LOCUS       NM_013197               1899 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus 5'-aminolevulinate synthase 2 (Alas2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_013197 XM_001062452
VERSION     NM_013197.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1899)
  AUTHORS   Barupala,D.P., Dzul,S.P., Riggs-Gelasco,P.J. and Stemmler,T.L.
  TITLE     Synthesis, delivery and regulation of eukaryotic heme and Fe-S
            cluster cofactors
  JOURNAL   Arch Biochem Biophys 592, 60-75 (2016)
   PUBMED   26785297
  REMARK    Review article
REFERENCE   2  (bases 1 to 1899)
  AUTHORS   Larion,S., Caballes,F.R., Hwang,S.I., Lee,J.G., Rossman,W.E.,
            Parsons,J., Steuerwald,N., Li,T., Maddukuri,V., Groseclose,G.,
            Finkielstein,C.V. and Bonkovsky,H.L.
  TITLE     Circadian rhythms in acute intermittent porphyria--a pilot study
  JOURNAL   Eur J Clin Invest 43 (7), 727-739 (2013)
   PUBMED   23650938
REFERENCE   3  (bases 1 to 1899)
  AUTHORS   Ducamp,S., Schneider-Yin,X., de Rooij,F., Clayton,J., Fratz,E.J.,
            Rudd,A., Ostapowicz,G., Varigos,G., Lefebvre,T., Deybach,J.C.,
            Gouya,L., Wilson,P., Ferreira,G.C., Minder,E.I. and Puy,H.
  TITLE     Molecular and functional analysis of the C-terminal region of human
            erythroid-specific 5-aminolevulinic synthase associated with
            X-linked dominant protoporphyria (XLDPP)
  JOURNAL   Hum Mol Genet 22 (7), 1280-1288 (2013)
   PUBMED   23263862
REFERENCE   4  (bases 1 to 1899)
  AUTHORS   To-Figueras,J., Ducamp,S., Clayton,J., Badenas,C., Delaby,C.,
            Ged,C., Lyoumi,S., Gouya,L., de Verneuil,H., Beaumont,C.,
            Ferreira,G.C., Deybach,J.C., Herrero,C. and Puy,H.
  TITLE     ALAS2 acts as a modifier gene in patients with congenital
            erythropoietic porphyria
  JOURNAL   Blood 118 (6), 1443-1451 (2011)
   PUBMED   21653323
REFERENCE   5  (bases 1 to 1899)
  AUTHORS   Haraguchi,T., Yanaka,N., Eguchi,Y., Kudo,T., Hirata,A. and Kato,N.
  TITLE     Fish oil feeding up-regulates the expression of 5-aminolevulinate
            synthase 2 mRNA in rat brain
  JOURNAL   Biosci Biotechnol Biochem 75 (7), 1383-1385 (2011)
   PUBMED   21737922
REFERENCE   6  (bases 1 to 1899)
  AUTHORS   Cotter,P.D., May,A., Fitzsimons,E.J., Houston,T., Woodcock,B.E.,
            al-Sabah,A.I., Wong,L. and Bishop,D.F.
  TITLE     Late-onset X-linked sideroblastic anemia. Missense mutations in the
            erythroid delta-aminolevulinate synthase (ALAS2) gene in two
            pyridoxine-responsive patients initially diagnosed with acquired
            refractory anemia and ringed sideroblasts
  JOURNAL   J Clin Invest 96 (4), 2090-2096 (1995)
   PUBMED   7560104
REFERENCE   7  (bases 1 to 1899)
  AUTHORS   Meguro,K., Igarashi,K., Yamamoto,M., Fujita,H. and Sassa,S.
  TITLE     The role of the erythroid-specific delta-aminolevulinate synthase
            gene expression in erythroid heme synthesis
  JOURNAL   Blood 86 (3), 940-948 (1995)
   PUBMED   7620186
REFERENCE   8  (bases 1 to 1899)
  AUTHORS   Senda,N., Hoshi,K. and Fujino,S.
  TITLE     Effects of perphenazine, chlorpromazine or CoCl2 on the activities
            of delta-aminolevulinic acid synthetase and heme oxygenase and on
            the content of hemoprotein in rat liver
  JOURNAL   Res Commun Chem Pathol Pharmacol 65 (1), 57-64 (1989)
   PUBMED   2781150
REFERENCE   9  (bases 1 to 1899)
  AUTHORS   Srivastava,R.C., Dwivedi,R.S., Kaur,G. and Srivastava,R.
  TITLE     Haem and drug-metabolizing enzymes in regenerating rat liver
  JOURNAL   Br J Exp Pathol 63 (1), 1-4 (1982)
   PUBMED   6895999
REFERENCE   10 (bases 1 to 1899)
  AUTHORS   Ariyoshi,T., Eguchi,M., Muraki,Y., Yasumatsu,H., Suetsugu,N. and
            Arizono,K.
  TITLE     Effects of chlorinated benzenes of the activities of
            delta-aminolevulinic acid synthetase and heme oxygenase and on the
            content of hemoprotein in the liver of rats
  JOURNAL   J Pharmacobiodyn 4 (1), 69-76 (1981)
   PUBMED   6895089
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D86297.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001062452.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86297.1, BC081857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1899
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1899
                     /gene="Alas2"
                     /note="5'-aminolevulinate synthase 2"
                     /db_xref="GeneID:25748"
                     /db_xref="RGD:2084"
     exon            1..196
                     /gene="Alas2"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1779
                     /gene="Alas2"
                     /EC_number="2.3.1.37"
                     /function="catalyses the condensation of succinyl-CoA and
                     glycine to form delta-aminolevulinic acid"
                     /note="ALAS-E; delta-ALA synthetase; delta-ALA synthase 2;
                     5-aminolevulinic acid synthase 2; delta-aminolevulinate
                     synthase 2; Aminolevulinate synthase 2, delta;
                     erythroid-specific delta-aminolevulinate synthase ALAS-E;
                     aminolevulinic acid synthase 2, erythroid;
                     aminolevulinate, delta-, synthase 2; aminolevulinic acid
                     synthase 2, erythroid-like"
                     /codon_start=1
                     /product="5-aminolevulinate synthase, erythroid-specific,
                     mitochondrial"
                     /protein_id="NP_037329.1"
                     /db_xref="GeneID:25748"
                     /db_xref="RGD:2084"
                     /translation="MVAAAMLLRSCPVLSKGPTGLLGKVAKTYQFLFGIGRCPILATQ
                     GPTCSQIHLKATKAGADSPSWTKSHCPFMLSELQDRKSKIVQRAAPEVQEDVKTFKTD
                     LLSFMESTTRSQSVPRFQDPEQTGGAPPLLIQNNMTGSQAFGYDQFFRDKIMEKKQDH
                     TYRVFKTVNRWANAYPFAQHFSEASMDSKDVSVWCSNDYLGISRHPRVLQAIEETLKN
                     HGAGAGGTRNISGTSKFHVELEQELAELHHKDSALLFSSCFVANDSTLFTLAKLLPGC
                     EIYSDAGNHASMIQGIRNSGAVKFVFRHNDPGHLKKLLEKSDPKTPKIVAFETVHSMD
                     GAICPLEELCDVAHQYGALTFVDEVHAVGLYGTRGAGIGERDGIMHKLDIISGTLGKA
                     FGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEGQALRRAH
                     QRNVKHMRQLLMDRGFPVIPCPSHIIPIRVGNAALNSKICDLLLAKHSIYVQAINYPT
                     VPRGEELLRLAPSPHHSPQMMENFVEKLLLAWTEVGLPLQDVSVAACNFCRRPVHFEL
                     MSEWERSYFGNMGPQYVTTYA"
     exon            197..319
                     /gene="Alas2"
                     /inference="alignment:Splign:2.1.0"
     exon            320..430
                     /gene="Alas2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..653
                     /gene="Alas2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..838
                     /gene="Alas2"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1018
                     /gene="Alas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1183
                     /gene="Alas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1452
                     /gene="Alas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1615
                     /gene="Alas2"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1899
                     /gene="Alas2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactttgggc tcaggatggt ggcagcagct atgttgctac ggtcctgtcc agtgctctct
       61 aagggcccca caggcctcct aggcaaagtg gctaaaactt accagttcct atttggtatt
      121 ggacgctgcc ccatcctggc cactcaagga ccaacctgtt ctcaaatcca tcttaaggca
      181 accaaggctg gagcagactc tccgtcttgg actaagagcc attgtccttt catgctgtca
      241 gaactccaag acaggaagag caagattgtg cagagggcag ctccagaagt ccaagaggat
      301 gtcaagactt tcaagacaga cctgctgagc ttcatggagt caactacccg aagccaatca
      361 gtgcctcgtt tccaggatcc agagcagact ggaggggcac ctcccctgct gattcagaat
      421 aatatgactg gaagccaggc ttttggttat gaccaatttt ttagagacaa gatcatggaa
      481 aagaagcagg accacacata ccgtgtgttc aagactgtga atcgctgggc taatgcctac
      541 ccctttgccc aacacttctc cgaggcatct atggactcaa aggatgtttc tgtctggtgc
      601 agtaatgact atttgggcat aagcaggcac cctcgtgtct tgcaggccat agaggagacc
      661 ctgaagaatc atggagctgg agctgggggc actcgcaata tctcaggtac aagcaagttt
      721 catgtggagc ttgaacagga gctggctgaa ctacatcata aggactcggc tctgctcttc
      781 tcctcctgtt ttgtggccaa tgattctact ctctttacac tggccaagct tctgccaggg
      841 tgtgagatct actcagacgc aggcaatcat gcctccatga tccaaggcat tcgtaacagt
      901 ggtgcagtca agtttgtctt cagacacaat gacccaggcc acctgaagaa acttcttgag
      961 aagtccgatc ccaagacacc aaaaattgtg gcttttgaga ctgttcactc catggatggt
     1021 gccatctgtc ctctggagga attgtgtgat gtggcccacc agtacggggc cctgaccttc
     1081 gtggatgaag tccatgccgt aggactatat ggaacccggg gtgcagggat cggggagcgt
     1141 gatggaatta tgcacaagct tgacatcatc tctggaactc ttggcaaggc ctttggctgt
     1201 gtcggtggct atatcgccag cactcgggac ttggtggaca tggtgcgctc ctacgctgca
     1261 ggcttcatct ttaccacttc actgcctccc atggtgctct ctggagctct agagtctgtg
     1321 cgtctactca agggagagga gggtcaagcc ctgaggcgtg cacaccagcg caacgtcaaa
     1381 catatgcgcc agctactaat ggacaggggc tttcctgtta tcccctgtcc cagccacatc
     1441 atccccataa gggtgggtaa tgcggcactc aacagcaaga tctgtgatct tctgctcgcc
     1501 aagcacagca tctatgtgca ggccatcaac tacccaactg tgcctcgtgg tgaggagctg
     1561 ctgcgcttgg ccccctcccc ccaccacagc cctcagatga tggaaaactt tgtggagaag
     1621 ttgctgctgg cctggactga ggtggggttg cccctccaag atgtgtctgt ggctgcatgc
     1681 aacttctgcc gtcgtcctgt gcactttgag cttatgagcg agtgggagcg atcctacttt
     1741 gggaacatgg gaccccaata tgttactacc tatgcctaag gagccagctg ccttagatgc
     1801 caaccccacc tgcactcccc ctggggatgg tcttcctcct actctctgct ttgctgtgtg
     1861 cttctagctg acttgattct aaaaataaag agcaacctg
//
