LOCUS       NM_033230               1606 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus AKT serine/threonine kinase 1 (Akt1), mRNA.
ACCESSION   NM_033230
VERSION     NM_033230.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1606)
  AUTHORS   Liu,H., Lin,X., Chilufya,M.M., Qiao,L., Bao,M., Wen,X., Xiang,R.,
            He,H., Li,M. and Han,J.
  TITLE     Synergistic effects of T-2 toxin and selenium deficiency exacerbate
            renal fibrosis through modulation of the ERalpha/PI3K/Akt signaling
            pathway
  JOURNAL   Ecotoxicol Environ Saf 269, 115748 (2024)
   PUBMED   38029582
  REMARK    GeneRIF: Synergistic effects of T-2 toxin and selenium deficiency
            exacerbate renal fibrosis through modulation of the
            ERalpha/PI3K/Akt signaling pathway.
REFERENCE   2  (bases 1 to 1606)
  AUTHORS   Hirai,T., Wang,W., Murono,N., Iwasa,K. and Inoue,M.
  TITLE     Potential role of Akt in the regulation of fibroblast growth factor
            21 by berberine
  JOURNAL   J Nat Med 78 (1), 169-179 (2024)
   PUBMED   37951850
REFERENCE   3  (bases 1 to 1606)
  AUTHORS   Lin,Y.K., Hsiao,L.C., Wu,M.Y., Chen,Y.F., Lin,Y.N., Chang,C.M.,
            Chung,W.H., Chen,K.W., Lu,C.R., Chen,W.Y., Chang,S.S., Shyu,W.C.,
            Lee,A.S., Chen,C.H., Jeng,L.B. and Chang,K.C.
  TITLE     PD-L1 and AKT Overexpressing Adipose-Derived Mesenchymal Stem Cells
            Enhance Myocardial Protection by Upregulating CD25+ T Cells in
            Acute Myocardial Infarction Rat Model
  JOURNAL   Int J Mol Sci 25 (1), 134 (2023)
   PUBMED   38203304
  REMARK    GeneRIF: PD-L1 and AKT Overexpressing Adipose-Derived Mesenchymal
            Stem Cells Enhance Myocardial Protection by Upregulating CD25[+] T
            Cells in Acute Myocardial Infarction Rat Model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1606)
  AUTHORS   Yang,R. and Zeng,C.
  TITLE     MiR-182 promotes apoptosis of neural cells in cerebral infarction
            rats by PI3K/AKT signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 139-143 (2023)
   PUBMED   38063104
  REMARK    GeneRIF: MiR-182 promotes apoptosis of neural cells in cerebral
            infarction rats by PI3K/AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1606)
  AUTHORS   Li,F. and Liu,H.
  TITLE     MiR- 211 represses apoptosis of nerve cells in rats with cerebral
            infarction through PI3K/AKT signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 150-155 (2023)
   PUBMED   38063101
  REMARK    GeneRIF: MiR- 211 represses apoptosis of nerve cells in rats with
            cerebral infarction through PI3K/AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1606)
  AUTHORS   Cross,D.A., Alessi,D.R., Cohen,P., Andjelkovich,M. and
            Hemmings,B.A.
  TITLE     Inhibition of glycogen synthase kinase-3 by insulin mediated by
            protein kinase B
  JOURNAL   Nature 378 (6559), 785-789 (1995)
   PUBMED   8524413
REFERENCE   7  (bases 1 to 1606)
  AUTHORS   Konishi,H., Kuroda,S., Tanaka,M., Matsuzaki,H., Ono,Y.,
            Kameyama,K., Haga,T. and Kikkawa,U.
  TITLE     Molecular cloning and characterization of a new member of the RAC
            protein kinase family: association of the pleckstrin homology
            domain of three types of RAC protein kinase with protein kinase C
            subspecies and beta gamma subunits of G proteins
  JOURNAL   Biochem Biophys Res Commun 216 (2), 526-534 (1995)
   PUBMED   7488143
REFERENCE   8  (bases 1 to 1606)
  AUTHORS   Franke,T.F., Yang,S.I., Chan,T.O., Datta,K., Kazlauskas,A.,
            Morrison,D.K., Kaplan,D.R. and Tsichlis,P.N.
  TITLE     The protein kinase encoded by the Akt proto-oncogene is a target of
            the PDGF-activated phosphatidylinositol 3-kinase
  JOURNAL   Cell 81 (5), 727-736 (1995)
   PUBMED   7774014
REFERENCE   9  (bases 1 to 1606)
  AUTHORS   Datta,K., Franke,T.F., Chan,T.O., Makris,A., Yang,S.I.,
            Kaplan,D.R., Morrison,D.K., Golemis,E.A. and Tsichlis,P.N.
  TITLE     AH/PH domain-mediated interaction between Akt molecules and its
            potential role in Akt regulation
  JOURNAL   Mol Cell Biol 15 (4), 2304-2310 (1995)
   PUBMED   7891724
REFERENCE   10 (bases 1 to 1606)
  AUTHORS   Konishi,H., Shinomura,T., Kuroda,S., Ono,Y. and Kikkawa,U.
  TITLE     Molecular cloning of rat RAC protein kinase alpha and beta and
            their association with protein kinase C zeta
  JOURNAL   Biochem Biophys Res Commun 205 (1), 817-825 (1994)
   PUBMED   7999118
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_033230.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D30040.1, SRR26643285.26018.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000006.1  137552527-137552610 c
            85-213              JAXUCZ010000006.1  137543223-137543351 c
            214-325             JAXUCZ010000006.1  137540434-137540545 c
            326-473             JAXUCZ010000006.1  137540003-137540150 c
            474-605             JAXUCZ010000006.1  137539466-137539597 c
            606-671             JAXUCZ010000006.1  137539320-137539385 c
            672-740             JAXUCZ010000006.1  137538760-137538828 c
            741-866             JAXUCZ010000006.1  137538364-137538489 c
            867-995             JAXUCZ010000006.1  137538168-137538296 c
            996-1210            JAXUCZ010000006.1  137537878-137538092 c
            1211-1298           JAXUCZ010000006.1  137537664-137537751 c
            1299-1401           JAXUCZ010000006.1  137536189-137536291 c
            1402-1606           JAXUCZ010000006.1  137535542-137535746 c
FEATURES             Location/Qualifiers
     source          1..1606
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1606
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /note="AKT serine/threonine kinase 1"
                     /db_xref="GeneID:24185"
                     /db_xref="RGD:2081"
     exon            1..84
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1481
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /EC_number="2.7.11.1"
                     /note="murine thymoma viral (v-akt) oncogene homolog 1;
                     RAC-PK-alpha; thymoma viral proto-oncogene 1; AKT1 kinase;
                     RAC protein kinase alpha RAC-PK alpha; PKB alpha; protein
                     kinase B alpha; v-akt murine thymoma viral oncogene
                     homolog 1"
                     /codon_start=1
                     /product="RAC-alpha serine/threonine-protein kinase"
                     /protein_id="NP_150233.1"
                     /db_xref="GeneID:24185"
                     /db_xref="RGD:2081"
                     /translation="MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQD
                     VEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTA
                     IQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGT
                     FGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQ
                     THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLK
                     LENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG
                     LGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRL
                     GGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITIT
                     PPDQDDSMECVDSERRPHFPQFSYSASGTA"
     exon            85..213
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     exon            214..325
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     exon            326..473
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     exon            474..605
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     exon            606..671
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     exon            672..740
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     exon            741..866
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     exon            867..995
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1210
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1298
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1401
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1606
                     /gene="Akt1"
                     /gene_synonym="Akt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccctgggtt accccggtgt gtgggggcca cggataccat gaacgacgta gccattgtga
       61 aggagggctg gctgcacaaa cgaggggaat atattaaaac ctggcggcca cgctacttcc
      121 tcctcaagaa tgatggcacc tttattggct acaaggaacg gcctcaggat gtggagcagc
      181 gcgagtcccc actcaacaac ttctcagtgg cacaatgtca gctgatgaag acagagcggc
      241 cgaggcccaa caccttcatc atccgctgcc tgcagtggac cacggtcatt gagcgcacct
      301 tccatgtgga aacgcctgag gagcgggaag agtggaccac cgccattcag actgtggctg
      361 atggactcaa acggcaggag gaggagacga tggacttccg gtcaggttca cccagtgaca
      421 actcaggtgc tgaggagatg gaggtggccc tggccaagcc caagcaccgt gtgaccatga
      481 acgagtttga gtacctgaag ctactgggca agggcacctt tgggaaggtg atcctggtga
      541 aggagaaggc cacaggtcgc tactatgcca tgaagatcct caagaaggag gtcatcgttg
      601 ccaaggatga ggttgcccac acgcttactg agaaccgtgt cctgcagaac tctaggcatc
      661 ccttccttac agccctcaag tactcattcc agacccacga ccgcctctgc tttgtcatgg
      721 agtacgccaa tgggggcgag ctcttcttcc acctgtctcg tgagcgcgtg ttttcagagg
      781 accgggcccg cttctacggt gcggagattg tgtccgccct ggactacttg cactccgaga
      841 agaacgtggt gtaccgggac ctcaagctgg agaacctcat gctggacaag gacgggcaca
      901 tcaagataac ggacttcggg ctgtgcaagg agggtatcaa ggacggtgcc accatgaaga
      961 cgttctgcgg gacacccgag tacctggccc ctgaggtgct ggaggacaac gactatggcc
     1021 gtgcagtgga ctggtggggg ctgggcgtgg tcatgtacga gatgatgtgc ggccgcctgc
     1081 ccttctacaa ccaggaccat gagaagctgt tcgagctcat cctaatggag gagatccgct
     1141 tcccacgcac actcgggccg gaggccaagt ccctgctctc ggggctgctc aagaaggacc
     1201 ctacacagag gctcggtggg ggctccgagg acgccaagga gatcatgcag caccgcttct
     1261 ttgccaacat cgtgtggcaa gatgtgtatg agaagaagct gagcccacct ttcaagcccc
     1321 aggtcacctc tgagaccgac accaggtatt ttgatgagga gttcacagct cagatgatca
     1381 ccatcacgcc gcctgatcaa gatgacagca tggagtgtgt ggacagtgaa cggaggccgc
     1441 actttcccca gttctcctac tcagccagtg gcacagcctg aggcctgggg tggtggctgg
     1501 cagccctgca cccctctgca ttgccgagtc cagaagcccc gcatggatca tctgtacctg
     1561 atggttttgt ttctcggatg tgctggggag gaacctcgcc agcctc
//
