LOCUS       NM_134326               2020 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus albumin (Alb), mRNA.
ACCESSION   NM_134326 XM_001072597
VERSION     NM_134326.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2020)
  AUTHORS   Wan,S., Xiang,Y., Fang,W., Zheng,Y., Li,B., Hu,Y., Lang,C.,
            Huang,D., Sun,Q., Xiong,Y., Huang,X., Lv,J., Luo,Y., Shen,L.,
            Yang,H., Huang,G. and Yang,R.
  TITLE     Clinical features and treatment of COVID-19 patients in northeast
            Chongqing
  JOURNAL   J Med Virol 92 (7), 797-806 (2020)
   PUBMED   32198776
REFERENCE   2  (bases 1 to 2020)
  AUTHORS   Li,S., Jiang,L., Li,X., Lin,F., Wang,Y., Li,B., Jiang,T., An,W.,
            Liu,S., Liu,H., Xu,P., Zhao,L., Zhang,L., Mu,J., Wang,H., Kang,J.,
            Li,Y., Huang,L., Zhu,C., Zhao,S., Lu,J., Ji,J. and Zhao,J.
  TITLE     Clinical and pathological investigation of patients with severe
            COVID-19
  JOURNAL   JCI Insight 5 (12), 138070 (2020)
   PUBMED   32427582
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2020)
  AUTHORS   Kutluhan,M.A., Urkmez,A., Sahin,A., Topaktas,R., Gumrukcu,G. and
            Verit,A.
  TITLE     Predictive value of ischaemia-modified albumin in spermatogenesis
            in an experimental testicular torsion model
  JOURNAL   Andrologia 52 (2), e13471 (2020)
   PUBMED   31691325
  REMARK    GeneRIF: Predictive value of ischaemia-modified albumin in
            spermatogenesis in an experimental testicular torsion model.
REFERENCE   4  (bases 1 to 2020)
  AUTHORS   Das,S., Hussain,M.S., Maras,J.S., Kumar,J., Shasthry,S.M.,
            Nayak,S., Arora,V., Vijayaraghavan,R., Sharma,S., Maiwall,R. and
            Sarin,S.K.
  TITLE     Modification Patterns of Urinary Albumin Correlates With Serum
            Albumin and Outcome in Severe Alcoholic Hepatitis
  JOURNAL   J Clin Gastroenterol 53 (6), e243-e252 (2019)
   PUBMED   29369844
REFERENCE   5  (bases 1 to 2020)
  AUTHORS   Farouk,S., Sabet,S., Abu Zahra,F.A. and El-Ghor,A.A.
  TITLE     Bone marrow derived-mesenchymal stem cells downregulate IL17A
            dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver
            fibrosis
  JOURNAL   PLoS One 13 (10), e0206130 (2018)
   PUBMED   30346985
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2020)
  AUTHORS   Smith,K.T., Failla,M.L. and Cousins,R.J.
  TITLE     Identification of albumin as the plasma carrier for zinc absorption
            by perfused rat intestine
  JOURNAL   Biochem J 184 (3), 627-633 (1979)
   PUBMED   540055
REFERENCE   7  (bases 1 to 2020)
  AUTHORS   Aoyagi,Y., Ikenaka,T. and Ichida,F.
  TITLE     Copper(II)-binding ability of human alpha-fetoprotein
  JOURNAL   Cancer Res 38 (10), 3483-3486 (1978)
   PUBMED   80265
REFERENCE   8  (bases 1 to 2020)
  AUTHORS   Isemura,S. and Ikenaka,T.
  TITLE     Amino acid sequences of fragments I and II obtained by cyanogen
            bromide cleavage of rat serum albumin
  JOURNAL   J Biochem 83 (1), 35-48 (1978)
   PUBMED   564345
REFERENCE   9  (bases 1 to 2020)
  AUTHORS   Lamers,C.B., Hafkenscheid,J.C. and van Tongeren,J.H.
  TITLE     Serum albumin levels in patients with the Zollinger-Ellison
            syndrome
  JOURNAL   Gastroenterology 73 (5), 975-979 (1977)
   PUBMED   908508
REFERENCE   10 (bases 1 to 2020)
  AUTHORS   Strauss,A.W., Bennett,C.D., Donohue,A.M., Rodkey,J.A. and
            Alberts,A.W.
  TITLE     Rat liver pre-proalbumin: complete amino acid sequence of the
            pre-piece. Analysis of the direct translation product of albumin
            messenger RNA
  JOURNAL   J Biol Chem 252 (19), 6846-6855 (1977)
   PUBMED   893447
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085359.1.
            
            On Oct 11, 2007 this sequence version replaced NM_134326.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085359.1, V01222.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2020
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /note="albumin"
                     /db_xref="GeneID:24186"
                     /db_xref="RGD:2085"
     exon            1..94
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1842
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /note="serum albumin"
                     /codon_start=1
                     /product="albumin precursor"
                     /protein_id="NP_599153.2"
                     /db_xref="GeneID:24186"
                     /db_xref="RGD:2085"
                     /translation="MKWVTFLLLLFISGSAFSRGVFRREAHKSEIAHRFKDLGEQHFK
                     GLVLIAFSQYLQKCPYEEHIKLVQEVTDFAKTCVADENAENCDKSIHTLFGDKLCAIP
                     KLRDNYGELADCCAKQEPERNECFLQHKDDNPNLPPFQRPEAEAMCTSFQENPTSFLG
                     HYLHEVARRHPYFYAPELLYYAEKYNEVLTQCCTESDKAACLTPKLDAVKEKALVAAV
                     RQRMKCSSMQRFGERAFKAWAVARMSQRFPNAEFAEITKLATDLTKINKECCHGDLLE
                     CADDRAELAKYMCENQATISSKLQACCDKPVLQKSQCLAEIEHDNIPADLPSIAADFV
                     EDKEVCKNYAEAKDVFLGTFLYEYSRRHPDYSVSLLLRLAKKYEATLEKCCAEGDPPA
                     CYGTVLAEFQPLVEEPKNLVKTNCELYEKLGEYGFQNAILVRYTQKAPQVSTPTLVEA
                     ARNLGRVGTKCCTLPEAQRLPCVEDYLSAILNRLCVLHEKTPVSEKVTKCCSGSLVER
                     RPCFSALTVDETYVPKEFKAETFTFHSDICTLPDKEKQIKKQTALAELVKHKPKATED
                     QLKTVMGDFAQFVDKCCKAADKDNCFATEGPNLVARSKEALA"
     exon            95..152
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            153..285
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            286..497
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            498..630
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            631..728
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            729..858
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1073
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1206
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1304
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1443
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1667
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1800
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1862
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2001
                     /gene="Alb"
                     /gene_synonym="Alb1; Albza"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagcctctg gcacaatgaa gtgggtaacc tttctcctcc tcctcttcat ctccggttct
       61 gccttttcca ggggtgtgtt tcgccgagaa gcacacaaga gtgagatcgc ccatcggttt
      121 aaggacttgg gagaacagca tttcaaaggc ctagtcctga ttgccttttc ccagtatctc
      181 cagaaatgcc catatgaaga gcatatcaaa ttggtgcagg aagtaacaga ctttgcaaaa
      241 acatgtgtcg ctgatgagaa tgccgaaaac tgtgacaagt ccattcacac tctcttcgga
      301 gacaagttat gcgccattcc aaagcttcgc gacaactacg gtgaactggc tgactgctgt
      361 gcaaaacaag agcccgaaag aaacgagtgt ttcctgcagc acaaggatga caaccccaac
      421 ctgccaccct tccagaggcc ggaggctgag gccatgtgca cctccttcca ggagaaccct
      481 accagctttc tgggacacta tttgcatgaa gttgccagga gacatcctta tttctatgcc
      541 ccagaactcc tttactatgc tgagaaatac aatgaggttc tgacccagtg ctgcacagag
      601 tctgacaaag cagcctgcct gacaccgaag cttgatgccg tgaaagagaa agcactggtc
      661 gcagctgtcc gtcagaggat gaagtgctcc agtatgcaga gatttggaga gagagccttc
      721 aaagcctggg cagtagctcg tatgagccag cgattcccca atgctgagtt cgcagaaatc
      781 accaaattgg caacagacct caccaaaatc aacaaggagt gctgtcacgg cgacctgttg
      841 gaatgcgcgg atgacagggc ggaacttgcc aagtacatgt gtgagaacca ggccactatc
      901 tccagcaaac tgcaggcttg ctgtgataag ccagtgctgc agaaatccca gtgtctcgct
      961 gagatagaac atgacaacat tcctgccgat ctgccctcaa tagctgctga ctttgttgag
     1021 gataaggaag tgtgtaagaa ctatgctgag gccaaggatg tcttcctggg cacgtttttg
     1081 tatgaatatt caagaaggca ccccgattac tccgtgtccc tgctgctgag acttgctaag
     1141 aaatatgaag ccacactgga gaagtgctgt gctgaaggcg atcctcctgc ctgctacggc
     1201 acagtgcttg cagaatttca gcctcttgta gaagaaccta agaacttggt caaaactaac
     1261 tgtgagcttt acgagaagct tggagagtat ggattccaaa acgccattct ggttcgatac
     1321 acccagaaag cacctcaggt gtcgacccca actctcgtgg aggcagcaag aaacctggga
     1381 agagtgggca ccaagtgttg tacccttcct gaagctcaga gactgccctg tgtggaagac
     1441 tatctgtctg ccatcctgaa ccgtctgtgt gtgctgcatg agaagacccc agtgagcgag
     1501 aaggtcacca agtgctgtag tgggtccctg gtggaaagac ggccatgttt ctctgctctg
     1561 acagttgacg agacatatgt ccccaaagag tttaaagctg agaccttcac cttccactct
     1621 gatatctgca cactcccaga caaggagaag cagataaaga agcaaacggc tctcgctgag
     1681 ctggtgaaac acaagcccaa ggccacagaa gatcagctga agacggtgat gggtgacttc
     1741 gcacaattcg tggacaagtg ttgcaaggct gccgacaagg ataactgctt cgccactgag
     1801 gggccaaacc ttgttgctag aagcaaagaa gccttagcct aaacacatca caaccatctc
     1861 aggctaccct gagaaaaaaa gacatgaaga ctcaggactc atctcttctg ttggtgtaaa
     1921 accaacaccc taaggaacac aaatttcttt gaacatttga cttcttttct ctgtgccgca
     1981 attaataaaa aatagaaaga aaaaaaaaaa aaaaaaaaaa
//
