LOCUS       NM_001013084            1446 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus aldo-keto reductase family 1 member B10
            (Akr1b10), mRNA.
ACCESSION   NM_001013084 XM_216117
VERSION     NM_001013084.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Torres-Mena,J.E., Salazar-Villegas,K.N., Sanchez-Rodriguez,R.,
            Lopez-Gabino,B., Del Pozo-Yauner,L., Arellanes-Robledo,J.,
            Villa-Trevino,S., Gutierrez-Nava,M.A. and Perez-Carreon,J.I.
  TITLE     Aldo-Keto Reductases as Early Biomarkers of Hepatocellular
            Carcinoma: A Comparison Between Animal Models and Human HCC
  JOURNAL   Dig Dis Sci 63 (4), 934-944 (2018)
   PUBMED   29383608
  REMARK    GeneRIF: Results demonstrate that Akr7a3 mRNA and protein levels
            are consistently co-expressed along with Akr1b10, in both
            experimental rat liver carcinogenesis and some human hepatocellular
            carcinoma samples.
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Ruiz,F.X., Porte,S., Gallego,O., Moro,A., Ardevol,A., Del
            Rio-Espinola,A., Rovira,C., Farres,J. and Pares,X.
  TITLE     Retinaldehyde is a substrate for human aldo-keto reductases of the
            1C subfamily
  JOURNAL   Biochem J 440 (3), 335-344 (2011)
   PUBMED   21851338
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Endo,S., Matsunaga,T., Ohta,C., Soda,M., Kanamori,A., Kitade,Y.,
            Ohno,S., Tajima,K., El-Kabbani,O. and Hara,A.
  TITLE     Roles of rat and human aldo-keto reductases in metabolism of
            farnesol and geranylgeraniol
  JOURNAL   Chem Biol Interact 191 (1-3), 261-268 (2011)
   PUBMED   21187079
REFERENCE   4  (bases 1 to 1446)
  AUTHORS   Bains,O.S., Grigliatti,T.A., Reid,R.E. and Riggs,K.W.
  TITLE     Naturally occurring variants of human aldo-keto reductases with
            reduced in vitro metabolism of daunorubicin and doxorubicin
  JOURNAL   J Pharmacol Exp Ther 335 (3), 533-545 (2010)
   PUBMED   20837989
REFERENCE   5  (bases 1 to 1446)
  AUTHORS   Endo,S., Matsunaga,T., Kuragano,T., Ohno,S., Kitade,Y., Tajima,K.,
            El-Kabbani,O. and Hara,A.
  TITLE     Properties and tissue distribution of a novel aldo-keto reductase
            encoding in a rat gene (Akr1b10)
  JOURNAL   Arch Biochem Biophys 503 (2), 230-237 (2010)
   PUBMED   20709016
  REMARK    GeneRIF: Properties and tissue distribution of a novel carbonyl
            reductase (NADPH) encoding in a rat gene are reported.
REFERENCE   6  (bases 1 to 1446)
  AUTHORS   Jin,Y. and Penning,T.M.
  TITLE     Aldo-keto reductases and bioactivation/detoxication
  JOURNAL   Annu Rev Pharmacol Toxicol 47, 263-292 (2007)
   PUBMED   16970545
  REMARK    Review article
REFERENCE   7  (bases 1 to 1446)
  AUTHORS   Murata,C., Taniyama,M., Kuriyama,S., Muramatsu,T., Atsumi,Y.,
            Matsuoka,K. and Suzuki,Y.
  TITLE     Meta-analysis of three diabetes population studies: association of
            inactive ALDH2 genotype with maternal inheritance of diabetes
  JOURNAL   Diabetes Res Clin Pract 66 Suppl 1, S145-S147 (2004)
   PUBMED   15563966
REFERENCE   8  (bases 1 to 1446)
  AUTHORS   Suzuki,Y., Taniyama,M., Muramatsu,T., Higuchi,S., Ohta,S.,
            Atsumi,Y. and Matsuoka,K.
  TITLE     ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy
            in type 2 diabetes
  JOURNAL   Alcohol Clin Exp Res 28 (8 Suppl Proceedings), 111S-116S (2004)
   PUBMED   15318096
REFERENCE   9  (bases 1 to 1446)
  AUTHORS   Crosas,B., Hyndman,D.J., Gallego,O., Martras,S., Pares,X.,
            Flynn,T.G. and Farres,J.
  TITLE     Human aldose reductase and human small intestine aldose reductase
            are efficient retinal reductases: consequences for retinoid
            metabolism
  JOURNAL   Biochem J 373 (Pt 3), 973-979 (2003)
   PUBMED   12732097
REFERENCE   10 (bases 1 to 1446)
  AUTHORS   Suzuki,Y., Matsuura,N., Suzuki,S., Muramatsu,T., Taniyama,M.,
            Ohta,S., Higuchi,S., Tsukahara,M., Atusmi,Y. and Matsuoka,K.
  TITLE     Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus
  JOURNAL   Diabetes Res Clin Pract 60 (2), 139-141 (2003)
   PUBMED   12706323
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079133.1.
            
            On Apr 20, 2005 this sequence version replaced XM_216117.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079133.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..1446
                     /gene="Akr1b10"
                     /note="aldo-keto reductase family 1 member B10"
                     /db_xref="GeneID:296972"
                     /db_xref="RGD:1308277"
     exon            1..37
                     /gene="Akr1b10"
                     /inference="alignment:Splign:2.1.0"
     exon            38..239
                     /gene="Akr1b10"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1124
                     /gene="Akr1b10"
                     /EC_number="1.1.1.2"
                     /note="aldo-keto reductase family 1, member B10 (aldose
                     reductase); aldose reductase-related protein 1-like"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member B10"
                     /protein_id="NP_001013102.1"
                     /db_xref="GeneID:296972"
                     /db_xref="RGD:1308277"
                     /translation="MAAFVKLSTKAKMPIVGLGTWKSPPDKVKEAVKAAIDAGYRHFD
                     CAYVYQNESEVGEAIQEKIKEKAVRREDLFIVSKLWPTFFEKSLVKKAFQKTLLDLKL
                     DYLDLYLIHWPQGFQSGNVFLPTDDKGNVLTSKYTFLDAWEGMEELVDQGLVKALGVS
                     NFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGIVVTAYSPLGSPDR
                     PSAKPEDPVLLEIPKIKEIASKHKKTAAQVLIRFHIERNVAVIPKSVTPSRIQENIQV
                     FDFQLSEEDMAAILSFNRNWRACGLFAASRNEDFPFHSEY"
     exon            240..407
                     /gene="Akr1b10"
                     /inference="alignment:Splign:2.1.0"
     exon            408..524
                     /gene="Akr1b10"
                     /inference="alignment:Splign:2.1.0"
     exon            525..602
                     /gene="Akr1b10"
                     /inference="alignment:Splign:2.1.0"
     exon            603..725
                     /gene="Akr1b10"
                     /inference="alignment:Splign:2.1.0"
     exon            726..832
                     /gene="Akr1b10"
                     /inference="alignment:Splign:2.1.0"
     exon            833..914
                     /gene="Akr1b10"
                     /inference="alignment:Splign:2.1.0"
     exon            915..998
                     /gene="Akr1b10"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1081
                     /gene="Akr1b10"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1421
                     /gene="Akr1b10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctcttta atcccagttc ttgggaagca gaagaagtgc ccgcccctag gctgtagctg
       61 cttgccagta ggaagaagag cctgtctcct caaggacacg gaaccagtcg ccagattcct
      121 aatttgggcc agagtcgtct gtctgctacc tttgaaccgt ttctgcagca aacatggccg
      181 ccttcgtgaa gctcagtacc aaagccaaga tgcccattgt gggcctgggc acctggaagt
      241 ctcccccaga taaagtcaag gaagctgtga aggcagccat tgatgctgga tatcgccact
      301 ttgactgtgc ctatgtgtat cagaacgaga gtgaggtggg agaagccatc caagagaaga
      361 tcaaagagaa ggctgtgagg agggaggacc tcttcatcgt cagcaagctg tggcccacct
      421 tctttgagaa aagcctggtg aagaaagcct tccagaaaac cctcttggat ctgaagctgg
      481 actatctgga cctgtatcta attcactggc cacagggatt tcagtctgga aatgtctttt
      541 tacccacaga tgataaaggc aatgttctca ccagtaaata tacattcttg gatgcttggg
      601 agggcatgga ggaactggtg gaccaggggc tggtgaaagc tctgggcgtc tccaacttca
      661 accacttcca gatcgaaagg ctcctgaaca agcctggact gaaacataag ccagtgacca
      721 accaggtcga gtgccaccct tacctcaccc aggaaaaact gatccagtac tgtcactcca
      781 agggcatcgt ggtcacagcc tacagtcccc tgggctcccc agacaggcct agtgccaagc
      841 ctgaggaccc tgtattgctg gagattccca agattaaaga aattgcttca aagcacaaga
      901 aaactgcagc ccaggttctg atccggttcc atatagagag gaacgtggcc gtgatcccca
      961 agtctgtgac accctcccgc atacaagaga acattcaggt ctttgacttc cagttgagtg
     1021 aggaggacat ggccgccatt ctcagcttca acaggaactg gagggcctgt ggcctgtttg
     1081 cggcaagtcg taatgaagac ttccctttcc actcggaata ctgaagctga attacctgat
     1141 gcgttcccgt ggaggacact cttcactgat ttccaaccta cccctcctga atcctatttc
     1201 ttgccaagcc tatcggatat cataccgggc cagccgtgat agggtaattc tcatttacat
     1261 tcttgtgttc aactagaatc agactgacac aggaaaatgc aactcggcaa aggacaatgt
     1321 tgttcactaa tttgacctga ctgaatgttt cccagacacc aggagcacta gttaacactg
     1381 aagcttaaaa ggataaaata gtaaaagtag caatagtcat aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaa
//
