LOCUS       NM_134407               1244 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus aldo-keto reductase family 7, member A2 (Akr7a2),
            mRNA.
ACCESSION   NM_134407
VERSION     NM_134407.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1244)
  AUTHORS   Bains,O.S., Grigliatti,T.A., Reid,R.E. and Riggs,K.W.
  TITLE     Naturally occurring variants of human aldo-keto reductases with
            reduced in vitro metabolism of daunorubicin and doxorubicin
  JOURNAL   J Pharmacol Exp Ther 335 (3), 533-545 (2010)
   PUBMED   20837989
REFERENCE   2  (bases 1 to 1244)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 1244)
  AUTHORS   Cui,Y., Tian,M., Zong,M., Teng,M., Chen,Y., Lu,J., Jiang,J., Liu,X.
            and Han,J.
  TITLE     Proteomic analysis of pancreatic ductal adenocarcinoma compared
            with normal adjacent pancreatic tissue and pancreatic benign
            cystadenoma
  JOURNAL   Pancreatology 9 (1-2), 89-98 (2009)
   PUBMED   19077459
REFERENCE   4  (bases 1 to 1244)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1244)
  AUTHORS   Praml,C., Savelyeva,L. and Schwab,M.
  TITLE     Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1
            in a region frequently altered in human tumour cells
  JOURNAL   Oncogene 22 (30), 4765-4773 (2003)
   PUBMED   12879023
REFERENCE   6  (bases 1 to 1244)
  AUTHORS   Kelly,V.P., Sherratt,P.J., Crouch,D.H. and Hayes,J.D.
  TITLE     Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate
            synthases that associate with the Golgi apparatus define a distinct
            subclass of aldo-keto reductase 7 family proteins
  JOURNAL   Biochem J 366 (Pt 3), 847-861 (2002)
   PUBMED   12071861
REFERENCE   7  (bases 1 to 1244)
  AUTHORS   Picklo,M.J. Sr., Olson,S.J., Hayes,J.D., Markesbery,W.R. and
            Montine,T.J.
  TITLE     Elevation of AKR7A2 (succinic semialdehyde reductase) in
            neurodegenerative disease
  JOURNAL   Brain Res 916 (1-2), 229-238 (2001)
   PUBMED   11597610
REFERENCE   8  (bases 1 to 1244)
  AUTHORS   Nishi,N., Shoji,H., Miyanaka,H. and Nakamura,T.
  TITLE     Androgen-regulated expression of a novel member of the aldo-keto
            reductase superfamily in regrowing rat prostate
  JOURNAL   Endocrinology 141 (9), 3194-3199 (2000)
   PUBMED   10965890
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_134407.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037424.1, BC061816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               JAXUCZ010000005.1  156835589-156835878
            291-478             JAXUCZ010000005.1  156839456-156839643
            479-583             JAXUCZ010000005.1  156839811-156839915
            584-680             JAXUCZ010000005.1  156842410-156842506
            681-780             JAXUCZ010000005.1  156842686-156842785
            781-910             JAXUCZ010000005.1  156843289-156843418
            911-1244            JAXUCZ010000005.1  156843794-156844127
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1244
                     /gene="Akr7a2"
                     /gene_synonym="Aiar"
                     /note="aldo-keto reductase family 7, member A2"
                     /db_xref="GeneID:171445"
                     /db_xref="RGD:620311"
     exon            1..290
                     /gene="Akr7a2"
                     /gene_synonym="Aiar"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1072
                     /gene="Akr7a2"
                     /gene_synonym="Aiar"
                     /EC_number="1.1.1.n11"
                     /note="rAFAR2; SSA reductase; succinic semialdehyde
                     reductase; aldo-keto reductase family 7, member A2
                     (aflatoxin aldehyde reductase)"
                     /codon_start=1
                     /product="aflatoxin B1 aldehyde reductase member 2"
                     /protein_id="NP_599234.1"
                     /db_xref="GeneID:171445"
                     /db_xref="RGD:620311"
                     /translation="MSRSPAPRAVSGAPLRPGTVLGTMEMGRRMDASASAATVRAFLE
                     RGLNELDTAFMYCDGQSESILGSLGLGLGSGDCTVKIATKANPWDGKSLKPDSVRSQL
                     ETSLKRLQCPRVDLFYLHAPDHGTPIVETLQACQQLHQEGKFVELGLSNYASWEVAEI
                     YTLCKSNGWILPTVYQGMYNATTRQVETELLPCLRYFGLRFYAYNPLAGGLLTGKYRY
                     EDKDGKQPEGRFFGNSWSETYRNRFWKEHHFEAIALVEKALKTTYGTSAPSMTSAALR
                     WMYHHSQLQGTRGDAVILGMSSLEQLEQNLAATEEGPLEPAVVEAFNQAWNVVAHECP
                     NYFR"
     exon            291..478
                     /gene="Akr7a2"
                     /gene_synonym="Aiar"
                     /inference="alignment:Splign:2.1.0"
     exon            479..583
                     /gene="Akr7a2"
                     /gene_synonym="Aiar"
                     /inference="alignment:Splign:2.1.0"
     exon            584..680
                     /gene="Akr7a2"
                     /gene_synonym="Aiar"
                     /inference="alignment:Splign:2.1.0"
     exon            681..780
                     /gene="Akr7a2"
                     /gene_synonym="Aiar"
                     /inference="alignment:Splign:2.1.0"
     exon            781..910
                     /gene="Akr7a2"
                     /gene_synonym="Aiar"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1244
                     /gene="Akr7a2"
                     /gene_synonym="Aiar"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgctgta cgctgcgcgt ggcgctctgg gccttcggtc gcgcgtcctc tcgccatgtc
       61 ccggtctccg gcaccccgcg ccgtctctgg cgcccctctc cggcccggta cggtgctggg
      121 caccatggag atggggcgcc gcatggatgc gagtgctagc gctgcgaccg tacgcgcctt
      181 cctggagcgc ggcctcaacg agctggacac cgccttcatg tattgcgacg gccagtccga
      241 aagcatcctg ggcagcctgg ggctcgggct gggcagcggc gactgcacag tgaaaattgc
      301 caccaaggcc aacccttggg acgggaagtc gctgaagcct gacagtgtcc ggtcccaatt
      361 agagacgtca ttgaagcggc tgcagtgtcc ccgggtggac ctcttctact tacacgctcc
      421 tgaccacggc actcctatcg tggagaccct gcaggcctgc caacagctgc atcaggaggg
      481 caagtttgtg gagcttggct tgtccaacta tgcctcctgg gaggtagccg agatctatac
      541 cctctgtaaa agcaacggct ggatcctgcc aactgtgtac cagggcatgt acaacgccac
      601 cacccggcag gtggagactg agctcctccc ctgcctcaga tacttcggac tgaggttcta
      661 tgcctacaac cctttggctg gaggcctgct gactggcaaa tacagatatg aagacaagga
      721 tgggaaacag cccgagggcc gcttctttgg gaatagctgg tctgagacct acaggaaccg
      781 cttctggaag gaacaccact ttgaggccat tgccctggta gaaaaggccc tgaagaccac
      841 ctatggcacc agtgccccca gcatgacctc ggctgccctg cgctggatgt accatcactc
      901 acagctccag ggcacccgag gggacgcagt catcttgggc atgtccagcc tggagcagct
      961 ggagcagaac ttggcggcca ctgaggaagg tcccctggag cccgctgtcg tggaggcctt
     1021 taaccaagcc tggaacgtgg tcgcccacga gtgtcccaac tacttcagat agactgtcgt
     1081 gactcaagac gccagggctt ttctgccaac tcttagagtc acaccctggc cactccttgc
     1141 ccagtgctga cctagtgtgg tcttttctgc tggtctccat ccactccctg ctcttttccc
     1201 gtctgaataa agcaggcgtc cgacctagct gcagccggac tgaa
//
