LOCUS       NM_031575               6854 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus AKT serine/threonine kinase 3 (Akt3), transcript
            variant 1, mRNA.
ACCESSION   NM_031575
VERSION     NM_031575.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6854)
  AUTHORS   Xiao,C., Liu,J., Cheng,Y., Wu,Y., Li,Q., Chen,X., Yuan,J., Dong,Q.,
            Li,L., Liu,Y. and Shen,F.
  TITLE     RUNX1 targeting AKT3 promotes alveolar hypercoagulation and
            fibrinolytic inhibition in LPS induced ARDS
  JOURNAL   Respir Res 25 (1), 54 (2024)
   PUBMED   38267920
  REMARK    GeneRIF: RUNX1 targeting AKT3 promotes alveolar hypercoagulation
            and fibrinolytic inhibition in LPS induced ARDS.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6854)
  AUTHORS   Meng,Z., Shen,W., Yu,L., Tong,F., He,H., Hu,Y., Wu,W. and Liu,J.
  TITLE     Bach1 modulates AKT3 transcription to participate in
            hyperglycaemia-mediated EndMT in vascular endothelial cells
  JOURNAL   Clin Exp Pharmacol Physiol 50 (6), 443-452 (2023)
   PUBMED   36752556
  REMARK    GeneRIF: Bach1 modulates AKT3 transcription to participate in
            hyperglycaemia-mediated EndMT in vascular endothelial cells.
REFERENCE   3  (bases 1 to 6854)
  AUTHORS   Wang,Y., Zhang,R., Li,J., Han,X., Lu,H., Su,J., Liu,Y., Tian,X.,
            Wang,M., Xiong,Y., Lan,T., Zhang,G. and Liu,Z.
  TITLE     MiR-22-3p and miR-29a-3p synergistically inhibit hepatic stellate
            cell activation by targeting AKT3
  JOURNAL   Exp Biol Med (Maywood) 247 (19), 1712-1731 (2022)
   PUBMED   35833537
  REMARK    GeneRIF: MiR-22-3p and miR-29a-3p synergistically inhibit hepatic
            stellate cell activation by targeting AKT3.
REFERENCE   4  (bases 1 to 6854)
  AUTHORS   Campion,T.J. 3rd, Sheikh,I.S., Smit,R.D., Iffland,P.H. 2nd,
            Chen,J., Junker,I.P., Krynska,B., Crino,P.B. and Smith,G.M.
  TITLE     Viral expression of constitutively active AKT3 induces CST axonal
            sprouting and regeneration, but also promotes seizures
  JOURNAL   Exp Neurol 349, 113961 (2022)
   PUBMED   34953897
  REMARK    GeneRIF: Viral expression of constitutively active AKT3 induces CST
            axonal sprouting and regeneration, but also promotes seizures.
REFERENCE   5  (bases 1 to 6854)
  AUTHORS   Alrubaye,A., Motovali-Bashi,M. and Miroliaei,M.
  TITLE     Rosmarinic acid inhibits DNA glycation and modulates the expression
            of Akt1 and Akt3 partially in the hippocampus of diabetic rats
  JOURNAL   Sci Rep 11 (1), 20605 (2021)
   PUBMED   34663861
  REMARK    GeneRIF: Rosmarinic acid inhibits DNA glycation and modulates the
            expression of Akt1 and Akt3 partially in the hippocampus of
            diabetic rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6854)
  AUTHORS   Borgatti,P., Martelli,A.M., Tabellini,G., Bellacosa,A., Capitani,S.
            and Neri,L.M.
  TITLE     Threonine 308 phosphorylated form of Akt translocates to the
            nucleus of PC12 cells under nerve growth factor stimulation and
            associates with the nuclear matrix protein nucleolin
  JOURNAL   J Cell Physiol 196 (1), 79-88 (2003)
   PUBMED   12767043
REFERENCE   7  (bases 1 to 6854)
  AUTHORS   Webster,C.R., Srinivasulu,U., Ananthanarayanan,M., Suchy,F.J. and
            Anwer,M.S.
  TITLE     Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated
            Na+/taurocholate cotransport and Ntcp translocation
  JOURNAL   J Biol Chem 277 (32), 28578-28583 (2002)
   PUBMED   12034724
REFERENCE   8  (bases 1 to 6854)
  AUTHORS   Kageyama,K., Ihara,Y., Goto,S., Urata,Y., Toda,G., Yano,K. and
            Kondo,T.
  TITLE     Overexpression of calreticulin modulates protein kinase B/Akt
            signaling to promote apoptosis during cardiac differentiation of
            cardiomyoblast H9c2 cells
  JOURNAL   J Biol Chem 277 (22), 19255-19264 (2002)
   PUBMED   11907032
  REMARK    GeneRIF: Overexpression of calreticulin modulates protein kinase
            B/Akt signaling to promote apoptosis
REFERENCE   9  (bases 1 to 6854)
  AUTHORS   Turinsky,J. and Damrau-Abney,A.
  TITLE     Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in
            vivo: study with insulin and exercise
  JOURNAL   Am J Physiol 276 (1), R277-R282 (1999)
   PUBMED   9887206
REFERENCE   10 (bases 1 to 6854)
  AUTHORS   Konishi,H., Kuroda,S., Tanaka,M., Matsuzaki,H., Ono,Y.,
            Kameyama,K., Haga,T. and Kikkawa,U.
  TITLE     Molecular cloning and characterization of a new member of the RAC
            protein kinase family: association of the pleckstrin homology
            domain of three types of RAC protein kinase with protein kinase C
            subspecies and beta gamma subunits of G proteins
  JOURNAL   Biochem Biophys Res Commun 216 (2), 526-534 (1995)
   PUBMED   7488143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 20, 2020 this sequence version replaced NM_031575.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2332745.1,
                                           SRR26360194.1517424.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000013.1  91747858-91747949   c
            93-218              JAXUCZ010000013.1  91629253-91629378   c
            219-330             JAXUCZ010000013.1  91606824-91606935   c
            331-475             JAXUCZ010000013.1  91594864-91595008   c
            476-607             JAXUCZ010000013.1  91591615-91591746   c
            608-673             JAXUCZ010000013.1  91568147-91568212   c
            674-742             JAXUCZ010000013.1  91566734-91566802   c
            743-865             JAXUCZ010000013.1  91529031-91529153   c
            866-994             JAXUCZ010000013.1  91521123-91521251   c
            995-1209            JAXUCZ010000013.1  91504939-91505153   c
            1210-1297           JAXUCZ010000013.1  91498145-91498232   c
            1298-1400           JAXUCZ010000013.1  91487070-91487172   c
            1401-6854           JAXUCZ010000013.1  91475839-91481292   c
FEATURES             Location/Qualifiers
     source          1..6854
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q25"
     gene            1..6854
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /note="AKT serine/threonine kinase 3"
                     /db_xref="GeneID:29414"
                     /db_xref="RGD:62390"
     exon            1..92
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1486
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /EC_number="2.7.11.1"
                     /note="AKT3 kinase; PKB gamma; RAC-PK-gamma; protein
                     kinase Akt-3; protein kinase B, gamma; thymoma viral
                     proto-oncogene 3; v-akt murine thymoma viral oncogene
                     homolog 3 (protein kinase B, gamma); v-akt murine thymoma
                     viral oncogene 3"
                     /codon_start=1
                     /product="RAC-gamma serine/threonine-protein kinase"
                     /protein_id="NP_113763.2"
                     /db_xref="GeneID:29414"
                     /db_xref="RGD:62390"
                     /translation="MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQD
                     VDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAI
                     QAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFG
                     KVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTK
                     DRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLEN
                     LMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGV
                     VMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGG
                     PDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPE
                     KYDDDGMDCMDNERRPHFPQFSYSASGRE"
     exon            93..218
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     exon            219..330
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     exon            331..475
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     exon            476..607
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     exon            608..673
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     exon            674..742
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     exon            743..865
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     exon            866..994
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1209
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1297
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1400
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..6854
                     /gene="Akt3"
                     /gene_synonym="Pkbg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcagagca ccatttctcc aagttggggg ctcagaggga gccatcatga gcgatgttac
       61 catcgttaaa gaaggctggg ttcagaagag gggagaatat ataaaaaatt ggaggccaag
      121 atacttcctt ttgaagacag acggctcatt cataggctat aaagagaaac ctcaagatgt
      181 ggacttacct tatcccctca acaacttctc agtggcaaaa tgtcaattaa tgaaaacaga
      241 acgaccaaag ccaaatacat ttattatcag atgtcttcag tggaccactg ttatagagag
      301 aacatttcat gtagatactc cagaggaaag agaagaatgg acagaagcta tccaagctgt
      361 agccgatcga ctgcagaggc aagaagagga gaggatgaat tgtagtccaa cgtcacagat
      421 tgataatatt ggagaggaag agatggatgc atctacaacc catcataaaa gaaagacaat
      481 gaatgatttt gactatttga aactgctagg taaaggcact tttgggaagg ttattttggt
      541 tcgagagaag gcaagtggaa aatactacgc tatgaagatt ctgaagaaag aagtcattat
      601 cgcaaaggat gaagtggcac atactctgac tgagagcaga gttctaaaga acaccagaca
      661 tccatttcta acatccttga aatattcctt ccagacaaaa gaccgtttgt gttttgtgat
      721 ggaatatgtt aatgggggag agctgttttt ccatttgtcg agagagcggg tgttctctga
      781 ggaccgcaca cgtttctatg gtgcagaaat tgtctctgct ttggactatc tacattctgg
      841 aaagattgtg taccgagatc tcaagttgga gaatttgatg ctagataagg atggccatat
      901 aaaaattacg gattttggac tttgcaaaga agggatcaca gatgcagcta ccatgaagac
      961 attctgtggt acaccagagt atctggcacc agaggtatta gaagataatg actatggccg
     1021 agctgtggac tggtggggcc taggtgttgt catgtatgaa atgatgtgtg ggaggttgcc
     1081 tttctacaac caggatcatg agaaactctt tgaactaata ctcatggaag acatcaaatt
     1141 cccccgaaca ctctcttcag atgcaaagtc attgctttca gggctcttga taaaggatcc
     1201 aaataaacgc cttggtggag ggccagatga tgcaaaagag ataatgaggc acagtttctt
     1261 ttctggagta aactggcagg acgtatatga caaaaagctt gtacctcctt ttaagcctca
     1321 agtaacatct gagacagaca ccagatattt cgatgaagaa tttacagctc agactattac
     1381 aataacacca cctgaaaagt atgacgacga cggcatggac tgcatggata atgagcggcg
     1441 gccacacttc cctcagttct cctactctgc aagcggacgg gaataagttc ctttcagtct
     1501 gtctctacac tgtcatctta gattttgcca ctgagaatga ttcctggaca tctccaccag
     1561 tcctcgctct tacagttagc aggggcacct tctgacatcc ctgaccagcc aagggtcttc
     1621 accctcacca cctctcaccc acatgaaacc atagacacag acactccagt tttgtttttg
     1681 catgaaattg tatctcagtc taaggtctca tgctgttgct gctactgtct tactattata
     1741 caactttcag aagtaatttt acaacctttg ggagtcatgg gcccattgtt catttgtgca
     1801 tcaagtgtca tcttcttttg gtttttggtt ttccctagca gtgaaggcta tatgagatac
     1861 actgattcta ggtacattgt taactttcta ggagataaat caagaactaa ttagactaag
     1921 aagatttagt ttctatttct gaacaagcag ttgttaaagg gtggtggtgt gtgtatgtaa
     1981 gagtttagca gcgcatgtct gaccagcaca tgaagtgtgt atcactgaca tttggctgga
     2041 aatccttagg aaacattgag aggactgaag ggccgatttg agatacacat agctttttaa
     2101 ttcctgctgg atattgtgga ggaagcccag tgccacctat ggacacccag atttcaaggg
     2161 cagatggaga ccgttcaacc aagcactgaa ggtgcagagt cacctagaaa ggcttagggt
     2221 ctactttgta ccagagagta tttcccctgg gcttggcaac cttttccctt tcttgacatt
     2281 tatcacctct gatggctgaa gaatgtagac agtacagtga tcctgctgtc accaaaatcc
     2341 atacaccaag gtggacgggt gtttgcctta ccagttttga agttgttact ttcagttata
     2401 ggtaaattag ctttttctca gatgttaaaa ctttgaatgt cctttatggt tttgtttcta
     2461 ttacggtagt atttattttt tagtggtaag aattgtgttg tcatgttagc aagcgcagct
     2521 ccaattcgca gctccaattc acaggtcatt gcctgtggtt tctttccacc catgtgcaag
     2581 gaatgtacac acccattaga atcatgcact tttctcctag gtaagaagaa atggtaaggc
     2641 tctgggattg tatctgtggt tagaatctgg ttagagcctt tgggagagga gatgctgtaa
     2701 tttgacccct tggagctgaa atgagaaaat cccaataccc aatgccaagg ggttggtaga
     2761 gcaagtggat atgagagtat agcctagcat aaagtaatgg agagagcgga gacccggtga
     2821 cgatgagaaa tgcactctcc tcagcaaagt gaacacatca caaccattca cacagtagca
     2881 aggaaaggat aagaagaagg tgatgtgttt attcttatca aggtacattc attactgaat
     2941 caagccatca gggaaaacaa caaaacaaaa cacctctagc ttttattttt ctgtacatac
     3001 tcatgtctcc caacccaaac atttctcact gagaggggac atgtatgcaa acctcatctt
     3061 tctccttcat taatgatgat cttcagatta aaccctttgg tgctaggagc tgacactttc
     3121 caaagcagac tatgaagtcc aaggatcaaa gcctttcttg cagcaagcaa gagggcaact
     3181 gctgctccaa ggagtgatta cggaaatgga ttccagctac tgactggcag ctcccaaatg
     3241 gaagacgaca gtgtgaccta gcagtgtcac tgcagtgtgg gtgtgcgtag gaagtcatgc
     3301 tctcatgcag atgtcttggc ctctgggctc ggacttaggg aagcagagcc gctgctggcg
     3361 gtggctggcc gctgggaccg ctgggaccgc tgggacgtaa agggcatttt actaaggcag
     3421 ctaagactga ctcagacata gattttgtcc tcatttttca tgtttctacc tgggtgagtt
     3481 tacccttagt gggaagtagg aagttaaaca ggtgtacagc cttacatctg cagtcttctt
     3541 ttttcctaca tacaagtatg ttgaatgttt cacactgaca agaaagtaga ttagatggta
     3601 tgtcctttaa gttaccttgc atccattctg gaagaaagaa gtaggagagg aagaaaagca
     3661 agccgagcct ggctgatgtt cagagcattt atccttcaga aggagcagac actgtatact
     3721 aagcacacag ctgcttttga ctcctcccaa gtcttaaggt aatttcatga ccttggccaa
     3781 ggatacttgg tgaagattaa tgaggggaca ttgacaatgc ctcaggctgg ccactcctca
     3841 cacctggcct ttggtcccca gcctttcaag ggactgctca tcccatccct aactccccgg
     3901 gtgtcacagc aggcgcattc ttggctttga tttcaagagt tctctcctgg caccttccac
     3961 cagatgtcag ttaaagggca ggagtagagc agagaggtgt ggggaggagg ctctgaaatc
     4021 ttaagttgcc taggcctaca gcttagggct ctggcagttg aaatggcccg aaacggggca
     4081 tcatcatgtc tggatgcggc tctggctttg tgattccagc tcctaccagc tccaccttga
     4141 cctcttgtca ccatgcaggg ctgtctggga ggaaactggc cacttgtgct cagactgctg
     4201 ccagcattct cacagctttg ctctccacat taatgaccta gattattcca gtattgtttc
     4261 catttcccac ctgacctcca gcttctcaga gctgacttct tgcaggggcc acatgcttct
     4321 ctttccctca ctaactgcag ggtctccagc acacctcagt gtacacactt tgctgctacc
     4381 gtctgtactg tctacatcac aattccctga gcttgctcct ggtactgcat tacaggcaag
     4441 catgaagtgt aaagtattta tttaaataaa aaggaaacct ctggattggt caccgagtca
     4501 cctccctata gattcgtagt ctgtggcata ttttgacttt ctagttcttc tgctagatcc
     4561 atacaaggtc tggtcatctg gttaagggtt tgaagcagac acagctacga acccggatgc
     4621 tgtcatcact gtcacggctg gctacactac agatgttcgt gtccttacat ttatgaccac
     4681 agggtgtgaa gtaactacca agaacctggt tttgtacact gtacacctcg gtatctcaca
     4741 ctctgacagg gacacacatg acttccttcg tacagacagc ttaaataaag ccctgtgtca
     4801 atccgctact cctctgtttg ttgttgttgg atatggctct gtaacttcag aaaactaaat
     4861 ttcgttcttt tctggaaaaa ggactatagc cccagctgtt attaaccagc ctgtatgacg
     4921 gtgtgacagg aaaagaggta aatagataag acacagacgg ggtgttcccc ttgaccaaaa
     4981 tgccaatagc ctgtgtgttt gtagcaactg atgaagggct aggagtgcag tccctggcca
     5041 ccagcagcag attttaaggc acatctacta ggatgccaga aaaagagtag attgcagacc
     5101 ctaaaggtct tgataagaaa tggtgtgggc cccaaattct caaggaatgc agcttgtcac
     5161 taatgtcttc ctgataacac acagctccag acacttcttt gcaagtgtat ctttaaccct
     5221 tcatgtcagt ttataacgta gacatagtaa tcgatggcca gaatgtctgg attacattgt
     5281 tttggatggg gtgtatttct gattttacct cataagctac aactgtagaa cttggctttg
     5341 ctcttgtgag ttcaacaggg agaggagtga cttttgggac cagttagtca ggcatgcatg
     5401 tgtatttctc acagccaaat ctggaggcat tcttacatgt gctgtcctca aaatcaactg
     5461 gggttggcag atccatgagg ctgaaataaa gtgacctcta caactcttta aaggtgctat
     5521 ttttagaata ttgtataatt tattcatggt ataaatacat aaaacagaat tgaggacagt
     5581 taaaatatgt gacagcttta ttgctagcac atttgatgaa accagaaact tctcagaata
     5641 gaagttctgc tgttcgaggc ttgcaccttt gacatgcccc agagatgagg atggcccatg
     5701 caccgtcctg ctaccaccac ctccatggcc taagctgcat gtttgtgagg ggcaggctga
     5761 gcatgtggac accaggcctc agctgagcgc cctgggctgc tgggctgctg ggctgctggc
     5821 agggagaggt gaggtgtcac atgcagcctt gcccccagtg tttcatccca ccctcaaacg
     5881 ccgtgaccat ctcagcatcc aggctctatt cctgtctgtc tgttcgcttt tgttttttgt
     5941 ttttgtcttc gttcgttttg tggagccggg agaggacccc ggggcctcac atgctgggca
     6001 agtgccctgc caccgagcta caccccagac cttccagtgt ccatttgtgt tcctttaaag
     6061 catttgaggg cttgactgta tagtagaaat actattttag actaagaata tgatctgtgt
     6121 acagatattt gatatactgt taagtaaatt ttctaatttc acatacattt gtttttaggc
     6181 tcctctcaag tactgctatt gaagacaaaa atctgacacc atcgagccaa agatgccttt
     6241 tttgggggag gggggagggg tttgctttgt gttgtttaga gaatgggaaa ataatgcaga
     6301 gtgcttcctg agtgcacaca gttcagtggg aaatgctgaa tgctggctac tggcagacat
     6361 gatcacgggg ggtgggggga gaaaatggtg accggcagga ggagaggtgg tcttcagtac
     6421 actttggctg acttcaaaca tgtgcctttt ggtgtgtttt gtcattgcta caaaatgaaa
     6481 aggaaacaga acaactcaag tctttagaaa gactttttat taatccctgt gcatacttta
     6541 gagacaaggg aaatcagtga cttgaagctg ttctgagcac acactcccga ctagccctag
     6601 ccagttgacg ctgaagcact ccctgtctgt agcacaggga caggccatgg cgtgaggacc
     6661 agcccccctg cagtccctgc tggtgtctcc ctggggaggt ttcggtgcac tgtgcacatt
     6721 aagtacaaat cagatgaatg taaatatctc tttgtaaatc atttatttca ctctgtttca
     6781 tccaggtcag caatcagatt gtggcatgct gggtaactgg aaaaaaatga taataaaaag
     6841 taagtttaaa taga
//
