LOCUS       NM_022680               2595 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus alkaline phosphatase 3, intestine, not Mn
            requiring (Akp3), mRNA.
ACCESSION   NM_022680
VERSION     NM_022680.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2595)
  AUTHORS   Kaliannan,K., Hamarneh,S.R., Economopoulos,K.P., Nasrin Alam,S.,
            Moaven,O., Patel,P., Malo,N.S., Ray,M., Abtahi,S.M., Muhammad,N.,
            Raychowdhury,A., Teshager,A., Mohamed,M.M., Moss,A.K., Ahmed,R.,
            Hakimian,S., Narisawa,S., Millan,J.L., Hohmann,E., Warren,H.S.,
            Bhan,A.K., Malo,M.S. and Hodin,R.A.
  TITLE     Intestinal alkaline phosphatase prevents metabolic syndrome in mice
  JOURNAL   Proc Natl Acad Sci U S A 110 (17), 7003-7008 (2013)
   PUBMED   23569246
REFERENCE   2  (bases 1 to 2595)
  AUTHORS   De Lisle,R.C., Mueller,R. and Boyd,M.
  TITLE     Impaired mucosal barrier function in the small intestine of the
            cystic fibrosis mouse
  JOURNAL   J Pediatr Gastroenterol Nutr 53 (4), 371-379 (2011)
   PUBMED   21970994
REFERENCE   3  (bases 1 to 2595)
  AUTHORS   Nakano,T., Inoue,I., Koyama,I., Kanazawa,K., Nakamura,K.,
            Narisawa,S., Tanaka,K., Akita,M., Masuyama,T., Seo,M., Hokari,S.,
            Katayama,S., Alpers,D.H., Millan,J.L. and Komoda,T.
  TITLE     Disruption of the murine intestinal alkaline phosphatase gene Akp3
            impairs lipid transcytosis and induces visceral fat accumulation
            and hepatic steatosis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 292 (5), G1439-G1449 (2007)
   PUBMED   17332477
REFERENCE   4  (bases 1 to 2595)
  AUTHORS   Harada,T., Koyama,I., Matsunaga,T., Kikuno,A., Kasahara,T.,
            Hassimoto,M., Alpers,D.H. and Komoda,T.
  TITLE     Characterization of structural and catalytic differences in rat
            intestinal alkaline phosphatase isozymes
  JOURNAL   FEBS J 272 (10), 2477-2486 (2005)
   PUBMED   15885097
  REMARK    GeneRIF: These data are consistent with the presence of a triad of
            zinc atoms at the active site of rat intestinal alkaline
            phosphatase isozymes rIAP-I, but not rIAP-II or human placental
            alkaline phosphatase.
REFERENCE   5  (bases 1 to 2595)
  AUTHORS   Xie,Q. and Alpers,D.H.
  TITLE     The two isozymes of rat intestinal alkaline phosphatase are
            products of two distinct genes
  JOURNAL   Physiol Genomics 3 (1), 1-8 (2000)
   PUBMED   11015594
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2595)
  AUTHORS   Goseki-Sone,M., Oida,S., Iimura,T., Yamamoto,A., Matsumoto,H.N.,
            Omi,N., Takeda,K., Maruoka,Y., Ezawa,I. and Sasaki,S.
  TITLE     Expression of mRNA encoding intestinal type alkaline phosphatase in
            rat liver and its increase by fat-feeding
  JOURNAL   Liver 16 (6), 358-364 (1996)
   PUBMED   9021713
REFERENCE   7  (bases 1 to 2595)
  AUTHORS   Engle,M.J., Mahmood,A. and Alpers,D.H.
  TITLE     Two rat intestinal alkaline phosphatase isoforms with different
            carboxyl-terminal peptides are both membrane-bound by a glycan
            phosphatidylinositol linkage
  JOURNAL   J Biol Chem 270 (20), 11935-11940 (1995)
   PUBMED   7744844
REFERENCE   8  (bases 1 to 2595)
  AUTHORS   Engle,M.J. and Alpers,D.H.
  TITLE     The two mRNAs encoding rat intestinal alkaline phosphatase
            represent two distinct nucleotide sequences
  JOURNAL   Clin Chem 38 (12), 2506-2509 (1992)
   PUBMED   1458592
REFERENCE   9  (bases 1 to 2595)
  AUTHORS   Strom,M., Krisinger,J. and DeLuca,H.F.
  TITLE     Isolation of a mRNA that encodes a putative intestinal alkaline
            phosphatase regulated by 1,25-dihydroxyvitamin D-3
  JOURNAL   Biochim Biophys Acta 1090 (3), 299-304 (1991)
   PUBMED   1954251
REFERENCE   10 (bases 1 to 2595)
  AUTHORS   Yang,W.J., Matsuda,Y., Sano,S., Masutani,H. and Nakagawa,H.
  TITLE     Purification and characterization of phytase from rat intestinal
            mucosa
  JOURNAL   Biochim Biophys Acta 1075 (1), 75-82 (1991)
   PUBMED   1654110
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 15, 2021 this sequence version replaced NM_022680.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000009.1  95252581-95252716
            137-253             JAXUCZ010000009.1  95252800-95252916
            254-369             JAXUCZ010000009.1  95253026-95253141
            370-544             JAXUCZ010000009.1  95253288-95253462
            545-717             JAXUCZ010000009.1  95253540-95253712
            718-852             JAXUCZ010000009.1  95254145-95254279
            853-925             JAXUCZ010000009.1  95254362-95254434
            926-1060            JAXUCZ010000009.1  95254558-95254692
            1061-1252           JAXUCZ010000009.1  95254766-95254957
            1253-1366           JAXUCZ010000009.1  95255188-95255301
            1367-2595           JAXUCZ010000009.1  95255388-95256616
FEATURES             Location/Qualifiers
     source          1..2595
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..2595
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /note="alkaline phosphatase 3, intestine, not Mn
                     requiring"
                     /db_xref="GeneID:64621"
                     /db_xref="RGD:621650"
     exon            1..136
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1746
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /EC_number="3.1.3.1"
                     /note="Intestinal alkaline phosphatase 2; Intestinal
                     alkaline phosphatase II; Intestinal-type alkaline
                     phosphatase 2; putative alkaline phosphatase; intestinal
                     alkaline phosphatase-II (IAP-II)"
                     /codon_start=1
                     /product="intestinal-type alkaline phosphatase 2
                     precursor"
                     /protein_id="NP_073171.2"
                     /db_xref="GeneID:64621"
                     /db_xref="RGD:621650"
                     /translation="MQGAWVLLLLGFRLQLSLSVIPVEEENPAFWNQKAADALNVAKK
                     LQPIQTSAKNLIIFLGDGMGVPTVTATRILKGQLEGNLGPETPLAMDHFPYMALSKTY
                     SVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQCNTTFGNEVLSVMYRAKKAGK
                     SVGVVTTTRVQHASPAGTYVHTVNRNWYGDADMPASALQEGCKDIATQLVSNMDINVI
                     LGGGRKYMFPAGTPDPEYPNDVNETGTRLDGKNLVQEWLSKHQGSQYVWNRQELIQKS
                     LDPSVTYLMGLFEPVDTKFEIQRDPLMDPSLKDMTEAALHVLSRNPKGFYLFVEGGRI
                     DRGHHLGTAYLALTEAVMFDSAIERASQLTSEQDTLTIVTADHSHVFSFGGYTLRGTS
                     IFGLAPLNALDGKPYTSILYGNGPGYVGTGERPNVTDAESHDPSYQQQAAVPVKSETH
                     GGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQ
                     NSTTTTTTTTTTTTTRVQNSASSLGPATGPLALALLAKALMLLLGAPADF"
     exon            137..253
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            254..369
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            370..544
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            545..717
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            718..852
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            853..925
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1060
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1252
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1366
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..2595
                     /gene="Akp3"
                     /gene_synonym="Alpi2; IAP-2; IAP-II"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgtgcttt cgttgatccc ctggtgtccc agctcctcgt ctgttgcagc cccaccacca
       61 gacccagcca tgcagggcgc ctgggtgctg ctgctgctgg gcttcaggct acaactgtcc
      121 cttagcgtca ttccagtgga ggaggagaac ccagcattct ggaaccagaa ggcagccgat
      181 gccctgaatg ttgccaagaa gctgcagccc attcagacgt cagccaagaa cctcatcatc
      241 ttcctgggtg atgggatggg ggtgcccaca gtgacagcta ctcggatcct aaagggacag
      301 ttggaaggta atctaggacc tgagacacct ctagccatgg accacttccc atatatggct
      361 ctgtccaaga catacagtgt ggacagacag gtcccagaca gtgcaagcac agccaccgcc
      421 tacctatgtg gggtcaagac gaactacaag accattggtg tgagcgcggc agcacgattt
      481 gaccagtgca acaccacatt tggcaacgag gtcctctctg tgatgtatcg tgccaaaaaa
      541 gcaggaaaat ccgtaggcgt ggtgaccacc accagggtgc agcacgcatc tccagcaggc
      601 acctatgttc acactgtgaa ccgcaattgg tacggggatg cggatatgcc tgcctctgca
      661 ctgcaggagg gctgcaagga cattgctaca caactcgtct ccaacatgga cattaacgtg
      721 atccttggtg ggggccgaaa atacatgttt cctgcaggaa ccccagaccc tgagtatccg
      781 aatgatgtta atgagactgg aaccagactg gacggcaaga acctggtgca ggaatggctg
      841 tcaaagcacc agggttccca gtatgtttgg aatcgccaag agctcattca gaagtccctg
      901 gatccatcag tgacgtatct catgggcctc tttgagcctg tagacacaaa attcgagatt
      961 caacgagacc ccctgatgga cccatctctg aaggatatga cagaggcagc cctgcatgtg
     1021 ctaagcagga accccaaagg cttctatcta tttgtggagg ggggccggat cgaccgcggt
     1081 caccatctgg gcacagctta tctggcgctg actgaagctg tgatgttcga ctcagccatc
     1141 gagagggcca gccagctcac tagtgagcag gacactctga ccatagtcac tgctgaccac
     1201 tcccatgtct tctcctttgg tggctacaca cttcgaggga cctccatctt tgggctggct
     1261 cccctcaatg ctctggatgg caagccctac acctccatcc tgtatggcaa tggcccaggc
     1321 tatgtcggta caggggaaag acccaacgtc accgatgctg aaagccatga cccatcgtac
     1381 cagcagcagg ctgctgtgcc ggtgaagtcg gagacccacg gtggggagga cgtggctata
     1441 ttcgcacgtg gcccgcaggc gcacttgcta cacggagtgc aggaacagaa ctacatcgcg
     1501 cacgtcatgg ccttcgcagg ctgcctggag ccctacaccg actgtggcct ggcgccccct
     1561 gcagacgaga acagaccaac caccccggtc cagaacagca ccactaccac caccaccacc
     1621 accaccacca ctaccacccg ggtccagaac agcgccagta gcctgggtcc agccaccggc
     1681 ccactggccc tggcactact ggccaaggcg ctgatgctac tactgggggc tcctgctgat
     1741 ttctaaactc caactcagcc agggtccacc caccaggtgt ctgctctctc accaggtcct
     1801 tctgctccct gacctcccac taatgtctcc tcatggtccc ctccccaact gcgcccttac
     1861 ccagtgctcc ctgcatgctg gctgtgggct ctaccccagg atcctctcgc tttcttctag
     1921 tggcctcaac gcttagccct acttagggtt gcagcttcta ggcccctgcc caggcattca
     1981 caagggggtg atcacctctg aggtagcagc cagcctcaga tcccacagag ctagctcctt
     2041 cccagacagc atgaccacca cagctctgag gctcggacct cacgggacag tcccaactct
     2101 ccttttgcct tcatccacca gcccctagca acacaggatc ccagcaataa tttgtgaagg
     2161 agtaaacatg catctaccca ttgatcctct cttcaggctt ggatccatcc ctgcaggctc
     2221 tggacccagg actaagacat aaggaagagg ctagcttctc atcactcctc agtctagtct
     2281 gatggcaggc agcaaggttg ctgtgctggt ttcccctagc cagcctttga cacagtcctt
     2341 cctcaccgtc actgggccag gtccacactc agaacccttc atgggcacag ccacaccaat
     2401 ccatagagcg gaagcttctg gagtccttca gcccttccac gtctttcact cagctaggaa
     2461 atgcaaggag ctgtatcccc cgccaccact cccaggtcat ctcaggctgc acctaaattt
     2521 ctgaaagccc ctcacttcct aggtctacat tcccctggga gagacagacc aataataaag
     2581 tattgtgcaa tacga
//
