LOCUS       NM_001033697            1208 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus aldo-keto reductase family 1, member C1 (Akr1c1),
            mRNA.
ACCESSION   NM_001033697 NM_001108419 XM_225538
VERSION     NM_001033697.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1208)
  AUTHORS   Zheng S, Damoiseaux R, Chen L and Black DL.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
REFERENCE   2  (bases 1 to 1208)
  AUTHORS   Ruiz FX, Porte S, Gallego O, Moro A, Ardevol A, Del Rio-Espinola A,
            Rovira C, Farres J and Pares X.
  TITLE     Retinaldehyde is a substrate for human aldo-keto reductases of the
            1C subfamily
  JOURNAL   Biochem J 440 (3), 335-344 (2011)
   PUBMED   21851338
REFERENCE   3  (bases 1 to 1208)
  AUTHORS   Bains OS, Grigliatti TA, Reid RE and Riggs KW.
  TITLE     Naturally occurring variants of human aldo-keto reductases with
            reduced in vitro metabolism of daunorubicin and doxorubicin
  JOURNAL   J Pharmacol Exp Ther 335 (3), 533-545 (2010)
   PUBMED   20837989
REFERENCE   4  (bases 1 to 1208)
  AUTHORS   Davies NJ, Hayden RE, Simpson PJ, Birtwistle J, Mayer K, Ride JP
            and Bunce CM.
  TITLE     AKR1C isoforms represent a novel cellular target for jasmonates
            alongside their mitochondrial-mediated effects
  JOURNAL   Cancer Res 69 (11), 4769-4775 (2009)
   PUBMED   19487289
REFERENCE   5  (bases 1 to 1208)
  AUTHORS   Azzarello J, Fung KM and Lin HK.
  TITLE     Tissue distribution of human AKR1C3 and rat homolog in the adult
            genitourinary system
  JOURNAL   J Histochem Cytochem 56 (9), 853-861 (2008)
   PUBMED   18574251
REFERENCE   6  (bases 1 to 1208)
  AUTHORS   Ishikura S, Matsumoto K, Sanai M, Horie K, Matsunaga T, Tajima K,
            El-Kabbani O and Hara A.
  TITLE     Molecular cloning of a novel type of rat cytoplasmic
            17beta-hydroxysteroid dehydrogenase distinct from the type 5
            isozyme
  JOURNAL   J Biochem 139 (6), 1053-1063 (2006)
   PUBMED   16788056
REFERENCE   7  (bases 1 to 1208)
  AUTHORS   Blouin K, Blanchette S, Richard C, Dupont P, Luu-The V and Tchernof
            A.
  TITLE     Expression and activity of steroid aldoketoreductases 1C in omental
            adipose tissue are positive correlates of adiposity in women
  JOURNAL   Am J Physiol Endocrinol Metab 288 (2), E398-E404 (2005)
   PUBMED   15494612
REFERENCE   8  (bases 1 to 1208)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   9  (bases 1 to 1208)
  AUTHORS   Deyashiki Y, Ohshima K, Nakanishi M, Sato K, Matsuura K and Hara A.
  TITLE     Molecular cloning and characterization of mouse estradiol 17
            beta-dehydrogenase (A-specific), a member of the aldoketoreductase
            family
  JOURNAL   J Biol Chem 270 (18), 10461-10467 (1995)
   PUBMED   7737980
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC104716.1.
            
            On or before Oct 11, 2007 this sequence version replaced
            NM_001108419.1, XM_225538.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104716.1, AB300410.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1208
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.2"
     gene            1..1208
                     /gene="Akr1c1"
                     /gene_synonym="Akr1c6; Hsd17b5"
                     /note="aldo-keto reductase family 1, member C1"
                     /db_xref="GeneID:307092"
                     /db_xref="RGD:1306847"
     exon            1..93
                     /gene="Akr1c1"
                     /gene_synonym="Akr1c6; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..981
                     /gene="Akr1c1"
                     /gene_synonym="Akr1c6; Hsd17b5"
                     /EC_number="1.1.1.149"
                     /note="type 5 17beta-hydroxysteroid dehydrogenase;
                     aldo-keto reductase family 1, member C6; aldo-keto
                     reductase family 1, member C1 (dihydrodiol dehydrogenase
                     1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)"
                     /codon_start=1
                     /product="aldo-keto reductase family 1, member C1"
                     /protein_id="NP_001028869.1"
                     /db_xref="GeneID:307092"
                     /db_xref="RGD:1306847"
                     /translation="MNSKQQTVRLSDGHFIPVLGFGTYAPREVPKSKALEATKIAIDA
                     GFRHIDSAAVYQNEKEVGLAIRSKIADGTVKREDIFYTSKVWCTFNHPERVQVCLEQS
                     LKQLQLEYVDLYLIHFPMALKPEEDLKAKDENEKLLFDVVDICDTWKAMEKCKDAGLA
                     KSIGVSNFNRRQLEKILNKPGLKHRPVCNQVECHPYLNQRKLLDFCKSKDIVLVAYSA
                     LGSHRETRCVDKSLPVLLADPVLCAIAKKYNWTPALIALRYQLERGVVVLAKSFTEKR
                     IKENMQVFEFQLTSEDMKVLDGLNKNIRYMSGSRFQGHPDFPFLDEY"
     exon            94..261
                     /gene="Akr1c1"
                     /gene_synonym="Akr1c6; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            262..378
                     /gene="Akr1c1"
                     /gene_synonym="Akr1c6; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            379..456
                     /gene="Akr1c1"
                     /gene_synonym="Akr1c6; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            457..579
                     /gene="Akr1c1"
                     /gene_synonym="Akr1c6; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            580..689
                     /gene="Akr1c1"
                     /gene_synonym="Akr1c6; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            690..855
                     /gene="Akr1c1"
                     /gene_synonym="Akr1c6; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            856..938
                     /gene="Akr1c1"
                     /gene_synonym="Akr1c6; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1182
                     /gene="Akr1c1"
                     /gene_synonym="Akr1c6; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagaagcca tgaattctaa gcagcagaca gtgcgactaa gtgatggtca cttcatccct
       61 gtactggggt ttggtaccta tgcacctcga gaggtaccta agagtaaggc tctagaagcc
      121 accaaaatag ctatagatgc tggtttccgc catatcgatt ctgctgctgt gtatcagaat
      181 gaaaaggaag taggactagc catccgaagc aagattgcag acggtactgt gaagagagag
      241 gacatatttt acacatcaaa ggtttggtgt acttttaatc atccagaacg ggtgcaggtc
      301 tgcttggaac agtcactgaa gcagctccag ttggagtacg tggatctgta cctcatccat
      361 ttcccaatgg ccctgaagcc ggaagaggat cttaaggcaa aagatgagaa tgaaaaatta
      421 ttatttgatg tagtggatat ctgtgacacc tggaaagcca tggagaagtg caaggatgca
      481 ggattggcca agtccattgg ggtgtccaac tttaaccgca ggcagctgga gaagatcctg
      541 aataagccgg ggctcaagca caggcctgtg tgcaaccagg tagaatgtca tccttatctt
      601 aaccagagaa aacttctgga tttctgcaag tctaaagaca ttgttctggt tgcttatagt
      661 gctctgggaa gccaccgtga aacaagatgt gtggacaaga gccttcctgt tcttttggct
      721 gatccagttc tttgtgccat agccaagaag tacaactgga ctccagccct gattgccctt
      781 cgttatcagc tggagcgtgg ggttgtggtc ctggctaaga gtttcactga gaagaggata
      841 aaagagaata tgcaggtttt tgaatttcag ttgacttcag aagacatgaa agtccttgat
      901 ggcctaaata aaaatatccg ttacatgagt ggttctagat tccagggcca ccctgatttt
      961 ccatttttgg atgaatatta acatggaggt ctgtgttatg ctttatgcca gaagtcactg
     1021 catgaaaaga gtatagagga tgggtcctct caaaaagtga tgattacata tcactctaat
     1081 ccatgcttat gagcaattct gcttctactg aatctacaag caaggaagca aaaactgttt
     1141 atttctcctt tctgaaaaat aaaagaatca ttttctttag caaaaaaaaa aaaaaaaaaa
     1201 aaaaaaaa
//
