LOCUS       NM_153300               3389 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 1 family, member A3
            (Aldh1a3), mRNA.
ACCESSION   NM_153300
VERSION     NM_153300.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Moretti,A., Li,J., Donini,S., Sobol,R.W., Rizzi,M. and
            Garavaglia,S.
  TITLE     Crystal structure of human aldehyde dehydrogenase 1A3 complexed
            with NAD+ and retinoic acid
  JOURNAL   Sci Rep 6, 35710 (2016)
   PUBMED   27759097
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Romand,R., Krezel,W., Beraneck,M., Cammas,L., Fraulob,V.,
            Messaddeq,N., Kessler,P., Hashino,E. and Dolle,P.
  TITLE     Retinoic acid deficiency impairs the vestibular function
  JOURNAL   J Neurosci 33 (13), 5856-5866 (2013)
   PUBMED   23536097
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Napoli,J.L.
  TITLE     Physiological insights into all-trans-retinoic acid biosynthesis
  JOURNAL   Biochim Biophys Acta 1821 (1), 152-167 (2012)
   PUBMED   21621639
  REMARK    Review article
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Wang,C., Kane,M.A. and Napoli,J.L.
  TITLE     Multiple retinol and retinal dehydrogenases catalyze
            all-trans-retinoic acid biosynthesis in astrocytes
  JOURNAL   J Biol Chem 286 (8), 6542-6553 (2011)
   PUBMED   21138835
REFERENCE   5  (bases 1 to 3389)
  AUTHORS   Molotkova,N., Molotkov,A. and Duester,G.
  TITLE     Role of retinoic acid during forebrain development begins late when
            Raldh3 generates retinoic acid in the ventral subventricular zone
  JOURNAL   Dev Biol 303 (2), 601-610 (2007)
   PUBMED   17207476
REFERENCE   6  (bases 1 to 3389)
  AUTHORS   Rexer,B.N. and Ong,D.E.
  TITLE     A novel short-chain alcohol dehydrogenase from rats with retinol
            dehydrogenase activity, cyclically expressed in uterine epithelium
  JOURNAL   Biol Reprod 67 (5), 1555-1564 (2002)
   PUBMED   12390888
REFERENCE   7  (bases 1 to 3389)
  AUTHORS   Rexer,B.N., Zheng,W.L. and Ong,D.E.
  TITLE     Retinoic acid biosynthesis by normal human breast epithelium is via
            aldehyde dehydrogenase 6, absent in MCF-7 cells
  JOURNAL   Cancer Res 61 (19), 7065-7070 (2001)
   PUBMED   11585737
REFERENCE   8  (bases 1 to 3389)
  AUTHORS   Pappas,P., Stephanou,P., Karamanakos,P., Vasiliou,V. and
            Marselos,M.
  TITLE     Phenobarbital inducibility and differences in protein expression of
            an animal model
  JOURNAL   Chem Biol Interact 130-132 (1-3), 275-283 (2001)
   PUBMED   11306051
REFERENCE   9  (bases 1 to 3389)
  AUTHORS   Grun,F., Hirose,Y., Kawauchi,S., Ogura,T. and Umesono,K.
  TITLE     Aldehyde dehydrogenase 6, a cytosolic retinaldehyde dehydrogenase
            prominently expressed in sensory neuroepithelia during development
  JOURNAL   J Biol Chem 275 (52), 41210-41218 (2000)
   PUBMED   11013254
REFERENCE   10 (bases 1 to 3389)
  AUTHORS   Suzuki,R., Shintani,T., Sakuta,H., Kato,A., Ohkawara,T., Osumi,N.
            and Noda,M.
  TITLE     Identification of RALDH-3, a novel retinaldehyde dehydrogenase,
            expressed in the ventral region of the retina
  JOURNAL   Mech Dev 98 (1-2), 37-50 (2000)
   PUBMED   11044606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 3, 2022 this sequence version replaced NM_153300.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166415.1, SRR26360186.1840975.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000001.1  129427480-129427643 c
            165-269             JAXUCZ010000001.1  129422009-129422113 c
            270-410             JAXUCZ010000001.1  129419516-129419656 c
            411-540             JAXUCZ010000001.1  129413496-129413625 c
            541-602             JAXUCZ010000001.1  129412907-129412968 c
            603-731             JAXUCZ010000001.1  129412077-129412205 c
            732-845             JAXUCZ010000001.1  129410255-129410368 c
            846-948             JAXUCZ010000001.1  129409007-129409109 c
            949-1133            JAXUCZ010000001.1  129407183-129407367 c
            1134-1298           JAXUCZ010000001.1  129403240-129403404 c
            1299-1456           JAXUCZ010000001.1  129401386-129401543 c
            1457-1531           JAXUCZ010000001.1  129400168-129400242 c
            1532-3389           JAXUCZ010000001.1  129392516-129394373 c
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3389
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /note="aldehyde dehydrogenase 1 family, member A3"
                     /db_xref="GeneID:266603"
                     /db_xref="RGD:628662"
     exon            1..164
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1604
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /EC_number="1.2.1.36"
                     /note="aldehyde dehydrogenase family 1 member A3; RALDH-3;
                     ralDH3; aldehyde dehydrogenase family 1, subfamily A3;
                     aldehyde dehydrogenase 6"
                     /codon_start=1
                     /product="retinaldehyde dehydrogenase 3"
                     /protein_id="NP_695212.2"
                     /db_xref="GeneID:266603"
                     /db_xref="RGD:628662"
                     /translation="MATTNGAVENGQPDGKPPALPRPIRNLEVKFTKIFINNDWHESK
                     SGRKFATYNPSTLEKICEVEEGDKPDVDKAVEAAQAAFQRGSPWRRLDALSRGQLLHQ
                     LADLIERDRAILATLETMDTGKPFLHAFFVDLEGCIKTFRYFAGWADKIQGRTIPTDD
                     NVMCFTRHEPIGVCGAITPWNFPLLMLAWKLAPALCCGNTVVLKPAEQTPLTALYLAS
                     LIKEVGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKR
                     VTLELGGRNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYGEFVRRS
                     VEFAKKRPVGDPFDAKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDRGLF
                     IKPTVFSDVTDNMRIAKEEIFGPVQPILKFKNLEEVIKRANSTDYGLTAAVFTKNLDK
                     ALKLASALESGTVWVNCYNAFYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLD
                     EKNP"
     exon            165..269
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     exon            270..410
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     exon            411..540
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     exon            541..602
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     exon            603..731
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     exon            732..845
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     exon            846..948
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1133
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1298
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1456
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1531
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..3389
                     /gene="Aldh1a3"
                     /gene_synonym="Aldh6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctgcgca ccgcccaggc cgagccggtg cgtcggggac acggaccagg gagtgcgaac
       61 cagtcatggc caccaccaac ggggctgtgg aaaacggaca gcctgatggg aaaccgcctg
      121 ccttgccgcg ccccatccgc aacttggagg tcaagttcac taagatattt atcaacaatg
      181 actggcacga atccaagagt ggaagaaagt ttgccacata taacccttca actctagaga
      241 aaatatgtga ggtggaagaa ggcgataagc ccgatgtgga caaggccgtg gaggccgccc
      301 aagctgcctt ccagaggggc tccccgtggc gcaggctgga tgccctgagt cgtggccagt
      361 tgttgcacca gttggctgat cttatagaaa gggaccgcgc tatcctggca actctagaga
      421 ccatggacac cggcaagccg ttccttcatg cctttttcgt cgacctggag ggctgtatta
      481 agaccttcag atattttgcc gggtgggcag acaaaatcca gggcaggacc atccccacag
      541 atgataatgt catgtgcttc accaggcatg agcccattgg ggtgtgtggg gccattacac
      601 catggaactt ccccctgttg atgctggcct ggaaactggc tcctgccctg tgctgcggga
      661 acaccgtggt cctgaagcca gctgagcaga cgcctctcac tgccctgtac ctcgcttctc
      721 tcatcaaaga ggtcgggttc cctccaggtg tggtgaacat tgtgccaggc tttgggccca
      781 cagtgggagc agcaatctcc tctcatccac agatcaacaa gatagccttc accggctcca
      841 cagaggttgg aaagctggtt aaagaagctg cctccaggag caacctgaag cgggtcacac
      901 tggagctggg aggcaggaac ccgtgcatcg tgtgtgcgga cgctgacctg gacttggctg
      961 tggagtgtgc tcaccaggga gtgttcttca accaaggcca gtgctgcaca gcggcctcca
     1021 gggtgtttgt ggaagagcag gtctacgggg agtttgtgag gaggagtgtg gagttcgcca
     1081 agaagaggcc agttggagac cccttcgatg ccaaaacgga gcaggggcct cagatcgacc
     1141 aaaagcagtt tgacaaaatc ctcgagctga tcgagagtgg gaagaaggaa ggggccaagc
     1201 tagaatgtgg ggggtcagcc atggaggaca gagggctgtt catcaaaccc accgtcttct
     1261 cagacgttac ggacaacatg aggattgcca aagaggagat ttttggacca gtgcaaccaa
     1321 tactgaagtt caaaaacctg gaggaagtaa tcaaaagagc gaacagcact gactatgggc
     1381 tcacggcggc cgtgttcacc aaaaacctcg acaaagccct gaagctggct tccgcgctcg
     1441 agtcggggac agtctgggtc aactgctaca acgcattcta tgcacaggct ccatttggtg
     1501 gcttcaaaat gtctggaaat ggcagagaac taggtgaata cgctttggct gaatacacag
     1561 aagtgaaaac tgtcaccatc aaacttgatg agaagaaccc ctgagcggca gaccggcttc
     1621 ttcctcaaaa tggacggctg atcgtggcaa ctctagctcg ccacgagcag aaagcaggat
     1681 gacgtgctca gcttcccagg acactctctt ctggacactc gatctactgg agctcaatgg
     1741 ttttgatttt cctctcacat tcatgcttta tggaccaaac tgtgggacca gatgtcatgt
     1801 gggaaactgc aggccgcctg gggaggaact cttctccagc tctgactttg ccttgagact
     1861 aagtacagga catggcaaag acatccagcg ctctttacta tgagctggtc tctgtggagt
     1921 gtcccatggt taatttaaat gctttttgac cccagtaggg atgtggaaca agttcatgga
     1981 atgttctgca aacaaatctg gtctgtggtc tccttggggt catctgtgca cagaacaggt
     2041 ccctcctcat tctgaggaaa aagtgggact attcacaagc aacggattag tgttgaagtg
     2101 aagggaggat ttcagggacc cagtgtggag aggttaggga agcatatgcc acgcaaaggc
     2161 accagaagcc tttggtgtgc aggagtgcag gtcctaaggg ctgcatatga acactgattc
     2221 cccttgaaaa cagttctgac tttggaatga ccaaatcaac atcccagaga gtttgcccta
     2281 tggtttgaga tggtcttcca taactaaggc ctatcttagg cagagaactt gtcatctatg
     2341 ccactaagga ctcatgtaag aacaactaga gcaaaccctg ggcaatgaag cctcacattt
     2401 gaccctcaga gccaccattc acttttacaa acatccccat ctaccatact cagtaacagg
     2461 cacgcccact ttcttttcct cttctccagc tctattacct gttctagatc agggaagttc
     2521 atgccactga gagacagctg ccacagcata gctctgtagt cttcaaaatc ccacctgtgc
     2581 ttccatttct tatttggtta acaagtaaca cctgggtccc ataggggacc cgacccatca
     2641 gccaagtgac ctaggtatct cagtcaggct gtaacattct ccctttcctc tttgatatac
     2701 ccataacatg tgcaattcca tgtttgaact cagaaagcta aaatggttcc cataaagctt
     2761 taaggataga accaaactcc ttgggtcgac tgctatttgg atactttcac tgtcagcagc
     2821 atgtgcctcc ctaattggac gtgatgctta catttgagga ttaaagttgg gctgggcgag
     2881 agtgagaatt aagccttcta tcataaccag catgtgcata aggaagatga tgtgtgaatt
     2941 ggggctctca gccctgtcag agacaagtaa cattccaatc cccttccttc ctccctccct
     3001 cagcaatact atcgcaactg gttgaatcag gattcggcct cggacactga atcttcggta
     3061 tctcaataac tctaggcact acccttcacc atagtacact agagggttgc tgtccttccg
     3121 ttgtacaaca atgcctttaa tatgaaacgt tacattattt ataattggta tcgttaatgt
     3181 atctttttat agctgtaagt acacagaggt agtatattta accttctgta atatactgta
     3241 cttagaaatg aaaaaaatct atatgttaga tttcacttct tttaaggttt acccctgtgg
     3301 tatggttttg aaatcgattg gactggggat tttgatctta acttcagatt gtgttcagca
     3361 atgaaaaaat aaagttggac attgagaaa
//
