LOCUS       NM_031753               2868 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus activated leukocyte cell adhesion molecule
            (Alcam), mRNA.
ACCESSION   NM_031753
VERSION     NM_031753.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2868)
  AUTHORS   Wu,Z., Tian,Y., Wang,C., Zhang,J. and Lin,J.
  TITLE     MiRNA-192-5p-targeted activated leukocyte cell adhesion molecule
            improved inflammatory injury of neonatal necrotizing enterocolitis
  JOURNAL   Pediatr Surg Int 40 (1), 126 (2024)
   PUBMED   38717494
  REMARK    GeneRIF: MiRNA-192-5p-targeted activated leukocyte cell adhesion
            molecule improved inflammatory injury of neonatal necrotizing
            enterocolitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2868)
  AUTHORS   Park,E.S., Jeon,S.M., Weon,H., Cho,H.J. and Youn,D.H.
  TITLE     Activated leukocyte cell adhesion molecule is involved in
            excitatory synaptic transmission and plasticity in the rat spinal
            dorsal horn
  JOURNAL   Neurosci Lett 656, 9-14 (2017)
   PUBMED   28720382
  REMARK    GeneRIF: the modulatory roles of ALCAM in the excitatory synaptic
            transmission and plasticity in the rat spinal dorsal horn
REFERENCE   3  (bases 1 to 2868)
  AUTHORS   Chappell,P.E., Garner,L.I., Yan,J., Metcalfe,C., Hatherley,D.,
            Johnson,S., Robinson,C.V., Lea,S.M. and Brown,M.H.
  TITLE     Structures of CD6 and Its Ligand CD166 Give Insight into Their
            Interaction
  JOURNAL   Structure 23 (8), 1426-1436 (2015)
   PUBMED   26146185
REFERENCE   4  (bases 1 to 2868)
  AUTHORS   Wade,A., Thomas,C., Kalmar,B., Terenzio,M., Garin,J., Greensmith,L.
            and Schiavo,G.
  TITLE     Activated leukocyte cell adhesion molecule modulates neurotrophin
            signaling
  JOURNAL   J Neurochem 121 (4), 575-586 (2012)
   PUBMED   22243278
  REMARK    GeneRIF: ALCAM synergizes with nerve growth factor to induce
            neuronal differentiation, raising the possibility that it functions
            not only as an adhesion molecule but also in the modulation of
            growth factor signaling in the nervous system
REFERENCE   5  (bases 1 to 2868)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 2868)
  AUTHORS   Bruder,S.P., Ricalton,N.S., Boynton,R.E., Connolly,T.J.,
            Jaiswal,N., Zaia,J. and Barry,F.P.
  TITLE     Mesenchymal stem cell surface antigen SB-10 corresponds to
            activated leukocyte cell adhesion molecule and is involved in
            osteogenic differentiation
  JOURNAL   J Bone Miner Res 13 (4), 655-663 (1998)
   PUBMED   9556065
REFERENCE   7  (bases 1 to 2868)
  AUTHORS   Matsumoto,A., Mitchell,A., Kurata,H., Pyle,L., Kondo,K., Itakura,H.
            and Fidge,N.
  TITLE     Cloning and characterization of HB2, a candidate high density
            lipoprotein receptor. Sequence homology with members of the
            immunoglobulin superfamily of membrane proteins
  JOURNAL   J Biol Chem 272 (27), 16778-16782 (1997)
   PUBMED   9201982
REFERENCE   8  (bases 1 to 2868)
  AUTHORS   Bowen,M.A., Bajorath,J., D'Egidio,M., Whitney,G.S., Palmer,D.,
            Kobarg,J., Starling,G.C., Siadak,A.W. and Aruffo,A.
  TITLE     Characterization of mouse ALCAM (CD166): the CD6-binding domain is
            conserved in different homologs and mediates cross-species binding
  JOURNAL   Eur J Immunol 27 (6), 1469-1478 (1997)
   PUBMED   9209500
REFERENCE   9  (bases 1 to 2868)
  AUTHORS   Peduzzi,J.D., Irwin,M.H. and Geisert,E.E. Jr.
  TITLE     Distribution and characteristics of a 90 kDa protein, KG-CAM, in
            the rat CNS
  JOURNAL   Brain Res 640 (1-2), 296-307 (1994)
   PUBMED   8004458
REFERENCE   10 (bases 1 to 2868)
  AUTHORS   Back,E., Vogel,W., Hertel,C. and Schuchmann,L.
  TITLE     Trisomy 10p due to t(5;10)(p15;p11) segregating in a large sibship
  JOURNAL   Hum Genet 41 (1), 11-17 (1978)
   PUBMED   631856
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            [WARNING] On Jul 16, 2024 this sequence was replaced by
            NM_031753.3.
            
            On Nov 26, 2020 this sequence version replaced NM_031753.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB008538.1, BC061970.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               JAXUCZ010000011.1  61805457-61805719
            264-364             JAXUCZ010000011.1  61956318-61956418
            365-584             JAXUCZ010000011.1  61959765-61959984
            585-649             JAXUCZ010000011.1  61969112-61969176
            650-737             JAXUCZ010000011.1  61970349-61970436
            738-920             JAXUCZ010000011.1  61970897-61971079
            921-1048            JAXUCZ010000011.1  61975032-61975159
            1049-1181           JAXUCZ010000011.1  61977024-61977156
            1182-1294           JAXUCZ010000011.1  61981799-61981911
            1295-1430           JAXUCZ010000011.1  61984379-61984514
            1431-1564           JAXUCZ010000011.1  61984622-61984755
            1565-1697           JAXUCZ010000011.1  61987821-61987953
            1698-1736           JAXUCZ010000011.1  61989759-61989797
            1737-1854           JAXUCZ010000011.1  61990096-61990213
            1855-1966           JAXUCZ010000011.1  62002358-62002469
            1967-2868           JAXUCZ010000011.1  62004349-62005250
FEATURES             Location/Qualifiers
     source          1..2868
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2868
                     /gene="Alcam"
                     /note="activated leukocyte cell adhesion molecule"
                     /db_xref="GeneID:79559"
                     /db_xref="RGD:619972"
     exon            1..263
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1942
                     /gene="Alcam"
                     /note="CD166 antigen; HB2; KG-CAM; SB-10 antigen"
                     /codon_start=1
                     /product="CD166 antigen precursor"
                     /protein_id="NP_113941.1"
                     /db_xref="GeneID:79559"
                     /db_xref="RGD:619972"
                     /translation="MASKGSPSCRLVFCLLISAAVLRPGLGWYTVNSAYGDTIVMPCR
                     LDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLSLSENYTLSINN
                     AKISDEKRFVCMLVTEDNVFEAPTLVKVFKQPSKPEIVNRAAFLETEQLKKLGDCISR
                     DSYPDGNITWYRNGKVLQPVDGEVSILFKKEIDPGTQLYTMTSSLEYKTTKSDIQMPF
                     TCSVTYYGPSGQKTIYSEQAIFDIYYPTEQVTIQVLPPKNAIKEGDNITLQCLGNGNP
                     PPEEFMFYLPGQAEGIRSSNTYTLTDVRRNATGDYKCSLIDQRNMAASTTITVHYLDL
                     SLNPSGEVTKQIGDTLPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVC
                     ETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIQWTIT
                     GSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEH
                     DEADDISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLG
                     NMEENKKLEENNHKTEA"
     exon            264..364
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            365..584
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            585..649
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            650..737
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            738..920
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1048
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1181
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1294
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1430
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1564
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1697
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1736
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1854
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1966
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2868
                     /gene="Alcam"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggaggaaa gttgcgtgtg gcacagaccc gacggcgcag cgccacagcg cccgggggat
       61 cgtgtgtctt ggaaaaaaaa gtcgctgtcc ccctaaagcg agacccacaa gcgagcgggc
      121 cccgtgggcc cggggacgac gccccctcct gcggcgtgga ctttgtcggt ggccttctag
      181 gaggaggaat atggcatcta aagggtcccc ttcttgccgt ctggttttct gcctcttgat
      241 ctccgccgcg gtcctcagac caggcctcgg atggtacact gtcaactcag catacggaga
      301 taccattgtc atgccttgca gactggatgt acctcagaac ctcatgtttg gcaaatggaa
      361 atatgaaaag cctgatgggt ccccagtatt tattgcattc agatcttcta caaagaaaag
      421 tgtgcagtat gatgatgtac cagagtacaa ggacagactg agcctctcag aaaactacac
      481 tctgtctatc aacaatgcaa agatcagtga cgaaaagaga tttgtgtgca tgctagtgac
      541 cgaggacaac gtgtttgagg cacctaccct ggtcaaggtg ttcaagcaac catctaaacc
      601 tgaaattgta aacagagcag cgtttcttga aacagagcag ctaaaaaagt taggtgactg
      661 catttcaaga gacagttacc cagacggcaa catcacgtgg tataggaatg ggaaagtgct
      721 acagcctgtt gatggagagg tgtccatact ttttaaaaag gaaattgatc caggtactca
      781 gttgtatacc atgacttcct ccttggagta caagacaacc aagtctgaca tacaaatgcc
      841 attcacctgt tctgtgacat attatggacc ttcgggccag aaaacaattt attctgaaca
      901 agcaatcttt gatatttact atcctacaga gcaggtgaca atacaagtac tgccaccaaa
      961 aaatgccatc aaagaagggg acaacatcac ccttcagtgc ttggggaatg gcaacccacc
     1021 tcctgaggag ttcatgtttt acttaccagg gcaggctgaa ggcataagaa gctcaaacac
     1081 ttacacactg acagacgtga gacgcaatgc caccggggac tacaaatgtt ctctcatcga
     1141 ccaaagaaac atggcagctt caacaaccat cactgttcac tacttggatt tatccttaaa
     1201 cccaagtggg gaagtgacca agcagatcgg tgataccctg cctgtgtctt gcacaatatc
     1261 tgcaagtagg aatgcaactg tggtgtggat gaaggataac atcaggctcc gatctagtcc
     1321 atccttttct agtcttcatt atcaggatgc tgggaactat gtctgtgaaa ctgctcttca
     1381 ggaggttgag ggactgaaga aaagggagtc gctgaccctc atcgtagaag gaaaacctca
     1441 aatcaaaatg acaaagaaaa ctgatcccag tggactgtct aagactataa tctgccatgt
     1501 ggaagggttt ccaaagccag ctatacagtg gaccattacc ggcagtggaa gcgtcataaa
     1561 ccaaacagag gagtctcctt atattaatgg caggtattat agtaaaatta tcatttcccc
     1621 tgaggagaat gttacattaa cttgcacagc agaaaaccaa ctggagagaa cagtaaactc
     1681 cctgaatgtc tctgcgataa gtattccaga acacgatgag gcagacgata taagtgatga
     1741 aaacagagaa aaggtgaatg accaggccaa actaattgtg ggcattgtgg ttggtctcct
     1801 cctcgccgcc ctcgtcgccg gtgtcgtcta ctggctgtac atgaagaaat cgaaaactgc
     1861 atcaaaacat gtaaacaagg accttggtaa tatggaggag aataaaaagc tagaagaaaa
     1921 caatcacaaa acagaagcct aagagaggag ttgtttagat gtcctgagaa aaaaacatat
     1981 aaagaaattg aagcatgaac gtggattgta tttaagacat atacaaagac aatgacagca
     2041 attcatggtt caagtattaa gatgttcatc ctactaagct gtcctgggat cttagagaat
     2101 tatctcaagt aaaacaatga aataaagtta taaaattaca acaagatttg gcagccatga
     2161 taataggtca tatgttgtat ttcgtttgat tttttttttc tgtaaatgtc tgcactgagg
     2221 atttctttca gtttgccttt tatgtaaatt ttttacgtag ctatttttat acactgtaag
     2281 ctttgttctg ggagtggctg ttaattggat gtacaatgta atgtttattt caattgttta
     2341 tatggatagt ctgagcaggt gcggttctga ttctgattgc tatcagtaat gccccaaact
     2401 ttcttgtgag gatctgaaac ccaaaggtgg cagttatgag attgggacat ggatcttgcc
     2461 caatcagaag ctgttttttt tttaaaaaaa aaaacctgga gagtcaggag caccataaga
     2521 tatgatggtc tctatgtgcc aacgggttcc ccgaagcggg tcacaaacac atacggcaac
     2581 accacatgtg aatgatactt ttaaactgac aatttcgtct tctctgaaaa aagacataca
     2641 cagagtttgt ataacacttt acttaacgac acttgctaga aaattacatt ctgtttttaa
     2701 aaaaaataag gaaaatgtaa agaagaatat ctaatatgtc agagaaagtt ggaaacaaat
     2761 cacagctcgc atccccatag tcgcagatca cgatgtaaat cactgtaatt aaaattggtg
     2821 ttaaatcctt tgggttatcc actgccttaa aatgacactt atttcctt
//
