LOCUS       NM_022407               2095 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus aldehyde dehydrogenase 1 family, member A1
            (Aldh1a1), mRNA.
ACCESSION   NM_022407
VERSION     NM_022407.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2095)
  AUTHORS   Zhu,Y., He,Y.J., Yu,Y., Xu,D., Yuan,S.Y. and Yan,H.
  TITLE     Aldehyde Dehydrogenase 2 Preserves Mitochondrial Function in the
            Ischemic Heart: A Redox-dependent Mechanism for AMPK Activation by
            Thioredoxin-1
  JOURNAL   J Cardiovasc Pharmacol 83 (1), 93-104 (2024)
   PUBMED   37816196
  REMARK    GeneRIF: Aldehyde Dehydrogenase 2 Preserves Mitochondrial Function
            in the Ischemic Heart: A Redox-dependent Mechanism for AMPK
            Activation by Thioredoxin-1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2095)
  AUTHORS   Tan,X., Chen,Y.F., Zou,S.Y., Wang,W.J., Zhang,N.N., Sun,Z.Y.,
            Xian,W., Li,X.R., Tang,B., Wang,H.J., Gao,Q. and Kang,P.F.
  TITLE     ALDH2 attenuates ischemia and reperfusion injury through regulation
            of mitochondrial fusion and fission by PI3K/AKT/mTOR pathway in
            diabetic cardiomyopathy
  JOURNAL   Free Radic Biol Med 195, 219-230 (2023)
   PUBMED   36587924
  REMARK    GeneRIF: ALDH2 attenuates ischemia and reperfusion injury through
            regulation of mitochondrial fusion and fission by PI3K/AKT/mTOR
            pathway in diabetic cardiomyopathy.
REFERENCE   3  (bases 1 to 2095)
  AUTHORS   Xia,G., Xu,J., Chen,M., Jin,J., Wang,X. and Ye,Y.
  TITLE     Loss of ALDH2 aggravates mitochondrial biogenesis disorder in
            cardiac myocytes induced by TAC
  JOURNAL   Biochem Biophys Res Commun 639, 189-196 (2023)
   PUBMED   36535138
  REMARK    GeneRIF: Loss of ALDH2 aggravates mitochondrial biogenesis disorder
            in cardiac myocytes induced by TAC.
REFERENCE   4  (bases 1 to 2095)
  AUTHORS   Yang,J., Duan,J., Li,M., Sun,H., Sun,Y., Pan,W. and Xi,H.
  TITLE     Aldehyde Dehydrogenase Isoform 1 Predicts a Poor Prognosis of Acute
            Cerebral Infarction
  JOURNAL   Contrast Media Mol Imaging 2022, 8199917 (2022)
   PUBMED   35909581
  REMARK    GeneRIF: Aldehyde Dehydrogenase Isoform 1 Predicts a Poor Prognosis
            of Acute Cerebral Infarction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2095)
  AUTHORS   Calleja,L.F., Yoval-Sanchez,B., Hernandez-Esquivel,L.,
            Gallardo-Perez,J.C., Sosa-Garrocho,M., Marin-Hernandez,A.,
            Jasso-Chavez,R., Macias-Silva,M. and Salud Rodriguez-Zavala,J.
  TITLE     Activation of ALDH1A1 by omeprazole reduces cell oxidative stress
            damage
  JOURNAL   FEBS J 288 (13), 4064-4080 (2021)
   PUBMED   33400378
  REMARK    GeneRIF: Activation of ALDH1A1 by omeprazole reduces cell oxidative
            stress damage.
REFERENCE   6  (bases 1 to 2095)
  AUTHORS   Kathmann,E.C. and Lipsky,J.J.
  TITLE     A preliminary report on the cloning of a constitutively expressed
            rat liver cytosolic ALDH cDNA by PCR
  JOURNAL   Adv Exp Med Biol 414, 69-72 (1997)
   PUBMED   9059608
REFERENCE   7  (bases 1 to 2095)
  AUTHORS   Bhat,P.V., Labrecque,J., Boutin,J.M., Lacroix,A. and Yoshida,A.
  TITLE     Cloning of a cDNA encoding rat aldehyde dehydrogenase with high
            activity for retinal oxidation
  JOURNAL   Gene 166 (2), 303-306 (1995)
   PUBMED   8543180
REFERENCE   8  (bases 1 to 2095)
  AUTHORS   Labrecque,J., Dumas,F., Lacroix,A. and Bhat,P.V.
  TITLE     A novel isoenzyme of aldehyde dehydrogenase specifically involved
            in the biosynthesis of 9-cis and all-trans retinoic acid
  JOURNAL   Biochem J 305 (Pt 2) (Pt 2), 681-684 (1995)
   PUBMED   7832787
REFERENCE   9  (bases 1 to 2095)
  AUTHORS   Hopkinson,D.A., Santisteban,I., Povey,S. and Smith,M.
  TITLE     Biochemical genetic analysis of human and rodent aldehyde
            dehydrogenase (ALDH)
  JOURNAL   Alcohol 2 (1), 73-78 (1985)
   PUBMED   4015840
REFERENCE   10 (bases 1 to 2095)
  AUTHORS   Inoue,K., Nishimukai,H. and Yamasawa,K.
  TITLE     Purification and partial characterization of aldehyde dehydrogenase
            from human erythrocytes
  JOURNAL   Biochim Biophys Acta 569 (2), 117-123 (1979)
   PUBMED   224930
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF001898.1.
            
            On Jun 9, 2003 this sequence version replaced NM_022407.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF001898.1, BC061526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..2095
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /note="aldehyde dehydrogenase 1 family, member A1"
                     /db_xref="GeneID:24188"
                     /db_xref="RGD:2087"
     exon            1..94
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1534
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /EC_number="1.2.1.3"
                     /EC_number="1.2.1.19"
                     /EC_number="1.2.1.36"
                     /EC_number="1.2.1.28"
                     /note="aldehyde dehydrogenase 1, subfamily A1; retinal
                     dehydrogenase 1; ALHDII; ralDH1; ALDH-E1; RALDH 1;
                     aldehyde dehydrogenase, cytosolic; aldehyde dehydrogenase
                     family 1 member A1; aldehyde dehydrogenase 2; aldehyde
                     dehydrogenase family 1, subfamily A1; 3-deoxyglucosone
                     dehydrogenase"
                     /codon_start=1
                     /product="aldehyde dehydrogenase 1A1"
                     /protein_id="NP_071852.2"
                     /db_xref="GeneID:24188"
                     /db_xref="RGD:2087"
                     /translation="MSSPAQPAVPAPLANLKIQHTKIFINNEWHDSVSGKKFPVLNPA
                     TEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLL
                     LATIEAINGGKVFANAYLSDLGGSIKALKYCAGWADKIHGQTIPSDGDIFTFTRREPI
                     GVCGQIIPWNFPLLMFIWKIGPALSCGNTVVVKPAEQTPLTALHMASLIKEAGFPPGV
                     VNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPC
                     IVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVRKSVERAKKYVLGN
                     PLTQGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTD
                     EMRIAKEEIFGPVQQIMKFKSIDDVIKRANNTTYGLAAGVFTKDLDRAITVSSALQAG
                     VVWVNCYMILSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS"
     exon            95..199
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            200..340
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            341..470
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            471..532
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..661
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..775
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..878
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1063
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1228
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1386
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1461
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..2088
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd2; Aldh1; Aldh2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacctgtgtt ccaggagcca aaccagcaat gtcttcccct gcacagcctg cagttcctgc
       61 cccactggcc aacttgaaga ttcaacacac caagatcttc ataaacaatg aatggcatga
      121 ttcagtgagt ggcaagaaat ttcctgtcct taaccctgca actgaggagg tcatctgcca
      181 tgtggaagaa ggggacaagg cagatgttga caaagctgtg aaggccgcaa gacaggcttt
      241 ccagattggc tccccatggc gcaccatgga tgcttcagag agaggacgct tgctgaacaa
      301 gctggctgac ttaatggaga gagatcgtct gctgctggct acaatagagg ccatcaatgg
      361 tgggaaagtc tttgccaatg cgtacttgtc ggatttagga ggcagcataa aagcattaaa
      421 gtactgtgca ggctgggctg acaagatcca tggtcaaaca ataccgagtg atggagacat
      481 tttcactttt acgagacgtg aacctattgg ggtgtgtggc caaatcatcc cttggaattt
      541 tccactgctt atgttcattt ggaagatagg ccctgccctc agctgtggga acacggtggt
      601 cgtcaagcca gcagagcaaa ctcctctcac tgctcttcac atggcatctt taataaaaga
      661 ggcagggttt cctcctggcg tggtgaacat tgtccctggt tatgggccaa ctgcgggggc
      721 agcgatctcc tctcacatgg atgtggacaa ggtggccttc acgggatcaa cccaggttgg
      781 caaattaatc aaggaagctg caggaaaaag caatctgaag agggtcacgc tggagcttgg
      841 gggaaagagc ccttgcattg tgtttgcaga tgccgacttg gacattgctg tcgagtttgc
      901 acaccatgga gtcttctacc atcaaggcca atgctgcgtc gcggcatccc ggattttcgt
      961 tgaggagtca gtttatgatg agtttgtgag aaagagtgtt gagcgagcca agaaatatgt
     1021 ccttggaaac cctctgaccc aaggaataaa tcagggccct cagattgaca aggagcaaca
     1081 tgataaaatc cttgatctca ttgagagtgg gaagaaagaa ggagccaaac tggagtgtgg
     1141 tggaggacgc tgggggaaca aaggcttctt tgtccagccc acagtcttct ccaatgtgac
     1201 cgatgagatg cgcattgcca aagaggagat atttggacca gtgcaacaaa tcatgaagtt
     1261 taagtccata gatgatgtga tcaagagagc aaacaatact acctatggtc tagcagcagg
     1321 agtcttcaca aaagacctgg acagggccat cactgtgtct tctgctctgc aggccggggt
     1381 agtgtgggtt aactgctata tgatcttgtc agcccagtgc cccttcggtg gattcaagat
     1441 gtctggaaat ggacgagaac tgggtgaaca tggtctttat gagtacactg agctcaagac
     1501 agttgcaatg aaaatatctc agaagaactc ctaagaagca gagtgaagag aaactctcag
     1561 ctgtggctac acgtctccta tcgtcaccag caaagtgttg ttttactata attttttctt
     1621 ctgttgattt ctttaacatg atgaatccat cagtgttact gttactcata gaaaacatgt
     1681 agcttaatcc tacaaaacca ctcaccttct aatatgtgac tccagtcctt atcccagaat
     1741 aaaaggatag atttaggtgc aagctctctg taactctgtc atgataggtg ctttctgtcg
     1801 tagctccctg tctagagtac tcatttggtg aggaggacca gtcgtgattt aagctctgtc
     1861 cctctgtgac cccttgaact gcttctcggc atgcatgata actgcagagt cggctgctct
     1921 gtttcccagg tgttgtgaaa tgttttctag aaagccatgc ctgcttatca aatgaaatgc
     1981 ccagctgtaa ttagaatgca aagctaataa agggaccctt gcatgatttt gttggtctgt
     2041 aattatttgg gaatcaacta ggattatggc aataaactct gctggtcaaa aaaaa
//
