LOCUS       NM_138510               1207 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus aldo-keto reductase family 1, member C3 (Akr1c3),
            mRNA.
ACCESSION   NM_138510
VERSION     NM_138510.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1207)
  AUTHORS   Sun,C.J., Jin,Y., Zhang,W.Y., Li,L. and Liu,X.W.
  TITLE     Role of AKR1C3 in renal injury and glibenclamide is
            anti-inflammatory in preeclamptic rats
  JOURNAL   Gene 662, 1-9 (2018)
   PUBMED   29627526
  REMARK    GeneRIF: AKR1C3 expression was decreased in the kidneys of
            L-NAME-induced preeclampsia rats.
REFERENCE   2  (bases 1 to 1207)
  AUTHORS   Moradi Manesh,D., El-Hoss,J., Evans,K., Richmond,J., Toscan,C.E.,
            Bracken,L.S., Hedrick,A., Sutton,R., Marshall,G.M., Wilson,W.R.,
            Kurmasheva,R.T., Billups,C., Houghton,P.J., Smith,M.A., Carol,H.
            and Lock,R.B.
  TITLE     AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical
            models of T-cell acute lymphoblastic leukemia
  JOURNAL   Blood 126 (10), 1193-1202 (2015)
   PUBMED   26116659
REFERENCE   3  (bases 1 to 1207)
  AUTHORS   Jin,Y., Sun,C. and Zhang,W.
  TITLE     [Effects of AKR1C3 on kidney damage of preeclamptic rats]
  JOURNAL   Zhonghua Yi Xue Za Zhi 95 (1), 30-33 (2015)
   PUBMED   25876805
REFERENCE   4  (bases 1 to 1207)
  AUTHORS   Tian,Y., Zhao,L., Zhang,H., Liu,X., Zhao,L., Zhao,X., Li,Y. and
            Li,J.
  TITLE     AKR1C3 overexpression may serve as a promising biomarker for
            prostate cancer progression
  JOURNAL   Diagn Pathol 9, 42 (2014)
   PUBMED   24571686
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1207)
  AUTHORS   Hamid,A.R., Pfeiffer,M.J., Verhaegh,G.W., Schaafsma,E., Brandt,A.,
            Sweep,F.C., Sedelaar,J.P. and Schalken,J.A.
  TITLE     Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and
            therapeutic target for castration-resistant prostate cancer
  JOURNAL   Mol Med 18 (1), 1449-1455 (2013)
   PUBMED   23196782
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1207)
  AUTHORS   Marcovistz,R., Le Bousse-Kerdiles,M.C., Maillere,B.,
            Smadja-Joffe,F., Poirrier,V. and Jasmin,C.
  TITLE     20 alpha-hydroxysteroid dehydrogenase expression in a murine
            virus-induced myeloproliferative syndrome
  JOURNAL   Biochimie 73 (11), 1351-1353 (1991)
   PUBMED   1665987
REFERENCE   7  (bases 1 to 1207)
  AUTHORS   Matsuyama,S., Shiota,K. and Takahashi,M.
  TITLE     Possible role of transforming growth factor-beta as a mediator of
            luteotropic action of prolactin in rat luteal cell cultures
  JOURNAL   Endocrinology 127 (4), 1561-1567 (1990)
   PUBMED   2401226
REFERENCE   8  (bases 1 to 1207)
  AUTHORS   Duleba,A.J., Kim,K.S., Ho Yuen,B. and Moon,Y.S.
  TITLE     Inhibition of 20 alpha-hydroxysteroid dehydrogenase activity by
            follicle-stimulating hormone and androgens in cultured rat
            granulosa cells: a search for the mechanism of action
  JOURNAL   Biol Reprod 33 (2), 401-410 (1985)
   PUBMED   2994767
REFERENCE   9  (bases 1 to 1207)
  AUTHORS   Jones,P.B. and Hsueh,A.J.
  TITLE     Direct stimulation of ovarian progesterone-metabolizing enzyme by
            gonadotropin-releasing hormone in cultured granulosa cells
  JOURNAL   J Biol Chem 256 (3), 1248-1254 (1981)
   PUBMED   6778878
REFERENCE   10 (bases 1 to 1207)
  AUTHORS   Kuhn,N.J. and Briley,M.S.
  TITLE     The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy
            steroid dehydrogenase in the control of progesterone synthesis
            preceding parturition and lactogenesis in the rat
  JOURNAL   Biochem J 117 (2), 193-201 (1970)
   PUBMED   4392955
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138510.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L32601.1, BC086579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000017.1  71020884-71021004
            122-289             JAXUCZ010000017.1  71026824-71026991
            290-406             JAXUCZ010000017.1  71027766-71027882
            407-484             JAXUCZ010000017.1  71028856-71028933
            485-607             JAXUCZ010000017.1  71029911-71030033
            608-717             JAXUCZ010000017.1  71033925-71034034
            718-883             JAXUCZ010000017.1  71034288-71034453
            884-966             JAXUCZ010000017.1  71035356-71035438
            967-1207            JAXUCZ010000017.1  71037539-71037779
FEATURES             Location/Qualifiers
     source          1..1207
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.2"
     gene            1..1207
                     /gene="Akr1c3"
                     /gene_synonym="Akr1c18"
                     /note="aldo-keto reductase family 1, member C3"
                     /db_xref="GeneID:171516"
                     /db_xref="RGD:708428"
     exon            1..121
                     /gene="Akr1c3"
                     /gene_synonym="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1009
                     /gene="Akr1c3"
                     /gene_synonym="Akr1c18"
                     /EC_number="1.1.1.149"
                     /note="20-alpha-hydroxysteroid dehydrogenase;
                     20alpha-hydroxysteroid dehydrogenase; HSD1; 20-alpha-HSD;
                     aldo-keto reductase family 1, member C18; aldo-keto
                     reductase family 1, member C3 (3-alpha hydroxysteroid
                     dehydrogenase, type II)"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member C18"
                     /protein_id="NP_612519.1"
                     /db_xref="GeneID:171516"
                     /db_xref="RGD:708428"
                     /translation="MNSKIQKMELNDGHSIPVLGFGTYATEENLRKKSMESTKIAIDV
                     GFRHIDCSHLYQNEEEIGQAIVSKIEDGTVKREDIFYTSKLWSTSHRPELVRPSLENS
                     LRKLNLDYVDLYLIHFPVSLKPGDELLPQDEHGNLILDTVDLCDTWEAMEKCKDAGLA
                     KSIGVSNFNRRQLEKILNKPGLKHRPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGA
                     LGTQRYKYCINEDTPVLLDDPILCTMAKKYKRTPALIALRYQLERGIVTLVKSFNEER
                     IRENLQVFDFQLASDDMEILDNLDRNLRYFPANMFKAHPNFPFSDEY"
     exon            122..289
                     /gene="Akr1c3"
                     /gene_synonym="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            290..406
                     /gene="Akr1c3"
                     /gene_synonym="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            407..484
                     /gene="Akr1c3"
                     /gene_synonym="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            485..607
                     /gene="Akr1c3"
                     /gene_synonym="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            608..717
                     /gene="Akr1c3"
                     /gene_synonym="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            718..883
                     /gene="Akr1c3"
                     /gene_synonym="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            884..966
                     /gene="Akr1c3"
                     /gene_synonym="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1207
                     /gene="Akr1c3"
                     /gene_synonym="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaagcgac tcttctaggg aagagcagca tctgagaatg aattccaaaa ttcagaagat
       61 ggagttaaac gatggtcact ccatccctgt actgggcttt ggcacctatg caaccgaaga
      121 gaatctcaga aaaaagtcta tggagtccac gaaaatagct atagatgttg ggttccgcca
      181 tattgattgt tctcacttgt accagaatga agaagagata ggtcaggcca ttgtaagcaa
      241 gattgaagat ggcactgtga aaagggaaga tatattctat acttcaaagc tttggtcaac
      301 ttcccatcgt ccagagttgg tcagacccag cttggaaaat tcactgagga aacttaattt
      361 ggactatgta gacctctatc tcattcattt cccggtatct ctgaagccag gggatgagct
      421 tttacctcaa gatgagcatg gaaacttaat acttgataca gtggatctct gcgacacctg
      481 ggaggccatg gagaagtgta aggatgcagg attggccaag tccatcgggg tgtccaactt
      541 taaccgcagg cagctggaga agatcctgaa taagccgggg ctcaagcaca ggcctgtgtg
      601 caaccaggta gaatgccatc tttatctcaa ccagagcaag ctgctcgctt actgcaagat
      661 gaatgacatc gttctggttg cctatggtgc cctgggaact cagagataca aatactgtat
      721 taatgaagat accccagttc tcttggatga tcccattctt tgtaccatgg caaagaagta
      781 caagcggact ccagccctga ttgcccttcg ctaccagctg gagcgtggga ttgtgaccct
      841 agtcaagagt ttcaatgagg agagaatcag agagaacctg caggtctttg atttccagtt
      901 ggcttcagat gacatggaaa ttttagataa cctggacaga aatcttcggt actttcctgc
      961 taatatgttt aaggctcacc ctaactttcc attctctgat gaatactaag atggcagccc
     1021 tagccatgag ttctgctcga agctcctttg tgtgatgctg gactctcaga ggccaataat
     1081 acaacacact gactccaatc catactgctt agcaactcac ccccagtttg agctgtgtct
     1141 gtacatcggg gagcaaattc actaaatttt cctgcttttc tgtaaataaa taaaaatatt
     1201 ttgcttc
//
