LOCUS       NM_024484               2197 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus 5'-aminolevulinate synthase 1 (Alas1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_024484
VERSION     NM_024484.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2197)
  AUTHORS   Barupala,D.P., Dzul,S.P., Riggs-Gelasco,P.J. and Stemmler,T.L.
  TITLE     Synthesis, delivery and regulation of eukaryotic heme and Fe-S
            cluster cofactors
  JOURNAL   Arch Biochem Biophys 592, 60-75 (2016)
   PUBMED   26785297
  REMARK    Review article
REFERENCE   2  (bases 1 to 2197)
  AUTHORS   Chen,H., Isayama,K., Kumazawa,M., Zhao,L., Yamauchi,N.,
            Shigeyoshi,Y., Hashimoto,S. and Hattori,M.A.
  TITLE     Integration of the nuclear receptor REV-ERBalpha linked with
            circadian oscillators in the expressions of Alas1, Ppargc1a, and
            Il6 genes in rat granulosa cells
  JOURNAL   Chronobiol Int 32 (6), 739-749 (2015)
   PUBMED   26102301
  REMARK    GeneRIF: REV-ERBalpha has a role in circadian oscillation in the
            expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa
            cells
REFERENCE   3  (bases 1 to 2197)
  AUTHORS   Seo,Y.M., Park,J.I., Jeon,M.J., Park,E.W., Park,J.K., Lee,H.C.,
            Chang,W.K. and Chun,S.Y.
  TITLE     Gonadotropin regulation of genes differentially expressed in
            response to PKCzeta inhibitor during ovulation in the rat
  JOURNAL   Life Sci 85 (3-4), 153-160 (2009)
   PUBMED   19467246
REFERENCE   4  (bases 1 to 2197)
  AUTHORS   Higashida,K., Higuchi,M. and Terada,S.
  TITLE     Potential role of lipin-1 in exercise-induced mitochondrial
            biogenesis
  JOURNAL   Biochem Biophys Res Commun 374 (3), 587-591 (2008)
   PUBMED   18656451
REFERENCE   5  (bases 1 to 2197)
  AUTHORS   Niittynen,M., Tuomisto,J.T. and Pohjanvirta,R.
  TITLE     Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on heme
            oxygenase-1, biliverdin IXalpha reductase and delta-aminolevulinic
            acid synthetase 1 in rats with wild-type or variant AH receptor
  JOURNAL   Toxicology 250 (2-3), 132-142 (2008)
   PUBMED   18657588
REFERENCE   6  (bases 1 to 2197)
  AUTHORS   Yamamoto,M., Kure,S., Engel,J.D. and Hiraga,K.
  TITLE     Structure, turnover, and heme-mediated suppression of the level of
            mRNA encoding rat liver delta-aminolevulinate synthase
  JOURNAL   J Biol Chem 263 (31), 15973-15979 (1988)
   PUBMED   3182776
REFERENCE   7  (bases 1 to 2197)
  AUTHORS   Srivastava,G., Borthwick,I.A., Maguire,D.J., Elferink,C.J.,
            Bawden,M.J., Mercer,J.F. and May,B.K.
  TITLE     Regulation of 5-aminolevulinate synthase mRNA in different rat
            tissues
  JOURNAL   J Biol Chem 263 (11), 5202-5209 (1988)
   PUBMED   3356687
REFERENCE   8  (bases 1 to 2197)
  AUTHORS   Bitar,M. and Weiner,M.
  TITLE     Heme and hemoproteins in streptozotocin-diabetic female rats
  JOURNAL   Biochem Pharmacol 32 (12), 1921-1928 (1983)
   PUBMED   6688350
REFERENCE   9  (bases 1 to 2197)
  AUTHORS   Maines,M.D. and Kappas,A.
  TITLE     Enzymes of heme metabolism in the kidney: regulation by trace
            metals which do not form heme complexes
  JOURNAL   J Exp Med 146 (5), 1286-1293 (1977)
   PUBMED   925603
REFERENCE   10 (bases 1 to 2197)
  AUTHORS   Maines,M.D., Janousek,V., Tomio,J.M. and Kappas,A.
  TITLE     Cobalt inhibition of synthesis and induction of
            delta-aminolevulinate synthase in liver
  JOURNAL   Proc Natl Acad Sci U S A 73 (5), 1499-1503 (1976)
   PUBMED   818637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Mar 18, 2021 this sequence version replaced NM_024484.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061793.1, SRR26360172.1778024.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000008.1  115768506-115768642 c
            138-357             JAXUCZ010000008.1  115767491-115767710 c
            358-591             JAXUCZ010000008.1  115765049-115765282 c
            592-741             JAXUCZ010000008.1  115763448-115763597 c
            742-964             JAXUCZ010000008.1  115762916-115763138 c
            965-1149            JAXUCZ010000008.1  115760625-115760809 c
            1150-1329           JAXUCZ010000008.1  115759802-115759981 c
            1330-1494           JAXUCZ010000008.1  115759246-115759410 c
            1495-1763           JAXUCZ010000008.1  115757656-115757924 c
            1764-1926           JAXUCZ010000008.1  115756777-115756939 c
            1927-2197           JAXUCZ010000008.1  115755238-115755508 c
FEATURES             Location/Qualifiers
     source          1..2197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2197
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /note="5'-aminolevulinate synthase 1"
                     /db_xref="GeneID:65155"
                     /db_xref="RGD:68392"
     exon            1..137
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /inference="alignment:Splign:2.1.0"
     exon            138..357
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2087
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /EC_number="2.3.1.37"
                     /note="aminolevulinic acid synthase 1; 5-aminolevulinate
                     synthase 1; 5-aminolevulinate synthase, nonspecific,
                     mitochondrial; 5-aminolevulinate synthase, non-specific,
                     mitochondrial; delta-ALA synthetase; delta-ALA synthase 1;
                     5-aminolevulinic acid synthase 1; delta-aminolevulinate
                     synthase 1; aminolevulinate, delta-, synthase 1"
                     /codon_start=1
                     /product="5-aminolevulinate synthase, non-specific,
                     mitochondrial precursor"
                     /protein_id="NP_077810.2"
                     /db_xref="GeneID:65155"
                     /db_xref="RGD:68392"
                     /translation="METVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPA
                     PRTVSTSAAQCQQVKETPPANEKEKTAKAAVQQAPDESQMAQTPDGTQLPPGHPSPST
                     SQSSGSKCPFLAAQLSQTGSSVFRKASLELQEDVQEMHAVRKEVAQSPVLPSLVNAKR
                     DGEGPSPLLKNFQDIMRKQRPERVSHLLQDNLPKSVSTFQYDHFFEKKIDEKKNDHTY
                     RVFKTVNRRAQIFPMADDYTDSLITKKQVSVWCSNDYLGMSRHPRVCGAVIETVKQHG
                     AGAGGTRNISGTSKFHVELEQELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEI
                     YSDSGNHASMIQGIRNSRVPKYIFRHNDVNHLRELLQRSDPSVPKIVAFETVHSMDGA
                     VCPLEELCDVAHEFGAITFVDEVHAVGLYGASGGGIGDRDGVMPKMDIISGTLGKAFG
                     CVGGYIASTSLLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSNEGRALRRQHQR
                     NVKLMRQMLMDAGLPVIHCPSHIIPVRVADAAKNTEICDELMTRHNIYVQAINYPTVP
                     RGEELLRIAPTPHHTPQMMNFFLEKLLLTWKRVGLELKPHSSAECNFCRRPLHFEVMS
                     EREKAYFSGMSKMVSAQA"
     exon            358..591
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /inference="alignment:Splign:2.1.0"
     exon            592..741
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /inference="alignment:Splign:2.1.0"
     exon            742..964
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1149
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1329
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1494
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1763
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1926
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2197
                     /gene="Alas1"
                     /gene_synonym="ALA-S; ALAS; ALAS-H; ALAS-N"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatgcgcag cggtcacccc cggctctata ttaggccaac agcggcccta gccgaggctg
       61 ttcgtgaaga agggcactgg tcggtttagc gtcctccgct cgagtgccca ccgccgtctc
      121 gtcgagagcc cgcgcaggac ccgggacact ttgcagacat ggagactgtc gttcgcagat
      181 gcccattctt atcccgagtc cctcaggcct ttctgcagaa ggcagggaaa tctctgctgt
      241 tctatgctca aaactgcccc aagatgatgg aagtcggggc caagccggct cctcggaccg
      301 tgtccacttc agcagcacag tgccagcagg tcaaagaaac ccctccagcc aatgagaaag
      361 agaaaactgc caaagccgca gtccagcagg ctcctgacga gtcccagatg gcacagactc
      421 cagacggcac acagctcccg cctggacacc cgtcaccctc tacaagccag agctctggga
      481 gcaagtgccc tttcctggca gcacagctga gccagacggg cagcagcgtc ttccgcaagg
      541 ccagtctgga gcttcaggag gacgtgcagg aaatgcatgc tgtgaggaaa gaggttgctc
      601 aaagcccagt gctccccagc ttggtcaatg caaaaaggga tggagaaggt ccaagcccac
      661 tgctgaagaa cttccaggac atcatgagaa agcaaaggcc agaaagagtg tctcatcttc
      721 ttcaggataa cttgccaaag tccgtttcca cttttcaata tgatcatttc tttgagaaga
      781 aaattgacga gaaaaaaaat gaccacacct accgagtttt taaaactgtg aaccggagag
      841 cacagatctt ccctatggca gatgactaca cggactccct catcaccaaa aagcaggtgt
      901 cggtctggtg cagcaatgac tatctaggca tgagtcgaca cccacgggtg tgtggggctg
      961 tcatagagac tgtgaaacag catggtgccg gagcaggtgg aactagaaat atttctggaa
     1021 cgagcaagtt ccatgtggaa ctggagcagg agctggctga cctccacggc aaggacgcgg
     1081 cgctcttgtt ctcttcctgc ttcgtggcca acgactccac tctcttcacc ctggctaaga
     1141 tgatgccagg ctgtgaaatt tactctgatt ccgggaacca tgcctccatg atccaaggga
     1201 ttcgcaacag tcgagtgcca aagtatatct tccgccacaa tgatgtcaac catctcagag
     1261 aactgttgca gagatccgac ccctcggtcc ccaagatcgt agcattcgaa actgtccatt
     1321 caatggatgg agcagtgtgc cccctggaag agctgtgtga tgtggcccat gagtttggag
     1381 cgatcacgtt tgtggacgag gtccatgcag tagggctcta tggggcttca ggtggaggga
     1441 tcggtgatcg ggatggagtc atgccaaaaa tggacatcat ttctggaaca ctcggtaaag
     1501 cgttcggctg tgttggagga tacattgcca gcacgagttt gctgatcgac accgtccggt
     1561 cctacgctgc gggcttcatc ttcaccacct ccctgccacc aatgctgctg gctggagccc
     1621 tggagtctgt gcggatcctg aagagcaatg agggacgtgc ccttcgccgc cagcaccagc
     1681 gcaatgtcaa gcttatgagg cagatgctaa tggacgctgg cctcccagtc atccactgcc
     1741 ccagccacat catccctgtg cgggttgccg atgctgctaa aaacacagaa atctgtgatg
     1801 agttgatgac caggcataat atctacgtcc aggccattaa ttacccaaca gtgcctcgtg
     1861 gggaggagct cctccggatc gcccccaccc cgcaccacac accgcagatg atgaacttct
     1921 tcctagagaa gctgctgctc acgtggaagc gagtcgggct ggaactgaag ccacattcgt
     1981 cagctgaatg caacttctgc aggaggccct tacacttcga agtgatgagc gagagagaga
     2041 aagcctattt ctcaggcatg agcaagatgg tgtctgccca ggcctgactg tgactcagtt
     2101 attcacaaac cccagaccat taccataccc aaatagtagc cagaattgtc tttatatgtg
     2161 aagtaaatta tatattaaat cttaatctat agtaaaa
//
