LOCUS       NM_138547               2349 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Rattus norvegicus aldo-keto reductase family 1, member C14
            (Akr1c14), mRNA.
ACCESSION   NM_138547 XM_346501 XM_579650
VERSION     NM_138547.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Su,Y., Li,H., Chen,X., Wang,Y., Li,X., Sun,J. and Ge,R.S.
  TITLE     Ziram inhibits rat neurosteroidogenic 5alpha-reductase 1 and
            3alpha-hydroxysteroid dehydrogenase
  JOURNAL   Toxicol Mech Methods 28 (1), 38-44 (2018)
   PUBMED   28707553
  REMARK    GeneRIF: Ziram inhibited SRD5A1 and AKR1C14 activities, thus
            possibly interfering with neurosteroid production in rats.
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Wang,Y., Sun,J., Chen,L., Zhou,S., Lin,H., Wang,Y., Lin,N. and
            Ge,R.S.
  TITLE     Effects of resveratrol on rat neurosteroid synthetic enzymes
  JOURNAL   Fitoterapia 122, 61-66 (2017)
   PUBMED   28823883
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Guo,J., Li,L., Zhou,S., Su,Y., Li,X., Sun,J. and Ge,R.S.
  TITLE     Butylated hydroxyanisole alters rat 5alpha-reductase and
            3alpha-hydroxysteroid dehydrogenase: Implications for influences of
            neurosteroidogenesis
  JOURNAL   Neurosci Lett 653, 132-138 (2017)
   PUBMED   28552457
  REMARK    GeneRIF: Butylated hydroxyanisole alters rat 5alpha-reductase and
            3alpha-hydroxysteroid dehydrogenase: Implications for influences of
            neurosteroidogenesis.
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Kimoto,T., Ishii,H., Higo,S., Hojo,Y. and Kawato,S.
  TITLE     Semicomprehensive analysis of the postnatal age-related changes in
            the mRNA expression of sex steroidogenic enzymes and sex steroid
            receptors in the male rat hippocampus
  JOURNAL   Endocrinology 151 (12), 5795-5806 (2010)
   PUBMED   21047951
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Cheng,K.C.
  TITLE     Molecular cloning of rat liver 3alpha-hydroxysteroid dehydrogenase
            and identification of structurally related proteins from rat lung
            and kidney
  JOURNAL   J Steroid Biochem Mol Biol 43 (8), 1083-1088 (1992)
   PUBMED   22217852
  REMARK    GeneRIF: characterization of recombinant 3-alpha-hydroxysteroid
            dehydrogenase from liver: molecular weight; amino acid sequence;
            sequence alignment and homology with similar enzymes; inhibition by
            indomethacin
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Pawlowski,J., Huizinga,M. and Penning,T.M.
  TITLE     Isolation and partial characterization of a full-length cDNA clone
            for 3 alpha-hydroxysteroid dehydrogenase: a potential target enzyme
            for nonsteroidal anti-inflammatory drugs
  JOURNAL   Agents Actions 34 (1-2), 289-293 (1991)
   PUBMED   1793046
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   Stolz,A., Rahimi-Kiani,M., Ameis,D., Chan,E., Ronk,M. and
            Shively,J.E.
  TITLE     Molecular structure of rat hepatic 3 alpha-hydroxysteroid
            dehydrogenase. A member of the oxidoreductase gene family
  JOURNAL   J Biol Chem 266 (23), 15253-15257 (1991)
   PUBMED   1714456
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Cheng,K.C., White,P.C. and Qin,K.N.
  TITLE     Molecular cloning and expression of rat liver 3
            alpha-hydroxysteroid dehydrogenase
  JOURNAL   Mol Endocrinol 5 (6), 823-828 (1991)
   PUBMED   1922097
REFERENCE   9  (bases 1 to 2349)
  AUTHORS   Penning,T.M., Abrams,W.R. and Pawlowski,J.E.
  TITLE     Affinity labeling of 3 alpha-hydroxysteroid dehydrogenase with 3
            alpha-bromoacetoxyandrosterone and 11
            alpha-bromoacetoxyprogesterone. Isolation and sequence of active
            site peptides containing reactive cysteines; sequence confirmation
            using nucleotide sequence from a cDNA clone
  JOURNAL   J Biol Chem 266 (14), 8826-8834 (1991)
   PUBMED   2026597
REFERENCE   10 (bases 1 to 2349)
  AUTHORS   Pawlowski,J.E., Huizinga,M. and Penning,T.M.
  TITLE     Cloning and sequencing of the cDNA for rat liver 3
            alpha-hydroxysteroid/dihydrodiol dehydrogenase
  JOURNAL   J Biol Chem 266 (14), 8820-8825 (1991)
   PUBMED   1840601
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1 and BC091123.1.
            
            On Mar 12, 2015 this sequence version replaced NM_138547.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091123.1, M64393.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMN16676784 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                JAXUCZ010000017.1  71083170-71083184   c
            16-2349             BC091123.1         1-2334
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.2"
     gene            1..2349
                     /gene="Akr1c14"
                     /gene_synonym="Akr1c9"
                     /note="aldo-keto reductase family 1, member C14"
                     /db_xref="GeneID:191574"
                     /db_xref="RGD:708361"
     exon            1..141
                     /gene="Akr1c14"
                     /gene_synonym="Akr1c9"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1026
                     /gene="Akr1c14"
                     /gene_synonym="Akr1c9"
                     /EC_number="1.1.1.50"
                     /note="3-alpha-HSD; hydroxyprostaglandin dehydrogenase;
                     steroid 3-alpha-dehydrogenase"
                     /codon_start=1
                     /product="3-alpha-hydroxysteroid dehydrogenase"
                     /protein_id="NP_612556.1"
                     /db_xref="GeneID:191574"
                     /db_xref="RGD:708361"
                     /translation="MDSISLRVALNDGNFIPVLGFGTTVPEKVAKDEVIKATKIAIDN
                     GFRHFDSAYLYEVEEEVGQAIRSKIEDGTVKREDIFYTSKLWSTFHRPELVRTCLEKT
                     LKSTQLDYVDLYIIHFPMALQPGDIFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLA
                     KSIGVSNFNCRQLERILNKPGLKYKPVCNQVECHLYLNQSKMLDYCKSKDIILVSYCT
                     LGSSRDKTWVDQKSPVLLDDPVLCAIAKKYKQTPALVALRYQLQRGVVPLIRSFNAKR
                     IKELTQVFEFQLASEDMKALDGLNRNFRYNNAKYFDDHPNHPFTDE"
     exon            142..309
                     /gene="Akr1c14"
                     /gene_synonym="Akr1c9"
                     /inference="alignment:Splign:2.1.0"
     exon            310..426
                     /gene="Akr1c14"
                     /gene_synonym="Akr1c9"
                     /inference="alignment:Splign:2.1.0"
     exon            427..504
                     /gene="Akr1c14"
                     /gene_synonym="Akr1c9"
                     /inference="alignment:Splign:2.1.0"
     exon            505..627
                     /gene="Akr1c14"
                     /gene_synonym="Akr1c9"
                     /inference="alignment:Splign:2.1.0"
     exon            628..737
                     /gene="Akr1c14"
                     /gene_synonym="Akr1c9"
                     /inference="alignment:Splign:2.1.0"
     exon            738..903
                     /gene="Akr1c14"
                     /gene_synonym="Akr1c9"
                     /inference="alignment:Splign:2.1.0"
     exon            904..986
                     /gene="Akr1c14"
                     /gene_synonym="Akr1c9"
                     /inference="alignment:Splign:2.1.0"
     exon            987..2315
                     /gene="Akr1c14"
                     /gene_synonym="Akr1c9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttatcctg tgcaaaaaga agacccaaga cctgcttggt tgcatgagta acaagcgatg
       61 gattccatat ctctgcgtgt agcactaaat gatggtaact tcattcctgt actggggttt
      121 ggaaccactg tgcctgagaa ggttgctaag gatgaagtta tcaaggctac taaaatagct
      181 atagataatg gattccgcca ttttgactct gcttatttgt acgaagtaga agaggaagtg
      241 ggccaagcca ttagaagcaa gattgaagac ggcactgtga agagagaaga tatattctat
      301 acttcaaagc tttggagcac tttccataga ccagagctgg tccgaacttg cttggaaaag
      361 acactgaaaa gcactcaact ggactatgtg gatctttata ttattcattt cccaatggct
      421 ttgcagcctg gagatatatt tttcccacga gatgagcatg gaaaactatt gtttgaaaca
      481 gtggatatct gtgacacatg ggaggccatg gagaagtgta aggatgcagg attggccaag
      541 tctattgggg tgtccaactt taactgcagg cagctggaga ggattctgaa taagccaggg
      601 ctcaaataca agcctgtgtg caaccaggtg gaatgtcacc tttatctcaa ccagagcaaa
      661 atgctggact attgtaagtc aaaagacatc attctggttt cctactgcac gctgggaagt
      721 tcacgagaca aaacatgggt ggatcagaaa agtccagttc tcctagatga tccagttctt
      781 tgtgccatag caaagaagta caagcaaacc ccagccctag ttgcccttcg ctaccagctg
      841 cagcgtgggg ttgtgcccct gatcaggagt ttcaacgcga agcggatcaa agagctaaca
      901 caggtttttg aattccagtt ggcttcagag gacatgaaag ccctggatgg cttgaacaga
      961 aatttcagat acaacaatgc aaaatatttt gatgaccatc ccaatcatcc atttactgat
     1021 gaatagtaac atggtggact ttgtcagcat ttctatcgga agatctgttt atgcattgtg
     1081 atttgaaaga tatcttggat actggtgact gaacgcatca gaccactgtt tctgttaatt
     1141 cacagtcagc tggagcaatg tccacagtgc tatgagggaa gccatgtttt tgtcacactc
     1201 tgaaatggaa catcacgttg cttttccttg tgtttttaaa tattcattta ttttgctttc
     1261 catatatgaa tattttccct acatgtatgt gtatctcatg aatgtctatg tccatgcagg
     1321 gttgaagagt gttgcaggtc acttggaacc ggagttacat tgattatgga gttaccatgt
     1381 gggtgctggg agccaaacct aggtcttctg tgagactagc aagtgccttt gaatgctgag
     1441 ccatctcatt aggtccaacc ctaaagatcc ttgcctgcca ctatttctgt gatctcaatg
     1501 ttttgttttc tcctgacttc tgacaccaag ctgatttgct agaagtcttg ggcatgaagt
     1561 gggtgttgag gacagttatt gcaaagggat ttctgggtgg gagttgaaag aacgttcaac
     1621 attcagggaa ttaattgttc gaggttattg attagtcaat attccccata ttctttgagg
     1681 aagaagaaag tactccatag attttccctt tttcttagtt ttgaggtagg gcacctgtgg
     1741 caggagtgac caagagaccc agggttctct ccaacagccc aagaaccaga gctccaagaa
     1801 cctggagagc aagttcttgt gggaaggttg gaatgttggt aagaagagaa ccaatctaaa
     1861 agcatcatca tgattcagat gtggggagtt tgagaggaaa tttgaatgtg tctctctttt
     1921 tgggaaatat atcatctttt ttctttttgt aattacatgt tgggagcaat gcccttgaaa
     1981 ccctccatta ttgatgttat ggttagaatt aagtatgact gggttcatgg aaaatcccca
     2041 gccagctgca gaagactaat acaaatctgg tggtcaggat gaataatgat atgataaagt
     2101 tctgaccttg ctgagaaata catctgacat caagataccc aatgtgatga cctgtaagct
     2161 ttctgaaaaa ccaacatcct gttgacatca gctgactaca tgtatactgt gcccttggcc
     2221 tgtgtaaatg tttcacactt cccccctccc tctgttaccc atgttatggt ataaattcag
     2281 ccttggtaaa aaataaaatt gtcgccttga tcagaaaaaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaa
//
