LOCUS       NM_013215               1259 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus aldo-keto reductase family 7 member A3 (Akr7a3),
            mRNA.
ACCESSION   NM_013215
VERSION     NM_013215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1259)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1259)
  AUTHORS   Torres-Mena,J.E., Salazar-Villegas,K.N., Sanchez-Rodriguez,R.,
            Lopez-Gabino,B., Del Pozo-Yauner,L., Arellanes-Robledo,J.,
            Villa-Trevino,S., Gutierrez-Nava,M.A. and Perez-Carreon,J.I.
  TITLE     Aldo-Keto Reductases as Early Biomarkers of Hepatocellular
            Carcinoma: A Comparison Between Animal Models and Human HCC
  JOURNAL   Dig Dis Sci 63 (4), 934-944 (2018)
   PUBMED   29383608
  REMARK    GeneRIF: Results demonstrate that Akr7a3 mRNA and protein levels
            are consistently co-expressed along with Akr1b10, in both
            experimental rat liver carcinogenesis and some human hepatocellular
            carcinoma samples.
REFERENCE   3  (bases 1 to 1259)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1259)
  AUTHORS   Ellis,E.M., Slattery,C.M. and Hayes,J.D.
  TITLE     Characterization of the rat aflatoxin B1 aldehyde reductase gene,
            AKR7A1. Structure and chromosomal localization of AKR7A1 as well as
            identification of antioxidant response elements in the gene
            promoter
  JOURNAL   Carcinogenesis 24 (4), 727-737 (2003)
   PUBMED   12727802
  REMARK    GeneRIF: structure and chromosomal localization and idetification
            of antioxidant response elements in the gene promoter
REFERENCE   5  (bases 1 to 1259)
  AUTHORS   Kelly,V.P., Sherratt,P.J., Crouch,D.H. and Hayes,J.D.
  TITLE     Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate
            synthases that associate with the Golgi apparatus define a distinct
            subclass of aldo-keto reductase 7 family proteins
  JOURNAL   Biochem J 366 (Pt 3), 847-861 (2002)
   PUBMED   12071861
REFERENCE   6  (bases 1 to 1259)
  AUTHORS   Kozma,E., Brown,E., Ellis,E.M. and Lapthorn,A.J.
  TITLE     The crystal structure of rat liver AKR7A1. A dimeric member of the
            aldo-keto reductase superfamily
  JOURNAL   J Biol Chem 277 (18), 16285-16293 (2002)
   PUBMED   11839745
  REMARK    GeneRIF: A dimeric member of the aldo-keto reductase superfamily;
            structure resolved to 1.38A resolution (AKR7A1, aflatoxin
            dialdehyde reductase AKR7A1)
REFERENCE   7  (bases 1 to 1259)
  AUTHORS   Knight,L.P., Primiano,T., Groopman,J.D., Kensler,T.W. and
            Sutter,T.R.
  TITLE     cDNA cloning, expression and activity of a second human aflatoxin
            B1-metabolizing member of the aldo-keto reductase superfamily,
            AKR7A3
  JOURNAL   Carcinogenesis 20 (7), 1215-1223 (1999)
   PUBMED   10383892
REFERENCE   8  (bases 1 to 1259)
  AUTHORS   Ellis,E.M., Judah,D.J., Neal,G.E. and Hayes,J.D.
  TITLE     An ethoxyquin-inducible aldehyde reductase from rat liver that
            metabolizes aflatoxin B1 defines a subfamily of aldo-keto
            reductases
  JOURNAL   Proc Natl Acad Sci U S A 90 (21), 10350-10354 (1993)
   PUBMED   8234296
REFERENCE   9  (bases 1 to 1259)
  AUTHORS   Hayes,J.D., Judah,D.J. and Neal,G.E.
  TITLE     Resistance to aflatoxin B1 is associated with the expression of a
            novel aldo-keto reductase which has catalytic activity towards a
            cytotoxic aldehyde-containing metabolite of the toxin
  JOURNAL   Cancer Res 53 (17), 3887-3894 (1993)
   PUBMED   8395332
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013215.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078872.1, AF045464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               JAXUCZ010000005.1  156876721-156876986
            267-454             JAXUCZ010000005.1  156879796-156879983
            455-559             JAXUCZ010000005.1  156880178-156880282
            560-656             JAXUCZ010000005.1  156880495-156880591
            657-756             JAXUCZ010000005.1  156880829-156880928
            757-886             JAXUCZ010000005.1  156883184-156883313
            887-1259            JAXUCZ010000005.1  156884227-156884599
FEATURES             Location/Qualifiers
     source          1..1259
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1259
                     /gene="Akr7a3"
                     /gene_synonym="Afar; Akr7a1"
                     /note="aldo-keto reductase family 7 member A3"
                     /db_xref="GeneID:26760"
                     /db_xref="RGD:628635"
     exon            1..266
                     /gene="Akr7a3"
                     /gene_synonym="Afar; Akr7a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1048
                     /gene="Akr7a3"
                     /gene_synonym="Afar; Akr7a1"
                     /EC_number="1.1.1.n11"
                     /note="rAFAR1; AFB1-AR; aflatoxin B1 aldehyde reductase
                     member 1; aldo-keto reductase family 7, member A3
                     (aflatoxin aldehyde reductase)"
                     /codon_start=1
                     /product="aflatoxin B1 aldehyde reductase member 3"
                     /protein_id="NP_037347.1"
                     /db_xref="GeneID:26760"
                     /db_xref="RGD:628635"
                     /translation="MSQARPATVLGAMEMGRRMDVTSSSASVRAFLQRGHTEIDTAFV
                     YANGQSETILGDLGLGLGRSGCKVKIATKAAPMFGKTLKPADVRFQLETSLKRLQCPR
                     VDLFYLHFPDHGTPIEETLQACHQLHQEGKFVELGLSNYVSWEVAEICTLCKKNGWIM
                     PTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGRYKYQDKDGKNPESR
                     FFGNPFSQLYMDRYWKEEHFNGIALVEKALKTTYGPTAPSMISAAVRWMYHHSQLKGT
                     QGDAVILGMSSLEQLEQNLALVEEGPLEPAVVDAFDQAWNLVAHECPNYFR"
     exon            267..454
                     /gene="Akr7a3"
                     /gene_synonym="Afar; Akr7a1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..559
                     /gene="Akr7a3"
                     /gene_synonym="Afar; Akr7a1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..656
                     /gene="Akr7a3"
                     /gene_synonym="Afar; Akr7a1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..756
                     /gene="Akr7a3"
                     /gene_synonym="Afar; Akr7a1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..886
                     /gene="Akr7a3"
                     /gene_synonym="Afar; Akr7a1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1259
                     /gene="Akr7a3"
                     /gene_synonym="Afar; Akr7a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactgctgga accaacgtcc tctcttaccc tccaccttct tctgccacct ctaccacggt
       61 caccatgtcg caagcccggc ctgccactgt gctgggtgcc atggagatgg gtcgccgcat
      121 ggatgtgacc tccagctccg cgtcggtgcg cgccttcctg cagcgcggcc acacggagat
      181 agacaccgcc ttcgtgtatg cgaacggtca gtctgagacc atcctaggag acctggggct
      241 cggactgggc cgcagcggct gcaaagtaaa aattgccacc aaggctgccc caatgtttgg
      301 gaagacactg aagccagccg atgttcggtt ccagctggag acgtcactga agaggctgca
      361 gtgtccccgg gtggacctct tctatttaca ctttccagac cacggcactc ctatagagga
      421 gaccctgcag gcctgccacc agctgcatca ggagggcaag tttgtggagc ttggtctgtc
      481 caactatgtc tcctgggaag tggctgagat ttgtaccctc tgcaagaaaa atggctggat
      541 catgccaact gtgtaccagg gcatgtacaa cgccatcacc aggcaggtgg agactgagct
      601 cttcccctgc ctcagacact tcggactaag gttctatgcc ttcaaccctt tggctggggg
      661 cctgctgact ggcagatata aataccagga taaggatggg aagaatcctg agagccgctt
      721 ctttgggaat ccattttctc aactgtacat ggaccgctac tggaaggagg aacacttcaa
      781 tggcatcgcc ttggtggaga aggctctgaa gactacctat ggccccactg cccccagtat
      841 gatctcagct gccgtacggt ggatgtacca tcactcacag ctcaagggca cccaagggga
      901 tgcagtcatt ctgggcatgt ccagtctgga acaactggag cagaacttgg ccttggtcga
      961 ggaagggcct ctggagccag ctgttgtgga tgcctttgac caagcctgga acctagttgc
     1021 ccacgagtgt cccaactatt tccgctaaga tacatctgcc ttggggaggc gcagcttact
     1081 gcctgccccg ccttgtcctg ggctcgatct gatctggttc tttccttttt agacaggtca
     1141 ctgtctttct cttccctgct ttctatacag ccagttgctt tcaaagtgag agctggctga
     1201 gccccaatac ctcctgctga ataaaactgt tccctgtcac agcctgggct acaactgac
//
