LOCUS       NM_012498               1339 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus aldo-keto reductase family 1 member B1 (Akr1b1),
            mRNA.
ACCESSION   NM_012498
VERSION     NM_012498.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1339)
  AUTHORS   Li,L., Ling,Z., Wang,X., Zhang,X., Li,Y. and Gao,G.
  TITLE     Proteomics-based screening of AKR1B1 as a therapeutic target and
            validation study for sepsis-associated acute kidney injury
  JOURNAL   PeerJ 12, e16709 (2024)
   PUBMED   38188141
  REMARK    GeneRIF: Proteomics-based screening of AKR1B1 as a therapeutic
            target and validation study for sepsis-associated acute kidney
            injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1339)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1339)
  AUTHORS   Thiagarajan,R., Varsha,M.K.N.S., Srinivasan,V., Ravichandran,R. and
            Saraboji,K.
  TITLE     Vitamin K1 prevents diabetic cataract by inhibiting lens aldose
            reductase 2 (ALR2) activity
  JOURNAL   Sci Rep 9 (1), 14684 (2019)
   PUBMED   31604989
  REMARK    GeneRIF: Vitamin K1 prevents diabetic cataract by inhibiting lens
            aldose reductase 2 (ALR2) activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1339)
  AUTHORS   Chen,X., Chen,C., Hao,J., Qin,R., Qian,B., Yang,K., Zhang,J. and
            Zhang,F.
  TITLE     AKR1B1 Upregulation Contributes to Neuroinflammation and Astrocytes
            Proliferation by Regulating the Energy Metabolism in Rat Spinal
            Cord Injury
  JOURNAL   Neurochem Res 43 (8), 1491-1499 (2018)
   PUBMED   29948725
  REMARK    GeneRIF: AKR1B1 played a vital role in astrocyte proliferation and
            energy metabolism induced by spinal cord injury.
            Review article
REFERENCE   5  (bases 1 to 1339)
  AUTHORS   El Gamal,H., Eid,A.H. and Munusamy,S.
  TITLE     Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat
            against High Glucose-Induced Cellular Injury
  JOURNAL   Biomed Res Int 2017, 5903105 (2017)
   PUBMED   28386557
  REMARK    GeneRIF: Coincubation of cells with epalrestat prevented the
            signaling changes and renal cell injury induced by high glucose.
            Thus, aldose reductase inhibition represents a potential
            therapeutic strategy to prevent Diabetic nephropathy
            Erratum:[Biomed Res Int. 2019 Aug 22;2019:9406241. doi:
            10.1155/2019/9406241.. PMID: 31534968]
REFERENCE   6  (bases 1 to 1339)
  AUTHORS   Grimshaw,C.E.
  TITLE     Aldose reductase: model for a new paradigm of enzymic perfection in
            detoxification catalysts
  JOURNAL   Biochemistry 31 (42), 10139-10145 (1992)
   PUBMED   1420136
  REMARK    Review article
REFERENCE   7  (bases 1 to 1339)
  AUTHORS   Schwartz,G.J., Zavilowitz,B.J., Radice,A.D., Garcia-Perez,A. and
            Sands,J.M.
  TITLE     Maturation of aldose reductase expression in the neonatal rat inner
            medulla
  JOURNAL   J Clin Invest 90 (4), 1275-1283 (1992)
   PUBMED   1401064
REFERENCE   8  (bases 1 to 1339)
  AUTHORS   Graham,C., Szpirer,C., Levan,G. and Carper,D.
  TITLE     Characterization of the aldose reductase-encoding gene family in
            rat
  JOURNAL   Gene 107 (2), 259-267 (1991)
   PUBMED   1748296
REFERENCE   9  (bases 1 to 1339)
  AUTHORS   Powell,H.C., Garrett,R.S., Kador,P.F. and Mizisin,A.P.
  TITLE     Fine-structural localization of aldose reductase and
            ouabain-sensitive, K(+)-dependent p-nitro-phenylphosphatase in rat
            peripheral nerve
  JOURNAL   Acta Neuropathol 81 (5), 529-539 (1991)
   PUBMED   1650113
REFERENCE   10 (bases 1 to 1339)
  AUTHORS   Old,S.E., Sato,S., Kador,P.F. and Carper,D.A.
  TITLE     In vitro expression of rat lens aldose reductase in Escherichia
            coli
  JOURNAL   Proc Natl Acad Sci U S A 87 (13), 4942-4945 (1990)
   PUBMED   2114645
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M60322.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X05884.1, BC062034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1339
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..1339
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /note="aldo-keto reductase family 1 member B1"
                     /db_xref="GeneID:24192"
                     /db_xref="RGD:2092"
     exon            1..104
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..989
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /EC_number="1.1.1.21"
                     /EC_number="1.1.1.300"
                     /EC_number="1.1.1.54"
                     /EC_number="1.1.1.372"
                     /note="aldose reductase; AR; Aldehyde reductase 1 (low Km
                     aldose reductase) (5.8 kb PstI fragment, probably the
                     functional gene); aldo-keto reductase family 1 member B"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member B1"
                     /protein_id="NP_036630.1"
                     /db_xref="GeneID:24192"
                     /db_xref="RGD:2092"
                     /translation="MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHID
                     CAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQL
                     DYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVS
                     NFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDR
                     PWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKV
                     FDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV"
     exon            105..272
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /inference="alignment:Splign:2.1.0"
     exon            273..389
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /inference="alignment:Splign:2.1.0"
     exon            390..467
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /inference="alignment:Splign:2.1.0"
     exon            468..590
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /inference="alignment:Splign:2.1.0"
     exon            591..697
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /inference="alignment:Splign:2.1.0"
     exon            698..779
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /inference="alignment:Splign:2.1.0"
     exon            780..863
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /inference="alignment:Splign:2.1.0"
     exon            864..946
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1339
                     /gene="Akr1b1"
                     /gene_synonym="Akr1b3; Akr1b4; Aldr1; ALDRED; Alr;
                     ALR-P-I; RATALDRED"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcactcttgc gggtcgttgt gcgtaacttg cagcaatcat ggctagccat ctggaactca
       61 acaacggcac caagatgccc accctgggtc tgggcacctg gaagtctcct cctggccagg
      121 tgaccgaggc tgtgaaggtt gctatcgaca tggggtatcg ccacattgac tgcgcccagg
      181 tgtaccagaa tgagaaggag gtgggggtgg ccctccagga gaagctcaag gagcaggtgg
      241 tgaagcgcca ggatctcttc attgtcagca agctgtggtg cacgttccac gaccagagca
      301 tggtgaaagg ggcctgccag aagacgctga gcgacctgca gctggactac ctggacctct
      361 accttattca ctggccaact ggcttcaagc ctgggcctga ctatttcccc ctggatgcat
      421 cgggaaacgt gattcctagt gacaccgatt ttgtggacac ttggacggct atggagcaac
      481 tagtggatga aggtttggta aaagcaatcg gagtctccaa cttcaaccct cttcagattg
      541 agaggatctt gaacaaacct ggcttaaagt ataagcctgc tgttaaccag atcgagtgcc
      601 acccatacct aactcaggag aagctgattg agtactgcca ttgcaaaggc atcgtggtga
      661 ctgcatacag tccccttggt tctcctgaca ggccctgggc caagcctgag gacccctctc
      721 tcctggagga tcccaggatc aaggaaattg cagccaagta caataaaact acagcccagg
      781 tgctgatccg gttccccatc caaaggaacc tggtcgtgat ccccaagtct gtgacaccag
      841 cacgtattgc tgagaacttt aaggtctttg actttgagct gagcaatgag gacatggcca
      901 ctctactcag ctacaacagg aactggaggg tgtgcgcctt gatgagctgt gccaaacaca
      961 aggattaccc cttccacgca gaagtctgaa gctgtggtgg acgaatcctg ctcctcccca
     1021 agcgacttaa cacatgttct ttctgcctca tctgcccttg caagtgtccc tctgcactgg
     1081 gtggcacctt gcagaccaga tggtgagagt ttgttagttt gacgtagaat gtggagggca
     1141 gtaccagtag ctgaggagtt tcttcggcct ttcttggtct tcttcccacc tggaggactt
     1201 taacacgagt accttttcca accaaagaga aagcaagatt tatagcccaa gtcatgccac
     1261 taacacttaa atttgagtgc ttagaactcc agtcctatgg gggtcagact ttttgcctca
     1321 aataaaaact gcttttgtg
//
