LOCUS       NM_138884               3255 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus aldo-keto reductase family 1, member D1 (Akr1d1),
            mRNA.
ACCESSION   NM_138884 XM_346688
VERSION     NM_138884.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3255)
  AUTHORS   Zhu,Y., Fillenwarth,M.J., Crabb,D., Lumeng,L. and Lin,R.C.
  TITLE     Identification of the 37-kd rat liver protein that forms an
            acetaldehyde adduct in vivo as delta 4-3-ketosteroid 5
            beta-reductase
  JOURNAL   Hepatology 23 (1), 115-122 (1996)
   PUBMED   8550030
REFERENCE   2  (bases 1 to 3255)
  AUTHORS   Kondo,K.H., Kai,M.H., Setoguchi,Y., Eggertsen,G., Sjoblom,P.,
            Setoguchi,T., Okuda,K.I. and Bjorkhem,I.
  TITLE     Cloning and expression of cDNA of human delta 4-3-oxosteroid 5
            beta-reductase and substrate specificity of the expressed enzyme
  JOURNAL   Eur J Biochem 219 (1-2), 357-363 (1994)
   PUBMED   7508385
REFERENCE   3  (bases 1 to 3255)
  AUTHORS   Onishi,Y., Noshiro,M., Shimosato,T. and Okuda,K.
  TITLE     delta 4-3-Oxosteroid 5 beta-reductase. Structure and function
  JOURNAL   Biol Chem Hoppe Seyler 372 (12), 1039-1049 (1991)
   PUBMED   1789929
REFERENCE   4  (bases 1 to 3255)
  AUTHORS   Onishi,Y., Noshiro,M., Shimosato,T. and Okuda,K.
  TITLE     Molecular cloning and sequence analysis of cDNA encoding delta
            4-3-ketosteroid 5 beta-reductase of rat liver
  JOURNAL   FEBS Lett 283 (2), 215-218 (1991)
   PUBMED   1710579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 2, 2020 this sequence version replaced NM_138884.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17309.1, FQ219730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               JAXUCZ010000004.1  67121294-67121446
            154-318             JAXUCZ010000004.1  67123764-67123928
            319-435             JAXUCZ010000004.1  67127059-67127175
            436-513             JAXUCZ010000004.1  67136531-67136608
            514-636             JAXUCZ010000004.1  67141161-67141283
            637-746             JAXUCZ010000004.1  67143311-67143420
            747-912             JAXUCZ010000004.1  67144850-67145015
            913-995             JAXUCZ010000004.1  67149990-67150072
            996-3255            JAXUCZ010000004.1  67152284-67154543
FEATURES             Location/Qualifiers
     source          1..3255
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..3255
                     /gene="Akr1d1"
                     /note="aldo-keto reductase family 1, member D1"
                     /db_xref="GeneID:192242"
                     /db_xref="RGD:620752"
     exon            1..153
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1038
                     /gene="Akr1d1"
                     /EC_number="1.3.1.3"
                     /note="3-oxo-5-beta-steroid 4-dehydrogenase;
                     delta(4)-3-oxosteroid 5-beta-reductase;
                     delta(4)-3-ketosteroid 5-beta-reductase; aldo-keto
                     reductase family 1, member D1 (delta
                     4-3-ketosteroid-5-beta-reductase)"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member D1"
                     /protein_id="NP_620239.2"
                     /db_xref="GeneID:192242"
                     /db_xref="RGD:620752"
                     /translation="MNLSTANHHIPLNDGNSIPIIGLGTYSDPRPVPGKTFIAVKTAI
                     DEGYRHIDGAYVYRNEHEVGEAIREKVAEGKVKREEIFYCGKLWSTDHDPEMVRPALE
                     RTLQTLKLDYIDLYIIEMPMAFKPGEEFYPKDENGRVIYHKSNLCATWEALEACKDAG
                     LVKSLGVSNFNRRQLEVILNKPGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAY
                     SPLGTCRNPLWVNVSSPPLLKDELLTSLGKKYNKTQAQIVLRFDIQRGLVVIPKSTTP
                     ERIKENFQIFDFSLTKEEMKDIEALNKNVRFVEMLMWSDHPEYPFHDEY"
     exon            154..318
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..435
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..513
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..636
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..746
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..912
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..995
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            996..3255
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatttgtac ttctgtcctg ttcagaatca ctacttgaag cttcagatcc cttctctaca
       61 atgaacctca gcactgcaaa ccaccacata cccctaaatg atggtaacag cattccgatc
      121 atcgggcttg gaacctactc agaccctaga ccggtacccg gcaagacctt tatagcagtg
      181 aagacagcta ttgacgaggg gtaccggcat attgatgggg cctacgtcta ccgaaatgaa
      241 catgaagttg gtgaggccat cagagaaaag gtggcagaag ggaaggtaaa gagggaagag
      301 attttctact gtggaaagtt atggagtaca gaccatgatc cagagatggt ccgcccagcc
      361 ctggaaagga ccctgcagac cctcaagcta gattacatag acctttatat cattgagatg
      421 cccatggcct ttaagcctgg agaggaattt tatcctaaag atgagaatgg ccgagtgata
      481 taccacaaat caaatctgtg tgccacgtgg gaggcactgg aagcttgcaa agacgctggc
      541 ttggtgaaat cccttggggt gtctaatttt aaccgcaggc agctggaggt catcttgaac
      601 aagccaggac tcaagtacaa gcctgtcacc aaccaggtgg agtgccaccc gtatttcacc
      661 cagacaaaac tcttgaagtt ctgccagcag catgacatcg tcattgtcgc atacagcccc
      721 ttagggacct gtcgcaaccc gttatgggtg aatgtatctt ctccaccctt gttaaaggat
      781 gaactcctaa cctcgctggg gaaaaagtac aataagacac aagctcaaat tgtgttgcgt
      841 ttcgacatcc agcgagggtt ggttgtcatc cctaaaagta ctacccctga aaggatcaaa
      901 gaaaactttc agatctttga cttctctctc accaaagaag aaatgaagga cattgaagcc
      961 ttgaataaaa acgtgcgctt tgtggagatg ctcatgtgga gtgatcatcc tgaataccca
     1021 tttcatgacg aatactgaac atggaaattt cttcagtgga gttttttttg tctttcattc
     1081 gggatcttga gctgattaat cccctccagt cgtagaaata aatggggtct tgctatcttc
     1141 agattaagtt gagcagaata caccatgctt aacttgtgta tagtattaat tcaacttagc
     1201 tctgatgaag agaagattta aatatatcta aatagtttgt tggaaaatgc tttactagta
     1261 tctttagctc aatgtgttct agattgttga tggaaattac cgaactttaa ttcaaaaata
     1321 acaaaatata taaaatacaa gatacaatat aaaatataaa atacaaaaat ataaaaacag
     1381 gttctaaccc aggagtctga gactaccata gggagtttga tttgtttagc atttagcagg
     1441 acaacaaaga ggttggcatg cttccaggtg ctgaccataa ccatgaccca aacaaggtca
     1501 tggacacaag atggacacag ccaagacaca aatccacata ccaatattaa tgcaccttga
     1561 gtatagacag aactggaagt ctagaaagtc ctaaagaaga acataaagca ggatgtcccg
     1621 gggctagagg ttctcactgg aggacttgcc tggcagactg gagacccagg gtgagggtgt
     1681 gggtgaggac tatcagcaaa gccataacga ttctgttttt accctttgtt tccatccagt
     1741 gtgcccattc agcttttaat gtgcttgaag gacagacagt taccgattcc ttcttaaatt
     1801 gtttttgttc agggcagtgg ggaattgaga cagggtctca ggtagtctgc tcatgtagct
     1861 gcttacaaac ttgctgtgca gctgagacca gttttgaatt ctgaacccct ggtctctctt
     1921 ccatttttca tggcctgagc ttccacctga ctggtaagcc ccacttgtac tgtgctgtaa
     1981 tcattcttgc ccacattcat caaggaaacc accatgtaaa gtggcaagaa acaatcaata
     2041 tatacaaacc aagatttgta tcataaaatg gtctgaagat ggtgattttt aaaagaatga
     2101 tattttaaaa tagcccattt ctttctttct ttctgaatct tttaaaaatt atttttattt
     2161 tatgtgcatt ggtgtttagc ctgcatgtgt atctatgaga attgtttgaa ctcatggaac
     2221 tggagttaca gacagtggtg agctgtaggt aggtgctggg aattgaaccc aagtcattgg
     2281 gaagagctgc aagtgctctt aactgctgag ccatctcccc agcccccaaa tgaatttggg
     2341 aaatactaga agataaagct ttgtaaaagt agttttttaa gatcttaaga atatattgag
     2401 gtagctatct gaattttgac aaagctgcaa gttctttttt ttaaattgga tttttaaaaa
     2461 tttatttaca tttcaaatgt tatcccctct cctgggttcc catccacaga cctccctatc
     2521 tcatcccccc tctcccttct tctatgagag tgttcaccca cctacccact ccttccctcc
     2581 tccctgccct gacattcccc tacactaggg ggtcgagtct tggcaggacc aagggcctct
     2641 cctcccattg gtgcccaaca aggccatcct ctgctacata ggcagctgga gccatgggtc
     2701 tgtccatgtg tactctctgg atggtggttt agtccctggg agctctggtt ggttggttct
     2761 gttgttatgg ggttgcaaac cccttcagct cctttaatcc tttctctaat tcctccattg
     2821 gggaccctgt tctcagttct atggttggct gtgagcatcc acctgtgtat ttgtcatgct
     2881 ctggcagagc ctctcaggag aatcaggctc ctgtcagcag agcacaagta attttagcgt
     2941 atataaattt ttaaaaagtg aattaaatga ttacaactgt atctattttt aattcatctg
     3001 aaatacagta catttgttta tattagatca cttccaaagg gtgagagaat tcttcaaaaa
     3061 taatatattt ttaatatcaa tagaagaaat caaatggccc aaagagaaac aagtttttga
     3121 gaaattatca cttaaaaaat gtgatcaaca tgaaccattt ttgttcaata ctgttcaata
     3181 ttgttaacaa tgctgttctc tggaaaatat tttattcaca tgaattaata aaatataatg
     3241 atttgttcta ccaca
//
