LOCUS       NM_053896               2254 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 1 family, member A2
            (Aldh1a2), mRNA.
ACCESSION   NM_053896
VERSION     NM_053896.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2254)
  AUTHORS   Chen,Y., Zhu,J.Y., Hong,K.H., Mikles,D.C., Georg,G.I.,
            Goldstein,A.S., Amory,J.K. and Schonbrunn,E.
  TITLE     Structural Basis of ALDH1A2 Inhibition by Irreversible and
            Reversible Small Molecule Inhibitors
  JOURNAL   ACS Chem Biol 13 (3), 582-590 (2018)
   PUBMED   29240402
REFERENCE   2  (bases 1 to 2254)
  AUTHORS   Liu,X., Sun,X., Liao,H., Dong,Z., Zhao,J., Zhu,H., Wang,P.,
            Shen,L., Xu,L., Ma,X., Shen,C., Fan,F., Wang,C., Hu,K., Zou,Y.,
            Ge,J., Ren,J. and Sun,A.
  TITLE     Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization
            in Chronic Ischemia: Potential Impact on the Development of
            Coronary Collateral Circulation
  JOURNAL   Arterioscler Thromb Vasc Biol 35 (10), 2196-2206 (2015)
   PUBMED   26315408
REFERENCE   3  (bases 1 to 2254)
  AUTHORS   Reeder,A.L., Botham,R.A., Zaremba,K.M. and Nichol,P.F.
  TITLE     Haploinsufficiency of retinaldehyde dehydrogenase 2 decreases the
            severity and incidence of duodenal atresia in the fibroblast growth
            factor receptor 2IIIb-/- mouse model
  JOURNAL   Surgery 152 (4), 768-75 (2012)
   PUBMED   23021139
REFERENCE   4  (bases 1 to 2254)
  AUTHORS   Napoli,J.L.
  TITLE     Physiological insights into all-trans-retinoic acid biosynthesis
  JOURNAL   Biochim Biophys Acta 1821 (1), 152-167 (2012)
   PUBMED   21621639
  REMARK    Review article
REFERENCE   5  (bases 1 to 2254)
  AUTHORS   Broadhurst,M.J., Leung,J.M., Lim,K.C., Girgis,N.M., Gundra,U.M.,
            Fallon,P.G., Premenko-Lanier,M., McKerrow,J.H., McCune,J.M. and
            Loke,P.
  TITLE     Upregulation of retinal dehydrogenase 2 in alternatively activated
            macrophages during retinoid-dependent type-2 immunity to helminth
            infection in mice
  JOURNAL   PLoS Pathog 8 (8), e1002883 (2012)
   PUBMED   22927819
REFERENCE   6  (bases 1 to 2254)
  AUTHORS   Lamb,A.L. and Newcomer,M.E.
  TITLE     The structure of retinal dehydrogenase type II at 2.7 A resolution:
            implications for retinal specificity
  JOURNAL   Biochemistry 38 (19), 6003-6011 (1999)
   PUBMED   10320326
REFERENCE   7  (bases 1 to 2254)
  AUTHORS   Wendling,O., Chambon,P. and Mark,M.
  TITLE     Retinoid X receptors are essential for early mouse development and
            placentogenesis
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 547-551 (1999)
   PUBMED   9892670
REFERENCE   8  (bases 1 to 2254)
  AUTHORS   Zhao,D., McCaffery,P., Ivins,K.J., Neve,R.L., Hogan,P., Chin,W.W.
            and Drager,U.C.
  TITLE     Molecular identification of a major retinoic-acid-synthesizing
            enzyme, a retinaldehyde-specific dehydrogenase
  JOURNAL   Eur J Biochem 240 (1), 15-22 (1996)
   PUBMED   8797830
REFERENCE   9  (bases 1 to 2254)
  AUTHORS   Wang,X., Penzes,P. and Napoli,J.L.
  TITLE     Cloning of a cDNA encoding an aldehyde dehydrogenase and its
            expression in Escherichia coli. Recognition of retinal as substrate
  JOURNAL   J Biol Chem 271 (27), 16288-16293 (1996)
   PUBMED   8663198
REFERENCE   10 (bases 1 to 2254)
  AUTHORS   Moerman,P., Goddeeris,P., Lauwerijns,J. and Van der Hauwaert,L.G.
  TITLE     Cardiovascular malformations in DiGeorge syndrome (congenital
            absence of hypoplasia of the thymus)
  JOURNAL   Br Heart J 44 (4), 452-459 (1980)
   PUBMED   7426208
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE111477.1, BC098910.1 and EV764818.1.
            
            On Mar 28, 2009 this sequence version replaced NM_053896.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098910.1, U60063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BE111477.1         1-8
            9-2243              BC098910.1         1-2235
            2244-2254           EV764818.1         1-11                c
FEATURES             Location/Qualifiers
     source          1..2254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2254
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /note="aldehyde dehydrogenase 1 family, member A2"
                     /db_xref="GeneID:116676"
                     /db_xref="RGD:620250"
     exon            1..126
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1566
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /EC_number="1.2.1.36"
                     /note="retinal dehydrogenase, type II; ralDH2; RALDH 2;
                     aldehyde dehydrogenase family 1 member A2;
                     retinaldehyde-specific dehydrogenase type 2; aldehyde
                     dehydrogenase family 1, subfamily A2; RalDH(II); aldehyde
                     dehydrogenase 1A2"
                     /codon_start=1
                     /product="retinal dehydrogenase 2"
                     /protein_id="NP_446348.2"
                     /db_xref="GeneID:116676"
                     /db_xref="RGD:620250"
                     /translation="MTSSEIAMPGEVKADPAALMASLQLLPSPTPNLEIKYTKIFINN
                     EWQNSESGRVFPVCNPATGEQVCEVQEADKVDIDKAVQAARLAFSLGSVWRRMDASER
                     GRLLDKLADLVERDRATLATMESLNGGKPFLQAFYIDLQGVIKTLRYYAGWADKIHGM
                     TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFTWKIAPALCCGNTVVIKPAEQTPLS
                     ALYMGALIKEAGFPPGVVNILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG
                     RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYE
                     EFVKRSVERAKRRIVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGL
                     GRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVF
                     TNDINKALMVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKT
                     VTVKIPQKNS"
     exon            127..231
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..372
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            373..502
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..564
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..693
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            694..807
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..910
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1095
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1260
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1418
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1493
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1582
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..2244
                     /gene="Aldh1a2"
                     /gene_synonym="Raldh-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgccca tgacttccag cgagatcgcc atgcccggcg aggtgaaggc cgaccccgcc
       61 gcgctcatgg cctcgctgca gctcctgccg tcacccacgc ccaacctcga gatcaagtac
      121 accaagatct ttattaacaa tgaatggcag aactcagaga gtgggagagt gttccctgtc
      181 tgtaatccag ccacaggaga gcaagtgtgt gaagttcaag aagcagacaa ggtggatata
      241 gacaaggcag tgcaggcggc ccgcctggcc ttctctcttg gttctgtgtg gagaaggatg
      301 gacgcttctg aaagaggacg tctgctggac aagcttgcag acttggtgga acgggacagg
      361 gcaactcttg caactatgga atcactaaat ggcggtaagc cattcctgca agctttttac
      421 atcgatttgc agggagtcat caaaaccctg aggtattatg caggctgggc tgataaaatt
      481 cacggaatga ccattcctgt agatggagac tattttacct tcacgagaca tgagcccatc
      541 ggagtgtgtg gacagattat cccgtggaat ttccccctgc tgatgttcac ctggaaaatt
      601 gctcccgcac tgtgctgtgg taacactgtg gtcatcaagc ctgcagagca gacaccactc
      661 agtgcactgt atatgggagc cctcatcaag gaggctggct ttccacccgg ggtcgtcaac
      721 attctgccag ggtatgggcc aacagcaggg gcagcaatag cgtctcacat tggcatagac
      781 aagattgcat tcacaggctc tactgaggtt ggaaagctta ttcaagaagc agctggaaga
      841 agtaatttga agagagtaac tctggaactt ggagggaaaa gccctaatat tatttttgca
      901 gatgctgact tggactacgc tgtggagcag gctcaccagg gtgtgttctt caaccaaggc
      961 cagtgctgca ctgcggggtc tcgaatcttt gtggaggagt ccatctatga ggaatttgtg
     1021 aaaagaagtg tggaaagagc caagaggcgc attgtgggga gcccctttga tcccactact
     1081 gagcagggtc ctcagattga taagaagcaa tacaacaaaa tcctggagct catccagagc
     1141 ggtgtggccg agggcgccaa gctcgagtgt ggaggcaaag gactgggaag gaagggcttc
     1201 ttcattgagc ctaccgtgtt ctccaacgtt acagatgaca tgcggatcgc caaggaggag
     1261 atctttggtc ctgtccagga aattttgagg tttaagacta tggatgaagt tatagaaaga
     1321 gccaataact cagacttcgg gcttgtagcg gctgtcttca ctaatgacat caacaaggct
     1381 ctcatggtgt cctctgcaat gcaagctggg acagtttgga tcaattgtta caacgcctta
     1441 aatgctcaga gccccttcgg ggggttcaag atgtctggaa atgggagaga aatgggtgag
     1501 tttggcttac gggagtactc agaagtaaag accgtgacgg tgaagatccc ccagaagaac
     1561 tcctaagagg cccaggccga agagcaccag tgtgccaaga ctgccaccta tcaccaggcc
     1621 tccttcgtca tgccctgtgg cccgcccgac gtcggtttac cactcttgcc tcacaacaag
     1681 tgagcttcag cctgcagaag gggagctgtg aagcaagcct gactctcctt ccttccaacc
     1741 ccaccccctt ccctctgcct tccaatgaac cccattttgt gtgagcagca ctggcttcct
     1801 tcccttctct cctgagctgc caaatcgaag ccagtctcta acctgggtga ataccattta
     1861 tttaataatg ccaaacataa cctaggtgta gaatatggtc atgtatctat tgccttctct
     1921 atttaatggt tttttgcttt ctaaccaaac cagttttcag ttttctattt ataacctgcc
     1981 tgtccacgat gttttcaagc aagccctcca tactgttact gacaaatgag gacaacgcgc
     2041 tcagcagaca gccctgacat gggctttgag tccttccagc aggcgccctg ctcttcctac
     2101 agcgcaccca tgtgaacaca cgattaacca gctagctccc ttcaacccac agtatagaat
     2161 gtgaaaagga agatttatga cttttaattt acttcaaaag aaacctcgtg ctagcaataa
     2221 agcatttata ttgtgtacac ctcgaaaaaa aaaa
//
