LOCUS       NM_001013057            1398 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus aldo-keto reductase family 1, member C2 (Akr1c2),
            mRNA.
ACCESSION   NM_001013057 XM_225537
VERSION     NM_001013057.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1398)
  AUTHORS   Ruiz,F.X., Porte,S., Gallego,O., Moro,A., Ardevol,A., Del
            Rio-Espinola,A., Rovira,C., Farres,J. and Pares,X.
  TITLE     Retinaldehyde is a substrate for human aldo-keto reductases of the
            1C subfamily
  JOURNAL   Biochem J 440 (3), 335-344 (2011)
   PUBMED   21851338
REFERENCE   2  (bases 1 to 1398)
  AUTHORS   Hevir,N., Vouk,K., Sinkovec,J., Ribic-Pucelj,M. and Rizner,T.L.
  TITLE     Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance
            progesterone metabolism in ovarian endometriosis
  JOURNAL   Chem Biol Interact 191 (1-3), 217-226 (2011)
   PUBMED   21232532
REFERENCE   3  (bases 1 to 1398)
  AUTHORS   Buhrke,T., Lengler,I. and Lampen,A.
  TITLE     Analysis of proteomic changes induced upon cellular differentiation
            of the human intestinal cell line Caco-2
  JOURNAL   Dev Growth Differ 53 (3), 411-426 (2011)
   PUBMED   21492153
REFERENCE   4  (bases 1 to 1398)
  AUTHORS   Bains,O.S., Grigliatti,T.A., Reid,R.E. and Riggs,K.W.
  TITLE     Naturally occurring variants of human aldo-keto reductases with
            reduced in vitro metabolism of daunorubicin and doxorubicin
  JOURNAL   J Pharmacol Exp Ther 335 (3), 533-545 (2010)
   PUBMED   20837989
REFERENCE   5  (bases 1 to 1398)
  AUTHORS   Dhagat,U., Endo,S., Mamiya,H., Hara,A. and El-Kabbani,O.
  TITLE     Studies on a Tyr residue critical for the binding of coenzyme and
            substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase
            (AKR1C21): structure of the Y224D mutant enzyme
  JOURNAL   Acta Crystallogr D Biol Crystallogr 66 (Pt 2), 198-204 (2010)
   PUBMED   20124700
REFERENCE   6  (bases 1 to 1398)
  AUTHORS   Wang,S., Yang,Q., Fung,K.M. and Lin,H.K.
  TITLE     AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the
            PI3K/Akt proliferative signaling pathway in human prostate cancer
            cells
  JOURNAL   Mol Cell Endocrinol 289 (1-2), 60-66 (2008)
   PUBMED   18508192
REFERENCE   7  (bases 1 to 1398)
  AUTHORS   Faucher,F., Cantin,L., Pereira de Jesus-Tran,K., Lemieux,M.,
            Luu-The,V., Labrie,F. and Breton,R.
  TITLE     Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids
            differently from other aldo-keto reductases: identification and
            characterization of amino acid residues critical for substrate
            binding
  JOURNAL   J Mol Biol 369 (2), 525-540 (2007)
   PUBMED   17442338
REFERENCE   8  (bases 1 to 1398)
  AUTHORS   Faucher,F., Pereira de Jesus-Tran,K., Cantin,L., Luu-The,V.,
            Labrie,F. and Breton,R.
  TITLE     Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase
            (apoenzyme and enzyme-NADP(H) binary complex): identification of
            molecular determinants responsible for the unique 17alpha-reductive
            activity of this enzyme
  JOURNAL   J Mol Biol 364 (4), 747-763 (2006)
   PUBMED   17034817
REFERENCE   9  (bases 1 to 1398)
  AUTHORS   Ishikura,S., Usami,N., Nakajima,S., Kameyama,A., Shiraishi,H.,
            Carbone,V., El-Kabbani,O. and Hara,A.
  TITLE     Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid
            dehydrogenases of the aldo-keto reductase family
  JOURNAL   Biol Pharm Bull 27 (12), 1939-1945 (2004)
   PUBMED   15577209
REFERENCE   10 (bases 1 to 1398)
  AUTHORS   Hara,A., Matsuura,K., Tamada,Y., Sato,K., Miyabe,Y., Deyashiki,Y.
            and Ishida,N.
  TITLE     Relationship of human liver dihydrodiol dehydrogenases to hepatic
            bile-acid-binding protein and an oxidoreductase of human colon
            cells
  JOURNAL   Biochem J 313 (Pt 2) (Pt 2), 373-376 (1996)
   PUBMED   8573067
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078957.1.
            
            On Apr 20, 2005 this sequence version replaced XM_225537.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078957.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1398
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.2"
     gene            1..1398
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /note="aldo-keto reductase family 1, member C2"
                     /db_xref="GeneID:291283"
                     /db_xref="RGD:1311841"
     exon            1..70
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /inference="alignment:Splign:2.1.0"
     exon            71..283
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1156
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /EC_number="1.1.1.209"
                     /note="17-alpha-HSD; 3-alpha-hydroxysteroid dehydrogenase;
                     17-alpha-hydroxysteroid dehydrogenase; aldo-keto reductase
                     family 1, member C21; 3(or 17)-alpha-hydroxysteroid
                     dehydrogenase; 3(17)alpha-hydroxysteroid dehydrogenase"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member C21"
                     /protein_id="NP_001013075.1"
                     /db_xref="GeneID:291283"
                     /db_xref="RGD:1311841"
                     /translation="MNSKCHCVKLNDGHFIPVLGFGTAMPSELPKSKAKEVTKIAIDA
                     GFHHFDSAFVYNTEDHVGEAIREKIANGTTRREDIFYTSKLWCTSLHPELVRSSLECS
                     LKKLQLDYVDLYLIHFPMALKPGDENFPVDEHGKLLFDTVDLCATWEAMEKCKDAGLA
                     KSIGVSNFNRRQLEKILNKPGLKYKPVCNQVECHLYLNQMKLLDFCKTNGIILVAYGV
                     LGTQRYNGWVDQNSPVLLNEPVLSSMAKKYNQTPALIALRHQLQRGIVVLNTSLKEER
                     IKENMKLSPEDMKVLDDLNRNLRYIAGGIFEGHPNFPFLDEY"
     exon            284..451
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /inference="alignment:Splign:2.1.0"
     exon            452..568
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /inference="alignment:Splign:2.1.0"
     exon            569..646
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /inference="alignment:Splign:2.1.0"
     exon            647..769
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /inference="alignment:Splign:2.1.0"
     exon            770..879
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1045
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1113
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1369
                     /gene="Akr1c2"
                     /gene_synonym="Akr1c21; RAKg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatacgtt tctcgacccc agtgcactgg tttctgtcat cccatgaaat tgcagcaagg
       61 gcagtctctt ttgtgggaac agattaactc ctacacatga tgtagattca acacctgcca
      121 ggaaagcaga agcattactt aagtgtcctg tgaaggcaaa catcaagtca attcagctta
      181 tcttgaagag tggcaaacca tgaactccaa atgtcattgt gtgaaactga acgatggtca
      241 tttcattccg gtgctgggtt ttggaactgc tatgccttca gagttaccca agagtaaagc
      301 taaggaggtc accaaaatag ctatagatgc tggtttccat cattttgatt ctgcttttgt
      361 ctacaatacc gaagatcatg taggagaggc catccgagag aagattgcca atggcactac
      421 aaggagagaa gatatatttt acacatcaaa gctttggtgt acgagccttc acccagaact
      481 ggtgagatct tccttggaat gttcactgaa gaaacttcag ttggactatg tggacctgta
      541 tctcatacat tttccgatgg ccttgaaacc aggagatgaa aattttccag tagatgaaca
      601 tggaaagtta ctatttgaca cagtagatct ctgtgctacc tgggaggcca tggagaagtg
      661 taaggatgca ggactggcca agtccatcgg ggtgtccaac tttaaccgca ggcagctgga
      721 gaagatcctg aacaagccgg ggctcaaata caagcctgtg tgcaaccagg tagaatgcca
      781 tctttatctc aaccaaatga aactgctgga tttctgcaag acaaatggca ttatactggt
      841 tgcctatgga gttctgggaa cacaacgata taacggatgg gtagaccaga actcccctgt
      901 tctcttgaat gaaccagttc ttagttccat ggcaaaaaaa tacaatcaaa ctccagcctt
      961 gattgccctt cgccatcagt tgcagcgtgg gattgtggta cttaacacca gtctcaaaga
     1021 agagcggatc aaagagaaca tgaagctgag tccagaagat atgaaagtcc ttgatgacct
     1081 gaacagaaat ttgcggtaca tagctggtgg aatatttgaa ggccacccta attttccgtt
     1141 tttggatgaa tactaacatc ttcagggaag atgtctcccg aaagacctat ggttggaaca
     1201 ctgctcagct gctgctgaga cttgtcactt gtctacagac ttgtcacttc tgctttgttg
     1261 cagttgagaa cttcctggag ctactcttca gctaagacaa aaaaaataaa taaataaaaa
     1321 taaaaataaa aataaaaaat accactctga aaacaaatta aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaaaa aaaaaaaa
//
