LOCUS       NM_022547               3106 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 1 family, member L1
            (Aldh1l1), mRNA.
ACCESSION   NM_022547
VERSION     NM_022547.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3106)
  AUTHORS   Naz,N., Moshkdanian,G., Miyan,S., Eljabri,S., James,C. and Miyan,J.
  TITLE     A Paternal Methylation Error in the Congenital Hydrocephalic Texas
            (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements
  JOURNAL   Int J Mol Sci 24 (2), 1638 (2023)
   PUBMED   36675153
  REMARK    GeneRIF: A Paternal Methylation Error in the Congenital
            Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural
            Folate Supplements.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3106)
  AUTHORS   Tsybovsky,Y., Sereda,V., Golczak,M., Krupenko,N.I. and
            Krupenko,S.A.
  TITLE     Structure of putative tumor suppressor ALDH1L1
  JOURNAL   Commun Biol 5 (1), 3 (2022)
   PUBMED   35013550
  REMARK    GeneRIF: Structure of putative tumor suppressor ALDH1L1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3106)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 3106)
  AUTHORS   Han,H., Xu,L., Xiong,K., Zhang,T. and Wang,Z.
  TITLE     Exploration of Hepatoprotective Effect of Gentiopicroside on
            Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in
            Rats by Comprehensive Proteomic and Metabolomic Signatures
  JOURNAL   Cell Physiol Biochem 49 (4), 1304-1319 (2018)
   PUBMED   30223280
REFERENCE   5  (bases 1 to 3106)
  AUTHORS   Stover,P.J.
  TITLE     Polymorphisms in 1-carbon metabolism, epigenetics and
            folate-related pathologies
  JOURNAL   J Nutrigenet Nutrigenomics 4 (5), 293-305 (2011)
   PUBMED   22353665
  REMARK    Review article
REFERENCE   6  (bases 1 to 3106)
  AUTHORS   Chumanevich,A.A., Krupenko,S.A. and Davies,C.
  TITLE     The crystal structure of the hydrolase domain of
            10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis
            and its interplay with the dehydrogenase domain
  JOURNAL   J Biol Chem 279 (14), 14355-14364 (2004)
   PUBMED   14729668
  REMARK    GeneRIF: catalytic mechanism for the hydrolase reaction in which
            Asp-142 polarizes the catalytic water molecule and His-106 orients
            the carbonyl group of formyl.
REFERENCE   7  (bases 1 to 3106)
  AUTHORS   Krupenko,S.A. and Wagner,C.
  TITLE     Aspartate 142 is involved in both hydrolase and dehydrogenase
            catalytic centers of 10-formyltetrahydrofolate dehydrogenase
  JOURNAL   J Biol Chem 274 (50), 35777-35784 (1999)
   PUBMED   10585460
REFERENCE   8  (bases 1 to 3106)
  AUTHORS   Krupenko,S.A., Wagner,C. and Cook,R.J.
  TITLE     Cysteine 707 is involved in the dehydrogenase activity site of rat
            10-formyltetrahydrofolate dehydrogenase
  JOURNAL   J Biol Chem 270 (2), 519-522 (1995)
   PUBMED   7822273
REFERENCE   9  (bases 1 to 3106)
  AUTHORS   Cook,R.J., Lloyd,R.S. and Wagner,C.
  TITLE     Isolation and characterization of cDNA clones for rat liver
            10-formyltetrahydrofolate dehydrogenase
  JOURNAL   J Biol Chem 266 (8), 4965-4973 (1991)
   PUBMED   1848231
REFERENCE   10 (bases 1 to 3106)
  AUTHORS   Case,G.L., Kaisaki,P.J. and Steele,R.D.
  TITLE     Resolution of rat liver 10-formyltetrahydrofolate
            dehydrogenase/hydrolase activities
  JOURNAL   J Biol Chem 263 (21), 10204-10207 (1988)
   PUBMED   3392008
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 3, 2021 this sequence version replaced NM_022547.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M59861.1, BC089101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000004.1  124617220-124617358
            140-289             JAXUCZ010000004.1  124621673-124621822
            290-524             JAXUCZ010000004.1  124623819-124624053
            525-690             JAXUCZ010000004.1  124624733-124624898
            691-792             JAXUCZ010000004.1  124627602-124627703
            793-882             JAXUCZ010000004.1  124628320-124628409
            883-1020            JAXUCZ010000004.1  124629290-124629427
            1021-1146           JAXUCZ010000004.1  124631671-124631796
            1147-1238           JAXUCZ010000004.1  124632832-124632923
            1239-1386           JAXUCZ010000004.1  124635063-124635210
            1387-1506           JAXUCZ010000004.1  124636062-124636181
            1507-1634           JAXUCZ010000004.1  124637139-124637266
            1635-1785           JAXUCZ010000004.1  124640898-124641048
            1786-1856           JAXUCZ010000004.1  124642355-124642425
            1857-1962           JAXUCZ010000004.1  124644874-124644979
            1963-2050           JAXUCZ010000004.1  124648272-124648359
            2051-2144           JAXUCZ010000004.1  124654108-124654201
            2145-2244           JAXUCZ010000004.1  124655434-124655533
            2245-2343           JAXUCZ010000004.1  124656882-124656980
            2344-2509           JAXUCZ010000004.1  124659075-124659240
            2510-2615           JAXUCZ010000004.1  124661509-124661614
            2616-2815           JAXUCZ010000004.1  124662680-124662879
            2816-3106           JAXUCZ010000004.1  124663384-124663674
FEATURES             Location/Qualifiers
     source          1..3106
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..3106
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /note="aldehyde dehydrogenase 1 family, member L1"
                     /db_xref="GeneID:64392"
                     /db_xref="RGD:621294"
     exon            1..139
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            140..289
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2871
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /EC_number="1.5.1.6"
                     /note="FBP-CI; 10-FTHFDH; aldehyde dehydrogenase family 1
                     member L1; 10-formyltetrahydrofolate dehydrogenase"
                     /codon_start=1
                     /product="cytosolic 10-formyltetrahydrofolate
                     dehydrogenase"
                     /protein_id="NP_071992.2"
                     /db_xref="GeneID:64392"
                     /db_xref="RGD:621294"
                     /translation="MKIAVIGQSLFGQEVYCQLRKEGHEVVGVFTIPDKDGKADPLGL
                     EAEKDGVPVFKFPRWRARGQALPEVVAKYQALGAELNVLPFCSQFIPMEVINAPRHGS
                     IIYHPSLLPRHRGASAINWTLIHGDKKGGFTIFWADDGLDTGDLLLQKECEVLPDDTV
                     STLYNRFLFPEGIKGMVQAVRLIAEGTAPRCPQSEEGATYEGIQKKETAKINWDQPAE
                     AIHNWIRGNDKVPGAWTEACGQKLTFFNSTLNTSGLSTQGEALPIPGAHRPGVVTKAG
                     LILFGNDDRMLLVKNIQLEDGKMMPASQFFKGSASSDLELTEAELATAEAVRSSWMRI
                     LPNVPEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMATTFRGFIQLLV
                     RKLRGEDDESECVINYVEKAVNKLTLQMPYQLFIGGEFVDAEGSKTYNTINPTDGSVI
                     CQVSLAQVSDVDKAVAAAKEAFENGLWGKINARDRGRLLYRLADVMEQHQEELATIEA
                     LDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGV
                     CGIVIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVN
                     ILPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCALSNVKKVSLELGGKSPLII
                     FADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEESIHNQFVQKVVEEVEKMKIGNPL
                     ERDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCGGNQVPRPGFFFQPTVFTDVEDHM
                     YIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAG
                     TVFINTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRIKTVTFEY"
     exon            290..524
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            525..690
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            691..792
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            793..882
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1020
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1146
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1238
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1386
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1506
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1634
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1785
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1856
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1962
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2050
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2144
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2244
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2343
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2509
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2615
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2815
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..3106
                     /gene="Aldh1l1"
                     /gene_synonym="FDH; Fthfd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgtctggg agctcgcggt tcctgtgctg actctcaaag ggctgactga ccctcgcacc
       61 tagcaggtac ttctggattg caagtccagg gttctgggcc ggtgaccctg ttttctctac
      121 ttcctgtctt tgaccttggg taccttccaa cccactgttg ccatgaagat tgcagtaatc
      181 ggacagagcc tgtttggcca ggaggtttac tgccagctga ggaaggaggg ccacgaggtg
      241 gtgggtgtgt tcacaatccc agacaaggat gggaaagcag accccctggg cctggaggct
      301 gagaaggatg gcgtgcccgt gttcaagttt cctcggtggc gtgctcgggg acaggctctg
      361 cccgaggtgg tggccaaata ccaggctctg ggtgcagagc tcaatgtgct tcccttctgc
      421 agccagttca tacccatgga ggtcattaat gcccccaggc acggctccat catctaccat
      481 ccatccctgc tacccaggca tcgaggggct tcggccatca actggaccct cattcatgga
      541 gataagaaag gaggcttcac catcttctgg gctgatgatg gcctggacac tggtgacctt
      601 ctgctgcaga aggagtgtga ggtgcttcca gatgacaccg tgagcacgct gtacaatcgt
      661 ttcctcttcc cagagggcat caaagggatg gttcaggctg tgcgactgat cgcagagggt
      721 acagcccccc gctgccccca gtctgaggaa ggagccacct atgagggcat tcagaagaag
      781 gagacagcca agatcaattg ggaccagcca gcagaggcca ttcacaactg gatccgtggg
      841 aatgacaagg tgccaggtgc ctggacagag gcttgtgggc agaagctgac atttttcaac
      901 tcgacactca acacttcagg actgtcaacc cagggagaag ctttacccat cccaggagcc
      961 catcgtccag gcgtggtcac caaagcagga ctcatcctct ttgggaatga cgatagaatg
     1021 ttgctggtga agaacatcca gctggaagat ggcaagatga tgccagcctc ccagttcttc
     1081 aaggggtccg ctagcagtga cctggagctg acagaggcgg agttggccac ggcggaggct
     1141 gtgcggagct cttggatgcg aatcctgccg aacgtcccag aggtggaaga ctctacagat
     1201 ttcttcaagt caggagctgc ttctgtagat gttgtgaggc tggtggagga agtgaaggag
     1261 ctgtgtgacg ggctggagtt agaaaatgaa gacgtttaca tggccaccac ctttaggggg
     1321 tttatccagc tcctagtgag gaagctgaga ggggaggacg acgagagcga gtgtgtcatt
     1381 aactacgtgg aaaaggcagt gaacaagctg actctccaaa tgccctacca gctcttcata
     1441 ggcggcgagt tcgtggacgc tgagggctct aagacctaca ataccatcaa cccaacggat
     1501 ggaagtgtca tctgccaggt gtccctggct caggtgagcg atgttgacaa ggcagtggca
     1561 gcagcaaagg aagccttcga gaacggactg tggggaaaga taaatgctcg tgaccggggc
     1621 cggctcctgt acaggttggc ggatgtcatg gagcagcacc aggaagagct agccaccatt
     1681 gaggccctgg atgcaggtgc cgtctacacg ctggccctga agacgcacgt gggcatgtcc
     1741 atccagacct tccggtactt tgctggctgg tgtgataaga tccagggtgc caccatcccc
     1801 atcaaccagg ctagacccaa ccgcaacctg accttgacca agaaggaacc tgttggggtc
     1861 tgtggcattg tcatcccctg gaactatccc ttaatgatgc tatcctggaa gactgcagcc
     1921 tgcctggcgg ctgggaacac cgtggtgatc aagcctgccc aggtgacccc actcacagcc
     1981 ttgaagtttg ccgagctgac actgaaggct ggcattccca agggtgtggt caacatcctc
     2041 ccaggatctg gatccctggt tggccagaga ctctcagacc accctgatgt gaggaaaata
     2101 gggttcacag gctccacgga ggtggggaaa cacatcatga aaagctgtgc tctgagcaac
     2161 gtgaagaaag tctccctgga gctgggtgga aagtcacccc ttatcatatt tgctgactgc
     2221 gacctcaaca aggccgtgca gatgggcatg agctccgttt tcttcaacaa aggggagaac
     2281 tgcattgcgg caggccggct ctttgtggag gagtccatcc acaaccagtt tgtgcagaaa
     2341 gtggtggagg aggtggagaa gatgaaaatc ggcaatcccc tggagaggga caccaatcat
     2401 ggcccgcaga accatgaggc ccacctgagg aagctagtgg agtattgcca acgtggtgtg
     2461 aaggaagggg ccacactggt ctgtggtggg aaccaagtcc caaggccagg attcttcttt
     2521 cagccaaccg tcttcacaga cgtagaggac cacatgtaca tcgctaagga ggagtccttt
     2581 gggcccatca tgatcatctc tcggtttgct gatggggatg tggatgctgt gctgtcccgg
     2641 gccaatgcca cagaatttgg cctggcctct ggggtcttca cccgcgatat caacaaggcc
     2701 ctgtatgtca gtgacaaact gcaggcaggc actgtgttca tcaacacgta taacaagact
     2761 gatgtggccg caccttttgg aggattcaag caatctggat ttggcaaaga cctgggagag
     2821 gcagccctga atgagtacct gcggatcaag actgtgactt ttgagtactg aagccaagtc
     2881 tgtgatattt ctcctgtacc ctgttggcct cccctcaggg agccctggcc cctgtctggt
     2941 gtcttagcac cctcctgtcc ccaacactgt tcccttcagc tgctggagct atcagtgtgg
     3001 acccctgctg gtgacaggac accctccgga caattggaag tggttccaag tggagtgagc
     3061 agtcatgtcc cggatgaata aaggttgtga gcagaagtca cctgca
//
