LOCUS       NM_012899               1278 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus aminolevulinate dehydratase (Alad), mRNA.
ACCESSION   NM_012899
VERSION     NM_012899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1278)
  AUTHORS   Barupala,D.P., Dzul,S.P., Riggs-Gelasco,P.J. and Stemmler,T.L.
  TITLE     Synthesis, delivery and regulation of eukaryotic heme and Fe-S
            cluster cofactors
  JOURNAL   Arch Biochem Biophys 592, 60-75 (2016)
   PUBMED   26785297
  REMARK    Review article
REFERENCE   2  (bases 1 to 1278)
  AUTHORS   Calgaroto,N.S., Thome,G.R., da Costa,P., Baldissareli,J.,
            Hussein,F.A., Schmatz,R., Rubin,M.A., Signor,C., Ribeiro,D.A.,
            Carvalho,F.B., de Oliveira,L.S., Pereira,L.B., Morsch,V.M. and
            Schetinger,M.R.
  TITLE     Effect of vitamin D3 on behavioural and biochemical parameters in
            diabetes type 1-induced rats
  JOURNAL   Cell Biochem Funct 32 (6), 502-510 (2014)
   PUBMED   24947461
REFERENCE   3  (bases 1 to 1278)
  AUTHORS   Schmatz,R., Perreira,L.B., Stefanello,N., Mazzanti,C.,
            Spanevello,R., Gutierres,J., Bagatini,M., Martins,C.C.,
            Abdalla,F.H., Daci da Silva Serres,J., Zanini,D., Vieira,J.M.,
            Cardoso,A.M., Schetinger,M.R. and Morsch,V.M.
  TITLE     Effects of resveratrol on biomarkers of oxidative stress and on the
            activity of delta aminolevulinic acid dehydratase in liver and
            kidney of streptozotocin-induced diabetic rats
  JOURNAL   Biochimie 94 (2), 374-383 (2012)
   PUBMED   21864646
REFERENCE   4  (bases 1 to 1278)
  AUTHORS   Bardag-Gorce,F. and French,S.W.
  TITLE     Delta-aminolevulinic dehydratase is a proteasome interacting
            protein
  JOURNAL   Exp Mol Pathol 91 (2), 485-489 (2011)
   PUBMED   21640720
REFERENCE   5  (bases 1 to 1278)
  AUTHORS   Franca,R.T., Da Silva,A.S., Wolkmer,P., Oliveira,V.A.,
            Pereira,M.E., Leal,M.L., Silva,C.B., Nunes,M.A., Dressler,V.L.,
            Mazzanti,C.M., Monteiro,S.G. and Lopes,S.T.
  TITLE     Delta-aminolevulinate dehydratase activity in red blood cells of
            rats infected with Trypanosoma evansi
  JOURNAL   Parasitology 138 (10), 1272-1277 (2011)
   PUBMED   21854703
REFERENCE   6  (bases 1 to 1278)
  AUTHORS   Abdulla,M., Svensson,S. and Haeger-Aronsen,B.
  TITLE     Antagonistic effects of zinc and aluminum on lead inhibition of
            delta-aminolevulinic acid dehydratase
  JOURNAL   Arch Environ Health 34 (6), 464-469 (1979)
   PUBMED   518129
REFERENCE   7  (bases 1 to 1278)
  AUTHORS   Simon,N. and Kiss,M.
  TITLE     Study of erythrocyte delta-aminolevulinic acid dehydratase activity
            in porphyria cutanea tarda
  JOURNAL   Arch Dermatol Res 266 (2), 121-126 (1979)
   PUBMED   526041
REFERENCE   8  (bases 1 to 1278)
  AUTHORS   Maines,M.D. and Kappas,A.
  TITLE     Enzymes of heme metabolism in the kidney: regulation by trace
            metals which do not form heme complexes
  JOURNAL   J Exp Med 146 (5), 1286-1293 (1977)
   PUBMED   925603
REFERENCE   9  (bases 1 to 1278)
  AUTHORS   Anderson,K.E., Sassa,S., Peterson,C.M. and Kappas,A.
  TITLE     Increased erythrocyte uroporphyrinogen-l-synthetase,
            delta-aminolevulinic acid dehydratase and protoporphyrin in
            hemolytic anemias
  JOURNAL   Am J Med 63 (3), 359-364 (1977)
   PUBMED   900140
REFERENCE   10 (bases 1 to 1278)
  AUTHORS   Maines,M.D.
  TITLE     Evidence for the catabolism of polychlorinated biphenyl-induced
            cytochrome P-448 by microsomal heme oxygenase, and the inhibition
            of delta-aminolevulinate dehydratase by polychlorinated biphenyls
  JOURNAL   J Exp Med 144 (6), 1509-1519 (1976)
   PUBMED   826600
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061806.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_012899.3.
            
            On Feb 9, 2004 this sequence version replaced NM_012899.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061806.1, FQ213585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1278
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..1278
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /note="aminolevulinate dehydratase"
                     /db_xref="GeneID:25374"
                     /db_xref="RGD:2083"
     exon            1..90
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
     exon            91..278
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1158
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /EC_number="4.2.1.24"
                     /note="ALADH; porphobilinogen synthase; delta -
                     aminolevulinic acid dehydratase; aminolevulinate, delta-,
                     dehydratase"
                     /codon_start=1
                     /product="delta-aminolevulinic acid dehydratase"
                     /protein_id="NP_037031.1"
                     /db_xref="GeneID:25374"
                     /db_xref="RGD:2083"
                     /translation="MHHQSVLHSGYFHPLLRAWQTTPSTVSATNLIYPIFVTDVPDDV
                     QPIASLPGVARYGVNQLEEMLRPLVEAGLRCVLIFGVPSRVPKDEQGSAADSEDSPTI
                     EAVRLLRKTFPTLLVACDVCLCPYTSHGHCGLLSENGAFLAEESRQRLAEVALAYAKA
                     GCQVVAPSDMMDGRVEAIKAALLKHGLGNRVSVMSYSAKFASCFYGPFRDAAQSSPAF
                     GDRRCYQLPPGARGLALRAVARDIQEGADILMVKPGLPYLDMVQEVKDKHPELPLAVY
                     QVSGEFAMLWHGAKAGAFDLRTAVLESMTAFRRAGADIIITYFAPQLLKWLKEE"
     exon            279..329
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
     exon            330..426
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
     exon            427..562
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
     exon            563..646
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
     exon            647..735
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
     exon            736..791
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
     exon            792..879
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
     exon            880..966
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1096
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1237
                     /gene="Alad"
                     /gene_synonym="ALADR; aminolevulinatedelta-dehydratase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccccgccc ccacgtgggc ttgcgctttt agagcgggag agcgctgtgt caagaatccg
       61 ggctcggagc ggtggtgagc agcgtctctg agctgaggct gcagcacaca ccccaggagc
      121 ctagactccg tcttagcaga ctgctgtgtt ccgccggccc ccaccatgca ccaccagtcc
      181 gttctgcaca gtggctactt tcacccactg cttcgggcct ggcagaccac cccctccacc
      241 gtcagtgcca ccaacctcat ctatcccatc tttgtcacgg atgttcctga tgatgtccag
      301 cccattgcca gcctcccggg agtggccagg tatggcgtaa accagctaga ggagatgctg
      361 agacctctgg tggaagccgg ccttcgctgt gtcctgatct ttggcgtccc cagcagagtt
      421 cccaaggatg aacagggctc tgcagctgac tcagaggact ccccaactat tgaggctgtc
      481 cgtctgctga ggaagacctt ccctaccctc ctagtggcct gtgatgtctg cctgtgcccc
      541 tacacctccc atggccactg tggcctcctg agtgaaaatg gagccttcct agcagaggaa
      601 agccgacaac ggttggcaga ggtggcactg gcctatgcca aggcaggttg tcaggttgta
      661 gctccatcag acatgatgga tggacgagtt gaagccatca aggctgccct gctaaaacat
      721 ggacttggca acagggtctc tgtgatgagc tatagtgcca aatttgcctc ctgtttctat
      781 ggtcctttcc gggatgcagc tcagtcaagc ccagctttcg gagaccgacg ctgttatcag
      841 ctgcctcctg gagcccgtgg cctggccctc cgagcagtgg cccgggacat tcaagaggga
      901 gctgacatac tcatggtaaa gccgggatta ccctacctgg atatggtgca ggaggtgaag
      961 gacaagcacc ccgagctccc cctcgcagta taccaggtgt ccggagagtt tgccatgttg
     1021 tggcacggag ccaaggctgg ggcctttgat ctcaggactg ctgtactgga gtccatgacg
     1081 gccttccgca gagccggtgc tgacattatc atcacctact ttgcacccca gctgttgaag
     1141 tggctgaagg aagagtgaag gaaagtgaag gacttggtct tgacagagct ccctgggcct
     1201 tacagaaggg aaaaagtaaa ggcgctgtta gaactgtaaa aaaaaaaaaa aaaaaaaaaa
     1261 aaaaaaaaaa aaaaaaaa
//
