191778            3704 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 1 family, member L2
            (Aldh1l2), transcript variant 2, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001191778 XM_235005
VERSION     NM_001191778.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3704)
  AUTHORS   Strickland,K.C., Krupenko,N.I., Dubard,M.E., Hu,C.J., Tsybovsky,Y.
            and Krupenko,S.A.
  TITLE     Enzymatic properties of ALDH1L2, a mitochondrial
            10-formyltetrahydrofolate dehydrogenase
  JOURNAL   Chem Biol Interact 191 (1-3), 129-136 (2011)
   PUBMED   21238436
REFERENCE   2  (bases 1 to 3704)
  AUTHORS   Krupenko,N.I., Dubard,M.E., Strickland,K.C., Moxley,K.M.,
            Oleinik,N.V. and Krupenko,S.A.
  TITLE     ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate
            dehydrogenase
  JOURNAL   J Biol Chem 285 (30), 23056-23063 (2010)
   PUBMED   20498374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 14, 2022 this sequence version replaced NM_001191778.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760400, SAMEA5760476
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000007.1  22141872-22141987
            117-261             JAXUCZ010000007.1  22150932-22151076
            262-496             JAXUCZ010000007.1  22154573-22154807
            497-662             JAXUCZ010000007.1  22157319-22157484
            663-764             JAXUCZ010000007.1  22159316-22159417
            765-854             JAXUCZ010000007.1  22159609-22159698
            855-989             JAXUCZ010000007.1  22162145-22162279
            990-1115            JAXUCZ010000007.1  22163692-22163817
            1116-1207           JAXUCZ010000007.1  22164660-22164751
            1208-1355           JAXUCZ010000007.1  22166347-22166494
            1356-1475           JAXUCZ010000007.1  22171204-22171323
            1476-1603           JAXUCZ010000007.1  22171830-22171957
            1604-1758           JAXUCZ010000007.1  22173919-22174073
            1759-1792           JAXUCZ010000007.1  22174922-22174955
            1793-1825           JAXUCZ010000007.1  22175107-22175139
            1826-1931           JAXUCZ010000007.1  22176621-22176726
            1932-2019           JAXUCZ010000007.1  22178516-22178603
            2020-2113           JAXUCZ010000007.1  22179034-22179127
            2114-2213           JAXUCZ010000007.1  22180935-22181034
            2214-2312           JAXUCZ010000007.1  22185014-22185112
            2313-2478           JAXUCZ010000007.1  22187079-22187244
            2479-2584           JAXUCZ010000007.1  22189177-22189282
            2585-2784           JAXUCZ010000007.1  22190357-22190556
            2785-3704           JAXUCZ010000007.1  22192484-22193403
FEATURES             Location/Qualifiers
     source          1..3704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..3704
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /note="aldehyde dehydrogenase 1 family, member L2"
                     /db_xref="GeneID:299699"
                     /db_xref="RGD:1309458"
     exon            1..116
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2840
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /EC_number="1.5.1.6"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2;
                     mitochondrial 10-formyltetrahydrofolate dehydrogenase"
                     /codon_start=1
                     /product="mitochondrial 10-formyltetrahydrofolate
                     dehydrogenase isoform 2"
                     /protein_id="NP_001178707.2"
                     /db_xref="GeneID:299699"
                     /db_xref="RGD:1309458"
                     /translation="MLWRGSQALRHFSTGRVYFKNKLKLALIGQSLFGQEVYSHLLKE
                     GHRVVGVFTVPDKDGKADPLALAAEKDGTPVFKFPRWRVKGKTIKEVAEAYQSVGAEL
                     NVLPFCTQFIPMDIIDSPEHGSIIYHPSLLPRHRGASAINWTLIMGDKKAGFSVFWAD
                     DGLDTGPILLQRSCDVKPNDTVDSLYNRFLFPEGIKAMVEAVQLIADGKAPRTPQPEE
                     GATYEGIQKKENAEIPWDQPAEVLHNWIRGHDKVPGAWAEIDGQMVTFYGSSLLTSSV
                     PAGEPLDIRGAKKPGLVTKNGLVLFGNDGKALMVRNLQFEDGKMIPASQYFSSGETSV
                     VELTAEELKVAETIKVIWARILSNVPVIEDSTDFFKSGASSMDVARLVEEIRQKCGGL
                     QLQNEDVYMARKFGDFIQKVVRRLRGEDQEAELVVDYVSKEVNEMTVKMPYQCFINGQ
                     FVDAEDGETYATINPTDGTTLCRVSYASLADVDRAVAAAKDAFENGEWGRMNARDRGR
                     LMYRLADLMEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQVTKE
                     PENQARIHDTLGMSSEEPKVVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTP
                     LTALKFAELTVKAGFPKGVINIIPGSGGVAGQRLSQHPDIRKLGFTGSTSVGKQIMKS
                     CAVSNLKKVSLELGGKSPLIIFSDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEEAI
                     HDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGR
                     QVQRPGFFMEPTVFTGVEDHMYLAKEESFGPIMVISKFQNGDIDGVLQRANNTEYGLA
                     SGVFTRDISKAMYVSDRLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYL
                     KTKTVTLEY"
     exon            117..261
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            262..496
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            497..662
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            663..764
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            765..854
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            855..989
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1115
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1207
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1355
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1475
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1603
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1758
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1792
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1825
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1931
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2019
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2113
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2213
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2312
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2478
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2584
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2784
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..3704
                     /gene="Aldh1l2"
                     /gene_synonym="RGD1309458"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcaacctt ctgcagccct ggtacccact cctgccgcct gcctggcaat cactcgctcc
       61 tctgcaccat gctgtggcgg ggtagccagg cgctacggca cttctccacc ggccgggttt
      121 atttcaaaaa caagttgaag ttggcactta ttggccagag cctgtttgga caggaagtct
      181 acagccacct cctgaaagag ggtcaccgag tagtgggagt gttcacagtg ccagacaagg
      241 atggaaaggc cgatccactg gctttggccg cagagaaaga tgggacccct gtgttcaagt
      301 tccctcgatg gagagtcaag ggtaaaacca tcaaggaggt agcagaagcc tatcagtcgg
      361 taggtgctga gctcaacgtg cttcccttct gcacgcagtt catccccatg gacatcatcg
      421 acagcccaga gcacggctcc atcatctacc acccctcact cctacccagg cacagagggg
      481 cttctgccat caactggact ctaatcatgg gagataagaa agctgggttt tctgttttct
      541 gggcagatga tggtttagat acaggaccca tccttcttca gagatcgtgt gacgtcaaac
      601 ccaatgacac agtggactcg ctttataacc ggttcctttt tcctgagggg atcaaggcca
      661 tggtagaagc tgtccaactc atagctgatg gaaaggcgcc tcgcactccc cagccggaag
      721 agggggccac atatgaaggc atccagaaga aggaaaacgc tgagattcct tgggaccagc
      781 ctgctgaagt tttgcacaac tggattcgag gtcatgataa ggtccctgga gcctgggcag
      841 agatagacgg acagatggtg actttctacg gctcatcact gttgacaagt tctgtgcctg
      901 ctggagaacc actggacatt agaggtgcca agaagcctgg tcttgtcacc aaaaatggcc
      961 ttgttctttt tgggaatgat gggaaagcgc tgatggtgag aaacctgcag tttgaagacg
     1021 ggaagatgat tcccgcctcc cagtactttt cgtcgggtga gacatcggtg gtagaactta
     1081 cggctgagga gctgaaggtg gcagagacca taaaggtcat ctgggctaga atcttaagca
     1141 acgtcccagt gattgaggac tccacggact tctttaaatc tggagcgagc tcaatggatg
     1201 ttgcgaggct ggtggaagag atcagacaga agtgcggtgg gcttcagctg cagaacgaag
     1261 atgtctacat ggcccgcaag tttggagatt tcatccaaaa ggttgtgagg agactaagag
     1321 gagaggacca agaggctgag ctggtggtgg attatgtttc caaggaggta aacgagatga
     1381 cagtgaagat gccctaccag tgtttcataa acggacagtt tgtagatgcc gaggatggag
     1441 agacttacgc caccatcaac cccacagacg gaactacgct atgcagagtg tcctacgctt
     1501 ctttagcgga tgttgacaga gcagtagccg cggccaagga cgcctttgag aatggcgaat
     1561 ggggaaggat gaacgccagg gacagaggaa gactcatgta cagactcgcg gacctaatgg
     1621 aagaaaacca ggaggagctg gcgaccatag aagcgctgga ttccggggct gtctacaccc
     1681 tggctctgaa gactcatatt ggaatgtccg tgcagacctt cagatacttc gcaggctggt
     1741 gtgacaaaat tcaggtaaca aaggaaccag agaaccaggc tagaattcat gacactctgg
     1801 ggatgagctc ggaagaacca aaagttgtct gcgccatcat cattccctgg aactacccac
     1861 taatgatgct ggcctggaag agtgcagcct gcctggcagc aggcaacacc ctagtactca
     1921 agccagcgca ggtcacaccc ttgacagctc tgaagtttgc agagctgacg gtgaaagcag
     1981 gctttccgaa gggggtaatc aacatcattc ctggctcagg gggtgtggca ggacagcggc
     2041 tctctcagca ccctgacatc cgcaagcttg gtttcactgg ttccacctct gtgggcaaac
     2101 agatcatgaa aagctgtgct gtgagcaacc tgaagaaagt ttcccttgag cttggtggca
     2161 aatccccact tataatattc agcgactgtg aacttgacaa ggccgtccgg atgggcatgg
     2221 gcgcagtatt cttcaataaa ggagagaact gcattgcagc tggccggctg ttcgtggaag
     2281 aggccatcca cgatgaattc gtcaccagag tggtggaaga gattaaaaag atgaaaattg
     2341 gtgatcccct ggacagatct acggaccacg ggccccagaa ccacaaagcc catttggaaa
     2401 agctgctgca gtactgcgag acgggggtga aggagggggc cacactggtg tacggaggaa
     2461 gacaggtaca gaggccaggc tttttcatgg agcccactgt gttcacaggc gtggaggacc
     2521 acatgtacct cgccaaagag gaatccttcg ggcctatcat ggtcatctct aaattccaaa
     2581 atggggacat cgatggggtg ctgcagagag caaacaacac tgagtacggc ctggcctcag
     2641 gggtcttcac gagagacatc agcaaagcca tgtacgtgag tgacaggcta gaggcgggaa
     2701 cggttttcat taacacctac aacaagacgg acgtggcagc cccatttggt ggagtgaagc
     2761 agtctggctt tggaaaagac ttaggtgagg aggccctgaa cgaatacctg aaaaccaaaa
     2821 cagtgaccct cgagtattag agagacgcat caggaaacct gtgaccaaca gcccgcttct
     2881 caactcttca caagctgaaa accccaacgg tgctgaggaa gcaggggccg tctggaagta
     2941 gataaaagaa tcaggaagag ggtgtgacca cttgtgtgag catttacctg actaagggcc
     3001 tcaaaaaaat tccaggacac tgtttataac caaatgactt aactcttttt aaaaatgttg
     3061 gtggtgtatg tttttctaaa gtatcaaagg tccctcccct tcctccctga atgtctattc
     3121 gctcccaggt cacccatctt gaacacgctg acctcactca caggcccact taagaagagt
     3181 tctgggtctc aactcccaag ccgtatatac tgaacactgt taaccctttc tttagctgtg
     3241 cgttcaaaca acagggtatc ctacagagaa cataatgccc gtcctcgtcc cttctcgtat
     3301 tagaaggaag actcatctct gtgcctttga ctattatgta acctactctg acaaacgggc
     3361 agctcgtgag cctttcttcc acatcttcct acgtggtaca aaggactgtt aagttcagag
     3421 ggcaccaaat tactgacatc accttcgata ctgtagttta aatcctggta aactaactgt
     3481 gatggccaat ccctgtcata ctacaccggc ttactgtgtg agctggggga aactacccaa
     3541 cttgtctgag ctctggcctc ctcatgtgtt aaatagtggt agcagtgcct tcctttgaag
     3601 tctcattaca aggactctgc gaaaagaaaa gccccaggac tgttcataat tcatgtaaat
     3661 gttcaattaa aatttaaata tttctttcca ttactactct aaaa
//
