LOCUS       NM_053781               1420 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus aldo-keto reductase family 1, member B7 (Akr1b7),
            mRNA.
ACCESSION   NM_053781
VERSION     NM_053781.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Weber,S., Salabei,J.K., Moller,G., Kremmer,E., Bhatnagar,A.,
            Adamski,J. and Barski,O.A.
  TITLE     Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto
            reductase with activity toward steroids and 3-keto-acyl-CoA
            conjugates
  JOURNAL   J Biol Chem 290 (10), 6531-6545 (2015)
   PUBMED   25577493
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Sundaram,K., Endo,S., Matsunaga,T., Tanaka,N., Hara,A. and
            El-Kabbani,O.
  TITLE     Structure of the His269Arg mutant of the rat aldose reductase-like
            protein AKR1B14 complexed with NADPH
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 68 (Pt 4), 400-403
            (2012)
   PUBMED   22505406
  REMARK    GeneRIF: crystal structure of the AKR1B14 His269Arg mutant in
            complex with NADPH was refined at 1.87 A degrees resolution
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Endo,S., Matsunaga,T., Fujita,A., Kuragano,T., Soda,M.,
            Sundaram,K., Dhagat,U., Tajima,K., El-Kabbani,O. and Hara,A.
  TITLE     Activation of aldo-keto reductase family member 1B14 (AKR1B14) by
            bile acids: Activation mechanism and bile acid-binding site
  JOURNAL   Biochimie 93 (9), 1476-1486 (2011)
   PUBMED   21586312
  REMARK    GeneRIF: The bile acid binding to AKR1B14 mainly accelerates the
            NADP(+) dissociation, the rate-limited step of the enzyme reaction
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Lambert-Langlais,S., Pointud,J.C., Lefrancois-Martinez,A.M.,
            Volat,F., Manin,M., Coudore,F., Val,P., Sahut-Barnola,I.,
            Ragazzon,B., Louiset,E., Delarue,C., Lefebvre,H., Urade,Y. and
            Martinez,A.
  TITLE     Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of
            adrenal endocrine functions
  JOURNAL   PLoS One 4 (10), e7309 (2009)
   PUBMED   19809495
  REMARK    GeneRIF: Aldo keto reductase 1B7 and prostaglandin F2alpha are
            regulators of adrenal endocrine functions
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Chung,R., Endo,S., Hara,A. and El-Kabbani,O.
  TITLE     Crystallization and preliminary X-ray analysis of a rat aldose
            reductase-like protein (AKR1B14)
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 65 (Pt 4), 395-397
            (2009)
   PUBMED   19342790
  REMARK    GeneRIF: AKR1B14 was crystallized from polyethylene glycol
            solutions using the hanging-drop vapour-diffusion method and an
            X-ray diffraction data set was collected to 1.86 A resolution.
REFERENCE   6  (bases 1 to 1420)
  AUTHORS   Kotokorpi,P., Gardmo,C., Nystrom,C.S. and Mode,A.
  TITLE     Activation of the glucocorticoid receptor or liver X receptors
            interferes with growth hormone-induced akr1b7 gene expression in
            rat hepatocytes
  JOURNAL   Endocrinology 145 (12), 5704-5713 (2004)
   PUBMED   15358674
  REMARK    GeneRIF: expression of akr1b7 mRNA in rat liver is sexually
            differentiated, expressed in females but not in males, and
            regulated by the sexually dimorphic secretion pattern of GH.
REFERENCE   7  (bases 1 to 1420)
  AUTHORS   Val,P., Martinez,A., Sahut-Barnola,I., Jean,C., Veyssiere,G. and
            Lefrancois-Martinez,A.M.
  TITLE     A 77-base pair LINE-like sequence elicits androgen-dependent
            mvdp/akr1-b7 expression in mouse vas deferens, but is dispensable
            for adrenal expression in rats
  JOURNAL   Endocrinology 143 (9), 3435-3448 (2002)
   PUBMED   12193556
  REMARK    GeneRIF: expression in rat vas deferens is barely detectable and is
            not androgen sensitive
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 26, 2021 this sequence version replaced NM_053781.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086563.1, AF182168.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000004.1  64043970-64044195
            227-394             JAXUCZ010000004.1  64047514-64047681
            395-511             JAXUCZ010000004.1  64048202-64048318
            512-589             JAXUCZ010000004.1  64049375-64049452
            590-712             JAXUCZ010000004.1  64051175-64051297
            713-819             JAXUCZ010000004.1  64051563-64051669
            820-901             JAXUCZ010000004.1  64052064-64052145
            902-985             JAXUCZ010000004.1  64052643-64052726
            986-1068            JAXUCZ010000004.1  64053288-64053370
            1069-1420           JAXUCZ010000004.1  64056326-64056677
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..1420
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /note="aldo-keto reductase family 1, member B7"
                     /db_xref="GeneID:116463"
                     /db_xref="RGD:620257"
     exon            1..226
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1111
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /EC_number="1.1.1.21"
                     /note="androgen regulated vas deferens protein; aldose
                     reductase-related protein 1; aldehyde reductase; aldose
                     reductase-like protein AKR1B14"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member B7"
                     /protein_id="NP_446233.2"
                     /db_xref="GeneID:116463"
                     /db_xref="RGD:620257"
                     /translation="MTTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFD
                     CAYVYQNESEVGEAIQEKIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKL
                     DYLDLYLIHWPQGLQAGKEFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVS
                     NFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDR
                     PYAKPEDPVVLEIPKIKEIAAKHKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQV
                     FDFQLSEEDMAAILSLNRNWRACGLFVTSDEEDFPFHEEY"
     exon            227..394
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            395..511
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            512..589
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            590..712
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            713..819
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            820..901
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            902..985
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1068
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1420
                     /gene="Akr1b7"
                     /gene_synonym="Akr1b14; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaataaag cgtgcattct acaccaggga ggccgcactg tgctgagtga ggctgcttgc
       61 cagtgcggtc agagtccgcc tcctctatcc aggacataaa gacttcgcca gcctcctcac
      121 agaggaagca ggcatttcat ctgcatactt tgcagcaacc atgacaacct tcgtgaagct
      181 cagaaccaaa gccaagatgc ccctggtggg cctgggcacc tggaagtctc ccccaggcca
      241 agtcaaggaa gctgtgaagg cagccattga tgctggatat cgccactttg actgtgccta
      301 tgtgtatcag aatgagagtg aggtgggaga agccatccaa gagaagatca aagagaaggc
      361 tgtgaggcgg gaggacctct tcatcgtcag caagctgtgg tccactttct ttgagaaaag
      421 cctgatgaag gaagccttcc agaaaactct ctcagatctg aagctggact atctggacct
      481 gtatctaatt cactggccac agggacttca ggctgggaaa gaattcctac ccaaagacag
      541 tcaaggcaaa gttctcatga gtaaatccac gttcttggat gcctgggagg gcatggagga
      601 actggtggac caggggctgg tgaaagcttt gggcgtctcc aacttcaacc acttccagat
      661 cgaaaggctc ctgaataagc ctggactgaa acataagcca gtgaccaatc aggtcgagtg
      721 ccacccttac ctcacccagg aaaaactgat ccagtactgt cactccaagg gcatcgcggt
      781 catagcctac agtcccctgg gctccccaga caggccttat gctaagcctg aggaccccgt
      841 agtgctagag attcccaaga tcaaagagat tgctgcaaag cataagaaaa caatagctca
      901 ggttctgatt cgattccatg tccaaaggaa cgtggcagtg atccccaagt ctgtgacact
      961 ctcacacata aaggagaaca ttcaggtctt tgacttccag ttgagtgagg aggacatggc
     1021 cgccattctc agcctcaaca ggaactggag ggcctgtggc ctgtttgtca caagcgatga
     1081 agaggacttt cctttccacg aggaatactg atgttggttc gcttgatgag attcaagccg
     1141 ggtagattcc tttgtccttg tgtgagactc actcctcctg aagcagattt tagccacgtc
     1201 tctctaaaat caacctggat gtaggctacc atttggccat gtaggattta aatttttgtg
     1261 ttcatcaagg tgcagactct cacagggaaa agtgagtcca gagaaactaa ggtcaatggt
     1321 tttcactaat gagggctgag caaatgtttc tcatcaggaa tgcattacca tggtaacact
     1381 ggagacacag agataaaaca ataaaatgta ataacagtaa
//
