LOCUS       NM_017093               1984 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus AKT serine/threonine kinase 2 (Akt2), mRNA.
ACCESSION   NM_017093
VERSION     NM_017093.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1984)
  AUTHORS   Xu,Q., Yu,Z.X., Xie,Y.L., Bai,L., Liang,S.R., Ji,Q.H. and Zhou,J.
  TITLE     MicroRNA-137 inhibits pituitary prolactinoma proliferation by
            targeting AKT2
  JOURNAL   J Endocrinol Invest 46 (6), 1145-1154 (2023)
   PUBMED   36427136
  REMARK    GeneRIF: MicroRNA-137 inhibits pituitary prolactinoma proliferation
            by targeting AKT2.
REFERENCE   2  (bases 1 to 1984)
  AUTHORS   Kong,W., Peng,Y., Ji,C., Liu,Z., Gao,S., Zhang,Y., Chen,J., Li,X.,
            Bao,M., Zhang,Y., Jiang,Q., Wang,F., Li,Z., Bian,X. and Ye,J.
  TITLE     Akt2 deficiency alleviates oxidative stress in the heart and liver
            via up-regulating SIRT6 during high-fat diet-induced obesity
  JOURNAL   Clin Sci (Lond) 137 (10), 823-841 (2023)
   PUBMED   37184210
  REMARK    GeneRIF: Akt2 deficiency alleviates oxidative stress in the heart
            and liver via up-regulating SIRT6 during high-fat diet-induced
            obesity.
REFERENCE   3  (bases 1 to 1984)
  AUTHORS   Das,F., Ghosh-Choudhury,N., Lee,D.Y., Gorin,Y., Kasinath,B.S. and
            Choudhury,G.G.
  TITLE     Akt2 causes TGFbeta-induced deptor downregulation facilitating mTOR
            to drive podocyte hypertrophy and matrix protein expression
  JOURNAL   PLoS One 13 (11), e0207285 (2018)
   PUBMED   30444896
  REMARK    GeneRIF: data identify previously unrecognized Akt2 kinase as a
            driver of TGFbeta induced deptor downregulation and sustained
            mTORC1 and mTORC2 activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1984)
  AUTHORS   Nedvedova,I., Kolar,D., Elsnicova,B., Hornikova,D., Novotny,J.,
            Kalous,M., Pravenec,M., Neckar,J., Kolar,F. and Zurmanova,J.M.
  TITLE     Mitochondrial genome modulates myocardial Akt/Glut/HK salvage
            pathway in spontaneously hypertensive rats adapted to chronic
            hypoxia
  JOURNAL   Physiol Genomics 50 (7), 532-541 (2018)
   PUBMED   29676955
REFERENCE   5  (bases 1 to 1984)
  AUTHORS   Zhang,Z., Fang,P., Guo,L., He,B., Shi,M., Zhu,Y. and Bo,P.
  TITLE     Akt2-Dependent Beneficial Effect of Galanin on Insulin-Induced
            Glucose Uptake in Adipocytes of Diabetic Rats
  JOURNAL   Cell Physiol Biochem 41 (5), 1777-1787 (2017)
   PUBMED   28365702
  REMARK    GeneRIF: The results of this study suggest that phosphorylation of
            Akt2 mediates the beneficial effects of galanin on insulin-induced
            glucose uptake in the adipocytes of diabetic rats.
REFERENCE   6  (bases 1 to 1984)
  AUTHORS   Kupriyanova,T.A. and Kandror,K.V.
  TITLE     Akt-2 binds to Glut4-containing vesicles and phosphorylates their
            component proteins in response to insulin
  JOURNAL   J Biol Chem 274 (3), 1458-1464 (1999)
   PUBMED   9880520
REFERENCE   7  (bases 1 to 1984)
  AUTHORS   Turinsky,J. and Damrau-Abney,A.
  TITLE     Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in
            vivo: study with insulin and exercise
  JOURNAL   Am J Physiol 276 (1), R277-R282 (1999)
   PUBMED   9887206
REFERENCE   8  (bases 1 to 1984)
  AUTHORS   Calera,M.R., Martinez,C., Liu,H., Jack,A.K., Birnbaum,M.J. and
            Pilch,P.F.
  TITLE     Insulin increases the association of Akt-2 with Glut4-containing
            vesicles
  JOURNAL   J Biol Chem 273 (13), 7201-7204 (1998)
   PUBMED   9516411
REFERENCE   9  (bases 1 to 1984)
  AUTHORS   Konishi,H., Kuroda,S., Tanaka,M., Matsuzaki,H., Ono,Y.,
            Kameyama,K., Haga,T. and Kikkawa,U.
  TITLE     Molecular cloning and characterization of a new member of the RAC
            protein kinase family: association of the pleckstrin homology
            domain of three types of RAC protein kinase with protein kinase C
            subspecies and beta gamma subunits of G proteins
  JOURNAL   Biochem Biophys Res Commun 216 (2), 526-534 (1995)
   PUBMED   7488143
REFERENCE   10 (bases 1 to 1984)
  AUTHORS   Konishi,H., Shinomura,T., Kuroda,S., Ono,Y. and Kikkawa,U.
  TITLE     Molecular cloning of rat RAC protein kinase alpha and beta and
            their association with protein kinase C zeta
  JOURNAL   Biochem Biophys Res Commun 205 (1), 817-825 (1994)
   PUBMED   7999118
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D30041.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D30041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1984
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1984
                     /gene="Akt2"
                     /note="AKT serine/threonine kinase 2"
                     /db_xref="GeneID:25233"
                     /db_xref="RGD:2082"
     exon            1..196
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            197..327
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1727
                     /gene="Akt2"
                     /EC_number="2.7.11.1"
                     /note="murine thymoma viral (v-akt) oncogene homolog 2;
                     protein kinase B beta; PKB beta; RAC-PK-beta; protein
                     kinase Akt-2; thymoma viral proto-oncogene 2; AKT2 kinase;
                     RAC protein kinase beta RAC-PK beta; v-akt murine thymoma
                     viral oncogene homolog 2"
                     /codon_start=1
                     /product="RAC-beta serine/threonine-protein kinase"
                     /protein_id="NP_058789.1"
                     /db_xref="GeneID:25233"
                     /db_xref="RGD:2082"
                     /translation="MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEA
                     PDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWIRA
                     IQMVANSLKQRGPGEDAMDYKCGSPSDSSTSEMMEVAVSKARAKVTMNDFDYLKLLGK
                     GTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYA
                     FQTHDRLCFVMEYANGGDLFFHLSRERVFTEDRARFYGAEIVSALEYLHSTDVVYRDI
                     KLENLMLDKDGHIKITDFGLSKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWW
                     GLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLGPEAKSLLAGLLKKDPKQR
                     LGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITI
                     TPPDRYDSLGSLELDQRTHFPQFSYSASIRE"
     exon            328..456
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..568
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..722
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            723..854
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            855..920
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            921..989
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1112
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1241
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1456
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1544
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1647
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1984
                     /gene="Akt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcttagg aagccttcag tttggatccc aaggcctcct tgatcctgca cctggagctc
       61 tgttagcacc gttctttctg agtcctgttt ctgcgcgtgc tacgcttacg cacctgcctc
      121 cttgggcact caagctcgga actggatttc cactgacctt gtatctgatt ttctaaaagg
      181 ccttcactaa attaagacta tactgtatcg gaggagcctc ctacatgtcc tgctgccctg
      241 agctctctca agctaggtga cagcgtgtta atgctgccac catgaatgag gtatctgtca
      301 tcaaagaagg ctggctccac aaacgtggtg aatacatcaa gacctggagg ccccggtact
      361 tccttctgaa gagtgatgga tcttttattg ggtataaaga gagacctgag gcccccgacc
      421 agaccctacc cccccttaac aatttctctg tagcagaatg ccagctgatg aagactgaga
      481 ggccacgacc caacaccttt gtcatacgct gcctgcagtg gaccacagtc atcgagagga
      541 ccttccatgt cgactctcca gatgagaggg aagagtggat acgggctatc cagatggtag
      601 ccaacagtct gaagcagcgg ggccccgggg aggatgccat ggattacaag tgtggctccc
      661 ccagtgactc ttccacatct gagatgatgg aggtagcggt cagcaaggca cgggccaaag
      721 tgaccatgaa cgacttcgat tatctcaaac tcctcggcaa gggcaccttc ggcaaagtca
      781 ttctagttcg agagaaggcc actggccgct attatgccat gaagatcctg cggaaggagg
      841 tcatcattgc aaaggatgaa gtcgcccaca cagtcacaga gagccgagtc ctacagaata
      901 ccaggcaccc cttccttaca gccctgaagt atgccttcca gacccatgac cgcctgtgct
      961 ttgtgatgga gtatgccaac gggggcgacc tgtttttcca cctctctcgg gagcgagtct
     1021 tcacggagga tcgggcacgc ttttatggtg cagagattgt gtcagctctg gagtacttgc
     1081 actcgacgga tgtggtgtac cgcgacatca agctggaaaa ccttatgctg gacaaagatg
     1141 gccacatcaa gatcactgac tttggcttgt ccaaagaggg catcagtgat ggggccacca
     1201 tgaaaacctt ctgtggtacc ccggagtact tggcgcctga ggtgctagag gacaatgact
     1261 acgggcgtgc agtggactgg tggggactgg gcgtggtcat gtacgagatg atgtgcggcc
     1321 gcctgccctt ctacaaccag gaccacgagc gcctcttcga gctcatcctc atggaggaga
     1381 tccggttccc acgcacgctt gggccagagg ccaagtccct gctggctgga ctgctcaaga
     1441 aggaccccaa gcagaggctc ggtgggggtc ccagtgatgc caaggaggtc atggagcatc
     1501 ggttcttcct cagcatcaac tggcaggatg tggtacagaa gaagctcctg ccacccttca
     1561 aacctcaggt cacttcagaa gtggacacaa ggtactttga tgatgaattc accgcccagt
     1621 ccatcacaat cacaccccca gaccgatatg acagcctggg ctcgctggaa ctggaccagc
     1681 gcacacactt cccccagttc tcctactcag ccagcatccg agagtgagca gccctctgcc
     1741 accacaggac acagcatggg cgccatccac tgcctgggtg gctttttaaa aaaaacttta
     1801 ttttgccttt ggtttgcgtt cccttccctg tcccctcatc ccatatccag tttcttcttc
     1861 agttcttgct cagacttagt ggtcctggcg ggcctctcct ccgggctccc ctctgctccc
     1921 agaggagtgc tgggaacctg cccaaggaca ggccgttggg aggatggaga gtgaggttat
     1981 taat
//
