LOCUS       NM_001100576            1355 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus aldo-keto reductase family 1, member C19
            (Akr1c19), mRNA.
ACCESSION   NM_001100576 XM_001062695 XM_225544
VERSION     NM_001100576.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1355)
  AUTHORS   Satoshi,Endo., Matsunaga,T. and Hara,A.
  TITLE     Characterization of aldo-keto reductase 1C subfamily members
            encoded in two rat genes (akr1c19 and RGD1564865). Relationship to
            9-hydroxyprostaglandin dehydrogenase
  JOURNAL   Arch Biochem Biophys 700, 108755 (2021)
   PUBMED   33482148
  REMARK    GeneRIF: Characterization of aldo-keto reductase 1C subfamily
            members encoded in two rat genes (akr1c19 and RGD1564865).
            Relationship to 9-hydroxyprostaglandin dehydrogenase.
REFERENCE   2  (bases 1 to 1355)
  AUTHORS   Pawlowski,J., Huizinga,M. and Penning,T.M.
  TITLE     Isolation and partial characterization of a full-length cDNA clone
            for 3 alpha-hydroxysteroid dehydrogenase: a potential target enzyme
            for nonsteroidal anti-inflammatory drugs
  JOURNAL   Agents Actions 34 (1-2), 289-293 (1991)
   PUBMED   1793046
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On or before Aug 4, 2007 this sequence version replaced
            XM_225544.3, XM_001062695.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.61348.1,
                                           SRR26360172.423556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000017.1  70913916-70914027
            113-234             JAXUCZ010000017.1  70919236-70919357
            235-402             JAXUCZ010000017.1  70921487-70921654
            403-519             JAXUCZ010000017.1  70922430-70922546
            520-597             JAXUCZ010000017.1  70923807-70923884
            598-720             JAXUCZ010000017.1  70924560-70924682
            721-830             JAXUCZ010000017.1  70926018-70926127
            831-996             JAXUCZ010000017.1  70926381-70926546
            997-1079            JAXUCZ010000017.1  70933549-70933631
            1080-1355           JAXUCZ010000017.1  70934684-70934959
FEATURES             Location/Qualifiers
     source          1..1355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.2"
     gene            1..1355
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /note="aldo-keto reductase family 1, member C19"
                     /db_xref="GeneID:307096"
                     /db_xref="RGD:1562954"
     exon            1..112
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /inference="alignment:Splign:2.1.0"
     exon            113..234
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1122
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /note="NAD-preferring dehydrogenase for
                     17beta-hydroxysteroids and 9-hydroxyprostaglandins"
                     /codon_start=1
                     /product="aldo-keto reductase family 1, member C19"
                     /protein_id="NP_001094046.1"
                     /db_xref="GeneID:307096"
                     /db_xref="RGD:1562954"
                     /translation="MSSKQQLVKLNDGHFIPALGFGTYKPEEVPENKPLEAIHLAVEA
                     GFRHIDTAYVYQTENHVGQAIKSKIAAGIVKREDIFITTKLWCTFHRPEMVLSSLEKS
                     LKNLQLDYVDLYIIHYPMQMKSGEDMFPEDENGKTLFDTVDLCATWEAMEKCKDAGLA
                     KSIGVSNFNRRQLEKILNKPGLKYKPVCNQVECHLYLNQSKLLNYCKSRDIVLVAYCA
                     LGSQRPKRWVDPSSPVLLNDPVLCDVAKKHQRSSAQIALRYQLQRGNVVLAQSYKENE
                     IKENIQVFEFELPSEDMKILDSLDRNLRYAPAPFGQGHPEYPFSDEF"
     exon            235..402
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /inference="alignment:Splign:2.1.0"
     exon            403..519
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /inference="alignment:Splign:2.1.0"
     exon            520..597
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /inference="alignment:Splign:2.1.0"
     exon            598..720
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /inference="alignment:Splign:2.1.0"
     exon            721..830
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /inference="alignment:Splign:2.1.0"
     exon            831..996
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1079
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1355
                     /gene="Akr1c19"
                     /gene_synonym="RAKi; RGD1562954"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttggctg ctctctctgt tgtgcattcc atctacatta ttcacattgg aattcagaag
       61 aaccaagagt aaagctggag acctccccca ggacatctgg tgctcaatac aggagctgca
      121 gaacctgctt agaaagaaga gtggtaagca atgagttcca aacagcaact tgtaaaactg
      181 aacgatggcc acttcattcc tgcattgggc tttggcacct ataaaccgga agaggttcct
      241 gaaaataaac cactggaggc tatccattta gctgtagagg ctgggttccg ccatattgat
      301 actgcctatg tgtaccaaac tgaaaaccat gtagggcagg ctattaaaag caagattgca
      361 gctggcattg tgaaaagaga agacatattc atcactacaa agctttggtg cactttccat
      421 agaccagaga tggttctatc tagcttggaa aaatcattga aaaacctcca gctggattat
      481 gttgacctct atattataca ttatccaatg caaatgaagt cgggggaaga tatgtttcca
      541 gaagatgaga atgggaaaac attatttgac acagtggatc tctgtgccac atgggaggcc
      601 atggaaaagt gtaaggatgc gggattggcc aagtccattg gggtgtccaa ctttaaccgc
      661 aggcagctgg agaaaattct gaataagcca ggcctcaaat acaagcctgt gtgcaaccag
      721 gtggaatgcc atctctacct gaaccagagc aagctgttga actactgtaa gtcaagggac
      781 attgttctag ttgcctactg tgctcttgga tctcaacgac ctaaacgatg ggtagaccca
      841 agctccccag ttctcttgaa tgatccagtt ctttgtgatg tggcaaaaaa gcaccagcga
      901 agctctgctc agattgccct tcgctaccaa cttcaacgtg gaaatgtcgt tcttgcccag
      961 agttacaaag agaatgagat aaaagagaac atacaggtgt ttgaatttga gctgccttca
     1021 gaagatatga aaatcctaga tagcctggac agaaatttaa gatatgcacc tgctccattt
     1081 ggccagggac acccggaata tcccttttct gatgaatttt aatgtggaga cctgtgacct
     1141 gatttctcca cacagtctca atgtccccag tgcgaatgct gataggcatt acatcccaga
     1201 tgctgctgag ttgacatatt ctgtcacttc tactcagact gagctgcctg accagactct
     1261 ttcatccaga actgggtcca ccagtccaga atataaatca ttacattttc aacattcttt
     1321 gaaagaacgc ttgttataaa gttctttggt cagga
//
